Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the materi...Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the material basis for the production of medicine natures. Therefore, it is speculated that CMs with similar composition of substances should have similar medicinal nature. Modern work studies cold-hot medicine of CMs with chemical fingerprinting technology because the chemical fingerprint data of CM can reflect the whole composition of CM ingredients. Methods:To verify the hypothesis above, in this work, we study quantifying the similarity of CM ingredients to fingerprint similarity, and explore the relationship between the composition of CMs and cold-hot nature. Firstly, we utilize ultraviolet (UV) spectrum technology to analyze 61 CMs, which have clear cold-hot nature (including 30 ‘cold’ CMs and 31 ‘hot’ CMs). Secondly, with the constructed fingerprint database of CMs, a distance metric learning algorithm is studied to metric the similarity of UV fingerprints. Finally, a retrieval scheme is proposed to build a predictive identification model to identify cold-hot nature of CMs. Results:By means of numerous experiment analyses, ultraviolet spectrum data of petroleum ether solvent can better represent CMs to distinguish between cold and hot natures. Comparing with existing classical models, the proposed identification scheme has better predictive performance. Conclusion:The experimental results prove our inference that CMs with similar composition of substances should have similar medicinal nature. The proposed prediction model is proved to be effective and feasible.展开更多
为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州...为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州组合、雅江-兰州组合枯水遭遇概率以每10 a 1.46%~1.57%的速率显著上升,而大通-花园口组合以每10 a 1.04%的速率显著下降;大金站与雅江站的热点区域主要位于长江中上游与长三角地区,冷点区域位于黄河“几字弯”及长江两湖地区;兰州站与花园口站的热点区域位于黄河中游黄土高原以南,冷点区域集中于长江中下游;未来各站点组合枯水遭遇概率的多模式平均值均超过20%,其中大金-兰州组合与大通-花园口组合呈先减小后增大的趋势,雅江-兰州组合呈线性增大趋势,黄家港-花园口组合呈先减小后缓升趋势。展开更多
Objective：To explore the complex prescription compatibility law of the cold and hot nature of Mahuang Decoction（麻黄汤,MHD） and Maxing Shigan Decoction（麻杏石甘汤,MXSGD）,both categorized formulas but with differe...Objective：To explore the complex prescription compatibility law of the cold and hot nature of Mahuang Decoction（麻黄汤,MHD） and Maxing Shigan Decoction（麻杏石甘汤,MXSGD）,both categorized formulas but with different hot/cold natures.Methods：Oxygen consumption of mice was determined among three groups：MHD,MXSGD and the control;a cold-hot pad differentiating assay was used to observe the variability of temperature tropism among the groups of mice which was treated with MHD,MXSGD,and their compositions. Meanwhile,the total anti-oxidant capability（T-AOC） activity were detected.Results：After administration of MHD, the mice showed increased oxygen consumption（P0.01）.Compared with MHD group,the remaining rate of MXSGD mice on the hot pad was found to be significantly increased with the cold-hot pad differentiating assay （P0.05）.There was no significant difference（P0.05） among the remaining rates of MXSGD,MXSGD with high dose Gypsum Fibrosum（MXHGF） group,and MXSGD with low dose Gypsum Fibrosum（MXLGF） group mice.Compared with the MHD group,T-AOC activity of the mice in the Consensus Compositons group was significantly decreased（P=0.0494）.Compared with the MXSGD group,T-AOC activity of Gypsum Fibrosum （GF） group was increased significantly（P=0.0013）.Conclusions：The differences in cold and hot nature could be represented objectively between MHD with a hot nature and MXSGD with a cold nature.The reason may be the Gypsum Fibrosum which decreased the efficacy of the consensus compositions.However,increasing or decreasing the dose of Gypsum Fibrosum will not change the cold and hot nature of MXSGD.展开更多
基金National key basic research development program (973 Program)(Grant No.:2007CB512600)National Natural Science Foundation of China (Grant No.:81473369)+1 种基金Key research and development plan of Shandong province (Grant No.:2016CYJS08A01-1)Shandong Province TCM science and technology development plan project (2019-0037).
