选择性肿瘤动脉插管栓塞和灌注化疗,为中晚期癌症病人开辟了一条新的治疗途径。由于体外留置的导管可能发生堵塞、移位、滑脱、气栓、导管老化或损伤致出血与感染等并发症,而埋植式给药装置(Implantable Drug Delivery System,IDDS)既...选择性肿瘤动脉插管栓塞和灌注化疗,为中晚期癌症病人开辟了一条新的治疗途径。由于体外留置的导管可能发生堵塞、移位、滑脱、气栓、导管老化或损伤致出血与感染等并发症,而埋植式给药装置(Implantable Drug Delivery System,IDDS)既克服了体外留置导管的不足,又具有方便护理工作与病员生活等特点,还可以根据病情需要随时给药。展开更多
为探讨疼痛专科临床药师在植入鞘内药物输注系统(intrathecal drug delivery systems,IDDS)治疗难治性癌痛病例中的作用,临床药师参与1例植入IDDS治疗难治性癌痛患者的临床药物治疗,评估患者疼痛的性质,协助临床医师从镇痛药物的遴选、...为探讨疼痛专科临床药师在植入鞘内药物输注系统(intrathecal drug delivery systems,IDDS)治疗难治性癌痛病例中的作用,临床药师参与1例植入IDDS治疗难治性癌痛患者的临床药物治疗,评估患者疼痛的性质,协助临床医师从镇痛药物的遴选、药物剂量、药品不良反应、相互作用等方面制定个体化用药方案,密切关注患者的镇痛方案疗效及并发症状,为临床提供药物合理性建议,为患者实施药学监护并提供用药教育。治疗结果显示,患者疼痛控制满意,药物治疗全面优化,未发生严重药物不良反应,说明疼痛专科临床药师通过对癌痛患者进行动态、全面的疼痛评估,参与镇痛方案制定及不良反应监测,可从合理用药的角度协助优化鞘内镇痛用药方案,提高患者用药依从性,保障患者用药安全。展开更多
Aim To study the method and clinical significancehepatic arterial and portal venous angiographyimplantable drug delivery system (IDDS).Methods Intraoperative hepatic artery and poaalcatheterization were performed on 5...Aim To study the method and clinical significancehepatic arterial and portal venous angiographyimplantable drug delivery system (IDDS).Methods Intraoperative hepatic artery and poaalcatheterization were performed on 56 patients withneoplasm.viaveinliverCatheters were connected with IDDS implanted inthe skin of abdominal wall, 76% meglueaminediatrzoatewas regularly injected via the IDDS to observe both vesselsand take desired spot films.Resulte Satisfactory mdiologieal manifestitions ofvessels and their branches were obtained, 5 casesintrahepatic cancer ous recurrence that were not discoveredby CT scan were detected, 4 by arteriography,pertovenography.with IDDS, andangiography.Conclusionthe other byNo obvious adverse effect was connectedno obvious complication occurredduringHepatic angiography via IDDS is a useful wayto monitor postoperative cancerous receurrenee in liver,also a new way to study the blood supply of hepatic neoplasmand blood hydrodynamics of peaal vein.展开更多
在21世纪的医疗科技领域,智能药物传递系统(Intelligent Drug Delivery Systems,IDDS)正逐步成为治疗多种疾病的关键技术。本文将深入探讨智能药物传递系统的概念、重要性、技术基础、应用领域、面临的挑战以及未来的发展趋势,为读者呈...在21世纪的医疗科技领域,智能药物传递系统(Intelligent Drug Delivery Systems,IDDS)正逐步成为治疗多种疾病的关键技术。本文将深入探讨智能药物传递系统的概念、重要性、技术基础、应用领域、面临的挑战以及未来的发展趋势,为读者呈现这一前沿技术的全貌。展开更多
随着慢性疼痛和痉挛性疾病的治疗在临床越来越受到重视,植入式鞘内药物输注系统(Intrathecal Drug Delivery Systems,IDDS)也已经成为治疗该类疾病的重要方法之一。在我国,IDDS也逐渐被应用于临床治疗各种难治性疼痛和痉挛性疾病,但IDD...随着慢性疼痛和痉挛性疾病的治疗在临床越来越受到重视,植入式鞘内药物输注系统(Intrathecal Drug Delivery Systems,IDDS)也已经成为治疗该类疾病的重要方法之一。在我国,IDDS也逐渐被应用于临床治疗各种难治性疼痛和痉挛性疾病,但IDDS目前仍未国产化,进口价格居高不下。因此,本文就IDDS的一般结构、性能、疾病治疗范畴进行介绍,并总结了IDDS在国内外关于其软件和硬件方面的研究进展。通过对目前国内外IDDS的临床应用现状进展梳理,并对比分析国内外市场需求及目前进口产品的垄断价格,明确了进一步国产化研究的价值所在,探讨了国产化研究意义和国内临床的应用前景。展开更多
Intervertebral disc degeneration(IDD)is a progressive and dynamic process in which the senescence-associated secretory phenotype(SASP)of nucleus pulposus cells(NPC)plays a significant role.While impaired chaperone-med...Intervertebral disc degeneration(IDD)is a progressive and dynamic process in which the senescence-associated secretory phenotype(SASP)of nucleus pulposus cells(NPC)plays a significant role.While impaired chaperone-mediated autophagy(CMA)has been associated with inflammation and cellular senescence,its specific involvement in the self-perpetuating feedback loop of NPC senescence remains poorly understood.Through LAMP2A knockout in NPC,we identified a significant upregulation of DYRK1A,a core mediator of premature senescence in Down syndrome.Subsequent validation established DYRK1A as the critical driver of premature senescence in CMA-deficient NPC.Combinatorial transcription factor analysis revealed that under IL1B stimulation or CMA inhibition,elevated DYRK1A promoted FOXC1 phosphorylation and nuclear translocation,initiating transcriptional activation of cell cycle arrest.Intriguingly,CMA impairment concurrently enhanced glutamine metabolic flux in senescent NPC,thereby augmenting their survival fitness.Transcriptomic profiling demonstrated that CMA reactivation in senescent NPC facilitated fate transition from senescence to apoptosis,mediated by decreased glutamine flux via GLUL degradation.Therefore,CMA exerts protective effects against IDD by maintaining equilibrium between premature senescence and senolysis.This study elucidates CMA’s regulatory role in SASP-mediated senescence amplification circuits,providing novel therapeutic insights for IDD and other age-related pathologies.展开更多
