Hartree-Fock calculations are carried out to describe some properties of 16O and 40Ca nuclei using the two forms of fish-bone potential (I and II). A computer simulation search program has been introduced to solve thi...Hartree-Fock calculations are carried out to describe some properties of 16O and 40Ca nuclei using the two forms of fish-bone potential (I and II). A computer simulation search program has been introduced to solve this problem. The Hilbert space was restricted to three dimensional variational space spanned by single spherical harmonic oscillator orbits. Binding energies, root mean square radii and form factors are found to have a good fit with experimental data.展开更多
探究磷酸化鱼骨胶原肽(Phosphorylated fish bone collagen peptide,PFBCP)在模拟胃肠道下形成PFBCP-钙纳米粒的条件及其钙转运特性。通过浊度测定确定形成PFBCP-钙纳米粒的钙离子浓度条件,通过粒径分析和电镜观察考察其纳米粒特性。通...探究磷酸化鱼骨胶原肽(Phosphorylated fish bone collagen peptide,PFBCP)在模拟胃肠道下形成PFBCP-钙纳米粒的条件及其钙转运特性。通过浊度测定确定形成PFBCP-钙纳米粒的钙离子浓度条件,通过粒径分析和电镜观察考察其纳米粒特性。通过构建Caco-2单层细胞,研究PFBCP-钙纳米粒的钙转运效果及途径。结果表明,PFBCP在胃-肠道模拟体系下,能与7.5~20.0 mmol/L氯化钙形成近似球形、均匀分散、粒径为31~116 nm的肽-钙纳米粒。随着氯化钙浓度的增加,PFBCP-钙纳米粒的粒径增大,表面荷电性和表面疏水性均减小。酪蛋白、肌原纤维蛋白、硫酸软骨素、卵磷脂这些膳食成分对消化道模拟体系下PFBCP-钙纳米粒的形成具有显著的促进效果(P<0.05)。PFBCP-钙纳米粒的钙转运量显著高于氯化钙(P<0.05),主要通过胞吞和细胞旁路这两种特有途径递送钙,不依赖于TRPV6钙离子通道。胃肠道生成型PFBCP-钙纳米粒具有显著的钙转运效果,具有较好的应用开发前景。展开更多
文摘Hartree-Fock calculations are carried out to describe some properties of 16O and 40Ca nuclei using the two forms of fish-bone potential (I and II). A computer simulation search program has been introduced to solve this problem. The Hilbert space was restricted to three dimensional variational space spanned by single spherical harmonic oscillator orbits. Binding energies, root mean square radii and form factors are found to have a good fit with experimental data.
文摘探究磷酸化鱼骨胶原肽(Phosphorylated fish bone collagen peptide,PFBCP)在模拟胃肠道下形成PFBCP-钙纳米粒的条件及其钙转运特性。通过浊度测定确定形成PFBCP-钙纳米粒的钙离子浓度条件,通过粒径分析和电镜观察考察其纳米粒特性。通过构建Caco-2单层细胞,研究PFBCP-钙纳米粒的钙转运效果及途径。结果表明,PFBCP在胃-肠道模拟体系下,能与7.5~20.0 mmol/L氯化钙形成近似球形、均匀分散、粒径为31~116 nm的肽-钙纳米粒。随着氯化钙浓度的增加,PFBCP-钙纳米粒的粒径增大,表面荷电性和表面疏水性均减小。酪蛋白、肌原纤维蛋白、硫酸软骨素、卵磷脂这些膳食成分对消化道模拟体系下PFBCP-钙纳米粒的形成具有显著的促进效果(P<0.05)。PFBCP-钙纳米粒的钙转运量显著高于氯化钙(P<0.05),主要通过胞吞和细胞旁路这两种特有途径递送钙,不依赖于TRPV6钙离子通道。胃肠道生成型PFBCP-钙纳米粒具有显著的钙转运效果,具有较好的应用开发前景。
