AIM: To evaluate the frequency of blue-on-yellow perimetry (B/YP) deficits in ocular hypertension (OHT) patients and to correlate these findings with central corneal thickness (CCT), and to investigate the influence o...AIM: To evaluate the frequency of blue-on-yellow perimetry (B/YP) deficits in ocular hypertension (OHT) patients and to correlate these findings with central corneal thickness (CCT), and to investigate the influence of age, refraction and gender on the B/YP results in OHT patients. METHODS: The B/YP and CCT were checked respectively in 72 OHT patients with normal white-on-white perimetry (W/WP) and normal optic nerve head. The B/YP was tested by Octopus 101 automated perimetry using G2 strategy, while the CCT was checked with DGH-550 ultrasound pachymeter. All patients were chosen randomly one eye for statistical analysis, a binary regression model was used to determine the independent contribution of variables included in the model, and the differences of the intraocular pressure (TOP), CCT, age, refraction and gender between the normal B/YP group and abnormal B/YP group were compared. RESULTS: Forty-nine out of 72 patients with OHT showed normal B/YP results, whereas 23 of 72 patients (31.9%) demonstrated abnormal B/YP results. CCT showed a correlation with the B/YP results (B=-0.038, SE=0.019, P=0.044), whereas none of the TOP, age, refraction and gender was found to be correlated with the B/YP results. The mean CCT in OHT patients with abnormal B/YP group was lower than that with normal B/YP group (t=2.066, P=0.043). There was a significant positive correlation between TOP and CCT (R(2)=0.513, P=0.000). CONCLUSION: The mean CCT in OHT patients with abnormal B/YP results was lower than that with normal B/YP results. There was a significant positive correlation between TOP and CCT in OHT patients. The age, refraction and gender didn't influence the B/YP results in OHT patients.展开更多
目的:探讨改良睑板腺按摩联合玻璃酸钠对睑板腺功能障碍(meibomian gland dysfunction,MGD)性干眼患者角膜稳定性及泪膜功能的影响。方法:前瞻性选取2022年12月—2024年5月湖南中医药大学第二附属医院眼科收治的MGD性干眼患者90例,按随...目的:探讨改良睑板腺按摩联合玻璃酸钠对睑板腺功能障碍(meibomian gland dysfunction,MGD)性干眼患者角膜稳定性及泪膜功能的影响。方法:前瞻性选取2022年12月—2024年5月湖南中医药大学第二附属医院眼科收治的MGD性干眼患者90例,按随机数字表法分为按摩组(n=45)和常规组(n=45)。常规组给予玻璃酸钠滴眼治疗,按摩组在此基础上给予改良睑板腺按摩治疗。比较两组角膜稳定性(角膜荧光素染色评分)、泪膜功能[泪膜破裂时间(breakup time of tear film,BUT)、泪液分泌试验(SchirmerⅠtest,SⅠt)]、睑板腺功能[睑板腺排出功能评分(MGYLS)]、疗效及不良反应。结果:常规组和按摩组治疗后角膜荧光素染色评分、MGYLS低于治疗前,按摩组角膜荧光素染色评分、MGYLS低于常规组(P<0.05);两组治疗后BUT、SⅠt长于治疗前,按摩组BUT、SⅠt长于常规组(P<0.05);按摩组治疗总有效率高于常规组(P<0.05);常规组和按摩组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:改良睑板腺按摩联合玻璃酸钠治疗可改善MGD性干眼患者角膜稳定性及泪膜功能,促进睑板腺功能恢复,提高疗效,且安全性好。展开更多
基金Supported by Shanghai Leading Academi Discipline Project, China (No.S30205)Shanghai Municipal Health Bureau Project, China(No.034075)
文摘AIM: To evaluate the frequency of blue-on-yellow perimetry (B/YP) deficits in ocular hypertension (OHT) patients and to correlate these findings with central corneal thickness (CCT), and to investigate the influence of age, refraction and gender on the B/YP results in OHT patients. METHODS: The B/YP and CCT were checked respectively in 72 OHT patients with normal white-on-white perimetry (W/WP) and normal optic nerve head. The B/YP was tested by Octopus 101 automated perimetry using G2 strategy, while the CCT was checked with DGH-550 ultrasound pachymeter. All patients were chosen randomly one eye for statistical analysis, a binary regression model was used to determine the independent contribution of variables included in the model, and the differences of the intraocular pressure (TOP), CCT, age, refraction and gender between the normal B/YP group and abnormal B/YP group were compared. RESULTS: Forty-nine out of 72 patients with OHT showed normal B/YP results, whereas 23 of 72 patients (31.9%) demonstrated abnormal B/YP results. CCT showed a correlation with the B/YP results (B=-0.038, SE=0.019, P=0.044), whereas none of the TOP, age, refraction and gender was found to be correlated with the B/YP results. The mean CCT in OHT patients with abnormal B/YP group was lower than that with normal B/YP group (t=2.066, P=0.043). There was a significant positive correlation between TOP and CCT (R(2)=0.513, P=0.000). CONCLUSION: The mean CCT in OHT patients with abnormal B/YP results was lower than that with normal B/YP results. There was a significant positive correlation between TOP and CCT in OHT patients. The age, refraction and gender didn't influence the B/YP results in OHT patients.
文摘目的:探讨改良睑板腺按摩联合玻璃酸钠对睑板腺功能障碍(meibomian gland dysfunction,MGD)性干眼患者角膜稳定性及泪膜功能的影响。方法:前瞻性选取2022年12月—2024年5月湖南中医药大学第二附属医院眼科收治的MGD性干眼患者90例,按随机数字表法分为按摩组(n=45)和常规组(n=45)。常规组给予玻璃酸钠滴眼治疗,按摩组在此基础上给予改良睑板腺按摩治疗。比较两组角膜稳定性(角膜荧光素染色评分)、泪膜功能[泪膜破裂时间(breakup time of tear film,BUT)、泪液分泌试验(SchirmerⅠtest,SⅠt)]、睑板腺功能[睑板腺排出功能评分(MGYLS)]、疗效及不良反应。结果:常规组和按摩组治疗后角膜荧光素染色评分、MGYLS低于治疗前,按摩组角膜荧光素染色评分、MGYLS低于常规组(P<0.05);两组治疗后BUT、SⅠt长于治疗前,按摩组BUT、SⅠt长于常规组(P<0.05);按摩组治疗总有效率高于常规组(P<0.05);常规组和按摩组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:改良睑板腺按摩联合玻璃酸钠治疗可改善MGD性干眼患者角膜稳定性及泪膜功能,促进睑板腺功能恢复,提高疗效,且安全性好。
