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广东地区汉族人群HLA-B^(*)5801等位基因与别嘌醇致不良反应的相关性分析
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作者 张清华 温秀玲 +2 位作者 黄耿 李伟恩 谭文明 《临床医学研究与实践》 2026年第6期59-62,共4页
目的 明确广东地区汉族人群高尿酸血症与痛风患者HLA-B^(*)5801等位基因与别嘌醇致不良反应的相关性。方法 收集2019年6月至2024年11月在江门市中心医院接受HLA-B^(*)5801等位基因检测的254例高尿酸血症与痛风患者临床资料。根据是否发... 目的 明确广东地区汉族人群高尿酸血症与痛风患者HLA-B^(*)5801等位基因与别嘌醇致不良反应的相关性。方法 收集2019年6月至2024年11月在江门市中心医院接受HLA-B^(*)5801等位基因检测的254例高尿酸血症与痛风患者临床资料。根据是否发生不良反应将服用别嘌醇的患者分为不良反应组(14例)和耐受组(41例),以及未使用别嘌醇的患者作为对照组(199例)。分析HLA-B^(*)5801等位基因与别嘌醇致不良反应的相关性。结果 254例纳入患者中,HLA-B^(*)5801等位基因携带率为20.47%(52/254);其中不良反应组携带率为92.86%(13/14),耐受组为2.44%(1/41),对照组19.10%(38/199)。HLA-B^(*)5801等位基因阳性患者发生别嘌醇致不良反应的风险显著高于阴性患者(不良反应组与耐受组相比,OR=123.50,95%CI:15.76~967.67,P<0.001)。HLA-B^(*)5801等位基因预测别嘌醇致不良反应的灵敏度为92.86%、特异度为97.56%。结论 广东地区汉族高尿酸血症与痛风患者HLA-B^(*)5801等位基因与别嘌醇致不良反应具有强相关性。建议用药前常规进行HLA-B^(*)5801等位基因筛查,并结合患者年龄、肝肾功能等制定个体化治疗方案,以保障用药安全。 展开更多
关键词 高尿酸血症 痛风 hla-B^(*)5801等位基因 别嘌醇
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南宁地区HLA抗体介导的新生儿同种免疫血小板减少症的实验室诊断与临床资料分析
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作者 莫慧慧 卢芳 +5 位作者 李恒聪 陈洁润 陈迎 黄雨晨 钟周琳 周燕 《中国实验血液学杂志》 北大核心 2026年第1期185-191,共7页
目的:探讨HLA抗体介导的新生儿同种免疫血小板减少症(NAIT)的实验室诊断,并对患儿临床资料进行分析。方法:分别采用流式细胞术、ELISA、血小板抗原单克隆抗体特异性免疫固定检测技术(MAIPA)、Sanger测序技术、核酸飞行时间质谱技术(MALD... 目的:探讨HLA抗体介导的新生儿同种免疫血小板减少症(NAIT)的实验室诊断,并对患儿临床资料进行分析。方法:分别采用流式细胞术、ELISA、血小板抗原单克隆抗体特异性免疫固定检测技术(MAIPA)、Sanger测序技术、核酸飞行时间质谱技术(MALDI-TOFMS)对5例新生儿血小板减少症患儿及其父母的血液样本进行血小板抗体检测、HLA基因分型及HPA-1~5、-15基因分型;同时,将该5例患儿与文献报道的17例类似病例进行汇总,分析NAIT母亲妊娠史、HLA抗体类型对患儿血小板计数的影响。结果:5例患儿母亲血浆中均检出针对患儿父亲HLA抗原的抗体。病例1母亲含HLA-A29、HLA-B7抗体,患儿含HLA-B7抗体,患儿基因型为HLA-A*02:07,29:01;B*07:05,46:01;病例2母亲含HLA-B51抗体,患儿含HLA-B78抗体,患儿基因型为HLA-A*11:01,11:01;B*38:02,51:01;病例3母亲含HLA-B60抗体,患儿基因型为HLA-A*02:07,11:01;B*39:15,40:01;病例4母亲含HLA-A11抗体,患儿基因型为HLA-A*11:01,29:01;B*07:05,13:01;病例5母亲含HLA-A203、HLA-B60抗体,患儿含HLA-A203抗体,基因型为HLA-A*02:03,11:01;B*39:15,40:01。病例2、病例3的患儿与其母亲HPA-1~5、-15基因分型均相容;病例1与母亲存在HPA-2和HPA-3不相容;病例4与母亲存在HPA-15不相容;病例5与母亲存在HPA-2不相容,经MAIPA检测排除HPA抗体。在22例由HLA抗体介导的NAIT病例中,母亲为首次妊娠的患儿血小板计数显著低于母亲为多次妊娠的患儿(P<0.01),母亲同时含HLA-A抗体、HLA-B抗体的患儿较仅存在单一抗体类型的患儿血小板计数更低(P<0.01)。结论:HLA、HPA抗体的鉴定、排除和基因分型对于NAIT的诊断具有重要意义;首次妊娠和同时存在多种HLA抗体类型的母亲,其患儿可能面临更高的出血风险,需要密切监测和及时治疗。 展开更多
关键词 新生儿 血小板减少 hla抗体 首次妊娠
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基于Alltype^(TM)Fastplex^(TM)二代测序的HLA-B等位基因漏检原因分析
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作者 全湛柔 杨冰娜 +1 位作者 刘洁 邹红岩 《中国实验血液学杂志》 北大核心 2026年第1期255-260,共6页
目的:探讨1例基于Alltype^(TM)Fastplex^(TM)二代测序(NGS)的HLA-B等位基因漏检情况,以评估NGS在HLA基因分型中的准确性和局限性。方法:应用PCR-序列特异性寡核苷酸探针(SSOP)及Alltype^(TM)Fastplex^(TM)NGS进行HLA常规检测,发现1例HL... 目的:探讨1例基于Alltype^(TM)Fastplex^(TM)二代测序(NGS)的HLA-B等位基因漏检情况,以评估NGS在HLA基因分型中的准确性和局限性。方法:应用PCR-序列特异性寡核苷酸探针(SSOP)及Alltype^(TM)Fastplex^(TM)NGS进行HLA常规检测,发现1例HLA-B位点结果不一致的血小板无力症患者样本后,采用PCR-直接测序法(SBT)及AlloSeq Tx17杂交捕获的NGS技术对该样本进行复检,以验证Alltype^(TM)Fastplex^(TM)NGS的检测结果。结果:SSOP分型结果显示该患者HLA-B位点为B*15:01,40:01,而Alltype^(TM)Fastplex^(TM)NGS结果分析为B*40:01,40:01纯合子。为了确认NGS的检测结果,本研究对该纯合子样本进行了SBT和AlloSeq Tx17杂交捕获NGS复检。SBT分析结果显示,存在两种可能的组合,分别是B*15:01,40:01和B*15:07,40:01,表明SBT结果模棱两可。而AlloSeq Tx17 NGS结果则明确显示为B*15:01,40:01,与SSOP分型结果一致,从而确认了Alltype^(TM)Fastplex^(TM)NGS在HLA-B位点漏检了B*15:01等位基因。结论:扩增子文库构建的NGS法存在HLA等位基因漏检的局限性,特别是对于检出的纯合子样本,应采用多种实验方法进行复核,保证HLA基因分型结果的准确性。 展开更多
关键词 hla-B 基因分型 扩增子 杂交捕获 二代测序
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Study on the effect of preparation method on denitration performance of Co-modified Ce/TiO_(2) catalyst
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作者 YU Chao ZHANG Boya +2 位作者 SHEN Kai HAN Yuxuan ZHANG Yaping 《燃料化学学报(中英文)》 北大核心 2026年第3期79-91,共13页
