BACKGROUND Ileocecal laterally spreading tumors(LSTs)complicated by appendiceal tubular adenoma are rare and challenging to diagnose because of the absence of typical symptoms and specific diagnostic signs.Traditional...BACKGROUND Ileocecal laterally spreading tumors(LSTs)complicated by appendiceal tubular adenoma are rare and challenging to diagnose because of the absence of typical symptoms and specific diagnostic signs.Traditionally,the primary treatment has been laparoscopic appendectomy(LA).CASE SUMMARY A 63-year-old female presented with changes in bowel habits.Colonoscopy revealed an ileocecal LST.The patient underwent endoscopic submucosal dissection.Postoperative follow-up colonoscopy revealed mucosal elevation at the appendiceal orifice,with pathology confirming tubular adenoma.Abdominal computed tomography indicated a suspicious appendiceal tumor,leading to LA with partial cecectomy.The postoperative recovery was uneventful.At the 1-year follow-up,colonoscopy revealed no evidence of tumor recurrence.CONCLUSION Ileocecal LSTs with appendiceal tubular adenomas are traditionally treated with LA.endoscopic submucosal dissection can also yield favorable outcomes.展开更多
Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt pro...Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.展开更多
This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward...This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward spreading speeds for the infective individuals, which can be used to estimate how fast the disease spreads. To overcome the difficulty arising from the lack of comparison principle for such time-space periodic nonmonotone systems, our proof is mainly based on constructing a series of scalar time-space periodic equations, establishing the spreading speeds for such auxiliary equations and using comparison methods. It may be the first work to study the spreading speed for time-space periodic non-monotone systems.展开更多
Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered dri...Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.展开更多
BACKGROUND Colorectal laterally spreading tumors(LSTs)are best treated with endoscopic submucosal dissection or endoscopic mucosal resection.AIM To analyze the clinicopathological and endoscopic profiles of colorectal...BACKGROUND Colorectal laterally spreading tumors(LSTs)are best treated with endoscopic submucosal dissection or endoscopic mucosal resection.AIM To analyze the clinicopathological and endoscopic profiles of colorectal LSTs,determine predictive factors for high-grade dysplasia(HGD)/carcinoma(CA),submucosal invasion,and complications.METHODS We retrospectively assessed the endoscopic and histological characteristics of 375 colorectal LSTs at our hospital between January 2016 and December 2023.We performed univariate and multivariate analysis to identify risk factors associated with HGD/CA,submucosal invasion and complications.RESULTS The numbers of granular(LST-G)and non-granular LST(LST-NG)were 260 and 115,respectively.The rates of low-grade dysplasia and HGD/CA were 60.3%and 39.7%,respectively.Multivariate analysis indicated that a tumor size≥30 mm[odds ratio(OR)=1.934,P=0.032],LST granular nodular mixed type(OR=2.100,P=0.005),and LST non-granular pseudo depressed type(NG-PD)(OR=3.016,P=0.015)were independent risk factors significantly associated with higher odds of HGD/CA.NG-PD(OR=6.506,P=0.001),tumor size(20-29 mm)(OR=2.631,P=0.036)and tumor size≥30 mm(OR=3.449,P=0.016)were associated with increased odds of submucosal invasion.Tumor size≥30 mm(OR=4.888,P=0.003)was a particularly important predictor of complications.A nomogram model demonstrated a satisfactory fit,with an area under the receiver operating characteristic curve of 0.716(95%confidence interval:0.653-0.780),indicating strong predictive performance.CONCLUSION The novel nomogram incorporating tumor size,location,and morphology predicted HGD/CA during endoscopic resection for LSTs.NG-PD lesions larger than 20 mm were more likely to invade the submucosa.Tumor size≥30 mm was an important predictor of complications.展开更多
Widely distributed in Gyangzê-Chigu area, southern Tibet, NW- and nearly E-W-trending diabase（gabbro）-gabbro diorite dykes are regarded as the product of the large-scale spreading of the late Neo-Tethys Ocean. ...Widely distributed in Gyangzê-Chigu area, southern Tibet, NW- and nearly E-W-trending diabase（gabbro）-gabbro diorite dykes are regarded as the product of the large-scale spreading of the late Neo-Tethys Ocean. In order to constrain the emplacement age of these dykes, zircons of two samples from diabases in Nagarzê were dated by using the U-Pb SHRIMP method. Two nearly the same weighted mean ^206pb/^23SU ages were obtained in this paper, which are 134.9±1.8 Ma （MSWD=0.65） and 135.5 ± 2.1 Ma （MSWD=1.40）, respectively. They not only represent the crystallization age of the diabase, but also documented an important spreading event of the Neo-Tethys Ocean during the late Jurassic and early Cretaceous. This dating result is of great significance to reconstruct the temporal framework of the late Neo-Tethys Ocean in the Qinghai-Tibet Plateau.展开更多
Esophageal carcinoma(EC) is a highly lethal malignancywith a poor prognosis. One of the most important prognostic factors in EC is lymph node status. Therefore, lymphadenectomy has been recognized as a key that influe...Esophageal carcinoma(EC) is a highly lethal malignancywith a poor prognosis. One of the most important prognostic factors in EC is lymph node status. Therefore, lymphadenectomy has been recognized as a key that influences the outcome of surgical treatment for EC. However, the lymphatic drainage system of the esophagus, including an abundant lymph-capillary network in the lamina propria and muscularis mucosa, is very complex with cervical, mediastinal and celiac node spreading. The extent of lymphadenectomy for EC has always been controversial because of the very complex pattern of lymph node spreading. In this article, published literature regarding lymphatic spreading was reviewed and the current lymphadenectomy trends for EC are discussed.展开更多
