Cancer poses a major health problem worldwide.There is a trend of increasing incidence and mortality of several types of cancer in China.Although major breakthroughs have been made in cancer treatment,including advanc...Cancer poses a major health problem worldwide.There is a trend of increasing incidence and mortality of several types of cancer in China.Although major breakthroughs have been made in cancer treatment,including advances in surgical procedures,radiotherapy,chemotherapy,targeted therapy,and immunotherapy,the prognosis of cancer patients is still not optimal.It is widely accepted that malnutrition is commonly seen in cancer patients and that nutritional intervention can improve such patients’overall survival status by supplementing deficient nutrients,regulating abnormal metabolism,improving immune function,and modulating tumor growth.Thus,fighting malnutrition can improve patients’quality of life and survival.This review article provides a summary of development of nutritional oncology as an independent clinical discipline,recent advances,and problems and challenges faced by health care professionals in managing malnutrition among cancer patients.We propose several strategies and approaches to establish nutritional intervention programs in hospitals,including education,clinical nutritional diagnosis and treatment,which may meet the nutrition and treatment goals for patients with cancer in China.We hope that with national-wide development and implementation of nutritional intervention programs,more cancer patient in China will benefit from such endeavors,making nutritional oncology the frontier of cancer treatment not only in China,but also in whole world.展开更多
Gaussian network model(GNM)is an efficient method to investigate the structural dynamics of biomolecules.However,the application of GNM on RNAs is not as good as that on proteins,and there is still room to improve the...Gaussian network model(GNM)is an efficient method to investigate the structural dynamics of biomolecules.However,the application of GNM on RNAs is not as good as that on proteins,and there is still room to improve the model.In this study,two novel approaches,named the weighted GNM(wGNM)and the force-constant-decayed GNM(fcdGNM),were proposed to enhance the performance of ENM in investigating the structural dynamics of RNAs.In wGNM,the force constant for each spring is weighted by the number of interacting heavy atom pairs between two nucleotides.In fcdGNM,all the pairwise nucleotides were connected by springs and the force constant decayed exponentially with the separate distance of the nucleotide pairs.The performance of these two proposed models was evaluated by using a non-redundant RNA structure database composed of 51 RNA molecules.The calculation results show that both the proposed models outperform the conventional GNM in reproducing the experimental B-factors of RNA structures.Compared with the conventional GNM,the Pearson correlation coefficient between the predicted and experimental B-factors was improved by 9.85%and 6.76%for wGNM and fcdGNM,respectively.Our studies provide two candidate methods for better revealing the dynamical properties encoded in RNA structures.展开更多
文摘Cancer poses a major health problem worldwide.There is a trend of increasing incidence and mortality of several types of cancer in China.Although major breakthroughs have been made in cancer treatment,including advances in surgical procedures,radiotherapy,chemotherapy,targeted therapy,and immunotherapy,the prognosis of cancer patients is still not optimal.It is widely accepted that malnutrition is commonly seen in cancer patients and that nutritional intervention can improve such patients’overall survival status by supplementing deficient nutrients,regulating abnormal metabolism,improving immune function,and modulating tumor growth.Thus,fighting malnutrition can improve patients’quality of life and survival.This review article provides a summary of development of nutritional oncology as an independent clinical discipline,recent advances,and problems and challenges faced by health care professionals in managing malnutrition among cancer patients.We propose several strategies and approaches to establish nutritional intervention programs in hospitals,including education,clinical nutritional diagnosis and treatment,which may meet the nutrition and treatment goals for patients with cancer in China.We hope that with national-wide development and implementation of nutritional intervention programs,more cancer patient in China will benefit from such endeavors,making nutritional oncology the frontier of cancer treatment not only in China,but also in whole world.
文摘Gaussian network model(GNM)is an efficient method to investigate the structural dynamics of biomolecules.However,the application of GNM on RNAs is not as good as that on proteins,and there is still room to improve the model.In this study,two novel approaches,named the weighted GNM(wGNM)and the force-constant-decayed GNM(fcdGNM),were proposed to enhance the performance of ENM in investigating the structural dynamics of RNAs.In wGNM,the force constant for each spring is weighted by the number of interacting heavy atom pairs between two nucleotides.In fcdGNM,all the pairwise nucleotides were connected by springs and the force constant decayed exponentially with the separate distance of the nucleotide pairs.The performance of these two proposed models was evaluated by using a non-redundant RNA structure database composed of 51 RNA molecules.The calculation results show that both the proposed models outperform the conventional GNM in reproducing the experimental B-factors of RNA structures.Compared with the conventional GNM,the Pearson correlation coefficient between the predicted and experimental B-factors was improved by 9.85%and 6.76%for wGNM and fcdGNM,respectively.Our studies provide two candidate methods for better revealing the dynamical properties encoded in RNA structures.
