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Evidence of Human Origins in the Himalayas 被引量:1
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作者 Li Houqiang Li Hailong Yan Zhou Xingyu 《Contemporary Social Sciences》 2021年第3期1-18,共18页
Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a compl... Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a complex process,which required the co-existence of diverse favorable factors.Based on a review of existing research findings,this paper argues that modern humans originated in the Himalayas and presents multi-dimensional evidence from the perspectives of geology,seismology,climatology,archaeology,biology,genetics,and others.The evolution from ape to man may have also existed in regions other than the Himalayas.However,such evolution falls under“invalid origin”due to the lack of essential conditions for evolution,and particularly,the evolutionary process was interrupted by the erosion of frequent Quaternary glaciations.The homo sapiens originating in the Himalayas gradually migrated and settled down across the world several times during the interglacial periods,creating local cultures and colorful civilizations in parallel.The findings of this paper provide new orientations and approaches for the studies of human origins and the development of civilizations. 展开更多
关键词 human origin the Himalayas parallel civilization EVIDENCE
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Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians 被引量:7
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作者 柯越海 宿兵 +7 位作者 肖君华 陈华 黄薇 陈竺 褚嘉佑 谈家桢 金力 卢大儒 《Science China(Life Sciences)》 SCIE CAS 2001年第3期225-232,共8页
We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Ha... We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Han Chinese populations. The southern populations are much more polymorphic than northern populations. The latter has only a subset of the southern haplotypes. This result confirms the genetic difference observed between southern and northern ethnic populations in East Asia. It supports the hypothesis that the first settlement of modern hu-mans of African origin occurred in the southern part of East Asia during the last Ice Age, and a northward migration led to the peopling of northern China. 展开更多
关键词 Y-chromosome haplotype SNPS modern human origin emigration Chinese.
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Tracing the Origin and Migration of Humans-Significant Progress in Paleoanthropological and Paleolithic Fields Made by IVPP
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作者 PING Wanjing FU Qiaomei +2 位作者 YANG Ziyi ZHANG Xiaoling XING Song 《Bulletin of the Chinese Academy of Sciences》 2024年第3期190-196,共7页
Over the past 15 years,the Paleoanthropological and Paleolithic team from the Institute of Vertebrate Paleontology and Paleoanthropology(IVPP),Chinese Academy of Sciences,has made significant progress in understanding... Over the past 15 years,the Paleoanthropological and Paleolithic team from the Institute of Vertebrate Paleontology and Paleoanthropology(IVPP),Chinese Academy of Sciences,has made significant progress in understanding modern human origins and evolution through extensive fieldwork,fossil and artifact discoveries,and cutting-edge ancient molecular analysis.The new fossil findings from