The response of pile foundations near a quay wall under liquefaction-induced lateral spreading remains a complex problem. This study presents the results of a shake-table test on a 2×2 pile group behind a sheet-p...The response of pile foundations near a quay wall under liquefaction-induced lateral spreading remains a complex problem. This study presents the results of a shake-table test on a 2×2 pile group behind a sheet-pile quay wall that was subjected to lateral spreading. The quay wall was employed to trigger liquefaction-induced large lateral ground deformation. The discussions focus on the behavior of the pile and the soil and on the bending moment distributions within the group pile and the restoring force characteristics at the superstructure. Overall, the piles exhibited apparent pinning effects that reduced soil deformation. In addition, the rear-row piles near the quay wall experienced larger bending moments than did the front-row piles, indicating significant pile group effects. The tests showed that lateral spreading could be a primary cause of larger monotonic deformations and bending moments. It can also be concluded that the monotonic bending moments were significantly decreased due to the presence of slow soil flow. The stiffness at the superstructure was reduced because of accumulated excess pore pressure before liquefaction, and it was recovered during lateral spreading. The present study further enhances current understanding of the behavior of low-cap pile foundations under lateral spreading.展开更多
With the advent of the information age of networks,the study about rumor propagation in social networks has become increasingly significant.In this paper,a rumor propagation model with nonlinear functions and time del...With the advent of the information age of networks,the study about rumor propagation in social networks has become increasingly significant.In this paper,a rumor propagation model with nonlinear functions and time delay in social networks is proposed.First,according to the nextgeneration matrix method,we work out the basic reproduction number.Second,we discuss the existence of the rumor-prevailing equilibrium points.Third,we demonstrate the stabilities of equilibrium points and analyze the sufficient conditions for Hopf bifurcation.Finally,the correctness of the theory is verified and several vital conclusions are obtained by numerical simulations.展开更多
Experimental models have allowed inquiry into the pathophysiology of varicocele （VC） beyond that possible with human patients. A randomized controlled study in rats was designed to clarify the influence of the degre...Experimental models have allowed inquiry into the pathophysiology of varicocele （VC） beyond that possible with human patients. A randomized controlled study in rats was designed to clarify the influence of the degree of left renal vein constriction on the development of adolescent VC. Fifty adolescent male Sprague-Dawley rats （Rattus norvegicus） were randomly assigned to five groups of 10： the experimental groups （I-IV） underwent partial ligation of left renal veins with 0.5-, 0.6-, 0.7-, and 0.8-mm diameter needles, respectively. The control group （V） underwent a sham operation. The diameter of the left spermatic vein （LSV） was measured at baseline and 30 days postoperatively. In addition, the lesion of the left kidney was examined with the naked eye and assessed by Masson＇s trichrome staining. VC was successfully induced in 2 （20%）, 4 （40%）, 7 （70%）, and 10 （100%） rats in groups I-IV, respectively. The other rats failed to develop VCs primarily due to left renal atrophy. No VC was observed in group V. The postsurgical LSV diameters in VC rats in groups III and IV were 1.54 ± 0. 16 and 1.49 ± 0.13 mm, respectively （P〉 0.05）, and their increments were 1.36±0. 10 and 1.31±0. 10 ram, respectively （P 〉 0.05）. These results suggest that suitable constriction of the left renal vein is critical for adolescent VC development. In addition, the 0.8-mm diameter needle may be more suitable for inducing left renal vein constriction in adolescent rat models.展开更多
This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations ...This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations in terms of superstructure type, connection, continuity at support and foundation type, etc. render different damage resistant capability. Six classes of bridges are established based on their anticipated failure mechanisms under earthquake shaking. The numerical models that are capable of simulating the complex soil-structure interaction effects, nonlinear behavior of columns and connections are developed for each bridge class. The dynamic responses are obtained using nonlinear time history analyses for a suite of 250 earthquake motions with increasing intensity. An equivalent static analysis procedure is also implemented to evaluate the vulnerability of the bridges when subjected to liquefaction-induced lateral spreading. Fragility functions for each bridge class are derived and compared for both seismic shaking （based on nonlinear dynamic analyses） and lateral spreading （based on equivalent static analyses） for different performance states. The study finds that the fragility functions due to either ground shaking or lateral spreading show significant correlation with the structural characterizations, but differences emerge for ground shaking and lateral spreading conditions. Structural properties that will mostly affect the bridges＇ damage resistant capacity are also identified.展开更多
In this paper, we investigate the regularity of spreading of information and public opinions towards two competing products in complex networks. By building its mathematical model and simulating its evolution process,...In this paper, we investigate the regularity of spreading of information and public opinions towards two competing products in complex networks. By building its mathematical model and simulating its evolution process, we have found the statistical regularity for support rates of two different products at a steady stage. The research shows that strength of the public opinion spreading is proportional to the final support rates of a product.展开更多
