Clarifying the photosynthetic and population characteristics of conventional japonica rice at different yield levels is crucial for boosting yield and ensuring food security.Therefore,a two-year field trial with two c...Clarifying the photosynthetic and population characteristics of conventional japonica rice at different yield levels is crucial for boosting yield and ensuring food security.Therefore,a two-year field trial with two conventional japonica varieties was conducted at four planting densities:16 cm×30 cm(D1),14 cm×30 cm(D2),12 cm×30 cm(D3),and 10 cm×30 cm(D4).This study aimed to investigate how photosynthetic and population characteristics influence grain yield under varying planting densities.The results indicated that higher yields were primarily driven by increased grain weight and seed-setting rate(with a 9.68%‒11.40%higher single panicle weight),supported by optimized dry matter translocation and source-sink relationships.Elevated planting density(D2‒D4)enhanced panicle number and total spikelet number(by 3.91%‒15.00%)but reduced the number of spikelets per panicle,1000-grain weight,and photosynthetic efficiency due to mutual shading.Despite these trade-offs,yield increased by 4.10%‒12.42%under higher densities.The use of planting density D4 in japonica rice cultivation contributed to maximize yield.These findings provide important theoretical insights and practical significance for increasing the yield of conventional japonica rice and ensuring food security.展开更多
Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess sign...Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess significant immunomodulatory properties in addition to their established direct tumoricidal effects.Emerging immunotherapies have revolutionized the clinical management of various cancer types.Conventional therapy and immunotherapy have demonstrated remarkable clinical efficacy,leading to numerous ongoing clinical investiga-tions exploring their potential synergistic effects.However,trials investigating the combination of conventional therapy and immunotherapy have shown limited synergistic therapeutic efficacy.This unsatisfactory clinical outcome may be attributed to the suboptimal design of the combination approach and the inadequate understanding of the mechanisms and impacts of radiotherapy,chemotherapy,targeted ther-apy regimens(including dosing,timing,and administration route),and surgery on both cancer cells and the host immune system.Here,we comprehensively review preclinical and clinical investigations exploring the therapeutic effects and mechanisms of conventional therapy alone or in combination with immunotherapy.We proposed that optimizing the dosing,timing,and route of administration of conventional therapies can enhance the synergistic efficacy of combination therapies,thus offering significant clinical advantages.展开更多
Pore pressure is a decisive measure to assess the reservoir’s geomechanical properties,ensures safe and efficient drilling operations,and optimizes reservoir characterization and production.The conventional approache...Pore pressure is a decisive measure to assess the reservoir’s geomechanical properties,ensures safe and efficient drilling operations,and optimizes reservoir characterization and production.The conventional approaches sometimes fail to comprehend complex and persistent relationships between pore pressure and formation properties in the heterogeneous reservoirs.This study presents a novel machine learning optimized pore pressure prediction method with a limited dataset,particularly in complex formations.The method addresses the conventional approach's limitations by leveraging its capability to learn complex data relationships.It integrates the best Gradient Boosting Regressor(GBR)algorithm to model pore pressure at wells and later utilizes ContinuousWavelet Transformation(CWT)of the seismic dataset for spatial analysis,and finally employs Deep Neural Network for robust and precise pore pressure modeling for the whole volume.In the second stage,for the spatial variations of pore pressure in the thin Khadro Formation sand reservoir across the entire subsurface area,a three-dimensional pore pressure prediction is conducted using CWT.The relationship between the CWT and geomechanical properties is then established through supervised machine learning models on well locations to predict the uncertainties in pore pressure.Among all intelligent regression techniques developed using petrophysical and elastic properties for pore pressure prediction,the GBR has provided exceptional results that have been validated by evaluation metrics based on the R^(2) score i.e.,0.91 between the calibrated and predicted pore pressure.Via the deep neural network,the relationship between CWT resultant traces and predicted pore pressure is established to analyze the spatial variation.展开更多
Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of met...Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of metagenomic next-generation sequencing(mNGS)compared with that of conventional microbiological tests(CMTs)in identifying pathogens associated with spinal pathologies,with a special focus on infections leading to surgical interventions.Methods We enrolled 85 patients who underwent spinal surgery,comprising 63 patients with clinically diagnosed spinal infections,including patients with spinal tuberculosis,and 22 patients with noninfectious spinal conditions.The procedures involved irrigation and debridement for persistent wound drainage,with subsequent DNA extraction from plasma and joint fluid for mNGS and CMT analysis.Results Significantly increased C-reactive protein(CRP)levels were observed in patients with infections.The mNGS approach showed greater diagnostic sensitivity(92.06%)for detecting pathogens,including Mycobacterium tuberculosis,than did CMTs(36.51%).Despite its low specificity,mNGS had considerable negative predictive value(70.59%),underscoring its utility in ruling out infections.Conclusions The mNGS offers superior sensitivity over CMTs in the diagnosis of a variety of spinal infections,notably spinal tuberculosis.This study highlights the potential of mNGS in enhancing the diagnosis of complex spinal infections,thereby informing targeted treatment strategies.展开更多
BACKGROUND Underwater endoscopic mucosal resection(UEMR)has been shown to be a good treatment option for the management of nonpedunculated polyps≥10 mm since its introduction.However,there is a paucity of randomized ...BACKGROUND Underwater endoscopic mucosal resection(UEMR)has been shown to be a good treatment option for the management of nonpedunculated polyps≥10 mm since its introduction.However,there is a paucity of randomized controlled trials(RCTs)in Asia.AIM To compare the efficacy and safety of UEMR with those of conventional EMR(CEMR)in treating nonpedunculated colorectal lesions.METHODS We carried out this RCT at a tertiary hospital from October 2022 to July 2024.Patients with nonpedunculated colorectal neoplasms ranging from 10 mm to 30 mm in size were randomly assigned to either the UEMR or CEMR group.The primary outcome was the curative resection(R0)rate.The secondary outcomes included en bloc resection,procedure time,adverse events,and the number of clips used for defect closure.RESULTS A total of 260 patients with 260 lesions(130 in each UEMR and CEMR group)were recruited.The median age was 58(27-85)years,the male/female ratio was 1.74,and the median lesion size was 20(10-30 mm)mm.Compared with CEMR,UEMR was associated with a significantly greater curative resection(R0)rate(98.4%vs 90.3%;P=0.007),greater en bloc resection rate(100%vs 94.6%;P=0.014),shorter procedure time(65 vs 185 seconds;P<0.001),lower rate of bleeding complications(1.5%vs 10%;P=0.003),and fewer clips used(2 vs 3;P<0.001).No perforations were observed in either group.CONCLUSION Compared with CEMR,UEMR has a higher R0 rate,greater en bloc resection rate,shorter procedure time,fewer bleeding complications,and clips used in the management of nonpedunculated colorectal neoplasms.展开更多
The 2024 Geoscience Frontiers Annual Convention was held in Kuching,Malaysia,from November 18th to 22th,2024,jointly with the 2024 IAGR Annual Convention and the 21st International Conference on Gondwana to Asia.The I...The 2024 Geoscience Frontiers Annual Convention was held in Kuching,Malaysia,from November 18th to 22th,2024,jointly with the 2024 IAGR Annual Convention and the 21st International Conference on Gondwana to Asia.The IAGR Convention attracted over 150 participants from various countries,including China,India,Australia,the Republic of Korea,Japan,Malaysia,Indonesia,Thailand,Italy,Mexico,the United Kingdom,Saudi Arabia,France,and Brunei.展开更多
On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more...On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more than 160 mountain climbing enthusiasts from all over the country.展开更多