Hualongdong,Xuchang,the first report on Harbin,and the reevaluations of previously found fossils like Xujiayao revealed high population diversity in East Asia during the late Middle Pleistocene,implying multiple evolutionary lineages linked to modern humans,Neanderthals,or Denisovans.Different species names were proposed for these unique fossils.Discoveries from Zhiren Cave and Fuyan Cave refreshed our knowledge of modern human emergence in China,sparking debates between the“Recent African Origin”and“Multiregional Evolution”hypothesis.Additionally,new archaeological evidence from Nwya Devu and Xiamabei highlighted human adaptations to extreme climates and technological innovations.Genomic studies further revealed complex patterns of modern human dispersal,admixture,and adaptation in China,especially in the past 40,000 years.The first mitochondrial DNA of Denisovan outside Denisova Cave was successfully extracted from the sediments on the Plateau,suggesting the long-term occupation of this population in this area. 展开更多
关键词 Modern human origins Archaic Homo Denisovan Ancient DNA Lithic tools
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The Models of Modern Human Origins:Eastern Perspective
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作者 Fei PENG 《Journal of the Chinese Nation Studies》 2023年第4期149-176,共28页
The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camp... The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camps:the""Out of Africa"hypothesis and the"Multiregional Evolution"hypothesis.With the continuous accumulation of new materials and rapid technological advancements in the new century,there have been significant adjustments in the debate over the origin models of modern humans,with materials from the East Asia playing an increasingly important role.This article reviews the major hypotheses and models regarding the origin of modern humans and the evolution of modern behavior,tracing their sources,history,and development.It also provides a comprehensive overview of some of the latest archaeological discoveries and research progress.Furthermore,it discusses the motives and directions for adjusting the models of modern human origins and behavioral evolution,emphasizing the importance of considering a vast amount of archaeological evidence in the discussion of various models and reflecting on the cultural implications of"modernity".The article calls for increased investment in research on the origin of modern humans in China and emphasizes the need to provide a solid Eastern perspective for discussing modern human origin models. 展开更多
关键词 human origins and Evolution Modern humans Behavioral Modernity Eastern Perspective
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Zoonotic origins of human coronavirus 2019(HCoV-19/SARS-CoV-2):why is this work important? 被引量:15
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作者 Gary Wong Yu-Hai Bi +3 位作者 Qi-Hui Wang Xin-Wen Chen Zhi-Gang Zhang Yong-Gang Yao 《Zoological Research》 SCIE CAS CSCD 2020年第3期213-219,共7页
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the a... The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic. 展开更多
关键词 origin why is this work important HCoV-19/SARS-CoV-2 Zoonotic origins of human coronavirus 2019
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Study on the Rights to Subsistence and Development with Reference to the Origin of the Universal Declaration of Human Rights