The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model....The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model. Twenty-two male Sprague-Dawley rats （6 weeks old） were used and divided into three groups. In ME group （n=9）, an expander was activated for 5 days. In Alt-MEC group （9 animals）, an al- ternate expansion and constriction protocol （5-day expansion and 5-day constriction for one cycle） was conducted for 2.5 cycles （25 days total）. The control group comprised 4 animals with no appliances used, each of two sacrificed on day 5 and day 25 respectively. Midpalatal suture expansion or constriction levels were assessed qualitatively and quantitatively by bite-wing X-rays and cast models. Distances between two central incisors and two maxillary first molars were measured on cast models after each activation. Circumaxillary sutures （midpalatal, maxillopalatine, premaxillary, zygomaticotemporal and frontonasal suture） in each group were characterized histologically. Results showed that midpalatal suture was wid- ened and restored after each expansion and constriction. At the end of activation, the widths between both central incisors and first molars in Alt-MEC group were significantly larger than those in ME group （P〈0.05）. Histologically, all five circumaxillary sutures studied were widened in multiple zones in Alt- MEC group. However, only midpalatal suture was expanded with cellular fibrous tissue filling in ME group. Significant osteoclast hyperplasia was observed in all circumaxillary sutures after alternate expan- sions and constrictions, but osteoclast count increase was only observed in midpalatal suture in ME group. These results suggested that cranial and circumaxillary sutures were actively reconstructed after Alt-MEC, while only midpalatal suture had active reaction after ME.展开更多
A revised empirical model has been developed for predicting liquefaction-induced lateral spreading displacement （LD） as a function of both response spectral acceleration derived from strong-motion attenuation models...A revised empirical model has been developed for predicting liquefaction-induced lateral spreading displacement （LD） as a function of both response spectral acceleration derived from strong-motion attenuation models and geotechnical parameters from Youd＇s LD data set （Youd website）. This revised model is different from the model of Zhang and Zhao, which overcame some drawbacks of earlier models for predicting lateral spreading and was primarily used in Japan and the western U.S. The revised model can potentially be applied anywhere if ground shaking （in terms of 5% damped acceleration or displacement response spectra） can be estimated using local strong-motion attenuation relationships. The revised model is examined using data from Japan and the western U.S. and applied to Turkey and New Zealand, where the ground shaking is estimated using appropriate strong-motion attenuation relationships for each region. The accuracy of the revised model is evaluated by comparing its predicted lateral displacements with those measured in actual earthquakes. The results show that the revised model can account for the effects of local seismicity on lateral spreading displacements and is comparable with existing prediction models.展开更多
A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-propagating...A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-propagating scintillating scotoma. Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression （SD）, a self-propagating wave of depolarization that spreads across the cerebral cortex. Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels, such as plasma protein extravasation and pro-inflammatory peptide release. Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways. Although several issues remain to be resolved, recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation, which then contributes to migraine headaches via subsequent activation of trigeminal afferents.展开更多
Lateral spread of frozen ground crust over liquefied soil has caused extensive bridge foundation damage in the past winter earthquakes.A shake table experiment was conducted to investigate the performance of a model p...Lateral spread of frozen ground crust over liquefied soil has caused extensive bridge foundation damage in the past winter earthquakes.A shake table experiment was conducted to investigate the performance of a model pile in this scenario and revealed unique pile failure mechanisms.The modelling results provided valuable data for validating numerical models.This paper presents analyses and results of this experiment using two numerical modeling approaches： solid-fluid coupled finite element（FE） modeling and the beam-on-nonlinear-Winkler-foundation（BNWF） method.A FE model was constructed based on the experiment configuration and subjected to earthquake loading.Soil and pile response results were presented and compared with experimental results to validate this model.The BNWF method was used to predict the pile response and failure mechanism.A p-y curve was presented for modelling the frozen ground crust with the free-field displacement from the experiment as loading.Pile responses were presented and compared with those of the experiment and FE model.It was concluded that the coupled FE model was effective in predicting formation of three plastic hinges at ground surface,ground crust-liquefiable soil interface and within the medium dense sand layer,while the BNWF method was only able to predict the latter two.展开更多
Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the tra...Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the transmission dynamics and population dynamics with consideration of the impact of both of the changing number of online social network users and different levels of user activity. We numerically simulate the rumor spreading process. The results of numerical simulation show that the improved SIS model can successfully characterize the rumor spreading behavior in online social networks. We also give the effective strategies of curbing the rumor spreading in online social networks.展开更多