Objective:The management of urethral stricture disease depends on the location,length of stricture,and associated urethral pathology.These parameters are obtained from preoperative imaging,with conventional urethrogra...Objective:The management of urethral stricture disease depends on the location,length of stricture,and associated urethral pathology.These parameters are obtained from preoperative imaging,with conventional urethrogram(retrograde urethrogram and micturating cystourethrogram[RGU/MCU])being the diagnostic tool of choice despite its many shortcomings.Sono-urethrogram(SUG)is an alternative that addresses most issues of RGU/MCU.Studies comparing RGU/MCU with SUG are limited.With the objective of comparing these two imaging modalities in the evaluation of urethral stricture disease,a prospective study was conducted.Methods:Fifty-six patients suspected of urethral stricture disease on clinical evaluation and confirmed either on RGU/MCU or urethro-cystoscopy were included in the study.SUG was performed by the experienced consultant radiologist who was blinded to the report of RGU/MCU.Findings of RGU/MCU and SUG were compared to intraoperative findings,which served as the reference standard.Results:The median length of the stricture determined intraoperatively was 16.5 mm,by RGU/MCU was 5.8 mm,and by SUG was 13.5 mm.The diagnostic accuracy for determination of the stricture location was 93%for RGU/MCU and 98%for SUG.SUG identified spongiofibrosis in 90%of patients with higher accuracy for the severe degree of spongiofibrosis.Conclusion:SUG has been shown to be more accurate than RGU/MCU in estimating stricture length(both short and intermediate)and localizing the stricture location.Use of SUG in conjunction with RGU/MCU helps in better guidance of stricture management by improving preoperative assessment.Further studies with larger sample sizes are warranted.展开更多
Climate change and biodiversity loss are intricately linked,and as the severity of these challenges intensifies,the need for a cohesive international response has become increasingly evident.Since 1992,South Korea has...Climate change and biodiversity loss are intricately linked,and as the severity of these challenges intensifies,the need for a cohesive international response has become increasingly evident.Since 1992,South Korea has developed relevant legal and institutional frameworks;however,its initiatives addressing biodiversity loss have received less recognition and prioritization compared to its efforts concerning climate change.In this context,this study aims to analyze the disparities in South Korea’s policy responses to the United Nations Framework Convention on Climate Change(UNFCCC)and the Convention on Biological Diversity(CBD),while proposing an integrated policy direction.To achieve this,the study compares key policies related to both conventions by utilizing the OECD’s Policy Coherence for Sustainable Development(PCSD)indicators and evaluation criteria derived from previous research.Furthermore,the analysis incorporates variables identified in earlier studies,including legal enforceability,economic incentives,financial support,and industry participation,to enhance the depth of the analysis.Additionally,a review of international best practices was conducted to extract actionable insights for policy enhancement.The analysis reveals several challenges in biodiversity policies,including fragmented governance systems,low policy prioritization,weakened policy momentum,imbalanced financial support,and limited corporate awareness.Moreover,difficulties in quantitative evaluation hinder the verification of policy effectiveness due to the complex nature of biodiversity goals.This research aims to assess South Korea’s responsiveness in accordance with the integrated approach promoted by the international community.展开更多
BACKGROUND Non variceal upper gastrointestinal bleeding(NVUGIB)is a life-threatening condition requiring prompt and effective hemostasis.Various endoscopic inter-ventions,including novel hemostatic powders(HP),over-th...BACKGROUND Non variceal upper gastrointestinal bleeding(NVUGIB)is a life-threatening condition requiring prompt and effective hemostasis.Various endoscopic inter-ventions,including novel hemostatic powders(HP),over-the-scope clips(OTSC),and traditional approaches,have been employed to manage upper gastroin-testinal bleeding(UGIB).Despite advancements,comparative efficacy and safety of these modalities remain uncertain.AIM To evaluate the efficacy and safety of novel hemostatic interventions compared to conventional endoscopic techniques for managing UGIB.METHODS Cochrane,MEDLINE,PubMed and Scopus libraries were searched for rando-mized controlled trials(RCTs)published up to October 2024.Only RCTs compa-ring novel interventions,such as HP or OTSC,with conventional endoscopic treatments computed tomography(CT)were included.The primary outcome was the 30-day rebleeding rate.Secondary outcomes included initial hemostasis,short-term rebleeding rates,need for salvage therapy(surgical/angiographic),30-day all-cause mortality,and bleeding-related