目的骨质疏松症是中老年人群常见且重要的健康问题,肺功能受损可能对骨骼健康产生潜在影响。本研究基于2007-2010年NHANES数据,系统探讨肺功能指标、骨密度(bone mineral density,BMD)与骨质疏松症之间的关系。方法本研究为横断面研究,...目的骨质疏松症是中老年人群常见且重要的健康问题,肺功能受损可能对骨骼健康产生潜在影响。本研究基于2007-2010年NHANES数据,系统探讨肺功能指标、骨密度(bone mineral density,BMD)与骨质疏松症之间的关系。方法本研究为横断面研究,纳入3547名50岁及以上成年人。通过FEV1、FVC及FEV1/FVC评估肺功能,BMD测量部位为股骨颈,骨质疏松症的诊断依据世界卫生组织标准。采用多变量逻辑回归模型分析肺功能与骨质疏松症的关联,并调整年龄、性别、种族、吸烟、饮酒、BMI及共病情况等混杂因素。通过Hexbin图展示肺功能与BMD的联合分布,并采用限制立方样条(RCS)模型评估肺功能与骨质疏松症之间的非线性关系。进一步进行亚组分析,并使用森林图展示FEV1/FVC与不同人群骨质疏松风险之间的关联特征。结果较低的肺功能显著增加骨质疏松症的风险。在FEV1/FVC最高四分位数人群中,骨质疏松症的比值比(OR)为0.50(95%CI:0.29~0.85,P=0.015)。基础数据分析显示,骨质疏松症患者的FEV1/FVC值(0.71±0.10)显著低于无骨质疏松症者(0.75±0.09,P<0.001)。RCS分析揭示FEV1/FVC(P=0.014)和FVC(P=0.239)与骨质疏松症之间存在显著的非线性关系,而FEV1的非线性关联较弱(P=0.195)。亚组分析结果在各人群中一致,进一步支持该关联的稳健性。结论中老年人群中,肺功能下降(如FEV1、FVC及FEV1/FVC降低)与骨质疏松症风险增加密切相关。该研究提示,常规监测肺功能有望成为骨质疏松症早期预防和干预的重要策略。展开更多
目的:探寻支气管扩张症(BE)患者存在营养风险的危险因素,以减少其发生,改善BE患者生活质量及预后。方法:本研究纳入126例BE患者,依据NRS-2002分为有营养风险组与无营养风险组。收集患者一般基线资料、检查及检验结果,符合正态分布采用...目的:探寻支气管扩张症(BE)患者存在营养风险的危险因素,以减少其发生,改善BE患者生活质量及预后。方法:本研究纳入126例BE患者,依据NRS-2002分为有营养风险组与无营养风险组。收集患者一般基线资料、检查及检验结果,符合正态分布采用均数独立样本t检验,偏态分布采用Mann-Whitney U检验,计数资料采用x2检验并绘制受试者工作特征(ROC)曲线评估Reiff评分对支扩患者存在营养风险的预测价值。结果:有营养风险组相较无营养风险组,Reiff评分升高,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、白蛋白、白蛋白与球蛋白比值、血清钠离子水平均减低。结论:Reiff评分升高、FVC和FEV1减低、白蛋白及白蛋白与球蛋白比值减低、血清钠离子减低的患者更易存在营养风险。Reiff评分作为支扩患者存在营养风险的早期预测指标具有一定参考意义。Objective: To explore the risk factors of nutritional risk in patients with acute exacerbation of bronchiectasis (BE), in order to reduce the occurrence of nutritional risk and improve the quality of life and prognosis of BE patients. Methods: A total of 126 patients with BE were enrolled in this study and divided into nutritional risk group and non-nutritional risk group according to NRS-2002. Independent sample, t test was used for normal distribution, Mann-Whitney U test was used for skewed distribution, x2 test was used for count data, and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of Reiff score for nutritional risk in patients with bronchiectasis. Results: The Reiff score of the nutritional risk group was higher than that of the non-nutritional risk group, and the forced vital capacity (FVC), forced expiratory volume in one second (FEV1), albumin, albumin to globulin ratio, and serum sodium ion levels were lower. Conclusion: Patients with increased Reiff score, decreased FVC and FEV1, decreased albumin and albumin to globulin ratio, and decreased serum sodium are more likely to have nutritional risk. Reiff score has a certain predictive value for early detection of nutritional risk in patients with BE.展开更多