文摘选择性肿瘤动脉插管栓塞和灌注化疗,为中晚期癌症病人开辟了一条新的治疗途径。由于体外留置的导管可能发生堵塞、移位、滑脱、气栓、导管老化或损伤致出血与感染等并发症,而埋植式给药装置(Implantable Drug Delivery System,IDDS)既克服了体外留置导管的不足,又具有方便护理工作与病员生活等特点,还可以根据病情需要随时给药。
文摘为探讨疼痛专科临床药师在植入鞘内药物输注系统(intrathecal drug delivery systems,IDDS)治疗难治性癌痛病例中的作用,临床药师参与1例植入IDDS治疗难治性癌痛患者的临床药物治疗,评估患者疼痛的性质,协助临床医师从镇痛药物的遴选、药物剂量、药品不良反应、相互作用等方面制定个体化用药方案,密切关注患者的镇痛方案疗效及并发症状,为临床提供药物合理性建议,为患者实施药学监护并提供用药教育。治疗结果显示,患者疼痛控制满意,药物治疗全面优化,未发生严重药物不良反应,说明疼痛专科临床药师通过对癌痛患者进行动态、全面的疼痛评估,参与镇痛方案制定及不良反应监测,可从合理用药的角度协助优化鞘内镇痛用药方案,提高患者用药依从性,保障患者用药安全。
文摘Aim To study the method and clinical significancehepatic arterial and portal venous angiographyimplantable drug delivery system (IDDS).Methods Intraoperative hepatic artery and poaalcatheterization were performed on 56 patients withneoplasm.viaveinliverCatheters were connected with IDDS implanted inthe skin of abdominal wall, 76% meglueaminediatrzoatewas regularly injected via the IDDS to observe both vesselsand take desired spot films.Resulte Satisfactory mdiologieal manifestitions ofvessels and their branches were obtained, 5 casesintrahepatic cancer ous recurrence that were not discoveredby CT scan were detected, 4 by arteriography,pertovenography.with IDDS, andangiography.Conclusionthe other byNo obvious adverse effect was connectedno obvious complication occurredduringHepatic angiography via IDDS is a useful wayto monitor postoperative cancerous receurrenee in liver,also a new way to study the blood supply of hepatic neoplasmand blood hydrodynamics of peaal vein.
文摘随着慢性疼痛和痉挛性疾病的治疗在临床越来越受到重视,植入式鞘内药物输注系统(Intrathecal Drug Delivery Systems,IDDS)也已经成为治疗该类疾病的重要方法之一。在我国,IDDS也逐渐被应用于临床治疗各种难治性疼痛和痉挛性疾病,但IDDS目前仍未国产化,进口价格居高不下。因此,本文就IDDS的一般结构、性能、疾病治疗范畴进行介绍,并总结了IDDS在国内外关于其软件和硬件方面的研究进展。通过对目前国内外IDDS的临床应用现状进展梳理,并对比分析国内外市场需求及目前进口产品的垄断价格,明确了进一步国产化研究的价值所在,探讨了国产化研究意义和国内临床的应用前景。
基金supported by the National Natural Science Foundation of China (NSFC) (No.82172497)
文摘Intervertebral disc degeneration(IDD)is a progressive and dynamic process in which the senescence-associated secretory phenotype(SASP)of nucleus pulposus cells(NPC)plays a significant role.While impaired chaperone-mediated autophagy(CMA)has been associated with inflammation and cellular senescence,its specific involvement in the self-perpetuating feedback loop of NPC senescence remains poorly understood.Through LAMP2A knockout in NPC,we identified a significant upregulation of DYRK1A,a core mediator of premature senescence in Down syndrome.Subsequent validation established DYRK1A as the critical driver of premature senescence in CMA-deficient NPC.Combinatorial transcription factor analysis revealed that under IL1B stimulation or CMA inhibition,elevated DYRK1A promoted FOXC1 phosphorylation and nuclear translocation,initiating transcriptional activation of cell cycle arrest.Intriguingly,CMA impairment concurrently enhanced glutamine metabolic flux in senescent NPC,thereby augmenting their survival fitness.Transcriptomic profiling demonstrated that CMA reactivation in senescent NPC facilitated fate transition from senescence to apoptosis,mediated by decreased glutamine flux via GLUL degradation.Therefore,CMA exerts protective effects against IDD by maintaining equilibrium between premature senescence and senolysis.This study elucidates CMA’s regulatory role in SASP-mediated senescence amplification circuits,providing novel therapeutic insights for IDD and other age-related pathologies.
