Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(...Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(aged 19-90 years;male 72,female 56).The sera were analyzed for HbA_(1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C).According to the HbA_(1e) level,the patients were divided into three groups,group A(HbA_(?)<7%,n=31),group B(7%<HbA_(1c)<10%,n=48),and group C(HbA_(1c)>10%,n=49).The correlation of HbA_(1c)with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA(1c),LDL-C had a significantly increasing trend(P<0.05);whereas TC went up with the increased HbA(1c),without any significant differences between three groups.There was no significant correlation between HbA_(1c) and TG or HDL-C. With the increased level of HbA_(1c),TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups(P<0.05).The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.展开更多
Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health check-up.Methods:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) ...Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health check-up.Methods:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) test were included.Participates with HbA_(1c)≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test(OGTT).Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose(2 h-PG)≥11.1 mmol/L.The sensitivity and specificity of HbA_(1c) thresholds and FPG or combination test on screening of diabetes were analyzed.Results:A total of 842 subjects had HbA_(1c)<6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA_(1c)≥6.0%.Subjects with HbA_(1c)≥6.0% had significant increased disorder indexes than those with HbA_(1c)<6.0%.527 subjects who had HbA_(1c)≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123(123/234,52.56%) with FPG≥7.0 mmol/L,and 111 subjects(111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/L.Among 234 new diabetes,91.88%(215 subjects) had HbA_(1c)≥6.3%,and 77.40%(181 subjects) had HbA_(1c)≥6.5%.HbA_(1c)≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA_(1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population.Combined use of HbA_(1c)≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.展开更多
Objective: To determine the relationship between clinical parameters (HbA1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients...Objective: To determine the relationship between clinical parameters (HbA1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients with type 2 diabetes mellitus were evaluated. We obtained averages of: blood glucose (162.3 ± 73.10 mg/dl), glycated hemoglobin (HbA1c = 7.64% ± 1.77%), cholesterol (189.28 ± 35.25 mg/dl), triglycerides (189.11 ± 87.76 mg/dl), Systolic Blood Pressure (SBP = 119.69 ± 14.95 mmHg), Diastolic Blood Pressure (DBP = 77.15 ± 9.55 mmHg) and Media Blood Pressure (MBP = 91.36 ± 9.89 mmHg). We correlated variable HbA1c with vascular injury symptomatology. Results: Correlation was found between sensitivity dysfunction and HbA1c with a statistical significance of p = 0.01, and a correlation Kendal coefficient w = 0.01, any other parameter of metabolic control was not correlated with symptoms of vascular injury. Conclusion: It is remarkable that the sensitivity dysfunction is a symptom of poorly vascularized lower extremities caused for both functional impairment and structural changes in diabetic patients’ peripheral nerves, even in the preclinical stage of vascular disease. The HbA1c could also be investigated as a likely sensitivity dysfunction biomarker in DM due to the correlation presented in this study but more studies must be realized.展开更多
Background:Several biomarkers have been studied as prognostic indicators among people with diabetes and coro-nary artery disease(CAD).The purpose of this study was to determine the prognostic value of neutrophil count...Background:Several biomarkers have been studied as prognostic indicators among people with diabetes and coro-nary artery disease(CAD).The purpose of this study was to determine the prognostic value of neutrophil counts and the Gensini score in patients with diabetes and ACS undergoing percutaneous coronary intervention(PCI).Methods:A total of 694 people with ACS and T2DM who simultaneously had elevated HBA1c received PCI.Spear-man rank correlation estimates were used for correlation evaluation.Multivariate Cox regression and Kaplan-Meier analysis were used to identify characteristics associated with major adverse cardiovascular and cerebrovascular events(MACCEs)and patient survival.The effects of single-and multi-factor indices on MACCEs were evaluated through receiver operating characteristic curve analysis.Results:The Gensini score and neutrophil count significantly differed between the MACCE and non-MACCE groups among patients receiving PCI who had concomitant ACS and T2DM with elevated HBA1c(P<0.001).The Gensini score and neutrophil count were strongly associated with MACCEs(log-rank,P<0.001).The Gensini score and neu-trophil count,alone or in combination,were predictors of MACCEs,according to multivariate Cox regression analysis(adjusted hazard ratio[HR],1.005;95%confidence interval[CI],1.002–1.008;P=0.002;adjusted HR,1.512;95%CI,1.005–2.274;P=0.047,respectively).The Gensini score was strongly associated with neutrophil count(variance inflation factor≥5).Area under the curve analysis revealed that the combination of multivariate factors predicted the occurrence of MACCEs better than any single variable.Conclusion:In patients with T2DM and ACS with elevated HBA1c who underwent PCI,both the Gensini score and neutrophil count were independent predictors of outcomes.The combination of both predictors has a higher predict-ability.展开更多
文摘Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA_(1c)).Methods:Samples were collected from 128 type 2 diabetic patients(aged 19-90 years;male 72,female 56).The sera were analyzed for HbA_(1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C).According to the HbA_(1e) level,the patients were divided into three groups,group A(HbA_(?)<7%,n=31),group B(7%<HbA_(1c)<10%,n=48),and group C(HbA_(1c)>10%,n=49).The correlation of HbA_(1c)with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA(1c),LDL-C had a significantly increasing trend(P<0.05);whereas TC went up with the increased HbA(1c),without any significant differences between three groups.There was no significant correlation between HbA_(1c) and TG or HDL-C. With the increased level of HbA_(1c),TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups(P<0.05).The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.
