Objective:Patients with stage III non-small cell lung cancer(NSCLC)present with a heterogeneous disease profile and often require multifaceted treatment strategies.This research aimed to investigate the demographic fe...Objective:Patients with stage III non-small cell lung cancer(NSCLC)present with a heterogeneous disease profile and often require multifaceted treatment strategies.This research aimed to investigate the demographic features,therapeutic patterns,and survival outcomes of such patients in Vietnam.Methods:A retrospective descriptive study was conducted on 731 patients diagnosed with stage III NSCLC American Joint Committee on Cancer(AJCC)8th edition,at Nghe An Oncology Hospital from January 2018 to August 2024.Descriptive statistics summarized baseline and treatment characteristics.We calculated progression-free survival(PFS)and overall survival(OS)through the Kaplan–Meier approach and compared survival curves with the log-rank test.Prognostic variables were assessed using Cox regression analysis.Results:Patients had a median age of 64 years,and the majority(84%)were male.Disease stages IIIA,IIIB,and IIICaccounted for 26.0%,49.9%,and 24.1%of cases,respectively.Adenocarcinoma(60.7%)was the most common histological subtype.Initial treatments included surgery(8.5%),concurrent chemoradiotherapy(38.6%),sequential chemoradiotherapy(2.2%),radiotherapy alone(1.4%),systemic therapy(37.3%),and palliative care(12.0%).From 2018 to 2024,the use of systemic therapy declined(88.5%to 21.7%),while concurrent chemoradiotherapy rose significantly(1.1%to 51.5%).Median progression-free survival(mPFS)and median overall survival(mOS)were 8.9 months and 20.5 months,respectively.Patients with stage IIIA had significantly better outcomes(mPFS:12.6 months;mOS:32.4 months;p<0.001).Surgical treatment yielded the longest survival(mPFS:13.5 months;mOS:42.8 months).Favorable prognostic factors included adenocarcinoma subtype,presence of driver mutations,stage IIIA,and good performance status.Conclusion:For stage III NSCLC,concurrent chemoradiotherapy is still considered the standard treatment,whereas surgery can provide the highest survival advantage in carefully selected cases.Histology,molecular profile,and disease stage are key prognostic indicators.展开更多
Type III acute acquired comitant esotropia(AACE)is a special type of binocular coordination disorder with sudden onset characteristics,but its pathogenesis and treatment strategies remain unclear.This article analyzes...Type III acute acquired comitant esotropia(AACE)is a special type of binocular coordination disorder with sudden onset characteristics,but its pathogenesis and treatment strategies remain unclear.This article analyzes the incidence and classification characteristics of Type III AACE,and explores its pathogenesis from multiple perspectives including clinical medicine,neuroscience,and neuro-ophthalmology.It is found that this disease is associated with factors such as decompensation of phoria,dysfunction of the visual center,abnormalities in the physiological and anatomical structure of extraocular muscles,accommodative factors,and disorders of convergence and divergence.The prognosis of Type III AACE is excellent with treatments such as botulinum toxin injection and surgery,and adjunctive therapies like prism adaptation test and visual function training can enhance the management effect.This article provides an in-depth analysis of the pathogenesis and cutting-edge treatment techniques for patients with Type III AACE,which can offer guidance for the subsequent diagnosis and treatment of such patients.展开更多
Based upon the thiophene-2,5-dicarboxylic acid(H_(2)Tdc),a novel[Sc_(3)(μ_(2)-OH)_(3)(CO_(2))_(4)O_(6)]n inorganic chain-based Sc-MOF with decorated nitrate ions,{[Sc_(3)(OH)_(2)(Tdc)_(3)(NO_(3))]⋅H_(2)O}_(∞)(AEU-1;...Based upon the thiophene-2,5-dicarboxylic acid(H_(2)Tdc),a novel[Sc_(3)(μ_(2)-OH)_(3)(CO_(2))_(4)O_(6)]n inorganic chain-based Sc-MOF with decorated nitrate ions,{[Sc_(3)(OH)_(2)(Tdc)_(3)(NO_(3))]⋅H_(2)O}_(∞)(AEU-1;AEU for Army Engineering University of PLA),was synthesized,which shows good water and chemical stabilities.Significantly,due to channel constriction accompanied by the polar window caused by introducing nitrate ions,AEU-1 exhibits high C_(2)H_(6)/C_(2)H_(4)adsorption selectivity comparable to many famous C_(2)H_(6)-selective MOFs,making it a promising candidate for the purification of methanol-to-olefin(MTO)products.Furthermore,theoretical investigations reveal that the introduced nitrate ions in AEU-1 as the main adsorption sites could provide strong interactions between the framework and C2H6/C3H6 in the full-contacting mode,leading to an increase in the adsorption enthalpies(Qst)of C_(2)H_(6)and C_(3)H_(6),and thus further improving the C_(2)H_(6)/C_(2)H_(4)and C_(3)H_(6)/C_(2)H_(4)adsorption selectivity.Our work could open up a new avenue for constructing MOFs with inorganic polar moieties as adsorption sites for one-step C_(2)H_(4)purification and C3H6 recovery from MTO mixtures with high selectivity.展开更多
BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential metho...BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential methods to treat burn wounds,relatively few have had success in clinical practice.AIM To investigate the effect of the combined application of collagen III and adiposederived stem cells(ASCs)on vascular regeneration in skin wound healing.METHODS Burn wounds were created in 18 adult male Sprague-Dawley rats,and they were randomly divided into two groups.In the treatment group,each rat was injected with 4×10^(6) Zs-Green-labeled autologous ASCs suspended in collagen III.In the control group,each rat was injected with collagen III.Each rat received six injections.Images of the wounds were acquired every 3 days.RESULTS Multiple injections of autologous ASCs improved wound closure rate more efficiently compared to the control group.Moreover,autologous ASCs do not survive long-term during the skin wound healing process.CONCLUSION This study demonstrated that multiple injections of autologous ASCs combined with collagen III accelerated burn wound healing by increasing collagen deposition and improving angiogenesis.展开更多
BACKGROUND Correcting skeletal class III malocclusion with anterior crossbite in adolescents using only orthodontic treatment poses challenges.This report highlights a novel approach leveraging improved superelastic N...BACKGROUND Correcting skeletal class III malocclusion with anterior crossbite in adolescents using only orthodontic treatment poses challenges.This report highlights a novel approach leveraging improved superelastic Ni-Ti alloy wire(ISW)to address these conditions effectively.CASE SUMMARY A 17-year-old male patient presented with the chief complaint of an underbite.The patient was given a diagnosis of skeletal class III malocclusion and anterior crossbite.The orthodontic treatment plan was implemented and did not require teeth extractions or orthognathic surgery.Key interventions involved the app-lication of ISW,intermaxillary elastics,and ISW unilateral multi-bend edgewise archwire.The unique combination of these techniques enabled the correction without the need for extractions or surgery.This approach leverages the advanced biomechanical properties of ISW,including its super-elasticity and shape memory,to enhance treatment efficacy.The treatment lasted 17 months,and major improvements in overjet,overbite,and alignment were achieved.The results were favorable,and stability was discovered during follow-up.CONCLUSION The application of ISW for treating skeletal class III malocclusion with anterior crossbite in a 17-year-old male patient resulted in exceptional outcomes.The treatment led to a marked improvement in the patient’s facial profile and to proper overjet,overbite,and midline alignment.These results were maintained over a one-year follow-up,indicating that a minimally invasive orthodontic approach can effectively address complex skeletal discrepancies in adolescent patients.This case illustrates that with the careful use of advanced orthodontic techniques,major skeletal challenges can be resolved without resorting to surgical procedures.展开更多
BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully c...BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully corrected with improved super-elastic Ti-Ni alloy wire(ISW).CASE SUMMARY A 19 years old male came to our clinic with a chief complaint of anterior open bite and crossbite and not able to chew food well.Clinical examination revealed an angle class III malocclusion with anterior open bite,crossbite and spaced arch.Ra-diographic and clinical examination showed a skeletal class III pattern.We used ISW to level the upper and lower arch and to correct the anterior open bite and crossbite.Intermaxillary elastics were also used to achieve a better interdigitation.Finally,adequate overbite,overjet and a desirable occlusion were achieved.The active treatment time took 2 years and 2 months.CONCLUSION In a case of class III angular malocclusion with open bite and crossbite in the ante-rior teeth,ideal results were achieved using the ISW technique and the patient was satisfied with the outcome.展开更多
