BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in syndrome.AIM The paper aimed to describe the clinical and oncological ...BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in syndrome.AIM The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and treatment.METHODS Data of consecutive patients with MGISTs who were diagnosed at Peking University People’s Hospital(PKUPH)from 2008 to 2019 were retrospectively evaluated.Further,a literature search was conducted by retrieving data from PubMed,EMBASE,and the Cochrane library databases from inception up to November 30,2019.RESULTS In all,12 patients were diagnosed with MGISTs at PKUPH,and 43 published records were ultimately included following the literature review.Combined analysis of the whole individual patient data showed that female(59.30%),young(14.45%),and syndromic GIST(63.95%)patients comprised a large proportion of the total patient population.Tumors were mainly located in the small intestine(58.92%),and both CD117 and CD34 were generally positive.After a mean 78.32-mo follow-up,the estimated median overall survival duration(11.5 years)was similar to single GISTs,but recurrence-free survival was relatively poorer.CONCLUSION The clinical and oncological features are potentially different between MGISTs and single GIST.Further studies are needed to explore appropriate surgical approach and adjuvant therapy.展开更多
Daily and weekly reporting events of climate change and impacts on populations, cultures, economies and politics at local, national, regional and international scales suggest the need to construct databases that will ...Daily and weekly reporting events of climate change and impacts on populations, cultures, economies and politics at local, national, regional and international scales suggest the need to construct databases that will be useful in future scientific inquiry and global human/environmental policies. That need is evident in constructing a geographic or locational knowledge base that examines countries, regions and cities. This study constructs a database on the impacts of climate change using Google Scholar entries for 200 countries and capital cities. A series of maps reveal the vast unevenness in the database, especially between Global North and Global South countries. The discussion explores these sharp differences and suggests future research topics for much-needed global, interdisciplinary and international research.展开更多
One of the classical approaches in the analysis of a variational inequality problem is to transform it into an equivalent optimization problem via the notion of gap function. The gap functions are useful tools in deri...One of the classical approaches in the analysis of a variational inequality problem is to transform it into an equivalent optimization problem via the notion of gap function. The gap functions are useful tools in deriving the error bounds which provide an estimated distance between a specific point and the exact solution of variational inequality problem. In this paper, we follow a similar approach for set-valued vector quasi variational inequality problems and define the gap functions based on scalarization scheme as well as the one with no scalar parameter. The error bounds results are obtained under fixed point symmetric and locally α-Holder assumptions on the set-valued map describing the domain of solution space of a set-valued vector quasi variational inequality problem.展开更多
“需求牵引、技术推动”是装备体系建设发展的主要规律,围绕军事领域体系需求论证分析问题,在明确体系需求分析基本内涵的基础上,融合威胁和能力的优点提出体系需求分析流程;针对体系需求分析中能力差距度量和映射分析等关键技术问题,...“需求牵引、技术推动”是装备体系建设发展的主要规律,围绕军事领域体系需求论证分析问题,在明确体系需求分析基本内涵的基础上,融合威胁和能力的优点提出体系需求分析流程;针对体系需求分析中能力差距度量和映射分析等关键技术问题,建立了能力差距度量模型,采用质量功能展开(Quality Function Deployment,QFD)方法实现了能力需求-系统需求-技术需求之间的映射;并以典型空间目标监视体系分析为例,验证了本文提出的体系需求分析方法,为开展体系需求分析提供理论参考。展开更多
文摘BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in syndrome.AIM The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and treatment.METHODS Data of consecutive patients with MGISTs who were diagnosed at Peking University People’s Hospital(PKUPH)from 2008 to 2019 were retrospectively evaluated.Further,a literature search was conducted by retrieving data from PubMed,EMBASE,and the Cochrane library databases from inception up to November 30,2019.RESULTS In all,12 patients were diagnosed with MGISTs at PKUPH,and 43 published records were ultimately included following the literature review.Combined analysis of the whole individual patient data showed that female(59.30%),young(14.45%),and syndromic GIST(63.95%)patients comprised a large proportion of the total patient population.Tumors were mainly located in the small intestine(58.92%),and both CD117 and CD34 were generally positive.After a mean 78.32-mo follow-up,the estimated median overall survival duration(11.5 years)was similar to single GISTs,but recurrence-free survival was relatively poorer.CONCLUSION The clinical and oncological features are potentially different between MGISTs and single GIST.Further studies are needed to explore appropriate surgical approach and adjuvant therapy.
文摘Daily and weekly reporting events of climate change and impacts on populations, cultures, economies and politics at local, national, regional and international scales suggest the need to construct databases that will be useful in future scientific inquiry and global human/environmental policies. That need is evident in constructing a geographic or locational knowledge base that examines countries, regions and cities. This study constructs a database on the impacts of climate change using Google Scholar entries for 200 countries and capital cities. A series of maps reveal the vast unevenness in the database, especially between Global North and Global South countries. The discussion explores these sharp differences and suggests future research topics for much-needed global, interdisciplinary and international research.
文摘One of the classical approaches in the analysis of a variational inequality problem is to transform it into an equivalent optimization problem via the notion of gap function. The gap functions are useful tools in deriving the error bounds which provide an estimated distance between a specific point and the exact solution of variational inequality problem. In this paper, we follow a similar approach for set-valued vector quasi variational inequality problems and define the gap functions based on scalarization scheme as well as the one with no scalar parameter. The error bounds results are obtained under fixed point symmetric and locally α-Holder assumptions on the set-valued map describing the domain of solution space of a set-valued vector quasi variational inequality problem.
文摘“需求牵引、技术推动”是装备体系建设发展的主要规律,围绕军事领域体系需求论证分析问题,在明确体系需求分析基本内涵的基础上,融合威胁和能力的优点提出体系需求分析流程;针对体系需求分析中能力差距度量和映射分析等关键技术问题,建立了能力差距度量模型,采用质量功能展开(Quality Function Deployment,QFD)方法实现了能力需求-系统需求-技术需求之间的映射;并以典型空间目标监视体系分析为例,验证了本文提出的体系需求分析方法,为开展体系需求分析提供理论参考。