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作者 李君如 Hu Liang(译) 《The Journal of Human Rights》 2018年第5期461-464,共4页
I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason fo... I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence 展开更多
关键词 UN Study on the Rights to Subsistence and Development with Reference to the origin of the Universal Declaration of human Rights
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虚拟数字人表演视频的著作权归属研究
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作者 肖海 吴道松 《哈尔滨学院学报》 2026年第1期49-53,共5页
虚拟数字人作为元宇宙技术与人工智能飞速发展的产物,在便捷人们创作方式的同时,也给自然人作为主体的传统版权法秩序带来挑战。域外的人工智能版权归属规定各有不同,美国承认拟制主体,英国认为应当归属系统开发者或投资所有者,日本认... 虚拟数字人作为元宇宙技术与人工智能飞速发展的产物,在便捷人们创作方式的同时,也给自然人作为主体的传统版权法秩序带来挑战。域外的人工智能版权归属规定各有不同,美国承认拟制主体,英国认为应当归属系统开发者或投资所有者,日本认为归属操作使用者。我国法律应该结合社会实践并根据最大创作贡献的理念,建立一个以操作使用者为中心、约定归属为辅,以社会最大利益归属原则为例外的制度,来平衡解决虚拟数字人表演视频的著作权归属问题。 展开更多
关键词 虚拟数字人表演 作品 独创性 约定归属 社会最大利益
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指向人工智能素养培养的高职动漫课程教学设计与实践研究
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作者 刘洋 何婷婷 《教育与装备研究》 2026年第2期47-53,共7页
为应对人工智能(AI)技术对动漫创意产业带来的变革,该研究聚焦于人工智能素养与动漫专业课程的深度融合。以高职院校《动画原画设计》课程为例,构建了涵盖“知识、技能、思维、伦理、协同”五个维度的AI素养框架,并据此进行了系统的教... 为应对人工智能(AI)技术对动漫创意产业带来的变革,该研究聚焦于人工智能素养与动漫专业课程的深度融合。以高职院校《动画原画设计》课程为例,构建了涵盖“知识、技能、思维、伦理、协同”五个维度的AI素养框架,并据此进行了系统的教学设计与实践。课程采用模块化重构与项目驱动教学法,引入Midjourney、Stable Diffusion等AIGC工具,在双导师制下引导学生开展人机协同创作。教学实践表明,该模式能显著提升学生的AI工具应用能力、原画创作效率、伦理反思意识及批判性思维,尤其在知识理解与技能操作维度成效显著。研究也发现学生在人机协作与小组协作上存在能力差异。基于此,研究提出课程深度整合、强化真实项目训练、促进AI与传统技能互补等建议,以期为人工智能时代动漫专业人才培养提供参考。 展开更多
关键词 人工智能素养 动漫专业 课程融合 动画原画设计 项目式学习 人机协同
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伟大建党精神探源
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作者 李君 《湖南工业大学学报(社会科学版)》 2026年第1期87-94,共8页
伟大建党精神不是中共建党先驱们头脑中固有的,也不是建党之日突然产生的,而是中国共产党的先驱们在特定历史条件、时空范围内创党建党活动中孕育形成的革命理想、信念、情感、意志、品格的总称。伟大建党精神起源于十月革命开创的人类... 伟大建党精神不是中共建党先驱们头脑中固有的,也不是建党之日突然产生的,而是中国共产党的先驱们在特定历史条件、时空范围内创党建党活动中孕育形成的革命理想、信念、情感、意志、品格的总称。伟大建党精神起源于十月革命开创的人类觉醒的伟大时代,溯源于五四爱国运动,发源于上海、北京等重要地区,来源于与中国共产党创建相关的革命先驱们,根源于创党建党的实践活动。深入开展伟大建党精神的时代起源、时间溯源、空间发源、主体来源、实践根源的研究,弄清伟大建党精神具体是从哪里来的、怎么来的,具有重要的理论价值和现实意义。 展开更多
关键词 伟大建党精神 历史起源 空间发源 主体来源 实践根源
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神话大数据中的叙事认同:中华民族共同体意识的多维呈现与阐释
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作者 王京 《南宁师范大学学报(哲学社会科学版)》 2026年第2期98-113,共16页
中华民族数量众多的神话资源中蕴含着丰富的中华民族共同体意识。随着数字技术的普及,将数据理念与方法融入研究过程,已成为神话研究方法论的一项重要创新。利用一定规模的神话数据从不同视角阐释中华民族共同体意识,既具备坚实的现实... 中华民族数量众多的神话资源中蕴含着丰富的中华民族共同体意识。随着数字技术的普及,将数据理念与方法融入研究过程,已成为神话研究方法论的一项重要创新。利用一定规模的神话数据从不同视角阐释中华民族共同体意识,既具备坚实的现实资源基础,也是契合时代语境的重要路径。本文以“中国神话数据库”为主要数据来源,运用数据分析与母题学、类型学、叙事学相结合的跨学科方法,聚焦中华民族共同体意识的多维呈现形态、核心载体与传承规律三个核心问题,从时间纵深、地理分布、民族分布等维度对多民族同根同源神话进行案例分析,进一步挖掘和阐释神话中的中华民族共同文化符号与共同价值取向,为铸牢中华民族共同体意识提供深厚的传统文化支撑与跨学科研究范式参考。 展开更多
关键词 中华民族共同体意识 神话大数据 同根同源神话 文化符号 数字人文
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Humanism汉译名探析
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作者 白利军 《安康师专学报》 2002年第2期79-81,共3页
面对Humanism一词的三个汉译名被广泛误用的现实 ,本文从探究该词的多重词义下手 ,着力分析了各个汉译名的使用 ,指出人文主义主要适用于文艺复兴时期的文化思潮 ,人道主义主要适用于伦理学领域 。
关键词 "humanism" 人文主义 人道主义 人本主义 词义 英译汉 翻译
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The New Contribution to the Important Discourse on Human Rights by General Secretary xi Jinping 被引量:1
