Left ventricular assist devices (LVADs) represent a cornerstone therapy foradvanced heart failure. However, their efficacy in patients with type 2 diabetesmellitus (T2DM) is challenged by diabetes-exacerbated complica...Left ventricular assist devices (LVADs) represent a cornerstone therapy foradvanced heart failure. However, their efficacy in patients with type 2 diabetesmellitus (T2DM) is challenged by diabetes-exacerbated complications. To determineoptimal pharmacological strategies to mitigate major LVAD-relatedcomplications in patients with T2DM. This review provides evidence for pharmacologicalstrategies to mitigate major LVAD-related complications in T2DM, inwhich endothelial dysfunction (via impaired PI3K/Akt-NO signaling), chronicinflammation, and diabetic nephropathy amplify the risk of thrombosis, bleeding,infection, and right ventricular (RV) failure. For thromboembolism prevention,individualized warfarin management (international normalized ratio: 2.0-3.0)with intensified monitoring is essential, while aspirin omission in magneticallylevitated devices (2 trials) reduces bleeding. Phosphodiesterase-5 inhibitors showpromise for thrombosis reduction, but require bleeding risk assessment. Glycemiccontrol necessitates the proactive de-escalation of insulin/sulfonylureas post-LVAD owing to improved insulin sensitivity and hypoglycemia risks, favoringSGLT-2 inhibitors/GLP-1 receptor agonists for cardiometabolic benefits. Drivelineinfection management requires renal-adjusted antimicrobial prophylaxis, culturedirectedtherapy, and novel approaches for drug-resistant cases. The preventionof RV failure depends on preoperative hemodynamic optimization and postoperativeinotropic support. A multidisciplinary approach integrating anticoagulationprecision, infection control, glycemic tailoring, and hemodynamic stabilizationis critical to counter T2DM-pathophysiology interactions.展开更多
针对现场总线系统中现场设备集成与系统集成问题,研究了FDT(field device tool)技术特点.在此基础上,将FDT技术应用到NCS4000系统中,以满足设备综合管理的需要,并提出了系统软件框架模型和系统集成模型.详细说明了网关DTM(device type m...针对现场总线系统中现场设备集成与系统集成问题,研究了FDT(field device tool)技术特点.在此基础上,将FDT技术应用到NCS4000系统中,以满足设备综合管理的需要,并提出了系统软件框架模型和系统集成模型.详细说明了网关DTM(device type manager)的实现方法,分析了DTM程序与现场设备的交互过程.通过开发DTM并将其集成到系统中,验证了设计的可行性.展开更多
提出了一种核Fisher特征提取以及模糊模式识别的传感器故障诊断方法。提取传感器信号波形时域特征和频域特征构成初始特征,使用核Fisher方法对初始特征进行非线性变换增强信号特征。然后使用模糊数学方法建立了传感器故障诊断模型,通过...提出了一种核Fisher特征提取以及模糊模式识别的传感器故障诊断方法。提取传感器信号波形时域特征和频域特征构成初始特征,使用核Fisher方法对初始特征进行非线性变换增强信号特征。然后使用模糊数学方法建立了传感器故障诊断模型,通过使用隶属度函数获取特征向量对各状态的隶属度,运用最大隶属原则对特征向量进行定性分类,判定传感器状态。将该方法应用到FDT/DTM(Field Device Tool/Device Type Manager)设备管理系统中,对NCS4000水循环控制的压力传感器进行故障诊断,数值实验表明该算法具有实效性。展开更多
文摘Left ventricular assist devices (LVADs) represent a cornerstone therapy foradvanced heart failure. However, their efficacy in patients with type 2 diabetesmellitus (T2DM) is challenged by diabetes-exacerbated complications. To determineoptimal pharmacological strategies to mitigate major LVAD-relatedcomplications in patients with T2DM. This review provides evidence for pharmacologicalstrategies to mitigate major LVAD-related complications in T2DM, inwhich endothelial dysfunction (via impaired PI3K/Akt-NO signaling), chronicinflammation, and diabetic nephropathy amplify the risk of thrombosis, bleeding,infection, and right ventricular (RV) failure. For thromboembolism prevention,individualized warfarin management (international normalized ratio: 2.0-3.0)with intensified monitoring is essential, while aspirin omission in magneticallylevitated devices (2 trials) reduces bleeding. Phosphodiesterase-5 inhibitors showpromise for thrombosis reduction, but require bleeding risk assessment. Glycemiccontrol necessitates the proactive de-escalation of insulin/sulfonylureas post-LVAD owing to improved insulin sensitivity and hypoglycemia risks, favoringSGLT-2 inhibitors/GLP-1 receptor agonists for cardiometabolic benefits. Drivelineinfection management requires renal-adjusted antimicrobial prophylaxis, culturedirectedtherapy, and novel approaches for drug-resistant cases. The preventionof RV failure depends on preoperative hemodynamic optimization and postoperativeinotropic support. A multidisciplinary approach integrating anticoagulationprecision, infection control, glycemic tailoring, and hemodynamic stabilizationis critical to counter T2DM-pathophysiology interactions.
文摘针对现场总线系统中现场设备集成与系统集成问题,研究了FDT(field device tool)技术特点.在此基础上,将FDT技术应用到NCS4000系统中,以满足设备综合管理的需要,并提出了系统软件框架模型和系统集成模型.详细说明了网关DTM(device type manager)的实现方法,分析了DTM程序与现场设备的交互过程.通过开发DTM并将其集成到系统中,验证了设计的可行性.
文摘提出了一种核Fisher特征提取以及模糊模式识别的传感器故障诊断方法。提取传感器信号波形时域特征和频域特征构成初始特征,使用核Fisher方法对初始特征进行非线性变换增强信号特征。然后使用模糊数学方法建立了传感器故障诊断模型,通过使用隶属度函数获取特征向量对各状态的隶属度,运用最大隶属原则对特征向量进行定性分类,判定传感器状态。将该方法应用到FDT/DTM(Field Device Tool/Device Type Manager)设备管理系统中,对NCS4000水循环控制的压力传感器进行故障诊断,数值实验表明该算法具有实效性。