BACKGROUND Radial head fractures constitute approximately one-third of all elbow fractures,significantly impacting the young and active population.While open reduction and internal fixation is the preferred treatment ...BACKGROUND Radial head fractures constitute approximately one-third of all elbow fractures,significantly impacting the young and active population.While open reduction and internal fixation is the preferred treatment for displaced fractures,its high complication rate in comminuted fractures has led to the increasing use of radial head arthroplasty(RHA).RHA provides improved functional outcomes with fewer complications,yet its long-term efficacy remains a topic of debate.AIM To evaluate the functional outcomes of patients undergoing RHA with a modular metallic prosthesis for comminuted Mason type III and IV radial head fractures.METHODS A prospective and retrospective hospital-based study was conducted at Dayanand Medical College and Hospital,Ludhiana over 32 months(January 2021-August 2023).A total of 26 patients with Mason type III and IV fractures were included,with six retrospective and 20 prospective cases.Functional outcomes were assessed using the Mayo Elbow Performance Score(MEPS),elbow range of motion,pain via Visual Analog Scale,and activities of daily living at immediate postoperative,three-month,and six-month follow-ups.RESULTS MEPS at 6 months follow up for 4 cases(15.38%)had good scores,and 22 cases(84.62%)had excellent scores,with a mean±SD of 97.31±6.67.Comparisons showed significant improvement from immediate post-operative to 3 months(P<0.0001),from immediate post-operative to 6 months(P<0.0001),and between 3 months and 6 months(P<0.0001).None of the patients had elbow instability after radial head replacement and 22 cases(84.62%)had no complications,while 3 cases(11.54%)had a stiff elbow,and 1 case(3.85%)had heterotopic ossification.CONCLUSION RHA is an effective treatment for comminuted radial head fractures,providing stable elbow function with minimal complications.展开更多
The Cr（III） desorption experiments of Gaomiaozi （GMZ） bentonite in aqueous solutions were performed. The variables affecting the desorption behaviors, such as contact time, concentration of the desorbent, pH value...The Cr（III） desorption experiments of Gaomiaozi （GMZ） bentonite in aqueous solutions were performed. The variables affecting the desorption behaviors, such as contact time, concentration of the desorbent, pH value of the solution, temperature and desorption isotherms, were investigated by the batch experiments. The results show that the adsorbed Cr（III） on GMZ bentonite can be easily extracted by the desorbent. Kinetics examination shows that desorption is slower than adsorption, and the desorption rate increases with time and reaches the equilibrium after 3 h. The final desorption ratios of Cr（III） are 89.4%, 56.5%and 77.2%in the desorption solution with 0.1 mol/L HCl, 1 mol/L NaCl, and 1 mol/L CaCl2, respectively, and the concentration can promote the desorption progress. Furthermore, the results of successive regeneration cycles indicate that the bentonite has a good regeneration ability and reusability. The pH value is an important factor in the Cr（III） desorption from the GMZ bentonite. The results of adsorption and desorption isotherms show that both adsorption and desorption isotherms are consistent with the Freundlich equation. The comparison of adsorption and desorption isotherms implies that the adsorption/desorption hysteresis is negligible and the transport of Cr（III） in bentonite can be described by a reversible adsorption process.展开更多
文摘Objective:Patients with stage III non-small cell lung cancer(NSCLC)present with a heterogeneous disease profile and often require multifaceted treatment strategies.This research aimed to investigate the demographic features,therapeutic patterns,and survival outcomes of such patients in Vietnam.Methods:A retrospective descriptive study was conducted on 731 patients diagnosed with stage III NSCLC American Joint Committee on Cancer(AJCC)8th edition,at Nghe An Oncology Hospital from January 2018 to August 2024.Descriptive statistics summarized baseline and treatment characteristics.We calculated progression-free survival(PFS)and overall survival(OS)through the Kaplan–Meier approach and compared survival curves with the log-rank test.Prognostic variables were assessed using Cox regression analysis.Results:Patients had a median age of 64 years,and the majority(84%)were male.Disease stages IIIA,IIIB,and IIICaccounted for 26.0%,49.9%,and 24.1%of cases,respectively.Adenocarcinoma(60.7%)was the most common histological subtype.Initial treatments included surgery(8.5%),concurrent chemoradiotherapy(38.6%),sequential chemoradiotherapy(2.2%),radiotherapy alone(1.4%),systemic therapy(37.3%),and palliative care(12.0%).From 2018 to 2024,the use of systemic therapy declined(88.5%to 21.7%),while concurrent chemoradiotherapy rose significantly(1.1%to 51.5%).Median progression-free survival(mPFS)and median overall survival(mOS)were 8.9 months and 20.5 months,respectively.Patients with stage IIIA had significantly better outcomes(mPFS:12.6 months;mOS:32.4 months;p<0.001).Surgical treatment yielded the longest survival(mPFS:13.5 months;mOS:42.8 months).Favorable prognostic factors included adenocarcinoma subtype,presence of driver mutations,stage IIIA,and good performance status.Conclusion:For stage III NSCLC,concurrent chemoradiotherapy is still considered the standard treatment,whereas surgery can provide the highest survival advantage in carefully selected cases.Histology,molecular profile,and disease stage are key prognostic indicators.
