Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physici...Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physician Bian Que(扁鹊)and his students.Since their discovery,the medical,historical,and archaeological communities have given them considerable attention.This paper sorts out the diagnostic content of Tian Hui Yi Jian from various aspects of inspection,palpation,inquiry,listening and smelling examination and provides a summary and analysis of four features:the concept of the correspondence between heaven and man is the foundation,the idea of the five elements throughout the whole process,extremely focus on pulse diagnosis,emphasize a comprehensive analysis of four examinations.These analyses can investigate the value and significance of Tian Hui Yi Jian in developing traditional Chinese medicine(TCM)diagnosis history.In this way,we aim to reproduce the overview and level of TCM diagnostics at that time,clear up some ambiguous understanding of its development history,and provide a reference for further research on the origin and development of TCM.展开更多
In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotypin...In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. A pharmacokinetic study was then carried out in three groups with CYP3A4＊1/＊1 （n = 6）, CYP3A4＊1/＊18 （n = 6） and CYP3A4＊18/＊18 （n = 6） genotypes. Plasma levels of zolpidem were determined by HPLC-FLD method before and after a single oral dose of 10 mg zolpidem tartrate tablet. Significant differences were observed in the pharmacokinetic parameters of zolpidem among the three genotype groups （P〈0.05）. Compared with the CYP3A4＊1/＊1 group, the Cm,x of zolpidem in ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.89 （0.65-1.12） and 0.57 （0.47-0.66）, respectively, and the AUC0-1 in the ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.74 （0.22-1.26） and 0.61 （0.24-0.98）, respectively. There was a significant trend towards lower Cmax and AUC0-1 values of zolpidem in individuals with more CYP3A＊ 18 alleles, suggesting a gene-dosage effect. The study demonstrated that the CYP3A4＊ 18 allele played an important role in the pharmacokinetics of the zolpidem after oral administration.展开更多
Targeted at the residence status in rural settlements of Hui people in central Ningxia Hui Nationality Autonomous Region, this research revealed that the construction of new countryside and the transformation of old c...Targeted at the residence status in rural settlements of Hui people in central Ningxia Hui Nationality Autonomous Region, this research revealed that the construction of new countryside and the transformation of old countryside all have to be on the basis of present topography, landform, environment, social-economic level, education, religion, customs, living habits and so on. The primary goal of this research was to find a method of ecology, low energy consumption and sustainable development to bring the green planning implementation strategies, to provide guidance for sustainable planning in the rural settlements of Hui Nationality in central Ningxia.展开更多
AIM: To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region.
Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the st...Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the studies focusing on the non-motor symptoms in Chinese PD patients from different ethnicity are scarce.The aim of this retrospective study was to investigate neuropsychiatric symptoms and cognitive impairment in Chinese PD patients from Han and Hui populations from central China.Seventy-two Han Chinese PD patients(Han PD group)and 71 age-and sex-matched Hui Chinese PD patients(Hui PD group)were enrolled from Zhongnan Hospital of Wuhan University between Sept.2011 and Aug.2014 in the study.The neuropsychiatric symptoms and cognitive impairment were assessed using Neuropsychiatric Inventory(NPI)and Mini Mental State Examination(MMSE).We found that the proportion of depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were higher in the Han PD group than in the Hui PD group(P<0.05 or P<0.01).But the proportion of delusion,hallucination,agitation,disinhibition,aberrant motor behavior and change in appetite were not significantly different between the Han PD group and the Hui PD group(P>0.05).The total mean scores of the MMSE from patients in the Han PD group were similar to those in the Hui PD group(P>0.05).However,the subscale scores of recall domain and language domain in the Han PD group were significantly different from those in the Hui PD group(P<0.05).No significant difference was noted in the orientation,memory and calculation domains between the two PD groups(P>0.05).This study first showed the recall domain and language domain were different between the Han PD patients and the Hui PD patients.Depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were less presented in the Hui PD patients.All these differences may be related to the different ethnicity,which would be helpful for clinical physicians to recognize the different non-motor symptoms in Chinese PD patients with different ethnicity.展开更多