This study systematically conducted preparation optimization and performance investigations on Co-modified Ce/TiO_(2) catalysts,with a focus on examining how preparation methods and Co loading regulate the catalyst’s... This study systematically conducted preparation optimization and performance investigations on Co-modified Ce/TiO_(2) catalysts,with a focus on examining how preparation methods and Co loading regulate the catalyst’s low-temperature denitrification activity.After identifying optimal preparation parameters via condition screening,multiple characterization techniques-including BET,XRD,XPS,H_(2)-TPR and in situ DRIFTS-were employed to deeply analyze the catalyst’s physicochemical properties and reaction mechanism.Results demonstrated that compared to the impregnation and co-precipitation methods,the Ce-Co_(0.025)/TiO_(2)-SG catalyst(prepared by the sol-gel method with a Co/Ti mass ratio of 0.025)exhibited significantly superior denitrification activity:NO conversion remained stably above 95%in the 225−350℃ temperature range,and it displayed high N_(2) selectivity.Characterization analysis revealed that abundant surface oxygen vacancies,a high proportion of Ce^(3+) species,and prominent acidic sites collectively contributed to enhancing its low-temperature denitrification performance.This work provides reference value for the development of highly efficient low-temperature denitrification catalysts. 展开更多
关键词 preparation method Co Ce/TiO_(2) low-temperature denitration NH3-SCR
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A New Inversion-free Iterative Method for Solving the Nonlinear Matrix Equation and Its Application in Optimal Control
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作者 GAO Xiangyu XIE Weiwei ZHANG Lina 《应用数学》 北大核心 2026年第1期143-150,共8页
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ... In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method. 展开更多
关键词 Nonlinear matrix equation Maximal positive definite solution Inversion-free iterative method Optimal control
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Broadband ground motion simulation and analysis of a near-fault 3D basin-mountain coupling site based on the hybrid method
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作者 Liu Zhongxian Tang Kang +2 位作者 Li Chengcheng Yuan Xiaoming Zhang Hai 《Earthquake Engineering and Engineering Vibration》 2026年第1期87-110,共24页
This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SE... This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions. 展开更多
关键词 hybrid ground motion simulation method spectral element method three-dimensional stochastic finite fault method near-fault basin-mountain coupling effect basin effect nonlinear effect
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Establishment of a Determination Method for Fruit Texture in Chieh-qua Using Texture Analyzer
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作者 Ying WANG Xuan DU Na LIU 《Agricultural Biotechnology》 2026年第1期54-59,共6页
[Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and pun... [Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and puncture,the index data of the fruit were obtained by setting different trigger forces,deformation levels,test speeds,as well as puncture speeds and puncture depths.The data included TPA hardness,adhesiveness,springiness,cohesiveness,gumminess,chewiness,resilience,as well as skin hardness,skin toughness,flesh hardness,fracturability,and compactness.[Results]Different deformation levels had a significant impact on all parameters.Hardness,adhesiveness,gumminess and chewiness showed a trend of first increasing and then decreasing with the deformation level increasing.When the deformation level was 30%,the adhesiveness,gumminess and chewiness reached their maximum values.When the deformation level was 50%,TPA hardness reached its maximum.When the compression speed was 3 mm/s,the measured values of TPA hardness,adhesiveness,chewiness,and resilience were at their maximums.The skin hardness varied significantly under different trigger forces.When the trigger force was 15 g,the skin hardness reached a maximum value of 944.63 g,and the skin toughness,flesh hardness,fracturability,and compactness also reach their maximum values respectively.When the puncture depth was 12 mm,the flesh hardness and skin toughness reached their maximums of 682.51 g and 1.82 mm,respectively.In the TPA mode,the flesh hardness of chieh-qua showed an extremely significant negative correlation with springiness,cohesiveness,and resilience(P<0.01).The fruit fracturability detected by puncture had an extremely significant positive correlation with compactness(P<0.01).[Conclusions]The evaluation method for measuring chieh-qua texture by combining TPA and the puncture mode could accurately and quantitatively reflect the differences in the flesh texture quality of chieh-qua.The optimal parameters for texture measurement of chieh-qua fruit were determined as a 15 g trigger force with 50%deformation and a 3 mm/s compression speed in TPA mode,and a 15 g trigger force with a 12 mm puncture depth in puncture mode.Puncture speed was found to have no significant effect on the texture indices of chieh-qua. 展开更多
