Objective:To investigate the efficacy of drug retention enema combined with deep hyperthermia in the treatment of radiation proctitis in patients with cervical cancer.Methods:A randomized controlled study was conducte...Objective:To investigate the efficacy of drug retention enema combined with deep hyperthermia in the treatment of radiation proctitis in patients with cervical cancer.Methods:A randomized controlled study was conducted,selecting 60 patients with radiation proctitis after cervical cancer,who were randomly divided into a control group and an experimental group of 30 cases each using the random number table method.Both groups of patients received conventional treatment.On this basis,the control group received drug retention enema.The experimental group was treated with deep hyperthermia in addition to the control group.Both groups were treated continuously for 1 month.Compare the clinical symptoms,quality of life,inflammatory markers,and effective treatment rate of the two groups after treatment.Results:Compared with the control group,the improvement in clinical symptoms after treatment in the experimental group was significantly better than that in the former(P<0.05);The quality of life score was significantly higher than that of the control group(P<0.05),and the inflammatory markers were significantly lower than those of the control group(P<0.05);the effective treatment rate was significantly higher than that of the control group(P<0.05).Conclusion:Drug retention enema combined with deep hyperthermia has a good therapeutic effect on radiation proctitis in cervical cancer patients undergoing radiotherapy,which can alleviate patient symptoms,improve quality of life,inhibit inflammatory response,and increase the effective treatment rate.展开更多
Hyperthermia-induced decline in cognitive performance is a moderate complication that poses challenges to the maintenance of safety. Although the underlying mechanism can be attributed to the disruption of brain netwo...Hyperthermia-induced decline in cognitive performance is a moderate complication that poses challenges to the maintenance of safety. Although the underlying mechanism can be attributed to the disruption of brain networks, the propensity remains unclear. This study aimed to test the hypothesis that the extent of the alterations in cognitive performance is governed by the activity of deep brain structures, including monoaminergic neural systems. A decline in cognitive performance during mild hyperthermia and the beneficial effects of neck cooling were demonstrated using the Continuous Performance Test as a battery of cognitive tasks. Aspects of cognitive performance were characterized using the deep-brain activity (DBA) index as a neural activity parameter and the State-Trait Anxiety Inventory to assess the extent of alterations in cognitive performance as an individual measure. It was found that a higher average DBA index during tasks is essential for high cognitive performance in the heat. This beneficial effect of DBA is governed by the upper brainstem. This DBA benefit is more significant for individuals with higher average DBA indices at rest in a normal environment. Individual differences in cognitive performance in the heat are governed by differences in DBA. In addition, the beneficial effect of DBA on cognitive performance in heat only applies under conditions including neck cooling. This limited neck-cooling effect is attributed to anti-homeostatic thermoregulatory responses to cognitive tasks regulated by DBA.展开更多
基金Exploration of Radiotherapy Combined with Hyperthermia and Other Modalities to Reduce Radiation Enteritis in Gynecological Cancer Patients(Project No.2341ZF137).
文摘Objective:To investigate the efficacy of drug retention enema combined with deep hyperthermia in the treatment of radiation proctitis in patients with cervical cancer.Methods:A randomized controlled study was conducted,selecting 60 patients with radiation proctitis after cervical cancer,who were randomly divided into a control group and an experimental group of 30 cases each using the random number table method.Both groups of patients received conventional treatment.On this basis,the control group received drug retention enema.The experimental group was treated with deep hyperthermia in addition to the control group.Both groups were treated continuously for 1 month.Compare the clinical symptoms,quality of life,inflammatory markers,and effective treatment rate of the two groups after treatment.Results:Compared with the control group,the improvement in clinical symptoms after treatment in the experimental group was significantly better than that in the former(P<0.05);The quality of life score was significantly higher than that of the control group(P<0.05),and the inflammatory markers were significantly lower than those of the control group(P<0.05);the effective treatment rate was significantly higher than that of the control group(P<0.05).Conclusion:Drug retention enema combined with deep hyperthermia has a good therapeutic effect on radiation proctitis in cervical cancer patients undergoing radiotherapy,which can alleviate patient symptoms,improve quality of life,inhibit inflammatory response,and increase the effective treatment rate.
文摘Hyperthermia-induced decline in cognitive performance is a moderate complication that poses challenges to the maintenance of safety. Although the underlying mechanism can be attributed to the disruption of brain networks, the propensity remains unclear. This study aimed to test the hypothesis that the extent of the alterations in cognitive performance is governed by the activity of deep brain structures, including monoaminergic neural systems. A decline in cognitive performance during mild hyperthermia and the beneficial effects of neck cooling were demonstrated using the Continuous Performance Test as a battery of cognitive tasks. Aspects of cognitive performance were characterized using the deep-brain activity (DBA) index as a neural activity parameter and the State-Trait Anxiety Inventory to assess the extent of alterations in cognitive performance as an individual measure. It was found that a higher average DBA index during tasks is essential for high cognitive performance in the heat. This beneficial effect of DBA is governed by the upper brainstem. This DBA benefit is more significant for individuals with higher average DBA indices at rest in a normal environment. Individual differences in cognitive performance in the heat are governed by differences in DBA. In addition, the beneficial effect of DBA on cognitive performance in heat only applies under conditions including neck cooling. This limited neck-cooling effect is attributed to anti-homeostatic thermoregulatory responses to cognitive tasks regulated by DBA.
