OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hy...OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.展开更多
Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional con...Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional constipation of intestinal excess heat were randomly divided into a thread-embedding group(40 cases,2 cases dropped out)and a Chinese patent medication group(40 cases,1 case dropped out).Based on the theory of combined lower he-sea and front-mu points for diseases of fu organs,Zhongwan(CV12),Guanyuan(CV4)and bilateral Zusanli(ST36),Shangjuxu(ST37),Tianshu(ST25),Xiajuxu(ST39)were selected and threadembedding therapy was delivered in the thread-embedding group,once a week.Maren Runchang pll was given orally in the Chinese patent medication group,6-12 g each time,twice a day.Both groups were treated for 4 weeks.Before and after treatment,the scores of constipation assessment scale(CAS),Bristol stool form scale(BSFS),patient-assessment of constipation quality of life(PAC-QOL)and TCM syndrome were observed,and the clinical efficacy was evaluated after treatment in the two groups.Results After treatment,the CAS scores and the TCM syndrome scores were decreased compared with those before treatment(P<0.05),while the BSFS scores were increased compared with those before treatment(P<0.05)in the two groups;the total scores,as well as the physical discomfort and psychosocial discomfort scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the two groups,the worry and anxiety,and the satisfaction scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the thread-embedding group.After treatment,the CAS score,the total score and item-scores of PAC-QOL,as well as the TCM syndrome score in the thread-embedding groupwere lower than those in the Chinese patent medication group(P<0.05).The total effective rate was 78.9%(30/38)in the thread-embedding group,which was higher than 56.4%(22/39)in the Chinese patent medication group(P<0.05).Conclusion Thread-embedding at the combined lower he-sea and front-mu points can effectively treat functional constipation with intestinal excess heat and improve quality of life.展开更多
基金Supported by Central Universities Fundamental Research Funds Project(Graduate Programs)from the Beijing University of Chinese Medicine:Experiment Research on the Effects of Acupuncturing Shu,Yuan,and Mu Acupoints in a Rat Model of Gout and Hyperuricemia(No.2015-JYB-XS127)
文摘OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.
文摘Objective To observe the clinical efficacy of threadembedding at the combined lower he-sea and front-mu points for functional constipation with intestinal excess heat.Methods A total of 80 patients with functional constipation of intestinal excess heat were randomly divided into a thread-embedding group(40 cases,2 cases dropped out)and a Chinese patent medication group(40 cases,1 case dropped out).Based on the theory of combined lower he-sea and front-mu points for diseases of fu organs,Zhongwan(CV12),Guanyuan(CV4)and bilateral Zusanli(ST36),Shangjuxu(ST37),Tianshu(ST25),Xiajuxu(ST39)were selected and threadembedding therapy was delivered in the thread-embedding group,once a week.Maren Runchang pll was given orally in the Chinese patent medication group,6-12 g each time,twice a day.Both groups were treated for 4 weeks.Before and after treatment,the scores of constipation assessment scale(CAS),Bristol stool form scale(BSFS),patient-assessment of constipation quality of life(PAC-QOL)and TCM syndrome were observed,and the clinical efficacy was evaluated after treatment in the two groups.Results After treatment,the CAS scores and the TCM syndrome scores were decreased compared with those before treatment(P<0.05),while the BSFS scores were increased compared with those before treatment(P<0.05)in the two groups;the total scores,as well as the physical discomfort and psychosocial discomfort scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the two groups,the worry and anxiety,and the satisfaction scores of PAC-QOL were decreased compared with those before treatment(P<0.05)in the thread-embedding group.After treatment,the CAS score,the total score and item-scores of PAC-QOL,as well as the TCM syndrome score in the thread-embedding groupwere lower than those in the Chinese patent medication group(P<0.05).The total effective rate was 78.9%(30/38)in the thread-embedding group,which was higher than 56.4%(22/39)in the Chinese patent medication group(P<0.05).Conclusion Thread-embedding at the combined lower he-sea and front-mu points can effectively treat functional constipation with intestinal excess heat and improve quality of life.
文摘目的 探讨俞募配穴针刺联合大黄粉贴脐治疗腰椎术后患者的临床效果。方法 选取2021年1月—2022年12月于福州市中医院行腰椎骨折术后发生术后便秘的患者94例,按随机数字表法分成试验组和对照组,每组47例,对照组实施腹部按摩治疗和大黄粉贴脐治疗;试验组在此基础上进行俞募配穴针刺治疗。比较2组的中医疗效、现代医学疗效、便秘及满意度情况。结果 治疗后,试验组中医疗效评定总有效率为100%,总满意率为97.87%,对照组分别为87.23%、85.11%,试验组高于对照组,差异有统计学意义(P<0.05)。试验组现代医学临床症状评分总分为(0.30±0.12)分、便秘症状(7.61±1.68)分、便秘患者生活质量自评量表评分(patient-assessment of constipation quality of life,PAC-QOL)为(34.01±5.28)分,对照组分别为(0.62±0.19)分、(10.47±2.03)分、(39.52±5.36)分,试验组低于对照组,差异均有统计学意义(P<0.05)。结论 俞募配穴针刺联合大黄粉贴脐对腰椎手术后便秘患者的治疗效果良好,能够有效改善便秘症状、改善生活质量、提高治疗效果和满意度。
