摘要
入选2013~2014年于复旦大学附属中山医院首诊的1型糖尿病住院患者共33例,收集其临床资料进行数据统计分析。结果显示,33例患者中共有暴发型1型糖尿病(FTlDM)7例、急性起病型1型糖尿病(AT1DM)12例及缓慢进展型1型糖尿病(SPIDDM)14例。FT1DM患者空腹C肽、负荷后C肽水平低于其他2组患者,糖化白蛋白(GA)/HbA。平均血糖波动幅度(MAGE)高于其他2组患者,差异均存在显著意义(均P〈0.05)。对所有1型糖尿病患者进行Pearson相关分析,结果提示GA/HbA1C比值与空腹c肽、MAGE、最高最低血糖差(ABG)水平均显著相关(P〈0.05);多元线性逐步回归分析提示GA/HbA。比值与MAGE、ABG独立相关(P〈0.05)。Logistic回归分析结果显示GA、HbAM、GA/HbA。与FT1DM均独立相关(P〈0.05)。
Thirty-three patients with new-onset type 1 diabetes from Zhongshan Hospital,Fudan University were recruited from 2013 to 2014.Relevant clinical data were collected for the statistical analysis.Among the 33 patients with type 1 diabetes,there were 7 with fulminant type 1 diabetes(FT1DM),12 acute onset type 1 diabetes(ATIDM),and 14 with slowly progressive type 1 diabetes(SPIDDM).The fasting and stimulated C-peptide levels were significantly lower while glycated albumin(GA)/HbA1C and mean amplitude of glucose excursions(MAGE)levels were significantly higher in FT1DM group compared with other two groups(all P〈0.05).Pearson correlation analysis in all patients with type 1 diabetes revealed that GA/HbA1C was correlated with fasting C-peptide,MAGE,and difference of the peak blood glucose to the lowest blood glucose(ABG)levels(all P〈0.05).Stepwise multivariate analysis showed that GA/HbA1C was independently correlated with MAGE and ABG(P〈0.05).Logistic regression model indicated that GA,HbA1C,and GA/HbA1C were independently correlated with FT1DM.
作者
王柏荣
陆志强
李晓牧
高鑫
Wang Bairong;Lu Zhiqiang;Li Xiaomu;Gao Xin(Department of Endocrinology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2017年第4期326-329,共4页
Chinese Journal of Endocrinology and Metabolism
基金
上海市自然科学基金项目(15ZR1406600)
