BACKGROUND Neoadjuvant therapy can reduce the size of gastroesophageal tumors to the extent that they are no longer macroscopically visible.This may increase the risk of microscopic-positive resection margins.One pote...BACKGROUND Neoadjuvant therapy can reduce the size of gastroesophageal tumors to the extent that they are no longer macroscopically visible.This may increase the risk of microscopic-positive resection margins.One potential method to reduce this uncertainty could be the preoperative endoscopic marking of proximal tumor margins with BioXmark®,a novel liquid fiducial marker.This study aimed to report the initial experiences of the first ten patients marked with BioXmark®.AIM To evaluate the visibility of BioXmark®on ultrasound after preoperative marking of the proximal resection line of an esophageal tumor.METHODS The circumference of the esophagus was endoscopically marked preoperatively with a fiducial marker in four quadrants,5 cm proximal to the tumor.During the surgery,the surgeon’s proposed proximal resection line was marked.Next,an ultrasound probe was used to identify the previously placed fiducial markers,and its placement was marked.The difference between the surgeon’s proposed resection line and the fiducial marker was measured intraoperatively and subsequently examined with respect to the resection margin and status.RESULTS BioXmark®was implanted in ten patients,5 cm proximal to the tumor.The surgeon’s proposed resection line was positioned 2-6 cm proximally to the surgical marker line.Technical success of injecting the fiducial marker was achieved in all ten patients.In six patients,the marker was successfully identified intraoperatively on ultrasound.No peri-or postoperative adverse events related to BioXmark®implantation were found.CONCLUSION Excellent technical success with the implantation of the fiducial surgical marker was achieved,but limited intraoperative visibility on ultrasound was achieved.Further studies are required to optimize its clinical application.展开更多
模型选择作为统计分析的一个重要工具,它能选出候选模型集中拟合数据生成过程最好的那个模型。为了得到更好的预测标准,本文提出了一种基于Fiducial预测密度的模型选择方法,同时加入容许集来进一步压缩候选模型集,给出理论的同时也给出...模型选择作为统计分析的一个重要工具,它能选出候选模型集中拟合数据生成过程最好的那个模型。为了得到更好的预测标准,本文提出了一种基于Fiducial预测密度的模型选择方法,同时加入容许集来进一步压缩候选模型集,给出理论的同时也给出了MH算法去应用它。最后,对本文提出的模型选择进行了模拟研究与实例分析,结果均表明我们的方法优于其他方法。Model selection is an essential tool in statistical analysis, enabling the identification of the best-fitting model for the data-generating process from a set of candidate models. To achieve better predictive performance, this paper proposes a model selection method based on Fiducial predictive density, incorporating an admissible set to further reduce the candidate model space. Theoretical foundations are provided, along with a Metropolis-Hastings (MH) algorithm for its implementation. Finally, simulation studies and empirical analyses are conducted to evaluate the proposed method. The results demonstrate that our method outperforms existing approaches in terms of both predictive accuracy and efficiency.展开更多
基金Supported by Nanovi A/S provided twenty vials of BioXmark®along with financial support for the evaluation of the implementation of the fiducial marker.
文摘BACKGROUND Neoadjuvant therapy can reduce the size of gastroesophageal tumors to the extent that they are no longer macroscopically visible.This may increase the risk of microscopic-positive resection margins.One potential method to reduce this uncertainty could be the preoperative endoscopic marking of proximal tumor margins with BioXmark®,a novel liquid fiducial marker.This study aimed to report the initial experiences of the first ten patients marked with BioXmark®.AIM To evaluate the visibility of BioXmark®on ultrasound after preoperative marking of the proximal resection line of an esophageal tumor.METHODS The circumference of the esophagus was endoscopically marked preoperatively with a fiducial marker in four quadrants,5 cm proximal to the tumor.During the surgery,the surgeon’s proposed proximal resection line was marked.Next,an ultrasound probe was used to identify the previously placed fiducial markers,and its placement was marked.The difference between the surgeon’s proposed resection line and the fiducial marker was measured intraoperatively and subsequently examined with respect to the resection margin and status.RESULTS BioXmark®was implanted in ten patients,5 cm proximal to the tumor.The surgeon’s proposed resection line was positioned 2-6 cm proximally to the surgical marker line.Technical success of injecting the fiducial marker was achieved in all ten patients.In six patients,the marker was successfully identified intraoperatively on ultrasound.No peri-or postoperative adverse events related to BioXmark®implantation were found.CONCLUSION Excellent technical success with the implantation of the fiducial surgical marker was achieved,but limited intraoperative visibility on ultrasound was achieved.Further studies are required to optimize its clinical application.
文摘模型选择作为统计分析的一个重要工具,它能选出候选模型集中拟合数据生成过程最好的那个模型。为了得到更好的预测标准,本文提出了一种基于Fiducial预测密度的模型选择方法,同时加入容许集来进一步压缩候选模型集,给出理论的同时也给出了MH算法去应用它。最后,对本文提出的模型选择进行了模拟研究与实例分析,结果均表明我们的方法优于其他方法。Model selection is an essential tool in statistical analysis, enabling the identification of the best-fitting model for the data-generating process from a set of candidate models. To achieve better predictive performance, this paper proposes a model selection method based on Fiducial predictive density, incorporating an admissible set to further reduce the candidate model space. Theoretical foundations are provided, along with a Metropolis-Hastings (MH) algorithm for its implementation. Finally, simulation studies and empirical analyses are conducted to evaluate the proposed method. The results demonstrate that our method outperforms existing approaches in terms of both predictive accuracy and efficiency.