文摘Type III acute acquired comitant esotropia(AACE)is a special type of binocular coordination disorder with sudden onset characteristics,but its pathogenesis and treatment strategies remain unclear.This article analyzes the incidence and classification characteristics of Type III AACE,and explores its pathogenesis from multiple perspectives including clinical medicine,neuroscience,and neuro-ophthalmology.It is found that this disease is associated with factors such as decompensation of phoria,dysfunction of the visual center,abnormalities in the physiological and anatomical structure of extraocular muscles,accommodative factors,and disorders of convergence and divergence.The prognosis of Type III AACE is excellent with treatments such as botulinum toxin injection and surgery,and adjunctive therapies like prism adaptation test and visual function training can enhance the management effect.This article provides an in-depth analysis of the pathogenesis and cutting-edge treatment techniques for patients with Type III AACE,which can offer guidance for the subsequent diagnosis and treatment of such patients.
基金supported by the Youth Autonomous Innovation Funding from Army Engineering University of PLA(KYJBJKQTZQ23005)the Basic Discipline Incubation Funding from Army Engineering University of PLA(KYJBJKQTZK23011).
文摘Based upon the thiophene-2,5-dicarboxylic acid(H_(2)Tdc),a novel[Sc_(3)(μ_(2)-OH)_(3)(CO_(2))_(4)O_(6)]n inorganic chain-based Sc-MOF with decorated nitrate ions,{[Sc_(3)(OH)_(2)(Tdc)_(3)(NO_(3))]⋅H_(2)O}_(∞)(AEU-1;AEU for Army Engineering University of PLA),was synthesized,which shows good water and chemical stabilities.Significantly,due to channel constriction accompanied by the polar window caused by introducing nitrate ions,AEU-1 exhibits high C_(2)H_(6)/C_(2)H_(4)adsorption selectivity comparable to many famous C_(2)H_(6)-selective MOFs,making it a promising candidate for the purification of methanol-to-olefin(MTO)products.Furthermore,theoretical investigations reveal that the introduced nitrate ions in AEU-1 as the main adsorption sites could provide strong interactions between the framework and C2H6/C3H6 in the full-contacting mode,leading to an increase in the adsorption enthalpies(Qst)of C_(2)H_(6)and C_(3)H_(6),and thus further improving the C_(2)H_(6)/C_(2)H_(4)and C_(3)H_(6)/C_(2)H_(4)adsorption selectivity.Our work could open up a new avenue for constructing MOFs with inorganic polar moieties as adsorption sites for one-step C_(2)H_(4)purification and C3H6 recovery from MTO mixtures with high selectivity.
基金Supported by the Natural Science Foundation of Hunan Province,China,No.2021JJ40638the Research Foundation of Education Bureau of Hunan Province,China,No.22B0897General Funding Project of Hunan Provincial Health Commission,China,No.202202055404.
文摘BACKGROUND Skin is the largest organ in the human body and plays crucial roles in human health.Efficient and rapid healing of burn wounds is of great significance.While stem cell therapies have offered potential methods to treat burn wounds,relatively few have had success in clinical practice.AIM To investigate the effect of the combined application of collagen III and adiposederived stem cells(ASCs)on vascular regeneration in skin wound healing.METHODS Burn wounds were created in 18 adult male Sprague-Dawley rats,and they were randomly divided into two groups.In the treatment group,each rat was injected with 4×10^(6) Zs-Green-labeled autologous ASCs suspended in collagen III.In the control group,each rat was injected with collagen III.Each rat received six injections.Images of the wounds were acquired every 3 days.RESULTS Multiple injections of autologous ASCs improved wound closure rate more efficiently compared to the control group.Moreover,autologous ASCs do not survive long-term during the skin wound healing process.CONCLUSION This study demonstrated that multiple injections of autologous ASCs combined with collagen III accelerated burn wound healing by increasing collagen deposition and improving angiogenesis.
文摘BACKGROUND Correcting skeletal class III malocclusion with anterior crossbite in adolescents using only orthodontic treatment poses challenges.This report highlights a novel approach leveraging improved superelastic Ni-Ti alloy wire(ISW)to address these conditions effectively.CASE SUMMARY A 17-year-old male patient presented with the chief complaint of an underbite.The patient was given a diagnosis of skeletal class III malocclusion and anterior crossbite.The orthodontic treatment plan was implemented and did not require teeth extractions or orthognathic surgery.Key interventions involved the app-lication of ISW,intermaxillary elastics,and ISW unilateral multi-bend edgewise archwire.The unique combination of these techniques enabled the correction without the need for extractions or surgery.This approach leverages the advanced biomechanical properties of ISW,including its super-elasticity and shape memory,to enhance treatment efficacy.The treatment lasted 17 months,and major improvements in overjet,overbite,and alignment were achieved.The results were favorable,and stability was discovered during follow-up.CONCLUSION The application of ISW for treating skeletal class III malocclusion with anterior crossbite in a 17-year-old male patient resulted in exceptional outcomes.The treatment led to a marked improvement in the patient’s facial profile and to proper overjet,overbite,and midline alignment.These results were maintained over a one-year follow-up,indicating that a minimally invasive orthodontic approach can effectively address complex skeletal discrepancies in adolescent patients.This case illustrates that with the careful use of advanced orthodontic techniques,major skeletal challenges can be resolved without resorting to surgical procedures.
