目的评价磁共振灌注加权成像(PWI)在分析脑泡型包虫病(CAE)的血流灌注特征及生物学活性中的价值。方法搜集新疆医科大学第一附属医院2013年6月至2020年1月期间确诊的17例CAE患者,行3.0 T MR常规增强及PWI检查,测定病灶的实质区、边缘区...目的评价磁共振灌注加权成像(PWI)在分析脑泡型包虫病(CAE)的血流灌注特征及生物学活性中的价值。方法搜集新疆医科大学第一附属医院2013年6月至2020年1月期间确诊的17例CAE患者,行3.0 T MR常规增强及PWI检查,测定病灶的实质区、边缘区、水肿区及对侧正常区的相对脑血流量(rCBF)、相对血容量(rCBV)、平均通过时间(MTT)、达峰时间(TTP)。10例患者同期行PET-CT,选取与灌注检查匹配的16个病灶,分析边缘区PWI参数与SUV_(max)的相关性,并绘制受试者工作特征(ROC)曲线评估诊断效能。结果病变边缘区rCBF、rCBV显著高于实质区(P<0.05),其TTP降低,提示边缘区血供丰富,实质区乏血供。边缘区TTP与SUV_(max)呈负相关(r=-0.319,P<0.05)。ROC分析显示rCBF、rCBV、SUV_(max)的ROC曲线下面积(AUC)分别为0.845、0.828、0.856(P<0.05)。结论PWI可有效评估CAE病灶活性,边缘区TTP与SUV_(max)相关,其可作为PET/CT的替代方法用于临床。展开更多
目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVm...目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVmax)与分型、分期及全身症状的关系。结果:病变部位处于前4位的分别为鼻(76.74%)、鼻咽部(41.86%)、咽淋巴环(30.23%)及副鼻窦(27.91%),有4例患者上呼吸消化道部位未发现18F-FD G摄取;PET/C T分期与全身症状关系有显著相关性(P<0.01);43例患者S U Vm ax为13.65±6.35,比较早期(Ⅰ/Ⅱ期)与进展期(Ⅲ/Ⅳ期)、Ⅰ期局限型与超腔型、是否合并全身症状等患者的S U Vm ax值差异有统计学意义;PET/CT分期与传统CT相比有21例不同,其中14例对制定治疗方案有影响;8例CT判断为早期,而PET/CT更改为进展期,21例早期病例中有6例如果应用PET/CT,则应更改放疗方案。结论:PET/CT能更准确显示ENKTL的病灶位置及范围,较传统CT分期方法更准确可靠,对治疗方案制定有较大的指导价值,值得临床推广应用。展开更多
Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favori...Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.展开更多
文摘目的评价磁共振灌注加权成像(PWI)在分析脑泡型包虫病(CAE)的血流灌注特征及生物学活性中的价值。方法搜集新疆医科大学第一附属医院2013年6月至2020年1月期间确诊的17例CAE患者,行3.0 T MR常规增强及PWI检查,测定病灶的实质区、边缘区、水肿区及对侧正常区的相对脑血流量(rCBF)、相对血容量(rCBV)、平均通过时间(MTT)、达峰时间(TTP)。10例患者同期行PET-CT,选取与灌注检查匹配的16个病灶,分析边缘区PWI参数与SUV_(max)的相关性,并绘制受试者工作特征(ROC)曲线评估诊断效能。结果病变边缘区rCBF、rCBV显著高于实质区(P<0.05),其TTP降低,提示边缘区血供丰富,实质区乏血供。边缘区TTP与SUV_(max)呈负相关(r=-0.319,P<0.05)。ROC分析显示rCBF、rCBV、SUV_(max)的ROC曲线下面积(AUC)分别为0.845、0.828、0.856(P<0.05)。结论PWI可有效评估CAE病灶活性,边缘区TTP与SUV_(max)相关,其可作为PET/CT的替代方法用于临床。
文摘目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVmax)与分型、分期及全身症状的关系。结果:病变部位处于前4位的分别为鼻(76.74%)、鼻咽部(41.86%)、咽淋巴环(30.23%)及副鼻窦(27.91%),有4例患者上呼吸消化道部位未发现18F-FD G摄取;PET/C T分期与全身症状关系有显著相关性(P<0.01);43例患者S U Vm ax为13.65±6.35,比较早期(Ⅰ/Ⅱ期)与进展期(Ⅲ/Ⅳ期)、Ⅰ期局限型与超腔型、是否合并全身症状等患者的S U Vm ax值差异有统计学意义;PET/CT分期与传统CT相比有21例不同,其中14例对制定治疗方案有影响;8例CT判断为早期,而PET/CT更改为进展期,21例早期病例中有6例如果应用PET/CT,则应更改放疗方案。结论:PET/CT能更准确显示ENKTL的病灶位置及范围,较传统CT分期方法更准确可靠,对治疗方案制定有较大的指导价值,值得临床推广应用。
文摘Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.
