The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated pa...The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated patients with advanced colorectal cancer received Bevacizumab plus FOLFIRI regimen as font-line therapy, in detail, irinotecan 180 mg/m2 was given intravenously on day1, then calcium folinate (CF) 200 mg/m2, F-fluorouracil (5-Fu) 400 mg/m2 given in bolus immediately after CF, day 1 - 2;5-Fu 600 mg/2 given continuously after bolus for 22 hours on day1, day2;Bevacizumab was given intravenously at dosage of 5 mg/kg, on day-1. Therapeutic and side effects were evaluated at least after four cycles of treatment. The results showed that all the cases among the group were valid for response evaluation, with CR 0, PR 10, SD 3, and PD 2. The response rate is 66.7% and median time to progression (mTTP) was 10.6 months. The main toxicities were bone marrow suppression, nausea and vomiting, stomach pain and diarrhea;there was no chemotherapy-related death. The data suggested that the combination regimen with Bevacizumab plus FOLFIRI regimen was effective as front-line therapy for Chinese patients with advanced colorectal cancer, and the side effects were tolerable and manageable.展开更多
AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-a...AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-arm phaseⅡstudy was designed.Thirty-nine patients were enrolled and included in the intention-to-treat analysis of efficacy and adverse events.Patients received 175mg/m2of paclitaxel over a 3 h infusion on 1 d,followed by nedaplatin 80 mg/m2in a 1 h infusion on 2 d every3 wk until the documented disease progression,unac-ceptable toxicity or patient’s refusal.RESULTS:Of the 36 patients assessable for efficacy,there were 2 patients(5.1%)with complete response and 16 patients(41.0%)with partial response,giving an overall response rate of 46.1%.The median progression-free survival and median overall survival for all patients were 7.1 mo(95%CI:4.6-9.7)and 12.4 mo(95%CI:9.5-15.3),respectively.Toxicities were moderate and manageable.Grade 3/4 toxicities included neutropenia(15.4%),nausea(10.3%),anemia(7.7%),thrombocytopenia(5.1%),vomiting(5.1%)and neutropenia fever(2.6%).CONCLUSION:The combination of paclitaxel and nedaplatin is active and well tolerated as a first-line therapy for patients with metastatic ESCC.展开更多
With insight from the methodology of phenomenology,Jan Patocka draws multiple meanings from the special front-line experience,including new understanding of the fringe of death,absolute freedom,universal responsibilit...With insight from the methodology of phenomenology,Jan Patocka draws multiple meanings from the special front-line experience,including new understanding of the fringe of death,absolute freedom,universal responsibility,and solidarity with enemies.The front-line experience is in sharp contrast with daily life experience,and is regarded by Patocka as a continuous consciousness of problematization toward history.This consciousness,which the front-line experience gives rise to,can be maintained through true care for reality and history.Patocka names this"care for the soul"and regards it as the core of the European spirit.The potential philosophical and historical value of the front-line experience urges Patocka to maintain an eternal fight,and he eventually concludes thatitis this eternal fight that brings forth eternal peace.展开更多
利用Weather Research and Forecasting(WRF)中尺度数值模式,结合常规观测资料、地面加密自动气象站资料、云迹风等资料较好地模拟了2006年6月10日严重影响浙江的一次强飑线演变过程,得到了与实况比较接近的飑线中尺度特征,结果表明:强...利用Weather Research and Forecasting(WRF)中尺度数值模式,结合常规观测资料、地面加密自动气象站资料、云迹风等资料较好地模拟了2006年6月10日严重影响浙江的一次强飑线演变过程,得到了与实况比较接近的飑线中尺度特征,结果表明:强对流活动与边界层内的中尺度辐合有密切联系,除了雷暴出流在其前沿形成的阵风锋外,还模拟得到了宁波东部地区的中尺度气流辐合线(简称宁东辐合线);宁东辐合线呈现出明显的西干东湿、东侧上湿下干和弱的稳定层结特征,其存在阻挡了边界层顶强不稳定的东传;在宁东辐合线东侧的山谷地带,近地面形成一个尺度仅为10～20km的中尺度垂直闭合环流,该环流导致地面弱的东风气流又反过来加强了宁东辐合线。当之前已存在的雷暴出流形成的阵风锋辐合线与宁东局地辐合线相遇时,形成一条新的阵风锋,边界层之上的湿度显著增强,强不稳定得到逐步释放,加剧了对流的爆发,天气现象进一步加重。展开更多
文摘The study was designed to evaluate the therapeutic and side effects of Bevacizumab plus FOLFIRI regimen as front-line therapy for Chinese patients with advanced colorectal cancer. A total of 15 previously untreated patients with advanced colorectal cancer received Bevacizumab plus FOLFIRI regimen as font-line therapy, in detail, irinotecan 180 mg/m2 was given intravenously on day1, then calcium folinate (CF) 200 mg/m2, F-fluorouracil (5-Fu) 400 mg/m2 given in bolus immediately after CF, day 1 - 2;5-Fu 600 mg/2 given continuously after bolus for 22 hours on day1, day2;Bevacizumab was given intravenously at dosage of 5 mg/kg, on day-1. Therapeutic and side effects were evaluated at least after four cycles of treatment. The results showed that all the cases among the group were valid for response evaluation, with CR 0, PR 10, SD 3, and PD 2. The response rate is 66.7% and median time to progression (mTTP) was 10.6 months. The main toxicities were bone marrow suppression, nausea and vomiting, stomach pain and diarrhea;there was no chemotherapy-related death. The data suggested that the combination regimen with Bevacizumab plus FOLFIRI regimen was effective as front-line therapy for Chinese patients with advanced colorectal cancer, and the side effects were tolerable and manageable.