In the present study,we aimed to investigate the influence of CYP2C9^＊2 genetic polymorphism on pharmacokinetics of losartan and its active metabolite E-3174 on the background of CYP3A4 wild genotype in healthy Chine...In the present study,we aimed to investigate the influence of CYP2C9^＊2 genetic polymorphism on pharmacokinetics of losartan and its active metabolite E-3174 on the background of CYP3A4 wild genotype in healthy Chinese Hui subjects.Blood samples were collected from subjects for CYP2C9 and CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） assay.A pharmacokinetic study was then carried out in two groups with CYP2 C9^＊1/^＊1（n = 8） and CYP2 C9^＊1/^＊2（n = 6） genotypes at the same time,and all the 14 subjects were CYP3A4 wild genotype.Plasma levels of losartan and E-3174 were determined by high-performance liquid chromatography-fluorescence（HPLC-FLD） method before and after a single oral dose of 50-mg dose of losartan in tablet form.The pharmacokinetic parameters were calculated by DAS 2.0 software and analyzed by SPSS 16.0 software.Pharmacokinetic parameters,including area under the curve from 0 h to the last measured point 24 h（AUC0–24）,area under the curve from 0 h to infinite time（AUC0–∞）,peak plasma concentration（Cmax）,time to reach Cmax（tmax）,oral clearance（CL）,oral volume of distribution（Vd） and elimination half-life（t1/2）,were determined.Compared with the CYP2C9^＊1/^＊2 group,the AUC0–24,AUC0–∞ and Cmax of E-3174 in CYP2C9^＊1/^＊1 group of Hui subjects were respectively 1.36,1.32 and 1.64 times more,and the statistic differences were significant（P〈0.05）.The CYP2C9^＊2 mutant allele played an important role in the pharmacokinetics of losartan after oral administration,and it might decrease the generation of E-3174.However,large-sample clinical trials are required to validate whether the dose adjustment according to CYP2C9 genotype is necessary.展开更多
基金financed by the grant from the Research Center of China Unearthed Medical Literature and Cultural Relics(No.CTYX17)。
文摘Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physician Bian Que(扁鹊)and his students.Since their discovery,the medical,historical,and archaeological communities have given them considerable attention.This paper sorts out the diagnostic content of Tian Hui Yi Jian from various aspects of inspection,palpation,inquiry,listening and smelling examination and provides a summary and analysis of four features:the concept of the correspondence between heaven and man is the foundation,the idea of the five elements throughout the whole process,extremely focus on pulse diagnosis,emphasize a comprehensive analysis of four examinations.These analyses can investigate the value and significance of Tian Hui Yi Jian in developing traditional Chinese medicine(TCM)diagnosis history.In this way,we aim to reproduce the overview and level of TCM diagnostics at that time,clear up some ambiguous understanding of its development history,and provide a reference for further research on the origin and development of TCM.
基金Funds of the Chinese Army Medical Science and Technology Research"Eleventh Five-Year Plan"Project(Grant No.06G023)
文摘In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. A pharmacokinetic study was then carried out in three groups with CYP3A4＊1/＊1 （n = 6）, CYP3A4＊1/＊18 （n = 6） and CYP3A4＊18/＊18 （n = 6） genotypes. Plasma levels of zolpidem were determined by HPLC-FLD method before and after a single oral dose of 10 mg zolpidem tartrate tablet. Significant differences were observed in the pharmacokinetic parameters of zolpidem among the three genotype groups （P〈0.05）. Compared with the CYP3A4＊1/＊1 group, the Cm,x of zolpidem in ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.89 （0.65-1.12） and 0.57 （0.47-0.66）, respectively, and the AUC0-1 in the ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.74 （0.22-1.26） and 0.61 （0.24-0.98）, respectively. There was a significant trend towards lower Cmax and AUC0-1 values of zolpidem in individuals with more CYP3A＊ 18 alleles, suggesting a gene-dosage effect. The study demonstrated that the CYP3A4＊ 18 allele played an important role in the pharmacokinetics of the zolpidem after oral administration.
