Aim of the study. -To evaluate mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria. Material and methods. -Prospective non randomized study in hospitalized children during ...Aim of the study. -To evaluate mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria. Material and methods. -Prospective non randomized study in hospitalized children during one year. Acute falcipamm malaria was defined by fever and a positive thin and/or thick smear. Malaria was presumed to have been contracted in Comoros archipelago and/or Madagascar 6 months previously. Patients were excluded, when quinine had to be used, according to World Health Organization’s severity criteria. Results. -Forty-nine children were included: 29 were treated with halofantrine and 20 with mefioquine. Patients features in the two groups of treatment were identical, with exception for the mean time between first clinical signs and diagnosis (shorter in mefloquine group). Fever’s and hospitalization’s durations under treatment were similar. An increase in QTc interval was frequently observed in patients treated with halofantrine (56 versus 0%), although patients with mefloquine experienced vomiting (45 versus 0%). Relapses seemed to bemore frequent with halofantrine (14 versus 0%). Discussion. -Halofantrine and mefloquine are efficient for falciparum malaria treatment in our pediatric series, despite a high rate of adverse events. Mefloquine’s tolerance may probably be improved with changes in regimen and dose. Relapses are more frequent with a single first treatment of halofantrine, than with mefloquine. Unfortunately, features of a second halofantrine treatment are not defined.展开更多
The area of the present investigation’s expanse constitutes the southernmost extent of the southeast Kumaun Himalaya and western Nepal Himalaya.Multidisciplinary approaches have been employed to understand the landfo...The area of the present investigation’s expanse constitutes the southernmost extent of the southeast Kumaun Himalaya and western Nepal Himalaya.Multidisciplinary approaches have been employed to understand the landforms associated with tectonic deformation,through detailed field investigation supplemented by the geodetic,chronological,and morphometric database.The morphogenic expressions of the Main Boundary Thrust(MBT)are reflected in the form of~25 km long E-W trending north dipping fault scarp.The deformation along the strike length of the Himalayan Frontal Thrust(HFT)is noticed in the form of uplifted and incised fill terraces,and strath terraces.The deformation within the fluvial sequences in the study area can be visualized in the form of sheared boulders and pebbles,tilted and faulted terrace deposits.Furthermore,the chronological data of fluvial landforms in the study area suggests two major phases of tectonic deformations that have occurred around 58.7±10.8 ka and 3.88±0.4 ka.The chronology of late-Quaternary landforms advocates that the initial stage of aggradations in the Himalayan foothills commenced around 75.1±0.58 ka.The aggradational landforms resulted from the diverse depositional regime as evident from the nature of the sediment sequences from clasts dominated to thick mud sequences.The rate of deformation in the southeastern Kumaun and western Nepal Himalaya is±7 mm/yr,as per the data obtained from the Persistent Scatterer Interferometric Synthetic Aperture Radar(PSInSAR).The landform deformation pattern,phase of incision and aggradation,frequent occurrence of landslides,and recent past earthquake activity within the wide zone of the HFT,the MBT,and Ramgarh Thrust suggests that the southernmost front of the Kumaun Himalaya is active and has potential for future geohazard.The foothill zone of Himalayan towns are actively growing in terms of population and infrastructural development.Therefore,such intradisciplinary studies for tectonically active regions are needed for future infrastructural development.展开更多
文摘Aim of the study. -To evaluate mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria. Material and methods. -Prospective non randomized study in hospitalized children during one year. Acute falcipamm malaria was defined by fever and a positive thin and/or thick smear. Malaria was presumed to have been contracted in Comoros archipelago and/or Madagascar 6 months previously. Patients were excluded, when quinine had to be used, according to World Health Organization’s severity criteria. Results. -Forty-nine children were included: 29 were treated with halofantrine and 20 with mefioquine. Patients features in the two groups of treatment were identical, with exception for the mean time between first clinical signs and diagnosis (shorter in mefloquine group). Fever’s and hospitalization’s durations under treatment were similar. An increase in QTc interval was frequently observed in patients treated with halofantrine (56 versus 0%), although patients with mefloquine experienced vomiting (45 versus 0%). Relapses seemed to bemore frequent with halofantrine (14 versus 0%). Discussion. -Halofantrine and mefloquine are efficient for falciparum malaria treatment in our pediatric series, despite a high rate of adverse events. Mefloquine’s tolerance may probably be improved with changes in regimen and dose. Relapses are more frequent with a single first treatment of halofantrine, than with mefloquine. Unfortunately, features of a second halofantrine treatment are not defined.
基金Council of Scientific and Innovative Research for providing fellowship (file number- 09/0420(15968)/2022-EMRI)
文摘The area of the present investigation’s expanse constitutes the southernmost extent of the southeast Kumaun Himalaya and western Nepal Himalaya.Multidisciplinary approaches have been employed to understand the landforms associated with tectonic deformation,through detailed field investigation supplemented by the geodetic,chronological,and morphometric database.The morphogenic expressions of the Main Boundary Thrust(MBT)are reflected in the form of~25 km long E-W trending north dipping fault scarp.The deformation along the strike length of the Himalayan Frontal Thrust(HFT)is noticed in the form of uplifted and incised fill terraces,and strath terraces.The deformation within the fluvial sequences in the study area can be visualized in the form of sheared boulders and pebbles,tilted and faulted terrace deposits.Furthermore,the chronological data of fluvial landforms in the study area suggests two major phases of tectonic deformations that have occurred around 58.7±10.8 ka and 3.88±0.4 ka.The chronology of late-Quaternary landforms advocates that the initial stage of aggradations in the Himalayan foothills commenced around 75.1±0.58 ka.The aggradational landforms resulted from the diverse depositional regime as evident from the nature of the sediment sequences from clasts dominated to thick mud sequences.The rate of deformation in the southeastern Kumaun and western Nepal Himalaya is±7 mm/yr,as per the data obtained from the Persistent Scatterer Interferometric Synthetic Aperture Radar(PSInSAR).The landform deformation pattern,phase of incision and aggradation,frequent occurrence of landslides,and recent past earthquake activity within the wide zone of the HFT,the MBT,and Ramgarh Thrust suggests that the southernmost front of the Kumaun Himalaya is active and has potential for future geohazard.The foothill zone of Himalayan towns are actively growing in terms of population and infrastructural development.Therefore,such intradisciplinary studies for tectonically active regions are needed for future infrastructural development.