文摘目的骨质疏松症是中老年人群常见且重要的健康问题,肺功能受损可能对骨骼健康产生潜在影响。本研究基于2007-2010年NHANES数据,系统探讨肺功能指标、骨密度(bone mineral density,BMD)与骨质疏松症之间的关系。方法本研究为横断面研究,纳入3547名50岁及以上成年人。通过FEV1、FVC及FEV1/FVC评估肺功能,BMD测量部位为股骨颈,骨质疏松症的诊断依据世界卫生组织标准。采用多变量逻辑回归模型分析肺功能与骨质疏松症的关联,并调整年龄、性别、种族、吸烟、饮酒、BMI及共病情况等混杂因素。通过Hexbin图展示肺功能与BMD的联合分布,并采用限制立方样条(RCS)模型评估肺功能与骨质疏松症之间的非线性关系。进一步进行亚组分析,并使用森林图展示FEV1/FVC与不同人群骨质疏松风险之间的关联特征。结果较低的肺功能显著增加骨质疏松症的风险。在FEV1/FVC最高四分位数人群中,骨质疏松症的比值比(OR)为0.50(95%CI:0.29~0.85,P=0.015)。基础数据分析显示,骨质疏松症患者的FEV1/FVC值(0.71±0.10)显著低于无骨质疏松症者(0.75±0.09,P<0.001)。RCS分析揭示FEV1/FVC(P=0.014)和FVC(P=0.239)与骨质疏松症之间存在显著的非线性关系,而FEV1的非线性关联较弱(P=0.195)。亚组分析结果在各人群中一致,进一步支持该关联的稳健性。结论中老年人群中,肺功能下降(如FEV1、FVC及FEV1/FVC降低)与骨质疏松症风险增加密切相关。该研究提示,常规监测肺功能有望成为骨质疏松症早期预防和干预的重要策略。
文摘目的:探寻支气管扩张症(BE)患者存在营养风险的危险因素,以减少其发生,改善BE患者生活质量及预后。方法:本研究纳入126例BE患者,依据NRS-2002分为有营养风险组与无营养风险组。收集患者一般基线资料、检查及检验结果,符合正态分布采用均数独立样本t检验,偏态分布采用Mann-Whitney U检验,计数资料采用x2检验并绘制受试者工作特征(ROC)曲线评估Reiff评分对支扩患者存在营养风险的预测价值。结果:有营养风险组相较无营养风险组,Reiff评分升高,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、白蛋白、白蛋白与球蛋白比值、血清钠离子水平均减低。结论:Reiff评分升高、FVC和FEV1减低、白蛋白及白蛋白与球蛋白比值减低、血清钠离子减低的患者更易存在营养风险。Reiff评分作为支扩患者存在营养风险的早期预测指标具有一定参考意义。Objective: To explore the risk factors of nutritional risk in patients with acute exacerbation of bronchiectasis (BE), in order to reduce the occurrence of nutritional risk and improve the quality of life and prognosis of BE patients. Methods: A total of 126 patients with BE were enrolled in this study and divided into nutritional risk group and non-nutritional risk group according to NRS-2002. Independent sample, t test was used for normal distribution, Mann-Whitney U test was used for skewed distribution, x2 test was used for count data, and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of Reiff score for nutritional risk in patients with bronchiectasis. Results: The Reiff score of the nutritional risk group was higher than that of the non-nutritional risk group, and the forced vital capacity (FVC), forced expiratory volume in one second (FEV1), albumin, albumin to globulin ratio, and serum sodium ion levels were lower. Conclusion: Patients with increased Reiff score, decreased FVC and FEV1, decreased albumin and albumin to globulin ratio, and decreased serum sodium are more likely to have nutritional risk. Reiff score has a certain predictive value for early detection of nutritional risk in patients with BE.
