A recent study published in Cell Metabolism entitled“Gut microbial alterations in arginine metabolism determine bone mechanical adaptation”demonstrated that administration of L-arginine enhanced bone mechanical adap...A recent study published in Cell Metabolism entitled“Gut microbial alterations in arginine metabolism determine bone mechanical adaptation”demonstrated that administration of L-arginine enhanced bone mechanical adaptation by activating a nitric oxide-calcium feedback loop in osteocytes.The findings revealed that mechanical regulation of bone adaptation is associated with gut microbiota.The underlying cause of heterogeneity of bone mechanoresponsiveness was the significant difference in the composition of the gut microbiota,in which the family Lachnospiraceae contributed to the inter-individual high variability in bone mechanical adaptation.Additionally,administration of Lachnospiraceae exhibited increased expression levels of L-citrulline and L-arginine and enhanced bone mechanoresponsiveness in recipients.Collectively,this study provides mechanistic insights into inter-individual variability of the gut microbial,which is related to the heterogeneity of bone mechanical adaptation and provides a novel preventive and therapeutic strategy to anti-osteoporotic for maximizing bone mechanoresponsiveness via the microbiota-metabolite axis.展开更多
背景:近年来,多项研究证实了肠道菌群可通过多种途径调节骨代谢,成为骨科和微生物学领域的研究热点,但目前仍无研究对该领域进行文献计量学和可视化分析。目的:分析肠道菌群调节骨代谢领域的研究现状、热点及发展趋势,为后续研究提供一...背景:近年来,多项研究证实了肠道菌群可通过多种途径调节骨代谢,成为骨科和微生物学领域的研究热点,但目前仍无研究对该领域进行文献计量学和可视化分析。目的:分析肠道菌群调节骨代谢领域的研究现状、热点及发展趋势,为后续研究提供一定的数据支持及参考依据。方法:以Web of Science核心合集数据库为检索平台,检索2004-2024年肠道菌群调节骨代谢领域的相关文献,应用Citespace软件对纳入文献进行可视化分析并生成可视化图谱。结果与结论:①最终纳入1035篇文献,近20年间肠道菌群调节骨代谢领域的发文量呈现显著增长趋势,美国和中国在该领域研究及出版活动中占据主导地位,哈佛大学和加州大学系统是发文量和研究中心性均较高的研究机构,埃默里大学的Pacifici R教授是发文量最大的作者;②炎症性肠病、链式脂肪酸、骨髓为核心关键词,绝经后骨质疏松症、类风湿性关节炎、氧化应激、线粒体功能障碍是最新研究前沿;③在文献被引频次排名前10的文献中,4篇文献探讨了短链脂肪酸影响骨代谢的机制;3篇文献探讨了肠道菌群分别在绝经后骨质疏松症、糖皮质激素性骨质疏松症和老年性骨质疏松症中的发病机制及治疗潜力;1篇文献探讨了肠道炎症与肠道菌群、甲状旁腺激素和骨代谢的关联性;1篇文献探讨了鼠李糖乳杆菌、T细胞对肠道菌群和骨代谢的影响;④《NUTRIENTS》期刊收录文献最多,《ENDOCRINOLOGY&METABOLISM》期刊收录的文献被引用次数最高;⑤综合文献共被引分析和关键词,探索肠道菌群在绝经后骨质疏松症和类风湿性关节炎疾病中的具体发病机制及治疗策略,揭示调控肠道菌群抑制氧化应激和改善线粒体功能障碍影响骨代谢的分子机制,将机制研究转化到临床应用,共同构成未来该领域的研究方向和趋势。展开更多
文摘A recent study published in Cell Metabolism entitled“Gut microbial alterations in arginine metabolism determine bone mechanical adaptation”demonstrated that administration of L-arginine enhanced bone mechanical adaptation by activating a nitric oxide-calcium feedback loop in osteocytes.The findings revealed that mechanical regulation of bone adaptation is associated with gut microbiota.The underlying cause of heterogeneity of bone mechanoresponsiveness was the significant difference in the composition of the gut microbiota,in which the family Lachnospiraceae contributed to the inter-individual high variability in bone mechanical adaptation.Additionally,administration of Lachnospiraceae exhibited increased expression levels of L-citrulline and L-arginine and enhanced bone mechanoresponsiveness in recipients.Collectively,this study provides mechanistic insights into inter-individual variability of the gut microbial,which is related to the heterogeneity of bone mechanical adaptation and provides a novel preventive and therapeutic strategy to anti-osteoporotic for maximizing bone mechanoresponsiveness via the microbiota-metabolite axis.
文摘背景:近年来,多项研究证实了肠道菌群可通过多种途径调节骨代谢,成为骨科和微生物学领域的研究热点,但目前仍无研究对该领域进行文献计量学和可视化分析。目的:分析肠道菌群调节骨代谢领域的研究现状、热点及发展趋势,为后续研究提供一定的数据支持及参考依据。方法:以Web of Science核心合集数据库为检索平台,检索2004-2024年肠道菌群调节骨代谢领域的相关文献,应用Citespace软件对纳入文献进行可视化分析并生成可视化图谱。结果与结论:①最终纳入1035篇文献,近20年间肠道菌群调节骨代谢领域的发文量呈现显著增长趋势,美国和中国在该领域研究及出版活动中占据主导地位,哈佛大学和加州大学系统是发文量和研究中心性均较高的研究机构,埃默里大学的Pacifici R教授是发文量最大的作者;②炎症性肠病、链式脂肪酸、骨髓为核心关键词,绝经后骨质疏松症、类风湿性关节炎、氧化应激、线粒体功能障碍是最新研究前沿;③在文献被引频次排名前10的文献中,4篇文献探讨了短链脂肪酸影响骨代谢的机制;3篇文献探讨了肠道菌群分别在绝经后骨质疏松症、糖皮质激素性骨质疏松症和老年性骨质疏松症中的发病机制及治疗潜力;1篇文献探讨了肠道炎症与肠道菌群、甲状旁腺激素和骨代谢的关联性;1篇文献探讨了鼠李糖乳杆菌、T细胞对肠道菌群和骨代谢的影响;④《NUTRIENTS》期刊收录文献最多,《ENDOCRINOLOGY&METABOLISM》期刊收录的文献被引用次数最高;⑤综合文献共被引分析和关键词,探索肠道菌群在绝经后骨质疏松症和类风湿性关节炎疾病中的具体发病机制及治疗策略,揭示调控肠道菌群抑制氧化应激和改善线粒体功能障碍影响骨代谢的分子机制,将机制研究转化到临床应用,共同构成未来该领域的研究方向和趋势。