mortality.We performed pairwise and network meta-analyses for all treatments.RESULTS Seventeen studies were included in this analysis.Regarding the 30-day rebleeding rate,OTSC and HP showed superior efficacy compared with CT[OTSC vs CT:Relative risk(RR):0.47,95%confidence interval(CI):0.33-0.65;HP vs CT:RR:0.73,95%CI:0.45-1.13],while OTSC and HP had comparable efficacy(RR:0.56,95%CI:0.30-1.05).OTSC ranked the highest in the network ranking estimate for this outcome.For the secondary outcomes,OTSC demonstrated superior efficacy for the short-term rebleeding rate(OTSC vs CT:RR:0.35,95%CI:0.14-0.74;HP vs CT:RR:0.62,95%CI:0.28-1.35;OTSC vs HP:RR:0.59,95%CI:0.17-1.67).Regarding the initial hemostasis rate,OTSC was slightly more effective than CT(OTSC vs CT:RR:1.20,95%CI:1.06-1.57)and comparable to HP(OTSC vs HP:RR:1.08,95%CI:0.89-1.40).There were no significant differences among treatments for all-cause mortality,bleeding-related mortality,or the necessity of surgical or angiographic salvage therapy.OTSC consistently ranked highest across most outcomes in the network ranking estimate.展开更多
Diaphragmatic function is central to respiration,and its evaluation is critical in intensive care unit(ICU)settings.Ultrasonography is a reliable bedside tool to assess diaphragmatic excursion(DE).[1,2]The conventiona...Diaphragmatic function is central to respiration,and its evaluation is critical in intensive care unit(ICU)settings.Ultrasonography is a reliable bedside tool to assess diaphragmatic excursion(DE).[1,2]The conventional M-mode(MM)offers high-resolution imaging but requires precise alignment,which can be diffi cult in ICU patients.[3-5]Anatomical M-mode(AMM)allows flexible line adjustment,enabling accurate DE measurements despite poor acoustic windows.[6]However,comparative data between MM and AMM are limited.This retrospective study evaluated the concordance between MM and AMM for assessing right DE.展开更多
Based on the petroleum exploration in the Cretaceous Qingshankou Formation,northern Songliao Basin,NE China,integrated with seismic,drilling and logging data,this study investigates the characteristics and genetic mec...Based on the petroleum exploration in the Cretaceous Qingshankou Formation,northern Songliao Basin,NE China,integrated with seismic,drilling and logging data,this study investigates the characteristics and genetic mechanisms of orderly distribution and the differential enrichment patterns of conventional and unconventional hydrocarbons in the formation.Key findings involve five aspects.First,the conventional and unconventional hydrocarbons coexist orderly.Laterally,conventional oil,tight oil,and shale oil form a pattern of orderly accumulation from basin margins to the center.Vertically,shale oil,tight oil,and conventional oil develop progressively upward.Second,the coupled tectonic-sedimentary processes govern sedimentary facies differentiation and diagenesis,influencing reservoir physical properties and lithology,thereby controlling the orderly distribution of conventional and unconventional hydrocarbons in space.Third,the coupling of source rock hydrocarbon generation evolution,fault sealing capacity,and reservoir densification determines the orderly coexistence pattern of conventional and unconventional hydrocarbons.Fourth,sequential variations in reservoir physical properties generate distinct dynamic fields that regulate hydrocarbon orderly accumulation.Fifth,enrichment controls are different depending on hydrocarbon types:buoyancy-driven,fault-transport,sandbody-connected,and trap-concentrated,for above-source conventional oil;overpressure-driven,fault-transport,multi-stacked sandbodies,and quasi-continuous distribution for near-source tight oil and gas;self-sourced reservoirs,retention through self-sealing,in-situ accumulation or micro-migration driven by hydrocarbon-generation overpressure for inner-source shale oil.From exploration practices,these findings will effectively guide the integrated deployment and three-dimensional exploration of conventional and unconventional hydrocarbon resources in the Qingshankou Formation,northern Songliao Basin.展开更多
基金funded by the National Key R&D Program of China (Grant No. 2024YFD2300301)the National Natural Science Foundation of China (Grant Nos. 32472223 and 31901447)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Qinglan Project of Jiangsu Province, China
