Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal ha...Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal haze and restoring vision.To our knowledge,this is the first report documenting the use of topical losartan,an angiotensin II receptor antagonist known to inhibit the transforming growth factor-β(TGF-β)pathway,for treating corneal haze resulting from bacterial keratitis.Case Description:A 30-year-old male presented with a persistent corneal scar in his right eye,178 days post-Pseudomonas keratitis.Despite a prolonged course of topical corticosteroids,his best-corrected visual acuity(BCVA)stabilized at 20/40 with a hybrid contact lens over a 2-month period.Given the lack of improvement,we initiated treatment with topical losartan at a concentration of 0.8 mg/mL,administered six times daily.After 4 months of therapy,the patient’s BCVA improved to 20/25.Slit-lamp examination and corneal tomography revealed a significant reduction in corneal haze,indicating a positive response to the treatment.Conclusions:This case suggests that topical losartan may be a promising therapeutic option for reducing corneal opacity following bacterial keratitis by inhibiting the TGF-βpathway.However,further clinical studies are necessary to confirm its efficacy and safety in broader patient populations.展开更多
License plate recognition in haze-affected images is challenging due to feature distortions such as blurring and elongation,which lead to pixel displacements.This article introduces a Displacement Region Recognition M...License plate recognition in haze-affected images is challenging due to feature distortions such as blurring and elongation,which lead to pixel displacements.This article introduces a Displacement Region Recognition Method(DR2M)to address such a problem.This method operates on displaced features compared to the training input observed throughout definite time frames.The technique focuses on detecting features that remain relatively stable under haze,using a frame-based analysis to isolate edges minimally affected by visual noise.The edge detection failures are identified using a bilateral neural network through displaced feature training.The training converges bilaterally towards the minimum edges from the maximum region.Thus,the training input and detected edges are used to identify the displacement between observed image frames to extract and differentiate the license plate region from the other vehicle regions.The proposed method maps the similarity feature between the detected and identified vehicle regions.This aids in leveraging the plate recognition precision with a high F1 score.Thus,this technique achieves a 10.27%improvement in identification precision,a 10.57%increase in F1 score,and a 9.73%reduction in false positive rate compared to baseline methods under maximum displacement conditions caused by haze.The technique attains an identification precision of 95.68%,an F1 score of 94.68%,and a false positive rate of 4.32%,indicating robust performance under haze-affected settings.展开更多
Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been...Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly elucidated.Here we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the winter.Markedly higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze days.Results from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze events.Carbonyl photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls inter-correlation.Diurnal variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for HCHO.This study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region.展开更多
The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in China.Increasing prominent nitrate pollution is one of the most challenging environmental issue...The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in China.Increasing prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control strategy.Herein,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”cities.Focusing on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term period.The synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate more.Such extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities.展开更多
Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather th...Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather that happened in eastern China in late January 2021. The research uses multi-party data and synoptic analysis methods to analyze the occurrence, evolution, and end of the haze weather. The polar vortex, the change of the atmospheric circulation, the change of the cold air force, the temperature and humidity, and the rain and snow weather are the important reasons for this weathering process. It can be used for reference in future research on haze weather.展开更多
With the rapid development of industrialisation and urbanisation, China is facing the challenge of severe HF (Haze-Fog) pollution. This essay compares the advantages and disadvantages of China’s HF management and sum...With the rapid development of industrialisation and urbanisation, China is facing the challenge of severe HF (Haze-Fog) pollution. This essay compares the advantages and disadvantages of China’s HF management and summarizes the important lessons China can teach the rest of the world about applying this tactic. China’s capabilities in the digital economy, National Innovation Demonstration Zones, and urban innovation systems are examined in this article, along with its shortcomings in information mechanisms and pollution sources. This essay also summarizes China’s achievements, particularly regarding local autonomy. The essay goes on to say, however, that China is probably going to be under more pressure to manage HF in the future, both in terms of long-term solutions and the economy.展开更多
Based on meteorology and environment monitoring data in January,2008 in Liaoning central region,a typical haze weather process was analyzed.The results showed that haze was formed due to the stable weather condition i...Based on meteorology and environment monitoring data in January,2008 in Liaoning central region,a typical haze weather process was analyzed.The results showed that haze was formed due to the stable weather condition in the earth surface and upper air layer in Liaoning central region.Especially because that the weakening of atmospheric dispersion ability in the urban boundary layer that was 500 m under earth surface,caused the pollutant in the air can not disperse.Thus,it resulted in the deterioration of air quality,increase of concentration of particulate mass,and declination of visibility.And in the end,haze formed.展开更多
In January 2013, China suffered large-scale haze weather four times, affecting 30 cities in all. The average number of haze weather days in many regions was higher than the same period in every year since 1961. PM2.s,...In January 2013, China suffered large-scale haze weather four times, affecting 30 cities in all. The average number of haze weather days in many regions was higher than the same period in every year since 1961. PM2.s, which is defined as fine particulate matter with an aerodynamic diameter of 2.5 micrometers or less, is the main health hazard in the context of haze weather. It can carry large amounts of poisonous and harmful substances, and penetrate deep into the lungs and blood circulation through the respiratory tract, thereby affecting human health.展开更多
文摘Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal haze and restoring vision.To our knowledge,this is the first report documenting the use of topical losartan,an angiotensin II receptor antagonist known to inhibit the transforming growth factor-β(TGF-β)pathway,for treating corneal haze resulting from bacterial keratitis.Case Description:A 30-year-old male presented with a persistent corneal scar in his right eye,178 days post-Pseudomonas keratitis.Despite a prolonged course of topical corticosteroids,his best-corrected visual acuity(BCVA)stabilized at 20/40 with a hybrid contact lens over a 2-month period.Given the lack of improvement,we initiated treatment with topical losartan at a concentration of 0.8 mg/mL,administered six times daily.After 4 months of therapy,the patient’s BCVA improved to 20/25.Slit-lamp examination and corneal tomography revealed a significant reduction in corneal haze,indicating a positive response to the treatment.Conclusions:This case suggests that topical losartan may be a promising therapeutic option for reducing corneal opacity following bacterial keratitis by inhibiting the TGF-βpathway.However,further clinical studies are necessary to confirm its efficacy and safety in broader patient populations.