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作者 刘海年 HU Liang(译) 《The Journal of Human Rights》 2018年第3期263-284,共22页
Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the streng... Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the strengthened trend of mainstreaming of human rights, Xi Jinping’s series of speeches and the 19 th CPC national Congress reports comprehensively explained the construction of human rights in China and the development of the international human rights. The important discourse on human rights by General Secretary Xi Jinping is people-centered: people’s yearning for a better life is our goal and reveals the source of human rights. Chinese dream is a dream of the country, of the nation, and of everyone in China. The close integration of individual and collective human rights points out that the state and people are important parts of collective human rights and it is an effective response to the "human rights over sovereignty" of Western countries. That there are not the best human rights, but the better ones; fighting for human rights is not always done, but always doing scientifically reveals the operational form of human rights. The right of survival and development is the primary human right; to attach importance to the right of peace conforms to the reality of our country and it has the support of the vast number of developing countries. Building a community with a shared future for human beings is a new vision for the development of the international human rights. only when the perfection and implementation of Constitution and law are paid attention to, and the democratization and legalization of the international human rights cause are promoted, can the guarantee be provided for the realization of human rights. The important discourse on human rights by General Secretary Xi Jinping is guided by Marxism, carries the communist party member’s original intention of serving people and is deeply rooted in the masses of the people. It inherits the theory of "benevolence" and "harmony" in Chinese culture,stands at the height of history and times, and points out the direction for the all-round development of Chinese people and the overall progress of society, and for the liberation of all mankind. This scientific theory is successfully guiding China’s human rights construction constantly towards new achievements and has had a profound and extensive impact on the international human rights cause. 展开更多
关键词 human rights theory the origin of human rights collective human rights operational patterns a community with a shared future for human beings
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华龙洞古人类化石及其在人类演化上的意义 被引量:3
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作者 刘武 吴秀杰 《人类学学报》 北大核心 2025年第5期727-741,I0005-I0007,共18页
2014年以来,对华龙洞遗址的发掘和剖面清理发现了50余件古人类化石(包括1件较为完整的头骨)以及古人类制作的石器等古人类生存活动证据。研究发现,华龙洞人类头骨、下颌骨、牙齿以及肢骨呈现与东亚中更新世直立人、更新世晚期人类及现... 2014年以来,对华龙洞遗址的发掘和剖面清理发现了50余件古人类化石(包括1件较为完整的头骨)以及古人类制作的石器等古人类生存活动证据。研究发现,华龙洞人类头骨、下颌骨、牙齿以及肢骨呈现与东亚中更新世直立人、更新世晚期人类及现代人分别相似的一些混合特征。华龙洞人头骨具有一系列与周口店等东亚更新世中期直立人相似的原始特征,包括略低矮的颅穹窿、额骨矢状脊、发达的眶上圆枕,以及相对小的颅容量等。同时,华龙洞人头骨、面骨、下颌骨和牙齿化石还呈现出一些与更新世晚期人类及现代人相似的特征,表现为头骨较薄,上面部扁平、颅穹窿部圆隆和面部形态纤细、下颌骨联合接近垂直并出现颏三角雏形、牙齿结构简单及尺寸较小等。这些研究发现提示,30万年前的华龙洞人已经出现向现代人演化过渡的趋势,是东亚地区迄今发现的年代最早、包含现代人特征最多的中更新世古人类。华龙洞人类化石的发现和研究为东亚中更新世晚期人类演化多样性提供了新的证据。 展开更多
关键词 华龙洞遗址 人类化石 人类演化 现代人起源 中更新世晚期