基金Supported by the Project of Natural Science Fund of Ningxia in 2009(NZ0943)the Project of College Science Research of Ningxia in 2008~~
文摘Targeted at the residence status in rural settlements of Hui people in central Ningxia Hui Nationality Autonomous Region, this research revealed that the construction of new countryside and the transformation of old countryside all have to be on the basis of present topography, landform, environment, social-economic level, education, religion, customs, living habits and so on. The primary goal of this research was to find a method of ecology, low energy consumption and sustainable development to bring the green planning implementation strategies, to provide guidance for sustainable planning in the rural settlements of Hui Nationality in central Ningxia.
文摘AIM: To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region.
文摘Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the studies focusing on the non-motor symptoms in Chinese PD patients from different ethnicity are scarce.The aim of this retrospective study was to investigate neuropsychiatric symptoms and cognitive impairment in Chinese PD patients from Han and Hui populations from central China.Seventy-two Han Chinese PD patients(Han PD group)and 71 age-and sex-matched Hui Chinese PD patients(Hui PD group)were enrolled from Zhongnan Hospital of Wuhan University between Sept.2011 and Aug.2014 in the study.The neuropsychiatric symptoms and cognitive impairment were assessed using Neuropsychiatric Inventory(NPI)and Mini Mental State Examination(MMSE).We found that the proportion of depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were higher in the Han PD group than in the Hui PD group(P<0.05 or P<0.01).But the proportion of delusion,hallucination,agitation,disinhibition,aberrant motor behavior and change in appetite were not significantly different between the Han PD group and the Hui PD group(P>0.05).The total mean scores of the MMSE from patients in the Han PD group were similar to those in the Hui PD group(P>0.05).However,the subscale scores of recall domain and language domain in the Han PD group were significantly different from those in the Hui PD group(P<0.05).No significant difference was noted in the orientation,memory and calculation domains between the two PD groups(P>0.05).This study first showed the recall domain and language domain were different between the Han PD patients and the Hui PD patients.Depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were less presented in the Hui PD patients.All these differences may be related to the different ethnicity,which would be helpful for clinical physicians to recognize the different non-motor symptoms in Chinese PD patients with different ethnicity.
基金A Research Grant from the 115 Project of Legionary Medical Treatment and Public Health(Grant No.06G023)
文摘In the present study,we aimed to investigate the influence of CYP2C9^＊2 genetic polymorphism on pharmacokinetics of losartan and its active metabolite E-3174 on the background of CYP3A4 wild genotype in healthy Chinese Hui subjects.Blood samples were collected from subjects for CYP2C9 and CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） assay.A pharmacokinetic study was then carried out in two groups with CYP2 C9^＊1/^＊1（n = 8） and CYP2 C9^＊1/^＊2（n = 6） genotypes at the same time,and all the 14 subjects were CYP3A4 wild genotype.Plasma levels of losartan and E-3174 were determined by high-performance liquid chromatography-fluorescence（HPLC-FLD） method before and after a single oral dose of 50-mg dose of losartan in tablet form.The pharmacokinetic parameters were calculated by DAS 2.0 software and analyzed by SPSS 16.0 software.Pharmacokinetic parameters,including area under the curve from 0 h to the last measured point 24 h（AUC0–24）,area under the curve from 0 h to infinite time（AUC0–∞）,peak plasma concentration（Cmax）,time to reach Cmax（tmax）,oral clearance（CL）,oral volume of distribution（Vd） and elimination half-life（t1/2）,were determined.Compared with the CYP2C9^＊1/^＊2 group,the AUC0–24,AUC0–∞ and Cmax of E-3174 in CYP2C9^＊1/^＊1 group of Hui subjects were respectively 1.36,1.32 and 1.64 times more,and the statistic differences were significant（P〈0.05）.The CYP2C9^＊2 mutant allele played an important role in the pharmacokinetics of losartan after oral administration,and it might decrease the generation of E-3174.However,large-sample clinical trials are required to validate whether the dose adjustment according to CYP2C9 genotype is necessary.
