摘要
目的旨在对比18F-FDG-PET/CT与CT在弥漫大B细胞淋巴瘤(DLBCL)中的分期诊断价值,分析DLBCL病灶的18F-FDG-PET/CT显像及分布特点。方法32例以淋巴结病理确诊的DLBCL患者,同时以18F-FDG-PET/CT及CT评价分期,18F-FDG-PET/CT及CT测量肿瘤病灶的部位、大小及SUVmax,计算与纵隔大血管主动脉弓血池SUVmax比值(T/MB)。结果18F-FDG-PET/CT及CT检测DLBCL病灶的一致率为70.6%,其敏感性分别为100%、75.8%,特异性分别为96%、4%,阳性预测值分别为99.7%、91.5%,阴性预测值分别为100%、1.2%,假阳性率分别为4%、96%,假阴性率分别为0、24.2%,准确率为99.7%、70.9%。结论18F-FDG-PET/CT对DLBCL检测的敏感性、特异性均明显好于CT,对多种结外病灶尤其是骨骼侵润的诊断较CT具有优越性,能够协助临床准确分期。DLBCL病灶的18F-FDG-PET/CT显像分布特点及T/MB值可供临床医生参考。
Objective To evaluate the value of positron emission tomography/computed tomography（PET/CT） and CT in staging of diffuse large B-cell lymphoma（DLBCL）.Methods Thirty-two patients with diffuse large B-cell non Hodgkin lymphoma were prospectively evaluated.All the patients who underwent a whole body 18F-FDG-PET/CT and CT（chest,abdomen and cavitas pelvis） were studied before therapy.The maximal standardized uptake value（SUVmax） of each single lesion and the SUVmax of mediastinal blood pool were measured and used to calculate the median T/MB value（tumor SUV/mediastinal SUV） of each patient.Results 18FFDG-PET/CT and CT were concordant in 70.6% lesions.The sensitivity,specificity,positive and negative predictive value,and the accurate rate of 18F-FDG-PET/CT was 100%,96%,99.7%,100% and 99.7%,respectively,which were much higher than those of CT（75.8%,4%,91.5%,1.2% and 70.9%）.Conclusion 18F-FDG-PET/CT is more sensitive and specific than CT for DLBCL,especially for organs except for lymph nodes.
出处
《军医进修学院学报》
CAS
2010年第5期422-424,433,共4页
Academic Journal of Pla Postgraduate Medical School
基金
首都医学科研发展基金资助项目(20072040)~~