文摘Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health check-up.Methods:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) test were included.Participates with HbA_(1c)≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test(OGTT).Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose(2 h-PG)≥11.1 mmol/L.The sensitivity and specificity of HbA_(1c) thresholds and FPG or combination test on screening of diabetes were analyzed.Results:A total of 842 subjects had HbA_(1c)<6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA_(1c)≥6.0%.Subjects with HbA_(1c)≥6.0% had significant increased disorder indexes than those with HbA_(1c)<6.0%.527 subjects who had HbA_(1c)≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123(123/234,52.56%) with FPG≥7.0 mmol/L,and 111 subjects(111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/L.Among 234 new diabetes,91.88%(215 subjects) had HbA_(1c)≥6.3%,and 77.40%(181 subjects) had HbA_(1c)≥6.5%.HbA_(1c)≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA_(1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population.Combined use of HbA_(1c)≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.
文摘Objective: To determine the relationship between clinical parameters (HbA1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients with type 2 diabetes mellitus were evaluated. We obtained averages of: blood glucose (162.3 ± 73.10 mg/dl), glycated hemoglobin (HbA1c = 7.64% ± 1.77%), cholesterol (189.28 ± 35.25 mg/dl), triglycerides (189.11 ± 87.76 mg/dl), Systolic Blood Pressure (SBP = 119.69 ± 14.95 mmHg), Diastolic Blood Pressure (DBP = 77.15 ± 9.55 mmHg) and Media Blood Pressure (MBP = 91.36 ± 9.89 mmHg). We correlated variable HbA1c with vascular injury symptomatology. Results: Correlation was found between sensitivity dysfunction and HbA1c with a statistical significance of p = 0.01, and a correlation Kendal coefficient w = 0.01, any other parameter of metabolic control was not correlated with symptoms of vascular injury. Conclusion: It is remarkable that the sensitivity dysfunction is a symptom of poorly vascularized lower extremities caused for both functional impairment and structural changes in diabetic patients’ peripheral nerves, even in the preclinical stage of vascular disease. The HbA1c could also be investigated as a likely sensitivity dysfunction biomarker in DM due to the correlation presented in this study but more studies must be realized.
基金The National Natural Science Foundation of China(Nos.2222007,82170281,and U2004203)the Henan Thousand Talents Program(No.ZYQR201912131)+1 种基金the Excellent Youth Science Foundation of Henan Province(No.202300410362)the Central Plains Youth Top Talent and Advanced Funds(No.2021-CCA-ACCESS-125)funded this research.
文摘Background:Several biomarkers have been studied as prognostic indicators among people with diabetes and coro-nary artery disease(CAD).The purpose of this study was to determine the prognostic value of neutrophil counts and the Gensini score in patients with diabetes and ACS undergoing percutaneous coronary intervention(PCI).Methods:A total of 694 people with ACS and T2DM who simultaneously had elevated HBA1c received PCI.Spear-man rank correlation estimates were used for correlation evaluation.Multivariate Cox regression and Kaplan-Meier analysis were used to identify characteristics associated with major adverse cardiovascular and cerebrovascular events(MACCEs)and patient survival.The effects of single-and multi-factor indices on MACCEs were evaluated through receiver operating characteristic curve analysis.Results:The Gensini score and neutrophil count significantly differed between the MACCE and non-MACCE groups among patients receiving PCI who had concomitant ACS and T2DM with elevated HBA1c(P<0.001).The Gensini score and neutrophil count were strongly associated with MACCEs(log-rank,P<0.001).The Gensini score and neu-trophil count,alone or in combination,were predictors of MACCEs,according to multivariate Cox regression analysis(adjusted hazard ratio[HR],1.005;95%confidence interval[CI],1.002–1.008;P=0.002;adjusted HR,1.512;95%CI,1.005–2.274;P=0.047,respectively).The Gensini score was strongly associated with neutrophil count(variance inflation factor≥5).Area under the curve analysis revealed that the combination of multivariate factors predicted the occurrence of MACCEs better than any single variable.Conclusion:In patients with T2DM and ACS with elevated HBA1c who underwent PCI,both the Gensini score and neutrophil count were independent predictors of outcomes.The combination of both predictors has a higher predict-ability.
