摘要
目的探讨准分子激光上皮下角膜磨镶术（LASEK）术中联合应用丝裂霉素C（MMC）对术后角膜上皮下雾状浑浊（haze）的预防作用。方法随机对60例（120眼）高度近视（-6．00D以上）左右眼分别做单纯LASEK手术和LASEK＋MMC手术，观察6个月，计算}hhaze反应的发生率并进行比较。结果统计术后1、3、6个月haze的发生率，单纯LASEK分别为：0．5级，58．33％、48．33％、40．00％；1级，13．33％、8．33％、5．00％；2级，0、1．67％、1．67％；3级以上均为0。LASEK＋MMC分别为：0．5级，36．67％、26．67％、13．33％；1级，1．67％、1．67％、3．33％；2级以上均为0。两组比较差异有统计学意义（P〈0．05）。结论LASEK术中应用MMC能减轻haze反应形成，情况显著优于单纯LASEK手术。
Objective To observe the applying of mitomycin C in LASEK surgery, to prevent the formation of subepithelial corneal haze in patients with high myopia. Methods Sixty patients （ 120 eyes） with high myopia were randomly performed LASEK on one eye, and they were performed 0.02% mitomycin C treatment during LASEK on the other eye separately. Regular follow-up of 6 month was done to observe the haze formation. Results In the LASEK group, the rate of the haze of grade 0.5 was 58.33% , 48.33% , 40.00% in 1 month, 3 months and 6 months, that of grade 1 was 13.33% , 8.33% , 5.00% , that of grade 2 was 0,1.67% , 1.67% , that of grade 3 and 4 was 0. In the LASEK ＋ MMC group, the rate of tile haze of grade 0.5 was 36.67% , 26.67% , 13.33% in 1 months, 3 months and 6 months respectively, that of grade 1 was 1.67% , 1.67% , 3.33% , that of grade 2, 3 and 4 was 0. There was significant difference （ P 〈 0.05 ） in the haze between the two groups. Conclusion The occurrence of the haze in the LASEK ＋ MMC- group is milder than that in the LASEK group.
出处
《中华眼外伤职业眼病杂志》
2011年第9期676-679,共4页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
关键词
LASEK
丝裂霉素C
HAZE
Laser subepithelial keratomileusis
Mitomycin C
Haze