文摘Clarifying the photosynthetic and population characteristics of conventional japonica rice at different yield levels is crucial for boosting yield and ensuring food security.Therefore,a two-year field trial with two conventional japonica varieties was conducted at four planting densities:16 cm×30 cm(D1),14 cm×30 cm(D2),12 cm×30 cm(D3),and 10 cm×30 cm(D4).This study aimed to investigate how photosynthetic and population characteristics influence grain yield under varying planting densities.The results indicated that higher yields were primarily driven by increased grain weight and seed-setting rate(with a 9.68%‒11.40%higher single panicle weight),supported by optimized dry matter translocation and source-sink relationships.Elevated planting density(D2‒D4)enhanced panicle number and total spikelet number(by 3.91%‒15.00%)but reduced the number of spikelets per panicle,1000-grain weight,and photosynthetic efficiency due to mutual shading.Despite these trade-offs,yield increased by 4.10%‒12.42%under higher densities.The use of planting density D4 in japonica rice cultivation contributed to maximize yield.These findings provide important theoretical insights and practical significance for increasing the yield of conventional japonica rice and ensuring food security.
基金supported by the National Science Foundation of China(No.82172726)the Youth Project of Science and Technology Department of Shanxi Province(No.202203021212105)the Research Project Supported by the Shanxi Scholarship Council of China(2021-156).
文摘Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess significant immunomodulatory properties in addition to their established direct tumoricidal effects.Emerging immunotherapies have revolutionized the clinical management of various cancer types.Conventional therapy and immunotherapy have demonstrated remarkable clinical efficacy,leading to numerous ongoing clinical investiga-tions exploring their potential synergistic effects.However,trials investigating the combination of conventional therapy and immunotherapy have shown limited synergistic therapeutic efficacy.This unsatisfactory clinical outcome may be attributed to the suboptimal design of the combination approach and the inadequate understanding of the mechanisms and impacts of radiotherapy,chemotherapy,targeted ther-apy regimens(including dosing,timing,and administration route),and surgery on both cancer cells and the host immune system.Here,we comprehensively review preclinical and clinical investigations exploring the therapeutic effects and mechanisms of conventional therapy alone or in combination with immunotherapy.We proposed that optimizing the dosing,timing,and route of administration of conventional therapies can enhance the synergistic efficacy of combination therapies,thus offering significant clinical advantages.
基金funded by the Basic Science Centre Project of the National Natural Science Foundation of China(Grant No.72088101)supported by the Higher Education Commission,Pakistan(Grant No.20-14925/NRPU/R&D/HEC/2021-2021)+1 种基金the Researchers Supporting Project Number(Grant No.RSP2025R351)King Saud University,Riyadh,Saudi Arabia,for funding this research article.
文摘Pore pressure is a decisive measure to assess the reservoir’s geomechanical properties,ensures safe and efficient drilling operations,and optimizes reservoir characterization and production.The conventional approaches sometimes fail to comprehend complex and persistent relationships between pore pressure and formation properties in the heterogeneous reservoirs.This study presents a novel machine learning optimized pore pressure prediction method with a limited dataset,particularly in complex formations.The method addresses the conventional approach's limitations by leveraging its capability to learn complex data relationships.It integrates the best Gradient Boosting Regressor(GBR)algorithm to model pore pressure at wells and later utilizes ContinuousWavelet Transformation(CWT)of the seismic dataset for spatial analysis,and finally employs Deep Neural Network for robust and precise pore pressure modeling for the whole volume.In the second stage,for the spatial variations of pore pressure in the thin Khadro Formation sand reservoir across the entire subsurface area,a three-dimensional pore pressure prediction is conducted using CWT.The relationship between the CWT and geomechanical properties is then established through supervised machine learning models on well locations to predict the uncertainties in pore pressure.Among all intelligent regression techniques developed using petrophysical and elastic properties for pore pressure prediction,the GBR has provided exceptional results that have been validated by evaluation metrics based on the R^(2) score i.e.,0.91 between the calibrated and predicted pore pressure.Via the deep neural network,the relationship between CWT resultant traces and predicted pore pressure is established to analyze the spatial variation.
