Objective:To develop a rapid,cost effective RT-PCR method for the mass scale diagnosis of such diseases at the vireraia stage to find out the actual disease burden in that area.Methods:For this purpose,cases with the ...Objective:To develop a rapid,cost effective RT-PCR method for the mass scale diagnosis of such diseases at the vireraia stage to find out the actual disease burden in that area.Methods:For this purpose,cases with the history of only short febrile illness were considered.Thus 157 samples with the history of dengue/chikungunya like illness and only 58 samples with a history of acute encephalitis syndrome(AES)were selected.Results:Out of 157 samples,42 and 74 were detected as dengue and chikungunya,respectively and out of 58 AES cases only 23 could be detected as Japanese encephalitis by this RT-PCR method.Conclusions:This cost effective RT-PCR method can detect the total positive cases that remain undetected by EL1SA method.Moreover,this method is capable to detect the viral RNA from patients'sera even after the appearance of IgM antibody at one fifth costs as compared with the other commercially available kits.展开更多
To making the decision of the developing blue prints,ideal point method was selected to estimate the life cycle cost with effectiveness of torpedo.At the same time,the concept of grey relational entropy of the grey sy...To making the decision of the developing blue prints,ideal point method was selected to estimate the life cycle cost with effectiveness of torpedo.At the same time,the concept of grey relational entropy of the grey system theory was adopted to compute the distance between each blue print and the ideal point(or negative ideal point).The blue print,nearest to the ideal point and farthest to the negative ideal point,is the best one.As an example,four blue prints of torpedo were estimated.The result indicates the practical value of this method.展开更多
BACKGROUND Although substantial evidence supports the advantages of cold snare polypectomy(CSP)in terms of polypectomy efficacy and reduced postoperative adverse events,few studies have examined the cost differences b...BACKGROUND Although substantial evidence supports the advantages of cold snare polypectomy(CSP)in terms of polypectomy efficacy and reduced postoperative adverse events,few studies have examined the cost differences between CSP and traditional endoscopic mucosal resection(EMR)for the treatment of intestinal polyps.AIM To compare the efficacy-cost of EMR and CSP in the treatment of intestinal polyps.METHODS A total of 100 patients with intestinal polyps were included in the retrospective data of our hospital from April 2022 to May 2023.According to the treatment methods,they were divided into EMR(n=46)group and CSP(n=54)group.The baseline data of the two groups were balanced by 1:1 propensity score matching(PSM),and the cost-effectiveness analysis was performed on the two groups after matching.The recurrence rate of the two groups of patients was followed up for 1 year,and they were divided into recurrence group and non-recurrence group according to whether they recurred.Multivariate logistic regression analysis was used to screen out the influencing factors affecting the recurrence of intestinal polyps after endoscopic resection.RESULTS Significant disparities were observed in the number of polyps and smoking background between the two groups before PSM(P<0.05).Following PSM,the number of polyps and smoking history were well balanced between the EMR and CSP groups.The direct cost incurred by the CSP group was markedly higher than that incurred by the EMR group.Concurrently,the cost-effectiveness ratio in the CSP group was substantially reduced when juxtaposed with that in the EMR group(P<0.05).Upon completion of the 1-year follow-up,the rate of recurrence after endoscopic intestinal polypectomy was 38.00%.Multivariate methods revealed that age≥60 years,male sex,number of polyps≥3,and pathological type of adenoma were risk factors for recurrence after endoscopic intestinal polypectomy(all P<0.05).CONCLUSION CSP was more cost-effective for the treatment of intestinal polyps.An age≥60 years,male sex,having a number of polyps≥3,and pathological type of adenoma are independent influencing factors for recurrence.展开更多
为优化变压器选型与成本控制,首先,采用全生命周期成本(life cycle cost,LCC)理论和逼近理想解排序(technique for order preference by similarity to an ideal solution,TOPSIS)法,基于多项变电站工程变压器数据,探究变压器LCC构成及...为优化变压器选型与成本控制,首先,采用全生命周期成本(life cycle cost,LCC)理论和逼近理想解排序(technique for order preference by similarity to an ideal solution,TOPSIS)法,基于多项变电站工程变压器数据,探究变压器LCC构成及电压等级、接线方式、冷却方式等7项影响因素,对影响因素进行加权评估,并计算变压器LCC的各分项成本;其次,通过控制变量法量化电压等级等4项关键因素对变压器LCC的影响,探究关键因素对变压器成本机制的耦合效应,确定35 kV、220 kV及330 kV变压器LCC最低方案。结果显示,电压等级显著影响变压器LCC,接线方式与冷却方式对其的影响也较大;各分项成本在LCC中的占比保持相对稳定;单因素影响下,电压等级越高,变压器LCC越高,而是否为智能变压器对短期成本影响较小,长期来看智能变压器更具经济性。展开更多
基金supported by the Department of Science and Technology,Goverment of West Bengal.India[grant No.705(Sanc.)ST/P/S&T/9G-27/2007]
文摘Objective:To develop a rapid,cost effective RT-PCR method for the mass scale diagnosis of such diseases at the vireraia stage to find out the actual disease burden in that area.Methods:For this purpose,cases with the history of only short febrile illness were considered.Thus 157 samples with the history of dengue/chikungunya like illness and only 58 samples with a history of acute encephalitis syndrome(AES)were selected.Results:Out of 157 samples,42 and 74 were detected as dengue and chikungunya,respectively and out of 58 AES cases only 23 could be detected as Japanese encephalitis by this RT-PCR method.Conclusions:This cost effective RT-PCR method can detect the total positive cases that remain undetected by EL1SA method.Moreover,this method is capable to detect the viral RNA from patients'sera even after the appearance of IgM antibody at one fifth costs as compared with the other commercially available kits.