The Zhongyebei （中业北） basin （ZYBB） is an NE-striking, narrow and small sedimentary basin superimposing the southern 1/2 segment of the proposed spreading axes of the SW subbasin of the South China Sea （SCS）. M...The Zhongyebei （中业北） basin （ZYBB） is an NE-striking, narrow and small sedimentary basin superimposing the southern 1/2 segment of the proposed spreading axes of the SW subbasin of the South China Sea （SCS）. More than 4 500 m strata were identified in the Zhongyebei basin, including the Paleogene lower structure layer and the Neogene upper structure layer. The SW subbasin of the South China Sea has been regarded as an oceanic basin opened by seafloor spreading, as evidenced by the flat and deep （〉 4 000 m mostly） seafloor with linear magnetic anomalies, and by the shallow Moho depth of 〈 12 km as estimated from gravity modeling. The classic model of seafloor spreading predicts that sediments on the oceanic crust are younger and thinner towards the spreading axes. But in the southwestern segment of the SW subbasin, contradictions appear. Firstly, the thick sedimentation in the ZYBB is along the proposed spreading axes. Secondly, the sediments are thinner （500-1 500 m） and younger away from the proposed spreading axes. Thirdly, geological elements of the two sides of spreading axes develop asymmetrically in the southwestern SW subbasin. Two models, the early opening model and the limited modeling model, are suggested for resolving this paradox. The former suggests that the opening of the SW subbasin was in Late Eocene and earlier than the oldest sediment in the ZYBB. The latter proposes that the opening of the SW subbasin was limited to its northeastern portion, and did not extend to the southwest portion. The ZYBB is a rift basin survived from the spreading but subjected to severe syn-spreading magmatic disturbance. The SW subbasin and the ZYBB of the SCS provide a unique opportunity for studying the structural evolution and dynamic mechanism at the tip of a propagating seafloor spreading. Both models have unresolved questions, and further studies are needed.展开更多
Summary： mRNAs of alpha-adrenoceptor （α-AR） subtypes are found in neurons in dorsal root ganglion （DRG） and change after peripheral nerve injury. In this study, the distribution of α-AR subtype proteins was stu...Summary： mRNAs of alpha-adrenoceptor （α-AR） subtypes are found in neurons in dorsal root ganglion （DRG） and change after peripheral nerve injury. In this study, the distribution of α-AR subtype proteins was studied in L5 DRG of normal rats and rats with chronic constriction injury of sciatic nerve （CCI）. Using immunofluorescence technique, it was found that α1A-, α1B-, and α2A-AR proteins were expressed in large, medium, and small size neurons in normal DRG, and significantly increased in all size neurons 14 days after CCI. α1D- and α2C-AR was also expressed in all size neurons in normal DRG. However, α1D-AR was significantly increased and α2C-AR was decreased in small size neurons 14 days post CCI. α2B-AR neurons were not detectable in normal and CCI DRG. Co-expression of α1A- and α2A-AR in the same neuron was observed in normal DRG and increased post CCI. Collectively, these results indicated that there is distinct distribution of α-AR subtypes in DRG neurons, and the distribution and levels of expression of α-AR subtypes change differently after CCI. The up-regulation of α-AR subtypes in DRG neurons may play an important role in the process of generating and transmitting neuropathic pain.展开更多
With processing and interpretation of 25 000 km full-coverage multibeam swath data fromthe eastern South China Sea, it is found that NE-trending and NW-trending linear morphological features such as scarps, horsts and...With processing and interpretation of 25 000 km full-coverage multibeam swath data fromthe eastern South China Sea, it is found that NE-trending and NW-trending linear morphological features such as scarps, horsts and grabens, govern the central part (14°-17° N) of eastern subbasin. Compared with reflection seismic profiles, these NE-trending linear morpho-structures are considered to be the representation of basement structures on seabed and can be divided into three linear structural zones. The trend of the central zone is NE45°-50° occurring around extinct spreading center, the trend of the second zone is NE70° - 78° on both sides of the central one and the trend of the third zone is about NE60° just on the north of the second one. These three NE-trending linear zones are formed in late-stage NW - SE-trending seafloor spreading of the eastern subbasin along NW-trending linear faults, and respectively correspond to three spreading episodes: 17.0- 19.0 Ma (5d-5e), 19.0 - 21.0 Ma (5e-6a) and 21.0 - 24.2 Ma (6a-6c) based on the contrast of morpho-structures to magnetic lineation anomalies.展开更多
文摘BACKGROUND Ileocecal laterally spreading tumors(LSTs)complicated by appendiceal tubular adenoma are rare and challenging to diagnose because of the absence of typical symptoms and specific diagnostic signs.Traditionally,the primary treatment has been laparoscopic appendectomy(LA).CASE SUMMARY A 63-year-old female presented with changes in bowel habits.Colonoscopy revealed an ileocecal LST.The patient underwent endoscopic submucosal dissection.Postoperative follow-up colonoscopy revealed mucosal elevation at the appendiceal orifice,with pathology confirming tubular adenoma.Abdominal computed tomography indicated a suspicious appendiceal tumor,leading to LA with partial cecectomy.The postoperative recovery was uneventful.At the 1-year follow-up,colonoscopy revealed no evidence of tumor recurrence.CONCLUSION Ileocecal LSTs with appendiceal tubular adenomas are traditionally treated with LA.endoscopic submucosal dissection can also yield favorable outcomes.