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Human Rights Value Based on the Legislation Principle of the Basic Healthcare and Health Promotion Law
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作者 张博源 《The Journal of Human Rights》 2019年第2期190-206,共17页
The draft of the Basic Healthcare and Health Promotion Law directly incorporates the concept of the right to health,which will have a positive significance in realizing the constitutional norms of the right to health ... The draft of the Basic Healthcare and Health Promotion Law directly incorporates the concept of the right to health,which will have a positive significance in realizing the constitutional norms of the right to health protection.China’s Constitution stipulates the general policy,concrete duties and specific obligations of the state to protect citizens’ right to health,which is the most fundamental logical starting point of legislative design.The implementation of state obligations requires the legislation to follow the principles as follows:people-centered public welfare,respecting and protecting the principle of citizens’ right to health,equitable access to basic medical and health services and the government responsibility for the purpose of the people’s health. 展开更多
关键词 RIGHT to health CONSTITUTIONAL origin LEGISLATION PRINCIPLE human RIGHTS
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论AIGC作品独创性司法认定标准的构建——基于提示词创作范式下的再思考 被引量:3
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作者 何炼红 谢天艺 《中国版权》 2025年第1期48-64,共17页
大模型时代,AIGC作品的独创性认定标准是版权司法实践中的一个核心问题,当前各国就AIGC作品独创性标准尚未达成共识。鉴于AIGC具有数据驱动特征,创作过程中数智技术客观化程度增强,形成统一独创性司法认定标准具有可行性。以独创性主观... 大模型时代,AIGC作品的独创性认定标准是版权司法实践中的一个核心问题,当前各国就AIGC作品独创性标准尚未达成共识。鉴于AIGC具有数据驱动特征,创作过程中数智技术客观化程度增强,形成统一独创性司法认定标准具有可行性。以独创性主观标准为基础,以人类干预原则为前提,构建AIGC人类干预司法判断模型,可回应独创性主观标准中人格因素的客观化与门槛问题,为AIGC独创性判断提供程式化、客观化指引。提示词在AIGC创作中发挥引导创作方向、决定内容质量、影响生成内容独创性的核心作用。运用司法判断模型应考量包括提示词在内的诸多要素,它们共同构成AIGC作品独创性的判断基础。 展开更多
关键词 AIGC作品 独创性标准 人类干预 提示词 司法判断模型
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On Native Origin of the American Indians
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作者 Tianxi Sun 《Open Journal of Applied Sciences》 2016年第9期636-647,共13页
There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entere... There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entered America from Asia through the Bering Straits 14,000 ~ 20,000 years ago, worn their “clothes” and carried kindling during the late Paleolithic, no matter how by “boat” across the Bering Sea or by foot through a “Bering Land Bridge” which might once link up Asia and North America during glacial period;and independently proposed a new hypothesis that American Indians might be originated from the Western Rift Valley of North America. On the basis of locus distribution of American ancient human’s remnants, the writer pointed out that American ancient humans might be first originated at Yukon Territory of Canada within the Western Rift Valley of North America (the Basin & Range Province), and then migrated south ward (Yukon Territory → Mojave Desert → Mexico → Peru → Chile). Moreover, American Indians would have long been a presence for 40,000 years, or even 100,000 ~ 200,000 years in the American continents. So far, the logical basis which American Indians came from Asia 14,000 ~ 20,000 years ago was crushed, and derived two inferences: 1) American Indians might be originated from the Western Rift Valley of North America;2) Only the Eskimo might be the mover eastward from Asia, because of their gene B. 展开更多