基金supported by the Hubei Provincial Natural Science Foundation of China(No.2023AFB646)Knowledge Innovation Program of Wuhan(No.2023020201010155)Educational Research Program of Huazhong University of Science and Technology(No.2022135).
文摘Objective and Background Early and accurate diagnosis of spinal infections,including spinal tuberculosis,is pivotal for effective treatment but remains challenging.This study aims to assess the diagnostic yield of metagenomic next-generation sequencing(mNGS)compared with that of conventional microbiological tests(CMTs)in identifying pathogens associated with spinal pathologies,with a special focus on infections leading to surgical interventions.Methods We enrolled 85 patients who underwent spinal surgery,comprising 63 patients with clinically diagnosed spinal infections,including patients with spinal tuberculosis,and 22 patients with noninfectious spinal conditions.The procedures involved irrigation and debridement for persistent wound drainage,with subsequent DNA extraction from plasma and joint fluid for mNGS and CMT analysis.Results Significantly increased C-reactive protein(CRP)levels were observed in patients with infections.The mNGS approach showed greater diagnostic sensitivity(92.06%)for detecting pathogens,including Mycobacterium tuberculosis,than did CMTs(36.51%).Despite its low specificity,mNGS had considerable negative predictive value(70.59%),underscoring its utility in ruling out infections.Conclusions The mNGS offers superior sensitivity over CMTs in the diagnosis of a variety of spinal infections,notably spinal tuberculosis.This study highlights the potential of mNGS in enhancing the diagnosis of complex spinal infections,thereby informing targeted treatment strategies.
文摘BACKGROUND Underwater endoscopic mucosal resection(UEMR)has been shown to be a good treatment option for the management of nonpedunculated polyps≥10 mm since its introduction.However,there is a paucity of randomized controlled trials(RCTs)in Asia.AIM To compare the efficacy and safety of UEMR with those of conventional EMR(CEMR)in treating nonpedunculated colorectal lesions.METHODS We carried out this RCT at a tertiary hospital from October 2022 to July 2024.Patients with nonpedunculated colorectal neoplasms ranging from 10 mm to 30 mm in size were randomly assigned to either the UEMR or CEMR group.The primary outcome was the curative resection(R0)rate.The secondary outcomes included en bloc resection,procedure time,adverse events,and the number of clips used for defect closure.RESULTS A total of 260 patients with 260 lesions(130 in each UEMR and CEMR group)were recruited.The median age was 58(27-85)years,the male/female ratio was 1.74,and the median lesion size was 20(10-30 mm)mm.Compared with CEMR,UEMR was associated with a significantly greater curative resection(R0)rate(98.4%vs 90.3%;P=0.007),greater en bloc resection rate(100%vs 94.6%;P=0.014),shorter procedure time(65 vs 185 seconds;P<0.001),lower rate of bleeding complications(1.5%vs 10%;P=0.003),and fewer clips used(2 vs 3;P<0.001).No perforations were observed in either group.CONCLUSION Compared with CEMR,UEMR has a higher R0 rate,greater en bloc resection rate,shorter procedure time,fewer bleeding complications,and clips used in the management of nonpedunculated colorectal neoplasms.
文摘The 2024 Geoscience Frontiers Annual Convention was held in Kuching,Malaysia,from November 18th to 22th,2024,jointly with the 2024 IAGR Annual Convention and the 21st International Conference on Gondwana to Asia.The IAGR Convention attracted over 150 participants from various countries,including China,India,Australia,the Republic of Korea,Japan,Malaysia,Indonesia,Thailand,Italy,Mexico,the United Kingdom,Saudi Arabia,France,and Brunei.