基金Project supported by the National Natural Science Foundation of China (Grant No. 72174121)the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Soft Science Research Project of Shanghai (Grant No. 22692112600)。
文摘Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.
基金supported by the Natural Science Basic Research Program of Shanxi(Grant No.2024JC-YBMS-025)the Innovation Capability Support Program of Shanxi(Grant No.2024RS-CXTD-88)。
文摘This paper is devoted to investigating the spreading speed of a time-space periodic epidemic model with vital dynamics and standard incidence in discrete media. We establish the existence of the leftward and rightward spreading speeds for the infective individuals, which can be used to estimate how fast the disease spreads. To overcome the difficulty arising from the lack of comparison principle for such time-space periodic nonmonotone systems, our proof is mainly based on constructing a series of scalar time-space periodic equations, establishing the spreading speeds for such auxiliary equations and using comparison methods. It may be the first work to study the spreading speed for time-space periodic non-monotone systems.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12305043 and 12165016)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220511)+1 种基金the Project of Undergraduate Scientific Research(Grant No.22A684)the support from the Jiangsu Specially-Appointed Professor Program。
文摘Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.
文摘BACKGROUND Colorectal laterally spreading tumors(LSTs)are best treated with endoscopic submucosal dissection or endoscopic mucosal resection.AIM To analyze the clinicopathological and endoscopic profiles of colorectal LSTs,determine predictive factors for high-grade dysplasia(HGD)/carcinoma(CA),submucosal invasion,and complications.METHODS We retrospectively assessed the endoscopic and histological characteristics of 375 colorectal LSTs at our hospital between January 2016 and December 2023.We performed univariate and multivariate analysis to identify risk factors associated with HGD/CA,submucosal invasion and complications.RESULTS The numbers of granular(LST-G)and non-granular LST(LST-NG)were 260 and 115,respectively.The rates of low-grade dysplasia and HGD/CA were 60.3%and 39.7%,respectively.Multivariate analysis indicated that a tumor size≥30 mm[odds ratio(OR)=1.934,P=0.032],LST granular nodular mixed type(OR=2.100,P=0.005),and LST non-granular pseudo depressed type(NG-PD)(OR=3.016,P=0.015)were independent risk factors significantly associated with higher odds of HGD/CA.NG-PD(OR=6.506,P=0.001),tumor size(20-29 mm)(OR=2.631,P=0.036)and tumor size≥30 mm(OR=3.449,P=0.016)were associated with increased odds of submucosal invasion.Tumor size≥30 mm(OR=4.888,P=0.003)was a particularly important predictor of complications.A nomogram model demonstrated a satisfactory fit,with an area under the receiver operating characteristic curve of 0.716(95%confidence interval:0.653-0.780),indicating strong predictive performance.CONCLUSION The novel nomogram incorporating tumor size,location,and morphology predicted HGD/CA during endoscopic resection for LSTs.NG-PD lesions larger than 20 mm were more likely to invade the submucosa.Tumor size≥30 mm was an important predictor of complications.
文摘Widely distributed in Gyangzê-Chigu area, southern Tibet, NW- and nearly E-W-trending diabase（gabbro）-gabbro diorite dykes are regarded as the product of the large-scale spreading of the late Neo-Tethys Ocean. In order to constrain the emplacement age of these dykes, zircons of two samples from diabases in Nagarzê were dated by using the U-Pb SHRIMP method. Two nearly the same weighted mean ^206pb/^23SU ages were obtained in this paper, which are 134.9±1.8 Ma （MSWD=0.65） and 135.5 ± 2.1 Ma （MSWD=1.40）, respectively. They not only represent the crystallization age of the diabase, but also documented an important spreading event of the Neo-Tethys Ocean during the late Jurassic and early Cretaceous. This dating result is of great significance to reconstruct the temporal framework of the late Neo-Tethys Ocean in the Qinghai-Tibet Plateau.