基金the Doctorate Foundation of Northwestern Polytechnical University (Grant No.CX200304)
文摘To making the decision of the developing blue prints,ideal point method was selected to estimate the life cycle cost with effectiveness of torpedo.At the same time,the concept of grey relational entropy of the grey system theory was adopted to compute the distance between each blue print and the ideal point(or negative ideal point).The blue print,nearest to the ideal point and farthest to the negative ideal point,is the best one.As an example,four blue prints of torpedo were estimated.The result indicates the practical value of this method.
文摘BACKGROUND Although substantial evidence supports the advantages of cold snare polypectomy(CSP)in terms of polypectomy efficacy and reduced postoperative adverse events,few studies have examined the cost differences between CSP and traditional endoscopic mucosal resection(EMR)for the treatment of intestinal polyps.AIM To compare the efficacy-cost of EMR and CSP in the treatment of intestinal polyps.METHODS A total of 100 patients with intestinal polyps were included in the retrospective data of our hospital from April 2022 to May 2023.According to the treatment methods,they were divided into EMR(n=46)group and CSP(n=54)group.The baseline data of the two groups were balanced by 1:1 propensity score matching(PSM),and the cost-effectiveness analysis was performed on the two groups after matching.The recurrence rate of the two groups of patients was followed up for 1 year,and they were divided into recurrence group and non-recurrence group according to whether they recurred.Multivariate logistic regression analysis was used to screen out the influencing factors affecting the recurrence of intestinal polyps after endoscopic resection.RESULTS Significant disparities were observed in the number of polyps and smoking background between the two groups before PSM(P<0.05).Following PSM,the number of polyps and smoking history were well balanced between the EMR and CSP groups.The direct cost incurred by the CSP group was markedly higher than that incurred by the EMR group.Concurrently,the cost-effectiveness ratio in the CSP group was substantially reduced when juxtaposed with that in the EMR group(P<0.05).Upon completion of the 1-year follow-up,the rate of recurrence after endoscopic intestinal polypectomy was 38.00%.Multivariate methods revealed that age≥60 years,male sex,number of polyps≥3,and pathological type of adenoma were risk factors for recurrence after endoscopic intestinal polypectomy(all P<0.05).CONCLUSION CSP was more cost-effective for the treatment of intestinal polyps.An age≥60 years,male sex,having a number of polyps≥3,and pathological type of adenoma are independent influencing factors for recurrence.
文摘为优化变压器选型与成本控制,首先,采用全生命周期成本(life cycle cost,LCC)理论和逼近理想解排序(technique for order preference by similarity to an ideal solution,TOPSIS)法,基于多项变电站工程变压器数据,探究变压器LCC构成及电压等级、接线方式、冷却方式等7项影响因素,对影响因素进行加权评估,并计算变压器LCC的各分项成本;其次,通过控制变量法量化电压等级等4项关键因素对变压器LCC的影响,探究关键因素对变压器成本机制的耦合效应,确定35 kV、220 kV及330 kV变压器LCC最低方案。结果显示,电压等级显著影响变压器LCC,接线方式与冷却方式对其的影响也较大;各分项成本在LCC中的占比保持相对稳定;单因素影响下,电压等级越高,变压器LCC越高,而是否为智能变压器对短期成本影响较小,长期来看智能变压器更具经济性。
