摘要
目的 :观察大鼠长期给予产复康冲剂是否产生毒性反应。方法 :将产复康冲剂制成水溶液 ,低、中、高剂量组分别按 12 g/kg,30 g/ kg,6 0 g/ kg连续灌胃四周 ,分别相当于临床用量的 10倍、2 5倍、5 0倍。于给药两周和四周时分别检测各组大鼠的体重、血液学、生化学指标 ;测量心、肝、脾、肺、肾、脑、胸腺、子宫、睾丸等脏器系数 (脏器重量 /体重 ) ,对各脏器组织进行病理学检查。结果 :产复康冲剂各剂量组各项指标均未见明显异常改变。结论
Objective: To investigate whether administering of Chanfukang granule to rats has toxicity. Methods: 4 groups Sprague-Dawley rats had been respectively feeding distilled water and Chanfukang granule in 60 g/kg (high dosage), 30 g/kg (middle dosage), 12 g/kg (low dosage) for 4 weeks, these dosages were respectively equal to 100, 80 and 50 times clinical dosage. 2 and 4 weeks later after discontinuation, all the body weights, hematological or biochemical indexes, both relative weight and morphologyces of heart, liver, spleen, lung, kidney, brain, thymus gland, uterus and testis were tested. Results: No evident abnormal change of every index was met in every group. Conclusion: The results suggested that Chanfukang granule long-term administration by Chanfukang orally to rats was safe.
出处
《时珍国医国药》
CAS
CSCD
2001年第4期310-312,共3页
Lishizhen Medicine and Materia Medica Research
关键词
产复康冲剂
长期毒性
毒理学
中药
Chanfukang granule
Chronic toxicity
Toxicology study