文摘Esophageal carcinoma(EC) is a highly lethal malignancywith a poor prognosis. One of the most important prognostic factors in EC is lymph node status. Therefore, lymphadenectomy has been recognized as a key that influences the outcome of surgical treatment for EC. However, the lymphatic drainage system of the esophagus, including an abundant lymph-capillary network in the lamina propria and muscularis mucosa, is very complex with cervical, mediastinal and celiac node spreading. The extent of lymphadenectomy for EC has always been controversial because of the very complex pattern of lymph node spreading. In this article, published literature regarding lymphatic spreading was reviewed and the current lymphadenectomy trends for EC are discussed.
基金National Natural Science Foundation of China under Grant Nos.51378161 and 51108134
文摘The response of pile foundations near a quay wall under liquefaction-induced lateral spreading remains a complex problem. This study presents the results of a shake-table test on a 2×2 pile group behind a sheet-pile quay wall that was subjected to lateral spreading. The quay wall was employed to trigger liquefaction-induced large lateral ground deformation. The discussions focus on the behavior of the pile and the soil and on the bending moment distributions within the group pile and the restoring force characteristics at the superstructure. Overall, the piles exhibited apparent pinning effects that reduced soil deformation. In addition, the rear-row piles near the quay wall experienced larger bending moments than did the front-row piles, indicating significant pile group effects. The tests showed that lateral spreading could be a primary cause of larger monotonic deformations and bending moments. It can also be concluded that the monotonic bending moments were significantly decreased due to the presence of slow soil flow. The stiffness at the superstructure was reduced because of accumulated excess pore pressure before liquefaction, and it was recovered during lateral spreading. The present study further enhances current understanding of the behavior of low-cap pile foundations under lateral spreading.
基金Project supported by the National Natural Science Foundation of China(Grant No.11571170)the Natural Science Research of the Jiangsu Higher Education Institutions of China(Grant No.19KJB110001)the Natural Science Foundation of Jiangsu Province,China(Grant No.SBK2019040208).
文摘With the advent of the information age of networks,the study about rumor propagation in social networks has become increasingly significant.In this paper,a rumor propagation model with nonlinear functions and time delay in social networks is proposed.First,according to the nextgeneration matrix method,we work out the basic reproduction number.Second,we discuss the existence of the rumor-prevailing equilibrium points.Third,we demonstrate the stabilities of equilibrium points and analyze the sufficient conditions for Hopf bifurcation.Finally,the correctness of the theory is verified and several vital conclusions are obtained by numerical simulations.
文摘Experimental models have allowed inquiry into the pathophysiology of varicocele （VC） beyond that possible with human patients. A randomized controlled study in rats was designed to clarify the influence of the degree of left renal vein constriction on the development of adolescent VC. Fifty adolescent male Sprague-Dawley rats （Rattus norvegicus） were randomly assigned to five groups of 10： the experimental groups （I-IV） underwent partial ligation of left renal veins with 0.5-, 0.6-, 0.7-, and 0.8-mm diameter needles, respectively. The control group （V） underwent a sham operation. The diameter of the left spermatic vein （LSV） was measured at baseline and 30 days postoperatively. In addition, the lesion of the left kidney was examined with the naked eye and assessed by Masson＇s trichrome staining. VC was successfully induced in 2 （20%）, 4 （40%）, 7 （70%）, and 10 （100%） rats in groups I-IV, respectively. The other rats failed to develop VCs primarily due to left renal atrophy. No VC was observed in group V. The postsurgical LSV diameters in VC rats in groups III and IV were 1.54 ± 0. 16 and 1.49 ± 0.13 mm, respectively （P〉 0.05）, and their increments were 1.36±0. 10 and 1.31±0. 10 ram, respectively （P 〉 0.05）. These results suggest that suitable constriction of the left renal vein is critical for adolescent VC development. In addition, the 0.8-mm diameter needle may be more suitable for inducing left renal vein constriction in adolescent rat models.
基金Supported by:Pacific Earthquake Engineering Research Center Lifelines Program Under Project Task No.9C
文摘This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations in terms of superstructure type, connection, continuity at support and foundation type, etc. render different damage resistant capability. Six classes of bridges are established based on their anticipated failure mechanisms under earthquake shaking. The numerical models that are capable of simulating the complex soil-structure interaction effects, nonlinear behavior of columns and connections are developed for each bridge class. The dynamic responses are obtained using nonlinear time history analyses for a suite of 250 earthquake motions with increasing intensity. An equivalent static analysis procedure is also implemented to evaluate the vulnerability of the bridges when subjected to liquefaction-induced lateral spreading. Fragility functions for each bridge class are derived and compared for both seismic shaking （based on nonlinear dynamic analyses） and lateral spreading （based on equivalent static analyses） for different performance states. The study finds that the fragility functions due to either ground shaking or lateral spreading show significant correlation with the structural characterizations, but differences emerge for ground shaking and lateral spreading conditions. Structural properties that will mostly affect the bridges＇ damage resistant capacity are also identified.