基金Supported by Natural Science Foundation of Anhui Province No.070413256XMedical Research Foundation of Anhui Provincial Health Department No.2010B001 and No.13zc012
文摘AIM:To evaluate the efficacy and safety of paclitaxelnedaplatin combination as a front-line regimen in Chinese patients with metastatic esophageal squamous cell carcinoma(ESCC).METHODS:A two-center,open-label,single-arm phaseⅡstudy was designed.Thirty-nine patients were enrolled and included in the intention-to-treat analysis of efficacy and adverse events.Patients received 175mg/m2of paclitaxel over a 3 h infusion on 1 d,followed by nedaplatin 80 mg/m2in a 1 h infusion on 2 d every3 wk until the documented disease progression,unac-ceptable toxicity or patient’s refusal.RESULTS:Of the 36 patients assessable for efficacy,there were 2 patients(5.1%)with complete response and 16 patients(41.0%)with partial response,giving an overall response rate of 46.1%.The median progression-free survival and median overall survival for all patients were 7.1 mo(95%CI:4.6-9.7)and 12.4 mo(95%CI:9.5-15.3),respectively.Toxicities were moderate and manageable.Grade 3/4 toxicities included neutropenia(15.4%),nausea(10.3%),anemia(7.7%),thrombocytopenia(5.1%),vomiting(5.1%)and neutropenia fever(2.6%).CONCLUSION:The combination of paclitaxel and nedaplatin is active and well tolerated as a first-line therapy for patients with metastatic ESCC.
基金This article is supported by the Humanities and Social Sciences Fund of the Ministry of Education of China(17YJCZH086).
文摘With insight from the methodology of phenomenology,Jan Patocka draws multiple meanings from the special front-line experience,including new understanding of the fringe of death,absolute freedom,universal responsibility,and solidarity with enemies.The front-line experience is in sharp contrast with daily life experience,and is regarded by Patocka as a continuous consciousness of problematization toward history.This consciousness,which the front-line experience gives rise to,can be maintained through true care for reality and history.Patocka names this"care for the soul"and regards it as the core of the European spirit.The potential philosophical and historical value of the front-line experience urges Patocka to maintain an eternal fight,and he eventually concludes thatitis this eternal fight that brings forth eternal peace.
文摘利用Weather Research and Forecasting(WRF)中尺度数值模式,结合常规观测资料、地面加密自动气象站资料、云迹风等资料较好地模拟了2006年6月10日严重影响浙江的一次强飑线演变过程,得到了与实况比较接近的飑线中尺度特征,结果表明:强对流活动与边界层内的中尺度辐合有密切联系,除了雷暴出流在其前沿形成的阵风锋外,还模拟得到了宁波东部地区的中尺度气流辐合线(简称宁东辐合线);宁东辐合线呈现出明显的西干东湿、东侧上湿下干和弱的稳定层结特征,其存在阻挡了边界层顶强不稳定的东传;在宁东辐合线东侧的山谷地带,近地面形成一个尺度仅为10～20km的中尺度垂直闭合环流,该环流导致地面弱的东风气流又反过来加强了宁东辐合线。当之前已存在的雷暴出流形成的阵风锋辐合线与宁东局地辐合线相遇时,形成一条新的阵风锋,边界层之上的湿度显著增强,强不稳定得到逐步释放,加剧了对流的爆发,天气现象进一步加重。