文摘BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully corrected with improved super-elastic Ti-Ni alloy wire(ISW).CASE SUMMARY A 19 years old male came to our clinic with a chief complaint of anterior open bite and crossbite and not able to chew food well.Clinical examination revealed an angle class III malocclusion with anterior open bite,crossbite and spaced arch.Ra-diographic and clinical examination showed a skeletal class III pattern.We used ISW to level the upper and lower arch and to correct the anterior open bite and crossbite.Intermaxillary elastics were also used to achieve a better interdigitation.Finally,adequate overbite,overjet and a desirable occlusion were achieved.The active treatment time took 2 years and 2 months.CONCLUSION In a case of class III angular malocclusion with open bite and crossbite in the ante-rior teeth,ideal results were achieved using the ISW technique and the patient was satisfied with the outcome.
文摘BACKGROUND Radial head fractures constitute approximately one-third of all elbow fractures,significantly impacting the young and active population.While open reduction and internal fixation is the preferred treatment for displaced fractures,its high complication rate in comminuted fractures has led to the increasing use of radial head arthroplasty(RHA).RHA provides improved functional outcomes with fewer complications,yet its long-term efficacy remains a topic of debate.AIM To evaluate the functional outcomes of patients undergoing RHA with a modular metallic prosthesis for comminuted Mason type III and IV radial head fractures.METHODS A prospective and retrospective hospital-based study was conducted at Dayanand Medical College and Hospital,Ludhiana over 32 months(January 2021-August 2023).A total of 26 patients with Mason type III and IV fractures were included,with six retrospective and 20 prospective cases.Functional outcomes were assessed using the Mayo Elbow Performance Score(MEPS),elbow range of motion,pain via Visual Analog Scale,and activities of daily living at immediate postoperative,three-month,and six-month follow-ups.RESULTS MEPS at 6 months follow up for 4 cases(15.38%)had good scores,and 22 cases(84.62%)had excellent scores,with a mean±SD of 97.31±6.67.Comparisons showed significant improvement from immediate post-operative to 3 months(P<0.0001),from immediate post-operative to 6 months(P<0.0001),and between 3 months and 6 months(P<0.0001).None of the patients had elbow instability after radial head replacement and 22 cases(84.62%)had no complications,while 3 cases(11.54%)had a stiff elbow,and 1 case(3.85%)had heterotopic ossification.CONCLUSION RHA is an effective treatment for comminuted radial head fractures,providing stable elbow function with minimal complications.
基金Project(41272287)supported by the National Natural Science Foundation of ChinaProject(13PJD029)supported by Shanghai Pujiang ProgramProject(SKLGDUEK1202)supported by State Key Laboratory for GeoMechanics and Deep Underground Engineering,China
文摘The Cr（III） desorption experiments of Gaomiaozi （GMZ） bentonite in aqueous solutions were performed. The variables affecting the desorption behaviors, such as contact time, concentration of the desorbent, pH value of the solution, temperature and desorption isotherms, were investigated by the batch experiments. The results show that the adsorbed Cr（III） on GMZ bentonite can be easily extracted by the desorbent. Kinetics examination shows that desorption is slower than adsorption, and the desorption rate increases with time and reaches the equilibrium after 3 h. The final desorption ratios of Cr（III） are 89.4%, 56.5%and 77.2%in the desorption solution with 0.1 mol/L HCl, 1 mol/L NaCl, and 1 mol/L CaCl2, respectively, and the concentration can promote the desorption progress. Furthermore, the results of successive regeneration cycles indicate that the bentonite has a good regeneration ability and reusability. The pH value is an important factor in the Cr（III） desorption from the GMZ bentonite. The results of adsorption and desorption isotherms show that both adsorption and desorption isotherms are consistent with the Freundlich equation. The comparison of adsorption and desorption isotherms implies that the adsorption/desorption hysteresis is negligible and the transport of Cr（III） in bentonite can be described by a reversible adsorption process.
