BACKGROUND IgE plays a critical role in allergic inflammation and asthma pathogenesis.This study investigates the involvement of IgE cells in asthma exacerbation and evaluates the effectiveness of targeted interventio...BACKGROUND IgE plays a critical role in allergic inflammation and asthma pathogenesis.This study investigates the involvement of IgE cells in asthma exacerbation and evaluates the effectiveness of targeted interventions.AIM To evaluate the role of IgE in the exacerbation of allergic asthma and to determine the clinical efficacy of anti-IgE therapy in improving disease outcomes.Specifically,the study investigates changes in serum IgE levels,lung function,asthma control scores,and the frequency of acute exacerbations among patients receiving standard therapy with or without anti-IgE intervention.METHODS A total of 200 patients diagnosed with moderate to severe asthma were enrolled in this experimental study conducted from April 2024 to April 2025.Participants were randomized to receive either standard asthma therapy or therapy combined with anti-IgE agents.IgE levels and asthma control parameters were monitored.RESULTS Participants receiving anti-IgE treatment demonstrated a significant reduction in serum IgE levels(P<0.001),improved Forced expiratory volume in one second scores,and fewer exacerbation episodes compared to the control group.CONCLUSION IgE cells significantly contribute to asthma severity,and targeted therapy against IgE can improve disease outcomes.These findings underscore the importance of immunomodulatory strategies in asthma management.展开更多
目的:探讨通辽地区支气管哮喘患者过敏原、呼出气一氧化氮(FeNO)、血清总免疫球蛋E (IgE)等因素的特点。方法:选取2019年1月~2024年4月就诊于内蒙古民族大学附属医院的支气管哮喘患者共94例,采用过敏原检测仪检测患者过敏原、血清FeNO、...目的:探讨通辽地区支气管哮喘患者过敏原、呼出气一氧化氮(FeNO)、血清总免疫球蛋E (IgE)等因素的特点。方法:选取2019年1月~2024年4月就诊于内蒙古民族大学附属医院的支气管哮喘患者共94例,采用过敏原检测仪检测患者过敏原、血清FeNO、总IgE的特点,为本地区哮喘的临床诊治及预防提供依据。结果:吸入性过敏原以豚草、艾蒿和苦艾最多,占37.0%;在食入性过敏原中,虾类、螃蟹类、扇贝类检出率最高,占11.1%。不同性别过敏原阳性率比较差异无显著性。在94名患有支气管哮喘的病人中,总共38例患者完成了FeNO的检测。38例支气管哮喘患者中,血清总IgE浓度 Objective: To investigate the characteristics of allergens, exhaled nitric oxide (FeNO) and serum total immune globule E (IgE) in patients with bronchial asthma in Tongliao area. Methods: A total of 94 patients with bronchial asthma admitted to the Affiliated Hospital of Inner Mongolia Minzu University from January 2019 to April 2024 were selected. Allergen detector was used to detect the characteristics of allergens, serum FeNO and total IgE in the patients, providing evidence for the clinical diagnosis, treatment and prevention of asthma in this region. Results: Ragweed, mugwort and absinthe were the most inhaled allergens, accounting for 37.0%. Among the ingestion allergens, shrimp, crab and scallop had the highest detection rate, accounting for 11.1%. There was no significant difference in the positive rate of different sex allergens. Of 94 patients with bronchial asthma, a total of 38 patients completed FeNO testing. In 38 patients with bronchial asthma, FeNO levels in patients with serum total IgE concentration < 100 IU/mL were significantly lower than those in patients with serum total IgE concentration of 100~200 IU/mL. Conclusion: Ragweed, mugwort and wormwood were the main inhalation allergens, and shrimp, crab and scallop were the main ingestion allergens in Tongliao area. The positive rate of inhalation allergens was significantly higher than that of food allergens in adult patients with bronchial asthma. In patients with allergen-positive asthma, there is a simultaneous change between total IgE and FeNO in the serum.展开更多
文摘BACKGROUND IgE plays a critical role in allergic inflammation and asthma pathogenesis.This study investigates the involvement of IgE cells in asthma exacerbation and evaluates the effectiveness of targeted interventions.AIM To evaluate the role of IgE in the exacerbation of allergic asthma and to determine the clinical efficacy of anti-IgE therapy in improving disease outcomes.Specifically,the study investigates changes in serum IgE levels,lung function,asthma control scores,and the frequency of acute exacerbations among patients receiving standard therapy with or without anti-IgE intervention.METHODS A total of 200 patients diagnosed with moderate to severe asthma were enrolled in this experimental study conducted from April 2024 to April 2025.Participants were randomized to receive either standard asthma therapy or therapy combined with anti-IgE agents.IgE levels and asthma control parameters were monitored.RESULTS Participants receiving anti-IgE treatment demonstrated a significant reduction in serum IgE levels(P<0.001),improved Forced expiratory volume in one second scores,and fewer exacerbation episodes compared to the control group.CONCLUSION IgE cells significantly contribute to asthma severity,and targeted therapy against IgE can improve disease outcomes.These findings underscore the importance of immunomodulatory strategies in asthma management.
文摘目的:探讨通辽地区支气管哮喘患者过敏原、呼出气一氧化氮(FeNO)、血清总免疫球蛋E (IgE)等因素的特点。方法:选取2019年1月~2024年4月就诊于内蒙古民族大学附属医院的支气管哮喘患者共94例,采用过敏原检测仪检测患者过敏原、血清FeNO、总IgE的特点,为本地区哮喘的临床诊治及预防提供依据。结果:吸入性过敏原以豚草、艾蒿和苦艾最多,占37.0%;在食入性过敏原中,虾类、螃蟹类、扇贝类检出率最高,占11.1%。不同性别过敏原阳性率比较差异无显著性。在94名患有支气管哮喘的病人中,总共38例患者完成了FeNO的检测。38例支气管哮喘患者中,血清总IgE浓度 Objective: To investigate the characteristics of allergens, exhaled nitric oxide (FeNO) and serum total immune globule E (IgE) in patients with bronchial asthma in Tongliao area. Methods: A total of 94 patients with bronchial asthma admitted to the Affiliated Hospital of Inner Mongolia Minzu University from January 2019 to April 2024 were selected. Allergen detector was used to detect the characteristics of allergens, serum FeNO and total IgE in the patients, providing evidence for the clinical diagnosis, treatment and prevention of asthma in this region. Results: Ragweed, mugwort and absinthe were the most inhaled allergens, accounting for 37.0%. Among the ingestion allergens, shrimp, crab and scallop had the highest detection rate, accounting for 11.1%. There was no significant difference in the positive rate of different sex allergens. Of 94 patients with bronchial asthma, a total of 38 patients completed FeNO testing. In 38 patients with bronchial asthma, FeNO levels in patients with serum total IgE concentration < 100 IU/mL were significantly lower than those in patients with serum total IgE concentration of 100~200 IU/mL. Conclusion: Ragweed, mugwort and wormwood were the main inhalation allergens, and shrimp, crab and scallop were the main ingestion allergens in Tongliao area. The positive rate of inhalation allergens was significantly higher than that of food allergens in adult patients with bronchial asthma. In patients with allergen-positive asthma, there is a simultaneous change between total IgE and FeNO in the serum.