文摘In this paper, we investigate the regularity of spreading of information and public opinions towards two competing products in complex networks. By building its mathematical model and simulating its evolution process, we have found the statistical regularity for support rates of two different products at a steady stage. The research shows that strength of the public opinion spreading is proportional to the final support rates of a product.
基金supported by Peking University School of Stomatology Youth Scientific Research Fund of China(No.PKUSS20120113)
文摘The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model. Twenty-two male Sprague-Dawley rats （6 weeks old） were used and divided into three groups. In ME group （n=9）, an expander was activated for 5 days. In Alt-MEC group （9 animals）, an al- ternate expansion and constriction protocol （5-day expansion and 5-day constriction for one cycle） was conducted for 2.5 cycles （25 days total）. The control group comprised 4 animals with no appliances used, each of two sacrificed on day 5 and day 25 respectively. Midpalatal suture expansion or constriction levels were assessed qualitatively and quantitatively by bite-wing X-rays and cast models. Distances between two central incisors and two maxillary first molars were measured on cast models after each activation. Circumaxillary sutures （midpalatal, maxillopalatine, premaxillary, zygomaticotemporal and frontonasal suture） in each group were characterized histologically. Results showed that midpalatal suture was wid- ened and restored after each expansion and constriction. At the end of activation, the widths between both central incisors and first molars in Alt-MEC group were significantly larger than those in ME group （P〈0.05）. Histologically, all five circumaxillary sutures studied were widened in multiple zones in Alt- MEC group. However, only midpalatal suture was expanded with cellular fibrous tissue filling in ME group. Significant osteoclast hyperplasia was observed in all circumaxillary sutures after alternate expan- sions and constrictions, but osteoclast count increase was only observed in midpalatal suture in ME group. These results suggested that cranial and circumaxillary sutures were actively reconstructed after Alt-MEC, while only midpalatal suture had active reaction after ME.
基金National Natural Science Foundation SF of China Under Grant No.41030742NBRP of China Under Grant No. 2011CB013605the Foundation for Research and Science and Technology of New Zealand Under Grant No.C05X0402
文摘A revised empirical model has been developed for predicting liquefaction-induced lateral spreading displacement （LD） as a function of both response spectral acceleration derived from strong-motion attenuation models and geotechnical parameters from Youd＇s LD data set （Youd website）. This revised model is different from the model of Zhang and Zhao, which overcame some drawbacks of earlier models for predicting lateral spreading and was primarily used in Japan and the western U.S. The revised model can potentially be applied anywhere if ground shaking （in terms of 5% damped acceleration or displacement response spectra） can be estimated using local strong-motion attenuation relationships. The revised model is examined using data from Japan and the western U.S. and applied to Turkey and New Zealand, where the ground shaking is estimated using appropriate strong-motion attenuation relationships for each region. The accuracy of the revised model is evaluated by comparing its predicted lateral displacements with those measured in actual earthquakes. The results show that the revised model can account for the effects of local seismicity on lateral spreading displacements and is comparable with existing prediction models.
基金supported in part by a consignment expense from the Molecular Imaging Program on "Research Base for Exploring New Drugs"KAKENHI(24659574) from the Ministry of Education,Culture,Sports,Science,and Technology(MEXT) of the Government of Japan
文摘A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-propagating scintillating scotoma. Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression （SD）, a self-propagating wave of depolarization that spreads across the cerebral cortex. Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels, such as plasma protein extravasation and pro-inflammatory peptide release. Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways. Although several issues remain to be resolved, recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation, which then contributes to migraine headaches via subsequent activation of trigeminal afferents.
基金US Department of Transportation through Alaska University Transportation Centerthe State of Alaska Department of Transportation and Public Facilities(AK DOT&PF)under Project AUTC#410015
文摘Lateral spread of frozen ground crust over liquefied soil has caused extensive bridge foundation damage in the past winter earthquakes.A shake table experiment was conducted to investigate the performance of a model pile in this scenario and revealed unique pile failure mechanisms.The modelling results provided valuable data for validating numerical models.This paper presents analyses and results of this experiment using two numerical modeling approaches： solid-fluid coupled finite element（FE） modeling and the beam-on-nonlinear-Winkler-foundation（BNWF） method.A FE model was constructed based on the experiment configuration and subjected to earthquake loading.Soil and pile response results were presented and compared with experimental results to validate this model.The BNWF method was used to predict the pile response and failure mechanism.A p-y curve was presented for modelling the frozen ground crust with the free-field displacement from the experiment as loading.Pile responses were presented and compared with those of the experiment and FE model.It was concluded that the coupled FE model was effective in predicting formation of three plastic hinges at ground surface,ground crust-liquefiable soil interface and within the medium dense sand layer,while the BNWF method was only able to predict the latter two.