关键词 CHIEH-QUA Texture analyzer Texture quality Determination method
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A novel scaling method for the elastic ring supporting structure of an aero-engine rotor system: analytical and experimental investigations
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作者 Lei LI Tianyue MA +4 位作者 Zhong LUO Dongwu GAO Xiangdong GE Hui MA Shibin WANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期1-18,共18页
The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometr... The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometric distortions, leading to a diminution in the predictive accuracy of the distorted similitude. To address this challenge, this study formulates a novel set of scaling laws, tailored to account for the intricate geometric distortions associated with elastic rings. The proposed scaling laws are formulated based on the intrinsic deformation characteristics of elastic rings, rather than the traditional systemic governing equations. Numerical and experimental cases are conducted to assess the efficacy and precision of the proposed scaling laws, and the obtained results are compared with those achieved by traditional methods. The outcomes demonstrate that the scaling laws put forth by this study significantly enhance the predictive capabilities for deformations of elastic rings. 展开更多
关键词 rotor system AERO-ENGINE elastic ring scaling method supporting structure
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Multiphysics Implicit Coupling Method for Fluid,Particles,and Large-Deformation Structures
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作者 Xiangxiang Wang Hualong Xie +3 位作者 Yue Yu Min Li Yubin Wang Fei Xing 《Computer Modeling in Engineering & Sciences》 2026年第2期367-401,共35页
This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,Calcu... This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems. 展开更多
关键词 Fluid-particle-structure interaction large deformation partitioned method non-intrusive coupling
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Healthcare professionals’perspectives on disclosure of diagnosis and related issues in childhood cancer:A mixed methods systematic review
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作者 Run Xie Xiaoyan Huang +4 位作者 Yiran Du Ying Gu Qiongfang Kang Hongsheng Wang Daqian Zhu 《International Journal of Nursing Sciences》 2026年第1期96-104,I0006,共10页
Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of... Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process. 展开更多
关键词 Communication CANCER DISCLOSURE Healthcare professionals Mixed methods PEDIATRIC Systematic review
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Investigation of equivalent strength parameters of soil-rock mixture using numerical manifold method
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作者 Junfeng Li Yongtao Yang +2 位作者 Yang Xia Hong Zheng Shuilin Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期637-650,共14页
As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalen... As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalent parameters of SRMs,which are typically obtained through experimental and numerical methods.In contrasted to other numerical methods,the numerical manifold method(NMM)is more effective in addressing SRM problems.This is because the high-precision regular mathematical meshes in NMM can be used without aligning with the soil-rock interfaces and boundaries of SRMs.In the current research,the equivalent strength parameters of SRMs,i.e.the equivalent cohesion ce and internal friction angleϕ_(e),are determined using NMM.Initially,an NMM triaxial numerical model is established and validated based on triaxial experiments.Subsequently,the soil and rock parameters are derived through parameter inversion.Moreover,the impacts of rock content,size,shape and rock blocks'major-axis orientation on ce andϕ_(e) of SRMs are thoroughly examined using the NMM triaxial numerical model.Additionally,a fitting function is proposed to linkϕ_(e) to the rock content and size of SRMs.When other influencing factors are fixed,the above fitting model leads to the following conclusions:(1)the predictedϕ_(e) of SRMs increase with the increase of rock content;and(2)SRM samples with smaller rocks display a higher predictedϕ_(e). 展开更多