基金supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2025R848)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabiathe Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia for funding this research work through the project number“NBU-FFR-2025-2932-09”.
文摘License plate recognition in haze-affected images is challenging due to feature distortions such as blurring and elongation,which lead to pixel displacements.This article introduces a Displacement Region Recognition Method(DR2M)to address such a problem.This method operates on displaced features compared to the training input observed throughout definite time frames.The technique focuses on detecting features that remain relatively stable under haze,using a frame-based analysis to isolate edges minimally affected by visual noise.The edge detection failures are identified using a bilateral neural network through displaced feature training.The training converges bilaterally towards the minimum edges from the maximum region.Thus,the training input and detected edges are used to identify the displacement between observed image frames to extract and differentiate the license plate region from the other vehicle regions.The proposed method maps the similarity feature between the detected and identified vehicle regions.This aids in leveraging the plate recognition precision with a high F1 score.Thus,this technique achieves a 10.27%improvement in identification precision,a 10.57%increase in F1 score,and a 9.73%reduction in false positive rate compared to baseline methods under maximum displacement conditions caused by haze.The technique attains an identification precision of 95.68%,an F1 score of 94.68%,and a false positive rate of 4.32%,indicating robust performance under haze-affected settings.
基金supported by the National Natural Science Foundation of China(Nos.42005092,42275127,42075112and 41775127)the Natural Science Foundation of Shandong Province(No.ZR2020QD058)。
文摘Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly elucidated.Here we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the winter.Markedly higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze days.Results from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze events.Carbonyl photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls inter-correlation.Diurnal variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for HCHO.This study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region.
基金National Natural Science Foundation of China (No.22206106)the Scientific Research Start-up Funds from Tsinghua Shenzhen International Graduate School (No.QD2021015C)the Natural Science Foundation of Guangdong Province (No.2022A1515010705)。
文摘The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in China.Increasing prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control strategy.Herein,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”cities.Focusing on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term period.The synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate more.Such extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities.
文摘Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather that happened in eastern China in late January 2021. The research uses multi-party data and synoptic analysis methods to analyze the occurrence, evolution, and end of the haze weather. The polar vortex, the change of the atmospheric circulation, the change of the cold air force, the temperature and humidity, and the rain and snow weather are the important reasons for this weathering process. It can be used for reference in future research on haze weather.
文摘With the rapid development of industrialisation and urbanisation, China is facing the challenge of severe HF (Haze-Fog) pollution. This essay compares the advantages and disadvantages of China’s HF management and summarizes the important lessons China can teach the rest of the world about applying this tactic. China’s capabilities in the digital economy, National Innovation Demonstration Zones, and urban innovation systems are examined in this article, along with its shortcomings in information mechanisms and pollution sources. This essay also summarizes China’s achievements, particularly regarding local autonomy. The essay goes on to say, however, that China is probably going to be under more pressure to manage HF in the future, both in terms of long-term solutions and the economy.
基金Supported by Liaoning Meteorology Bureau Scientific Research Fund (200808)China Meterological Administration Shenyang Atmospheric Science Research Bureau Scieatific Resarch Fund ProgramScientific Research Special Fund for Public Welfare Industry in 2008 (GYHY20080620)
文摘Based on meteorology and environment monitoring data in January,2008 in Liaoning central region,a typical haze weather process was analyzed.The results showed that haze was formed due to the stable weather condition in the earth surface and upper air layer in Liaoning central region.Especially because that the weakening of atmospheric dispersion ability in the urban boundary layer that was 500 m under earth surface,caused the pollutant in the air can not disperse.Thus,it resulted in the deterioration of air quality,increase of concentration of particulate mass,and declination of visibility.And in the end,haze formed.
文摘In January 2013, China suffered large-scale haze weather four times, affecting 30 cities in all. The average number of haze weather days in many regions was higher than the same period in every year since 1961. PM2.s, which is defined as fine particulate matter with an aerodynamic diameter of 2.5 micrometers or less, is the main health hazard in the context of haze weather. It can carry large amounts of poisonous and harmful substances, and penetrate deep into the lungs and blood circulation through the respiratory tract, thereby affecting human health.