文摘Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the material basis for the production of medicine natures. Therefore, it is speculated that CMs with similar composition of substances should have similar medicinal nature. Modern work studies cold-hot medicine of CMs with chemical fingerprinting technology because the chemical fingerprint data of CM can reflect the whole composition of CM ingredients. Methods:To verify the hypothesis above, in this work, we study quantifying the similarity of CM ingredients to fingerprint similarity, and explore the relationship between the composition of CMs and cold-hot nature. Firstly, we utilize ultraviolet (UV) spectrum technology to analyze 61 CMs, which have clear cold-hot nature (including 30 ‘cold’ CMs and 31 ‘hot’ CMs). Secondly, with the constructed fingerprint database of CMs, a distance metric learning algorithm is studied to metric the similarity of UV fingerprints. Finally, a retrieval scheme is proposed to build a predictive identification model to identify cold-hot nature of CMs. Results:By means of numerous experiment analyses, ultraviolet spectrum data of petroleum ether solvent can better represent CMs to distinguish between cold and hot natures. Comparing with existing classical models, the proposed identification scheme has better predictive performance. Conclusion:The experimental results prove our inference that CMs with similar composition of substances should have similar medicinal nature. The proposed prediction model is proved to be effective and feasible.
文摘为揭示变化环境下长江和黄河流域不同区域枯水遭遇对国家水网工程的规划、设计与运行的影响,采用Copula函数、空间插值、冷热点分析、SWAT模型等方法,分析了两流域枯水遭遇概率的时空演变特征并预测其未来趋势。结果表明:上游大金-兰州组合、雅江-兰州组合枯水遭遇概率以每10 a 1.46%~1.57%的速率显著上升,而大通-花园口组合以每10 a 1.04%的速率显著下降;大金站与雅江站的热点区域主要位于长江中上游与长三角地区,冷点区域位于黄河“几字弯”及长江两湖地区;兰州站与花园口站的热点区域位于黄河中游黄土高原以南,冷点区域集中于长江中下游;未来各站点组合枯水遭遇概率的多模式平均值均超过20%,其中大金-兰州组合与大通-花园口组合呈先减小后增大的趋势,雅江-兰州组合呈线性增大趋势,黄家港-花园口组合呈先减小后缓升趋势。
基金Supported by the Major State Basic Research Development Program of China(973 Program,No.2007CB512607)the National Science Fund for Distinguished Young Scholars (No.30625042)National Science and Technology Major Project of the Ministry of Science and Technology of China(No. 2009ZX10005-017)
文摘Objective：To explore the complex prescription compatibility law of the cold and hot nature of Mahuang Decoction（麻黄汤,MHD） and Maxing Shigan Decoction（麻杏石甘汤,MXSGD）,both categorized formulas but with different hot/cold natures.Methods：Oxygen consumption of mice was determined among three groups：MHD,MXSGD and the control;a cold-hot pad differentiating assay was used to observe the variability of temperature tropism among the groups of mice which was treated with MHD,MXSGD,and their compositions. Meanwhile,the total anti-oxidant capability（T-AOC） activity were detected.Results：After administration of MHD, the mice showed increased oxygen consumption（P0.01）.Compared with MHD group,the remaining rate of MXSGD mice on the hot pad was found to be significantly increased with the cold-hot pad differentiating assay （P0.05）.There was no significant difference（P0.05） among the remaining rates of MXSGD,MXSGD with high dose Gypsum Fibrosum（MXHGF） group,and MXSGD with low dose Gypsum Fibrosum（MXLGF） group mice.Compared with the MHD group,T-AOC activity of the mice in the Consensus Compositons group was significantly decreased（P=0.0494）.Compared with the MXSGD group,T-AOC activity of Gypsum Fibrosum （GF） group was increased significantly（P=0.0013）.Conclusions：The differences in cold and hot nature could be represented objectively between MHD with a hot nature and MXSGD with a cold nature.The reason may be the Gypsum Fibrosum which decreased the efficacy of the consensus compositions.However,increasing or decreasing the dose of Gypsum Fibrosum will not change the cold and hot nature of MXSGD.