关键词 Soil-rock mixtures Equivalent strength parameters Numerical manifold method
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Subtitle Translation Methods of The Good Wife From Functional Equivalence Perspective
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作者 WANG Ya-kun BAO De-wang 《Journal of Literature and Art Studies》 2026年第1期26-30,共5页
The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to... The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to analyze the methods of its English-to-Chinese subtitle translation by considering social,cultural,and historic backgrounds between China and America.After data collection and case analysis,the study found that:(1)Five major translation methods are adopted in the subtitle translation of The Good Wife.They are free translation,variation,literal translation,addition,and omission.Among them,free translation is the most frequently used,while omission is used least.(2)The subtitle translation of films and TV series is limited by time and space restrictions,social-cultural differences,and other factors.When translating,translators should try to use humorous words,euphemism,intonation,and other ways,and combine different methods such as literal translation,free translation,variation,addition,omission,and other methods to seek equivalence both in the meaning and function of subtitles under the guidance of Functional Equivalence Theory. 展开更多
关键词 subtitle translation Functional Equivalence Theory The Good Wife translation methods
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Pile installation effects in natural soft clays:A semi-analytical solution using strain path method
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作者 Liang Li Pan Zhou +3 位作者 Jingpei Li Seyedmohsen Miraei Peng Feng Mingdong Wei 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期728-744,共17页
This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture ... This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP. 展开更多
关键词 Pile penetration Strain path method Natural soft clays Anisotropy evolution Destructuration
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Crushing evolution in pebble bed based on a novel method:a crushable DEM study
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作者 Jian Wang Ming‑Zhun Lei +4 位作者 Ming‑Zong Liu Qi‑Gang Wu Zi‑Cong Cai Kai‑Song Wang Hai‑Shun Deng 《Nuclear Science and Techniques》 2026年第1期212-224,共13页
In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical m... In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing. 展开更多
关键词 Crushing behavior Granular material Discrete element method Pebble bed Fractal theory
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血清肿瘤标志物HLA-G在卵巢恶性肿瘤中的诊断价值
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作者 曾凡婷 马光顺 +2 位作者 卢琴 邓兴艳 冯宁 《吉林医学》 2026年第1期42-45,共4页
目的:探究人类白细胞抗原G(HLA-G)在卵巢恶性肿瘤中的诊断价值。方法:2023年10月~2024年10月,利用酶联免疫吸附试验(ELISA)检测黔西南州人民医院58例卵巢恶性肿瘤患者和18例正常对照血清标本中HLA-G的含量变化;全自动化学发光法检测人... 目的:探究人类白细胞抗原G(HLA-G)在卵巢恶性肿瘤中的诊断价值。方法:2023年10月~2024年10月,利用酶联免疫吸附试验(ELISA)检测黔西南州人民医院58例卵巢恶性肿瘤患者和18例正常对照血清标本中HLA-G的含量变化;全自动化学发光法检测人附睾蛋白4(HE4)和糖类抗原125(CA125)的浓度并利用皮尔逊相关系数(PCCs)分析HLAG、HE4、CA125三者之间的关系;采用受试者工作特征(ROC)曲线评估HLA-G、HE4、CA125单项或联合检测的诊断效能。结果:HLA-G在卵巢恶性肿瘤患者血清中的表达水平高于正常对照组,差异有统计学意义(P<0.05)。ROC曲线显示血清HE4、CA125及HLA-G诊断卵巢恶性肿瘤的曲线下面积(AUC)为0.953(95%CI:0.897~1)、0.84(95%CI:0.734~0.946)、0.796(95%CI:0.663~0.929);PCCs分析显示,卵巢恶性肿瘤患者血清HLA-G的表达与HE4、CA125无显著相关性(r^(2)=0.175,P=0.215;r^(2)=0.065,P=0.648);HLA-G联合HE4、CA125检测卵巢恶性肿瘤的AUC、敏感度和特异度分别为0.964(95%CI:0.916~1)、91.7%和100.00%,联合检测诊断效能高于单独检测。结论:HLA-G在卵巢恶性肿瘤早期诊断中具有重要的诊断价值并可能成为早期诊断及预后监测的独立肿瘤标志物,联合检测能够显著提升卵巢恶性肿瘤早期诊断的准确性,为临床治疗提供新的策略和方向。 展开更多