文摘On April 30,the 22nd China Xiza ng Mountai neering Conventi on in 2025 comme need.As its flagship eve nt,the Luodui Peak Mountaineering Expedition took place from May 2 to 3 in Yangbajain Town of Lhasa,attracting more than 160 mountain climbing enthusiasts from all over the country.
文摘Objective:The management of urethral stricture disease depends on the location,length of stricture,and associated urethral pathology.These parameters are obtained from preoperative imaging,with conventional urethrogram(retrograde urethrogram and micturating cystourethrogram[RGU/MCU])being the diagnostic tool of choice despite its many shortcomings.Sono-urethrogram(SUG)is an alternative that addresses most issues of RGU/MCU.Studies comparing RGU/MCU with SUG are limited.With the objective of comparing these two imaging modalities in the evaluation of urethral stricture disease,a prospective study was conducted.Methods:Fifty-six patients suspected of urethral stricture disease on clinical evaluation and confirmed either on RGU/MCU or urethro-cystoscopy were included in the study.SUG was performed by the experienced consultant radiologist who was blinded to the report of RGU/MCU.Findings of RGU/MCU and SUG were compared to intraoperative findings,which served as the reference standard.Results:The median length of the stricture determined intraoperatively was 16.5 mm,by RGU/MCU was 5.8 mm,and by SUG was 13.5 mm.The diagnostic accuracy for determination of the stricture location was 93%for RGU/MCU and 98%for SUG.SUG identified spongiofibrosis in 90%of patients with higher accuracy for the severe degree of spongiofibrosis.Conclusion:SUG has been shown to be more accurate than RGU/MCU in estimating stricture length(both short and intermediate)and localizing the stricture location.Use of SUG in conjunction with RGU/MCU helps in better guidance of stricture management by improving preoperative assessment.Further studies with larger sample sizes are warranted.
基金supported by the Carbon Neutrality,a specialized program of the Graduate School through the Korea Environmental Industry&Technology Institute(KEITI)funded by Ministriy of Environment(MOE,Korea).
文摘Climate change and biodiversity loss are intricately linked,and as the severity of these challenges intensifies,the need for a cohesive international response has become increasingly evident.Since 1992,South Korea has developed relevant legal and institutional frameworks;however,its initiatives addressing biodiversity loss have received less recognition and prioritization compared to its efforts concerning climate change.In this context,this study aims to analyze the disparities in South Korea’s policy responses to the United Nations Framework Convention on Climate Change(UNFCCC)and the Convention on Biological Diversity(CBD),while proposing an integrated policy direction.To achieve this,the study compares key policies related to both conventions by utilizing the OECD’s Policy Coherence for Sustainable Development(PCSD)indicators and evaluation criteria derived from previous research.Furthermore,the analysis incorporates variables identified in earlier studies,including legal enforceability,economic incentives,financial support,and industry participation,to enhance the depth of the analysis.Additionally,a review of international best practices was conducted to extract actionable insights for policy enhancement.The analysis reveals several challenges in biodiversity policies,including fragmented governance systems,low policy prioritization,weakened policy momentum,imbalanced financial support,and limited corporate awareness.Moreover,difficulties in quantitative evaluation hinder the verification of policy effectiveness due to the complex nature of biodiversity goals.This research aims to assess South Korea’s responsiveness in accordance with the integrated approach promoted by the international community.