基金Supported by National Natural Science Foundation of China under Grant Nos.11275017 and 11173028
文摘Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the transmission dynamics and population dynamics with consideration of the impact of both of the changing number of online social network users and different levels of user activity. We numerically simulate the rumor spreading process. The results of numerical simulation show that the improved SIS model can successfully characterize the rumor spreading behavior in online social networks. We also give the effective strategies of curbing the rumor spreading in online social networks.
基金supported by Guangdong Natural Science Foundation (No. 7007508)
文摘The Zhongyebei （中业北） basin （ZYBB） is an NE-striking, narrow and small sedimentary basin superimposing the southern 1/2 segment of the proposed spreading axes of the SW subbasin of the South China Sea （SCS）. More than 4 500 m strata were identified in the Zhongyebei basin, including the Paleogene lower structure layer and the Neogene upper structure layer. The SW subbasin of the South China Sea has been regarded as an oceanic basin opened by seafloor spreading, as evidenced by the flat and deep （〉 4 000 m mostly） seafloor with linear magnetic anomalies, and by the shallow Moho depth of 〈 12 km as estimated from gravity modeling. The classic model of seafloor spreading predicts that sediments on the oceanic crust are younger and thinner towards the spreading axes. But in the southwestern segment of the SW subbasin, contradictions appear. Firstly, the thick sedimentation in the ZYBB is along the proposed spreading axes. Secondly, the sediments are thinner （500-1 500 m） and younger away from the proposed spreading axes. Thirdly, geological elements of the two sides of spreading axes develop asymmetrically in the southwestern SW subbasin. Two models, the early opening model and the limited modeling model, are suggested for resolving this paradox. The former suggests that the opening of the SW subbasin was in Late Eocene and earlier than the oldest sediment in the ZYBB. The latter proposes that the opening of the SW subbasin was limited to its northeastern portion, and did not extend to the southwest portion. The ZYBB is a rift basin survived from the spreading but subjected to severe syn-spreading magmatic disturbance. The SW subbasin and the ZYBB of the SCS provide a unique opportunity for studying the structural evolution and dynamic mechanism at the tip of a propagating seafloor spreading. Both models have unresolved questions, and further studies are needed.
基金supported by grants from the National Natural Science Foundation of China(No.30160026)the Youth Science and Technology Innovation Special Foundation of Xinjiang Production and Construction Corps,China(No.2010JC33)
文摘Summary： mRNAs of alpha-adrenoceptor （α-AR） subtypes are found in neurons in dorsal root ganglion （DRG） and change after peripheral nerve injury. In this study, the distribution of α-AR subtype proteins was studied in L5 DRG of normal rats and rats with chronic constriction injury of sciatic nerve （CCI）. Using immunofluorescence technique, it was found that α1A-, α1B-, and α2A-AR proteins were expressed in large, medium, and small size neurons in normal DRG, and significantly increased in all size neurons 14 days after CCI. α1D- and α2C-AR was also expressed in all size neurons in normal DRG. However, α1D-AR was significantly increased and α2C-AR was decreased in small size neurons 14 days post CCI. α2B-AR neurons were not detectable in normal and CCI DRG. Co-expression of α1A- and α2A-AR in the same neuron was observed in normal DRG and increased post CCI. Collectively, these results indicated that there is distinct distribution of α-AR subtypes in DRG neurons, and the distribution and levels of expression of α-AR subtypes change differently after CCI. The up-regulation of α-AR subtypes in DRG neurons may play an important role in the process of generating and transmitting neuropathic pain.
基金This study was supported by the National Major Fundamental Research Development Project of China under contract No. G2000046704.
文摘With processing and interpretation of 25 000 km full-coverage multibeam swath data fromthe eastern South China Sea, it is found that NE-trending and NW-trending linear morphological features such as scarps, horsts and grabens, govern the central part (14°-17° N) of eastern subbasin. Compared with reflection seismic profiles, these NE-trending linear morpho-structures are considered to be the representation of basement structures on seabed and can be divided into three linear structural zones. The trend of the central zone is NE45°-50° occurring around extinct spreading center, the trend of the second zone is NE70° - 78° on both sides of the central one and the trend of the third zone is about NE60° just on the north of the second one. These three NE-trending linear zones are formed in late-stage NW - SE-trending seafloor spreading of the eastern subbasin along NW-trending linear faults, and respectively correspond to three spreading episodes: 17.0- 19.0 Ma (5d-5e), 19.0 - 21.0 Ma (5e-6a) and 21.0 - 24.2 Ma (6a-6c) based on the contrast of morpho-structures to magnetic lineation anomalies.