关键词 卵巢恶性肿瘤 hla-G 早期诊断 标志物
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Correction models of Reynolds number effects for through-flow method in axial compressors
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作者 Xiaochen WANG Chunwei GU 《Chinese Journal of Aeronautics》 2026年第1期78-94,共17页
Aerodynamic performances of axial compressors are significantly affected by variation of Reynolds number in aero-engines.In the design and analysis of compressors,previous correction methods for cascades and stages ha... Aerodynamic performances of axial compressors are significantly affected by variation of Reynolds number in aero-engines.In the design and analysis of compressors,previous correction methods for cascades and stages have difficulties in predicting comprehensively Reynolds number effects on airfoils,matching and characteristics curves.This study proposes Re-correction models for loss,deviation angle and endwall blockage based on classical theories and cascade tests,and loss and deviation models show good agreement in test data of NACA65 and C4 cascades.Throughflow method considering Reynolds number effects is developed by integrating the correction models into a verified Streamline Curvature(SLC)tool.A three-stage axial compressor is investigated through SLC and CFD methods from design Reynolds number(Red=2106)to low Re=4104,and the numerical methods are validated with test data of characteristic curves and spanwise distributions at Red.With Re reduction,SLC method with correction models well predicts variation in overall performances compared with CFD calculations and Wassell's model.Streamwise and spanwise matching such as total pressure and loss distributions in SLC predictions are basically consistent with those in CFD results at near-stall points under design and low Reynolds numbers.SLC and CFD methods share similar detections of stall risks in the third stage(Stg3),and their analyses of diffusion processes deviate to some extent due to different predictions in separated endwall flow.The correction models can be adopted to consider Reynolds number effects in through-flow design and analysis of axial compressors. 展开更多
关键词 Axial compressor Reynolds number effects Correction model Through-flow method Aerodynamic performance
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ANALYSIS OF A QUADRILATERAL EDGE ELEMENT METHOD FOR MAXWELL EQUATIONS
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作者 Zhijie DU Huoyuan DUAN Caihong WANG 《Acta Mathematica Scientia》 2026年第1期275-292,共18页
A new quadrilateral edge element method is proposed and analyzed for Maxwell equations.This proposed method is based on Duan-Liang quadrilateral element(Math.Comp.73(2004),pp.1–18).When applied to the eigenvalue prob... A new quadrilateral edge element method is proposed and analyzed for Maxwell equations.This proposed method is based on Duan-Liang quadrilateral element(Math.Comp.73(2004),pp.1–18).When applied to the eigenvalue problem,the method is spectral-correct and spurious-free.Stability and error estimates are obtained,including the interpolation error estimates and the error estimates between the finite element solution and the exact solution.The method is suitable for singular solution as well as smooth solution,and consequently,the method is valid for nonconvex domains which may have a number of reentrant corners.Of course,the method is suitable for arbitrary quadrilaterals(under the usual shape-regular condition). 展开更多
关键词 Maxwell equations finite element method quadrilateral mesh STABILITY error bound spectral approximation
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A Deep Reinforcement Learning-Based Partitioning Method for Power System Parallel Restoration
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作者 Changcheng Li Weimeng Chang +1 位作者 Dahai Zhang Jinghan He 《Energy Engineering》 2026年第1期243-264,共22页
Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision... Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training. 展开更多
关键词 Partitioning method parallel restoration deep reinforcement learning experience replay buffer partitioning modularity