关键词 American Indians Native origin Genetics of human Blood Rift Valley Controversy
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生成式人工智能著作权侵权问题研究 被引量:21
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作者 祝建军 《知识产权》 北大核心 2025年第2期44-60,共17页
生成式人工智能是目前人类创新活动的前沿性领域,具有广阔的发展前景。新技术应用往往会带来利益分配和纠纷解决的法律适用难题。在生成式人工智能领域,首当其冲的难题是著作权法适用。面对新问题,理论界与实务界均存在较大争议。立足... 生成式人工智能是目前人类创新活动的前沿性领域,具有广阔的发展前景。新技术应用往往会带来利益分配和纠纷解决的法律适用难题。在生成式人工智能领域,首当其冲的难题是著作权法适用。面对新问题,理论界与实务界均存在较大争议。立足审判实务,总结生成式人工智能著作权侵权纠纷的中外实践经验和裁判规则,依据著作权法的原理和制度内涵,生成式人工智能大模型训练主要是培育机器具有类似人的智力能力,而非传播作品牟利,故生成式人工智能大模型训练未经许可使用他人作品构成合理使用。人工智能生成内容是机器运行生成的结果,不是自然人智力创作直接产生的成果,不应作为作品受到著作权法保护,否认其可版权性,并不会阻碍人工智能的技术发展和产业应用。人工智能生成内容与他人作品相同或近似构成著作权侵权时,为保护他人作品不受侵害,人工智能服务提供商应尽必要的注意义务。适用著作权法处理生成式人工智能著作权侵权纠纷,既要保护著作权人的合法权益,又要促进人工智能技术的发展,平衡好相关方的利益。 展开更多
关键词 生成式人工智能 大模型训练 合理使用 自然人创作 独创性 注意义务
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人类学对农耕发轫与文化起源的探讨 被引量:2
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作者 王海龙 《深圳大学学报(人文社会科学版)》 北大核心 2025年第4期22-32,共11页
农耕发轫和文化起源的关系自古就是自然科学和人文学科共同关注的课题。现代人类学兴起以来,它利用其全方位、多角度科学探讨的综合优势,从考古学/史前学证据入手,考察人类进化和上古生态以及古地质-气候等因素,用大量上古生态科研证据... 农耕发轫和文化起源的关系自古就是自然科学和人文学科共同关注的课题。现代人类学兴起以来,它利用其全方位、多角度科学探讨的综合优势,从考古学/史前学证据入手,考察人类进化和上古生态以及古地质-气候等因素,用大量上古生态科研证据破译了诸多此前无数世纪难以解决的问题。人类学对此课题研究的另一特点是它利用其新的方法论结合上古化石及古气候-生物研究的成果,深入到被称作“活化石”的当代原始部落社群中去进行比较研究和平行研究,从而探讨人类远古的生存和生活状态,弥补化石学和成文史的资料缺项。它衔接了人类进化史和农业及文明发源证据链课题中的断链和缺环,从而将这项研究引入正确轨道。人类学方法将农耕发轫和人类文明起源课题有机融合在一起,将劳动、工具和人类体质及智能进化作为创造文明的前提和物质-智力准备,为人类进化成功进而臻至物质文明及精神文明起源的理论推想奠定了坚实的学科基础。 展开更多
关键词 人类学 农业起源 石器时代 人类进化 驯化 史前学 文明发源
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人工智能生成内容的版权管理问题研究——基于著作权制度理念的视角 被引量:1
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作者 刘翼辉 《中国高新科技》 2025年第8期30-33,共4页
人工智能生成内容的可版权性和版权归属目前是版权领域具有争议的话题,关乎未来人工智能技术进步和产业发展趋势。人工智能大模型生成内容在形式上与人类的作品近乎无异,但在内容上差别较大,原因在于人工智能虽然模拟人类的思维,但并不... 人工智能生成内容的可版权性和版权归属目前是版权领域具有争议的话题,关乎未来人工智能技术进步和产业发展趋势。人工智能大模型生成内容在形式上与人类的作品近乎无异,但在内容上差别较大,原因在于人工智能虽然模拟人类的思维,但并不具备人的思想情感,不具有创作意图。通过著作权制度的回溯和理念重塑,能够明确著作权制度人本主义的价值理念和独创性标准,依据人类的“贡献程度”可以对人工智能生成内容的可版权性进行分类,使其版权问题进一步明晰。 展开更多
关键词 人工智能生成内容 著作权制度 人本主义 独创性
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NKX3.1特殊表达模式:6例宫颈腺样基底癌临床病理分析
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作者 康份红 张永俊 《中国医药指南》 2025年第22期31-34,共4页
目的本研究旨在对宫颈腺样基底细胞癌(ABC)的临床病理特征进行深入探讨,并着重分析NKX3.1在肿瘤细胞内呈现的分层表达模式,挖掘其对肿瘤起源方面所蕴含的提示价值。方法对2020年1月至2024年9月厦门大学附属中山医收治的6例宫颈ABC患者... 目的本研究旨在对宫颈腺样基底细胞癌(ABC)的临床病理特征进行深入探讨,并着重分析NKX3.1在肿瘤细胞内呈现的分层表达模式,挖掘其对肿瘤起源方面所蕴含的提示价值。方法对2020年1月至2024年9月厦门大学附属中山医收治的6例宫颈ABC患者的临床病理资料展开回顾性分析。借助组织学评估手段,联合免疫组化检测(涵盖P16、P63、P40、NKX3.1、CK5/6、Ki-67等指标)以及分子检测技术(涉及高危型HPV分型、MYB荧光原位杂交检测),综合文献进行梳理,进而剖析肿瘤存在的双向分化特征。结果在纳入研究的6例患者当中,有5例为绝经后女性,仅1例为育龄期女性,且整体中位年龄为61岁。经检测发现,所有患者HPV均呈阳性反应,具体为HPV16、18型。术前影像学检查结果均为阴性;肿瘤标志物筛查中,1例鳞状细胞癌抗原检测(SCC)呈阳性,其余结果均为阴性。从病理层面观察,肿瘤结构主要由基底样细胞巢构成,其外周细胞呈现出栅栏状的排列方式,而在中央区域,则形成了具有腺样分化的结构;免疫组化显示P16弥漫强阳性(6/6),基底标志物P63、P40、CK5/6均阳性(6/6),NKX3.1核阳性局限于腺腔内层细胞,外层基底样细胞阴性,Ki-67指数≤10%,MYB基因无重排。中位随访20个月无复发或转移。结论NKX3.1的腔缘特异性表达(内层+,外层-)提示宫颈ABC可能起源于具有多向分化潜能的宫颈储备细胞,其内层细胞向腺腔表型(NKX3.1+)分化,外层保留基底/鳞状特征(P63+)。该分子表达模式为ABC的诊断及组织起源研究提供了关键依据,联合HPV检测可避免过度治疗。 展开更多
关键词 NKX3.1 人乳头瘤病毒 免疫组化 肿瘤起源
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