文摘BACKGROUND Non variceal upper gastrointestinal bleeding(NVUGIB)is a life-threatening condition requiring prompt and effective hemostasis.Various endoscopic inter-ventions,including novel hemostatic powders(HP),over-the-scope clips(OTSC),and traditional approaches,have been employed to manage upper gastroin-testinal bleeding(UGIB).Despite advancements,comparative efficacy and safety of these modalities remain uncertain.AIM To evaluate the efficacy and safety of novel hemostatic interventions compared to conventional endoscopic techniques for managing UGIB.METHODS Cochrane,MEDLINE,PubMed and Scopus libraries were searched for rando-mized controlled trials(RCTs)published up to October 2024.Only RCTs compa-ring novel interventions,such as HP or OTSC,with conventional endoscopic treatments computed tomography(CT)were included.The primary outcome was the 30-day rebleeding rate.Secondary outcomes included initial hemostasis,short-term rebleeding rates,need for salvage therapy(surgical/angiographic),30-day all-cause mortality,and bleeding-related mortality.We performed pairwise and network meta-analyses for all treatments.RESULTS Seventeen studies were included in this analysis.Regarding the 30-day rebleeding rate,OTSC and HP showed superior efficacy compared with CT[OTSC vs CT:Relative risk(RR):0.47,95%confidence interval(CI):0.33-0.65;HP vs CT:RR:0.73,95%CI:0.45-1.13],while OTSC and HP had comparable efficacy(RR:0.56,95%CI:0.30-1.05).OTSC ranked the highest in the network ranking estimate for this outcome.For the secondary outcomes,OTSC demonstrated superior efficacy for the short-term rebleeding rate(OTSC vs CT:RR:0.35,95%CI:0.14-0.74;HP vs CT:RR:0.62,95%CI:0.28-1.35;OTSC vs HP:RR:0.59,95%CI:0.17-1.67).Regarding the initial hemostasis rate,OTSC was slightly more effective than CT(OTSC vs CT:RR:1.20,95%CI:1.06-1.57)and comparable to HP(OTSC vs HP:RR:1.08,95%CI:0.89-1.40).There were no significant differences among treatments for all-cause mortality,bleeding-related mortality,or the necessity of surgical or angiographic salvage therapy.OTSC consistently ranked highest across most outcomes in the network ranking estimate.
文摘Diaphragmatic function is central to respiration,and its evaluation is critical in intensive care unit(ICU)settings.Ultrasonography is a reliable bedside tool to assess diaphragmatic excursion(DE).[1,2]The conventional M-mode(MM)offers high-resolution imaging but requires precise alignment,which can be diffi cult in ICU patients.[3-5]Anatomical M-mode(AMM)allows flexible line adjustment,enabling accurate DE measurements despite poor acoustic windows.[6]However,comparative data between MM and AMM are limited.This retrospective study evaluated the concordance between MM and AMM for assessing right DE.
基金Supported by the PetroChina Science and Technology Major Project(2023ZZ15).
文摘Based on the petroleum exploration in the Cretaceous Qingshankou Formation,northern Songliao Basin,NE China,integrated with seismic,drilling and logging data,this study investigates the characteristics and genetic mechanisms of orderly distribution and the differential enrichment patterns of conventional and unconventional hydrocarbons in the formation.Key findings involve five aspects.First,the conventional and unconventional hydrocarbons coexist orderly.Laterally,conventional oil,tight oil,and shale oil form a pattern of orderly accumulation from basin margins to the center.Vertically,shale oil,tight oil,and conventional oil develop progressively upward.Second,the coupled tectonic-sedimentary processes govern sedimentary facies differentiation and diagenesis,influencing reservoir physical properties and lithology,thereby controlling the orderly distribution of conventional and unconventional hydrocarbons in space.Third,the coupling of source rock hydrocarbon generation evolution,fault sealing capacity,and reservoir densification determines the orderly coexistence pattern of conventional and unconventional hydrocarbons.Fourth,sequential variations in reservoir physical properties generate distinct dynamic fields that regulate hydrocarbon orderly accumulation.Fifth,enrichment controls are different depending on hydrocarbon types:buoyancy-driven,fault-transport,sandbody-connected,and trap-concentrated,for above-source conventional oil;overpressure-driven,fault-transport,multi-stacked sandbodies,and quasi-continuous distribution for near-source tight oil and gas;self-sourced reservoirs,retention through self-sealing,in-situ accumulation or micro-migration driven by hydrocarbon-generation overpressure for inner-source shale oil.From exploration practices,these findings will effectively guide the integrated deployment and three-dimensional exploration of conventional and unconventional hydrocarbon resources in the Qingshankou Formation,northern Songliao Basin.