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Promoting psychological well-being in AI-enhanced english as a foreign language learning:A mixed-methods study of motivation,language learning anxiety and trust in higher education
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作者 Zhiyong Sun 《Journal of Psychology in Africa》 2026年第1期33-43,共11页
This mixed-methods study investigated how AI-enhanced English as a Foreign Language(EFL)learning environments influence students’psychological well-being through the mediating roles of motivation and language learnin... This mixed-methods study investigated how AI-enhanced English as a Foreign Language(EFL)learning environments influence students’psychological well-being through the mediating roles of motivation and language learning anxiety and the moderating role of trust.Participants were Chinese university students(N=310,62%female,mean age=18.9,SD=0.8),of whom 15 completed interviews to both add to and to clarify the evidence from the surveys.Structural equation modeling results revealed that AI use had significant indirect effects on well-being through increased motivation and reduced language learning anxiety.Trust in AI significantly moderated both paths,amplifying the motivational benefits and anxiety reduction associated with AI use.Thematic analysis supported these results,identifying three experiential themes:(1)motivational empowerment through personalization,(2)anxiety regulation through safe practice and feedback,and(3)trust as the emotional bridge between AI and well-being.The study extends AI psychology applications by empirically linking technology engagement with affective outcomes and underscores the need for human-centered and trust-enhancing design in AI-supported education.From these findings,we conclude that adaptive,transparent,and autonomy-supportive AI systems promote self-determined motivation,emotional safety,and overall psychological health among EFL learners. 展开更多
关键词 Artificial intelligence psychology EFL learning MOTIVATION anxiety trust WELL-BEING mixed methods self-determination theory
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Dynamic characteristics and sensitivity of water hammer problems in liquid propulsion system using lattice Boltzmann method with entropy limiter
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作者 Yuqi WEI Xianggeng WEI +4 位作者 Guoqiang HE Xiao ZHAO Jinying YE Xueren WANG Hongyu CHEN 《Chinese Journal of Aeronautics》 2026年第1期18-34,共17页
The water hammer problem is an important issue in the dynamics of liquid propulsion system.This paper aims to use the Lattice Boltzmann Method(LBM)with entropy limiter to study the water hammer problems in propellant ... The water hammer problem is an important issue in the dynamics of liquid propulsion system.This paper aims to use the Lattice Boltzmann Method(LBM)with entropy limiter to study the water hammer problems in propellant feedlines.The dynamic characteristics of valve-closing water hammer and filling water hammer are investigated by this method,and the sensitivity of filling water hammer is analyzed with a single factor sensitivity analysis with 8 factors and 9 levels and a multi-factor sensitivity analysis with L_(27)(3^(13))orthogonal experiment based on range method.It is found that the solving result of LBM with entropy limiter is basically in good agreement with finite volume method,and using the entropy limiter can eliminate numerical oscillations when solving valve-closing water hammer problems and solve the numerical"blow up"when solving filling water hammer problems.It can be seen that the dynamic characteristics of valve-closing water hammer are relatively simple,while there are many factors that affect the filling water hammer and the degree of these effects varies.The effects on the maximum water hammer pressure are relatively uniform,but those on the water hammer response time vary greatly through the skewness analysis. 展开更多
关键词 Dynamic analysis Lattice Boltzmann method Liquid propulsion system Propellant transfer Sensitivity analysis Water hammer
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