The electrochemical behavior of the degradation product of cefdinir（CDR） was studied in a 0.05 mol/L NaOH solution by means of linear sweep voltammetry（LSV） and cyclic voltammetry（CV）. The results indicate that ...The electrochemical behavior of the degradation product of cefdinir（CDR） was studied in a 0.05 mol/L NaOH solution by means of linear sweep voltammetry（LSV） and cyclic voltammetry（CV）. The results indicate that the C=N bond in the oxime group was reduced. Moreover, a saturated adsorption amount of 1.32× 10^-10 mol/cm2 at Hg electrode was obtained. The adsorption coefficient β was 1.56× 10^5 L/mol. Gibbs standard energy of adsorption AGO at 25 ℃ was -29.63 kJ/mol and the number of electrons transferred n was 2. A method for the determination of CDR was proposed by differential pulse voltammetry（DPV）. The reduction peak currents of the CDR＇s degradation product were found to be linear in a concentration range of 4.0×10^-7--4.0×10^- 6 mol/L and that of 4.0× 10^-8-4.0× 10^-7 mol/L, respectively. The detection limit was found to be 3.0× 10^-8 mol/L under the optimized conditions. The applica- bility of this approach was illustrated by the determination of CDR in capsules. In addition, the mechanism about the degradation of CDR in 0.2 mol/L NaOH was discussed by UV spectrophotometry.展开更多
The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that there are conflicts of interests between the authors and their organization. The scie...The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that there are conflicts of interests between the authors and their organization. The scientific community takes a very strong view on this matter, and the American Journal of Analytical Chemistry treats all unethical behavior seriously. This paper published in Vol. 6 No. 3 239-254, 2015 has been removed from this site. Title: Determination of Antibiotic Drug Cefdinir in Human Plasma Using Liquid Chromatography Tandem Mass Spectroscopy Author: Mohammad A. Al Bayyari, Raed S. Abu展开更多
In this work,the application of silver nanoparticles(Ag NPs)for spectrophotometric determination of cefdinir(CFD)and cefepime HCl(CFP)was developed.The method was based on the ability of the alkaline degradation produ...In this work,the application of silver nanoparticles(Ag NPs)for spectrophotometric determination of cefdinir(CFD)and cefepime HCl(CFP)was developed.The method was based on the ability of the alkaline degradation products of the cited drugs to reduce Ag+ions to silver nanoparticles(Ag-NPs)in the presence of gelatin as a capping agent.The linear concentration ranges were 5.0-40 and 10-100μg/mL for cefdinir and cefepime HCl,respectively.The lower detection limits were found to be 0.39 and 1.06μg/mL for CFD and CFP,respectively,while the quantitation limits were found to be 1.18 and 3.21μg/mL for CFD and CFP,respectively.The formed nanoparticles were characterized by ultraviolet-visible spectroscopy and transmission electron microscopy.The proposed method was applied successfully to determination of CFD and CFP in pure drugs,pharmaceutical preparations and human urine samples.展开更多
基金Supported by the Natural Science Foundation of Shaanxi Province in China(No.2005B28)
文摘The electrochemical behavior of the degradation product of cefdinir（CDR） was studied in a 0.05 mol/L NaOH solution by means of linear sweep voltammetry（LSV） and cyclic voltammetry（CV）. The results indicate that the C=N bond in the oxime group was reduced. Moreover, a saturated adsorption amount of 1.32× 10^-10 mol/cm2 at Hg electrode was obtained. The adsorption coefficient β was 1.56× 10^5 L/mol. Gibbs standard energy of adsorption AGO at 25 ℃ was -29.63 kJ/mol and the number of electrons transferred n was 2. A method for the determination of CDR was proposed by differential pulse voltammetry（DPV）. The reduction peak currents of the CDR＇s degradation product were found to be linear in a concentration range of 4.0×10^-7--4.0×10^- 6 mol/L and that of 4.0× 10^-8-4.0× 10^-7 mol/L, respectively. The detection limit was found to be 3.0× 10^-8 mol/L under the optimized conditions. The applica- bility of this approach was illustrated by the determination of CDR in capsules. In addition, the mechanism about the degradation of CDR in 0.2 mol/L NaOH was discussed by UV spectrophotometry.
文摘The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that there are conflicts of interests between the authors and their organization. The scientific community takes a very strong view on this matter, and the American Journal of Analytical Chemistry treats all unethical behavior seriously. This paper published in Vol. 6 No. 3 239-254, 2015 has been removed from this site. Title: Determination of Antibiotic Drug Cefdinir in Human Plasma Using Liquid Chromatography Tandem Mass Spectroscopy Author: Mohammad A. Al Bayyari, Raed S. Abu
基金supported by Department of Analytical Chemistry,Faculty of Pharmacy,Zagazig University,Egypt.
文摘In this work,the application of silver nanoparticles(Ag NPs)for spectrophotometric determination of cefdinir(CFD)and cefepime HCl(CFP)was developed.The method was based on the ability of the alkaline degradation products of the cited drugs to reduce Ag+ions to silver nanoparticles(Ag-NPs)in the presence of gelatin as a capping agent.The linear concentration ranges were 5.0-40 and 10-100μg/mL for cefdinir and cefepime HCl,respectively.The lower detection limits were found to be 0.39 and 1.06μg/mL for CFD and CFP,respectively,while the quantitation limits were found to be 1.18 and 3.21μg/mL for CFD and CFP,respectively.The formed nanoparticles were characterized by ultraviolet-visible spectroscopy and transmission electron microscopy.The proposed method was applied successfully to determination of CFD and CFP in pure drugs,pharmaceutical preparations and human urine samples.
