[ Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice, providing the basis for the further research of its effects on immune function. [ Method] Immunosuppressiv...[ Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice, providing the basis for the further research of its effects on immune function. [ Method] Immunosuppressive mouse model was established through twice intraperitoneal in- jection with cyclophosphamide at the dose of 40 mg/kg. After the mice were gavaged respectively with Chanfukang at the dose of 10, 15 and 20 g/kg, the level of cytokines （IL-1β, IL-2 and TNF α） were detected. [Result] Chanfukang significantly increased the level of IL-1β, IL-2 and TNF in the serum of mica gavaged only with Chanfukang; the level of IL-1β, IL-2 and TNF α was inhibited in mice treated with cyclophosphamide; Chanfukang significantly increased the level of IL-1β, IL-2 and TNF α in the serum of immunosuppressive mice. [Condudon] Chanfukang should antagonize the immunosuppression of cyclophosphamide and improve the immune function.words展开更多
[ Objective] To observe effect of Chanfukang on vascular endothelial cells of postpartum cows with Oi deficiency and Blood stasis, and to explore the treatment mechanism of Chanfukang. [Method] A total of 58 cows were...[ Objective] To observe effect of Chanfukang on vascular endothelial cells of postpartum cows with Oi deficiency and Blood stasis, and to explore the treatment mechanism of Chanfukang. [Method] A total of 58 cows were assigned to four groups. The cows in group 1 and group 2 suffered from Qi deficiency and Blood stasis. The cows in group 1 were gavaged with Chanfukang （0.5 g/kg-BW, 5 d） at 12 h post partum, but the cows in group 2 were not treated. The cows in group 3 were healthy and gavaged with Chanfukang （0.4 g/kg.BW, 5 d） at 12 h post partum. Cows in group 4 were healthy control cows. The plasma endothelin （ET） concentration and serum nitric oxide （NO） concentration were determined before and after parturition, respectively. [ Result ] The plasma ET concentration and serum NO concentration were significantly higher in the cows with Qi deficiency and Blood stasis than in the healthy control cows （P 〈 0.05）. The NO concentration decreased on Day 10 post partum in the cows with Qi deficiency and Blood stasis, but it was still higher than that in the healthy control cows. After taking Chanfukang for 7 d, the ET concentration and NO concentration decreased, and no significant difference was found between the cows with Qi deficiency and Blood stasis treated with Chanfukang and the healthy control cows. [ Conclusion] Chanfukang may relieve Qi deficiency and Blood stasis of postpartum cows through decreasing plasma ET concentration and serum NO concentration.展开更多
文摘[ Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice, providing the basis for the further research of its effects on immune function. [ Method] Immunosuppressive mouse model was established through twice intraperitoneal in- jection with cyclophosphamide at the dose of 40 mg/kg. After the mice were gavaged respectively with Chanfukang at the dose of 10, 15 and 20 g/kg, the level of cytokines （IL-1β, IL-2 and TNF α） were detected. [Result] Chanfukang significantly increased the level of IL-1β, IL-2 and TNF in the serum of mica gavaged only with Chanfukang; the level of IL-1β, IL-2 and TNF α was inhibited in mice treated with cyclophosphamide; Chanfukang significantly increased the level of IL-1β, IL-2 and TNF α in the serum of immunosuppressive mice. [Condudon] Chanfukang should antagonize the immunosuppression of cyclophosphamide and improve the immune function.words
基金funded by the grants from the National Technologies R&D Programme (2002BA518A04)
文摘[ Objective] To observe effect of Chanfukang on vascular endothelial cells of postpartum cows with Oi deficiency and Blood stasis, and to explore the treatment mechanism of Chanfukang. [Method] A total of 58 cows were assigned to four groups. The cows in group 1 and group 2 suffered from Qi deficiency and Blood stasis. The cows in group 1 were gavaged with Chanfukang （0.5 g/kg-BW, 5 d） at 12 h post partum, but the cows in group 2 were not treated. The cows in group 3 were healthy and gavaged with Chanfukang （0.4 g/kg.BW, 5 d） at 12 h post partum. Cows in group 4 were healthy control cows. The plasma endothelin （ET） concentration and serum nitric oxide （NO） concentration were determined before and after parturition, respectively. [ Result ] The plasma ET concentration and serum NO concentration were significantly higher in the cows with Qi deficiency and Blood stasis than in the healthy control cows （P 〈 0.05）. The NO concentration decreased on Day 10 post partum in the cows with Qi deficiency and Blood stasis, but it was still higher than that in the healthy control cows. After taking Chanfukang for 7 d, the ET concentration and NO concentration decreased, and no significant difference was found between the cows with Qi deficiency and Blood stasis treated with Chanfukang and the healthy control cows. [ Conclusion] Chanfukang may relieve Qi deficiency and Blood stasis of postpartum cows through decreasing plasma ET concentration and serum NO concentration.
