The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and old...The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. Patients were assessed based on the International Prostate Symptom Score (IPSS) and the IPSS-Quality of Life (IPSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS.展开更多
目的:对鼻咽癌病人接受放化疗后的症状群的相关研究进行全面的整合,旨在为鼻咽癌病人的症状管理提供有价值的参考。方法:计算机检索the Cochrane Library、PubMed、CINAHL、EMbase、Web of Science、中国知网、万方数据库、维普数据库...目的:对鼻咽癌病人接受放化疗后的症状群的相关研究进行全面的整合,旨在为鼻咽癌病人的症状管理提供有价值的参考。方法:计算机检索the Cochrane Library、PubMed、CINAHL、EMbase、Web of Science、中国知网、万方数据库、维普数据库、中国生物医学文献数据库中的相关文献,并对纳入文献的数据进行提取和综合分析。检索时限为建库至2024年7月8日。结果:共纳入文献10篇,提取11种鼻咽癌病人在放化疗期间的症状群,症状群的识别要素涵盖症状评估及分析方法,放化疗前疲乏相关症状群最突出,放化疗初期胃肠道症状群最突出,放化疗中后期口腔黏膜症状群最突出,放化疗结束后病耻感症状群最突出。结论:鼻咽癌病人在放化疗过程中出现多个症状群,且呈动态变化。后续研究可进一步探讨鼻咽癌的特定症状评价方法,并与机器学习等先进分析方法相结合,循序渐进地提高对鼻咽癌症状组的辨识能力,并探索建立精准的症状组管理模式。展开更多
文摘The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. Patients were assessed based on the International Prostate Symptom Score (IPSS) and the IPSS-Quality of Life (IPSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS.
文摘目的:对鼻咽癌病人接受放化疗后的症状群的相关研究进行全面的整合,旨在为鼻咽癌病人的症状管理提供有价值的参考。方法:计算机检索the Cochrane Library、PubMed、CINAHL、EMbase、Web of Science、中国知网、万方数据库、维普数据库、中国生物医学文献数据库中的相关文献,并对纳入文献的数据进行提取和综合分析。检索时限为建库至2024年7月8日。结果:共纳入文献10篇,提取11种鼻咽癌病人在放化疗期间的症状群,症状群的识别要素涵盖症状评估及分析方法,放化疗前疲乏相关症状群最突出,放化疗初期胃肠道症状群最突出,放化疗中后期口腔黏膜症状群最突出,放化疗结束后病耻感症状群最突出。结论:鼻咽癌病人在放化疗过程中出现多个症状群,且呈动态变化。后续研究可进一步探讨鼻咽癌的特定症状评价方法,并与机器学习等先进分析方法相结合,循序渐进地提高对鼻咽癌症状组的辨识能力,并探索建立精准的症状组管理模式。
