Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourtee...Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourteen new 3-substhad-6-(2,4-dichlorophenyl)-s-triazolo [3,4-b]-1,3,4-oxadiazoles were obtained by treating 2 -acylhydrazion- 5-(2,4-dichlorophenyl )- 1, 3,4-oxadiazoles with K2CO3 solution. All the new compounds showed significant antibacterial activity展开更多
The synthesis of the title molecule was achieved by the reaction of 2,4-dichloro- benzoyl chloride with potassium thiocyanate in 1：1 molar ratio in dry acetonitrile to afford the corresponding isothiocyante in situ f...The synthesis of the title molecule was achieved by the reaction of 2,4-dichloro- benzoyl chloride with potassium thiocyanate in 1：1 molar ratio in dry acetonitrile to afford the corresponding isothiocyante in situ followed by the treatment with 2-aminobiphenyl. The structure of the target compound was established by elemental analysis, FTIR, 1H, 13C NMR and mass spectroscopy and unequivocally confirmed by the crystallographic data. The title compound crystallizes in the monoclinic space group P21/n with a = 13.356（2）, b = 7.0761（11）, c = 20.539（3） A, β = 105.723（4）°, V= 1868.5（5） A3 and Z = 4.展开更多
Kinetic resolution of racemic 2-chloro-1-（3,4-dichlorophenyl）ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the （R）-isomer with ≥95% ee and the （S）-isom...Kinetic resolution of racemic 2-chloro-1-（3,4-dichlorophenyl）ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the （R）-isomer with ≥95% ee and the （S）-isomer with ≥90% ee. The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly.展开更多
文摘Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourteen new 3-substhad-6-(2,4-dichlorophenyl)-s-triazolo [3,4-b]-1,3,4-oxadiazoles were obtained by treating 2 -acylhydrazion- 5-(2,4-dichlorophenyl )- 1, 3,4-oxadiazoles with K2CO3 solution. All the new compounds showed significant antibacterial activity
文摘The synthesis of the title molecule was achieved by the reaction of 2,4-dichloro- benzoyl chloride with potassium thiocyanate in 1：1 molar ratio in dry acetonitrile to afford the corresponding isothiocyante in situ followed by the treatment with 2-aminobiphenyl. The structure of the target compound was established by elemental analysis, FTIR, 1H, 13C NMR and mass spectroscopy and unequivocally confirmed by the crystallographic data. The title compound crystallizes in the monoclinic space group P21/n with a = 13.356（2）, b = 7.0761（11）, c = 20.539（3） A, β = 105.723（4）°, V= 1868.5（5） A3 and Z = 4.
基金Project supported by the Doctoral Foundation of Qingdao University of Science and Technology （No. 0022266）, the Program for New Century Excellent Talents in Universities （No. NCET-04-0649）, and the Natural Science Foundation of Shandong Province （No. Z2006B01）.
文摘Kinetic resolution of racemic 2-chloro-1-（3,4-dichlorophenyl）ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the （R）-isomer with ≥95% ee and the （S）-isomer with ≥90% ee. The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly.
