Cervical cancer is the one of the most common cancer in female patients inThailand. Radiotherapy has the role for the treatment of cervical cancer by postoperative, radical and palliative treatments. For radical radio...Cervical cancer is the one of the most common cancer in female patients inThailand. Radiotherapy has the role for the treatment of cervical cancer by postoperative, radical and palliative treatments. For radical radiotherapy, the combination of external beam radiation therapy and brachytherapy will be used to increase the tumor dose to curative goal. With the new development of medical images (Computed tomography (CT), Magnetic Resonance Imaging (MRI) or Ultrasonography (US)), the treatment with brachytherapy will be developed from point-based to volume-based concepts. Many studies reported the benefit of image-based brachytherapy over conventional brachytherapy and clinical benefit of using image-based brachytherapy in the treatment of cervical cancer.展开更多
BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter per...BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter percutaneously into the targeted lesion. The aim of this study was to assess local tumor control, safety and efficacy of CT-HDRBT in the treatment of liver metastases of pancreatic cancer. METHODS： Twenty consecutive patients with 49 unresectable liver metastases of pancreatic cancer were included in this retrospective trial and treated with CT-HDRBT, applied as a single fraction high-dose irradiation（15-20 Gy） using a 192 Irsource. Primary endpoint was local tumor control and secondary endpoints were complications, progression-free survival and overall survival.RESULTS： The mean tumor diameter was 29 mm（range 10-73）. The mean irradiation time was 20 minutes（range 7-42）. The mean coverage of the clinical target volume was 98%（range 88%-100%）. The mean D100 was 18.1 Gy and the median D100 was 19.78 Gy. Three major complications occurred with post-interventional abscesses, three of which were seen in 15 patients with biliodigestive anastomosis（20%）and overall 15%. The mean follow-up time was 13.7 months（range 1.4-55.0）. The median progression-free survival was 4.9 months（range 1.4-42.9, mean 9.4）. Local recurrence occurred in 5（10%） of 49 metastases treated. The median overall survival after CT-HDRBT was 8.6 months（range 1.5-55.3）. Eleven patients received chemotherapy after ablation with a median progression-free survival of 4.9 months（mean 12.9）. Nine patients did not receive chemotherapy after intervention with a median progression-free survival of 3.2 months（mean 5.0）. The rate of local tumor control was 91% in both groups after 12 months.CONCLUSION： CT-HDRBT was safe and effective for the treatment of liver metastases of pancreatic cancer.展开更多
目的探讨基于CT引导的3D打印三维插植后装放疗治疗宫颈癌的临床疗效。方法选取2022年6月至2024年12月于赣州市肿瘤医院行宫颈癌后装放疗治疗的60例患者作为研究对象,采用抽签法分为对照组与观察组,每组30例。对照组采用常规三维插植后...目的探讨基于CT引导的3D打印三维插植后装放疗治疗宫颈癌的临床疗效。方法选取2022年6月至2024年12月于赣州市肿瘤医院行宫颈癌后装放疗治疗的60例患者作为研究对象,采用抽签法分为对照组与观察组,每组30例。对照组采用常规三维插植后装放疗,观察组采用基于CT引导下的3D打印三维插植后装放疗。比较两组高危肿瘤靶区90%体积受照剂量(dose received by 90%of high-risk-gross tumor volume,HR-GTV D_(90))、中危肿瘤靶区90%体积受照剂量(dose received by 90%of intermediate-gross tumor volume,IR-GTV D_(90))及其对应2 Gy分次放射等效剂量(equivalent dose in 2-Gy fractions,EQD_(2)),危及器官的危及器官的单次照射2 cm^(3)体积所接受剂量(D_(2)cm^(3))及其对应EQD_(2),插植针数、插植时间、CT扫描次数及放疗后放射性直肠炎、放射性膀胱炎严重程度。结果观察组靶区及其对应EQD_(2)的HR-GTV D_(90)及IR-GTV D_(90)均高于对照组,差异有统计学意义(P<0.05)。观察组直肠、乙状结肠、膀胱D_(2)cm^(3)及其对应EQD_(2)均低于对照组,差异有统计学意义(P<0.05)。观察组插植针数、CT扫描次数均少于对照组,插植时间短于对照组,差异有统计学意义(P<0.05)。观察组放射性直肠炎、放射性膀胱炎的严重程度均优于对照组,差异有统计学意义(P<0.05)。结论基于CT引导下的3D打印三维插植后装放疗治疗局部晚期宫颈癌有明显剂量学优势,可提高靶区剂量,降低危及器官受量,减少放射不良反应发生,且操作简便,用时短,临床可推广应用。展开更多
文摘Cervical cancer is the one of the most common cancer in female patients inThailand. Radiotherapy has the role for the treatment of cervical cancer by postoperative, radical and palliative treatments. For radical radiotherapy, the combination of external beam radiation therapy and brachytherapy will be used to increase the tumor dose to curative goal. With the new development of medical images (Computed tomography (CT), Magnetic Resonance Imaging (MRI) or Ultrasonography (US)), the treatment with brachytherapy will be developed from point-based to volume-based concepts. Many studies reported the benefit of image-based brachytherapy over conventional brachytherapy and clinical benefit of using image-based brachytherapy in the treatment of cervical cancer.
文摘BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter percutaneously into the targeted lesion. The aim of this study was to assess local tumor control, safety and efficacy of CT-HDRBT in the treatment of liver metastases of pancreatic cancer. METHODS： Twenty consecutive patients with 49 unresectable liver metastases of pancreatic cancer were included in this retrospective trial and treated with CT-HDRBT, applied as a single fraction high-dose irradiation（15-20 Gy） using a 192 Irsource. Primary endpoint was local tumor control and secondary endpoints were complications, progression-free survival and overall survival.RESULTS： The mean tumor diameter was 29 mm（range 10-73）. The mean irradiation time was 20 minutes（range 7-42）. The mean coverage of the clinical target volume was 98%（range 88%-100%）. The mean D100 was 18.1 Gy and the median D100 was 19.78 Gy. Three major complications occurred with post-interventional abscesses, three of which were seen in 15 patients with biliodigestive anastomosis（20%）and overall 15%. The mean follow-up time was 13.7 months（range 1.4-55.0）. The median progression-free survival was 4.9 months（range 1.4-42.9, mean 9.4）. Local recurrence occurred in 5（10%） of 49 metastases treated. The median overall survival after CT-HDRBT was 8.6 months（range 1.5-55.3）. Eleven patients received chemotherapy after ablation with a median progression-free survival of 4.9 months（mean 12.9）. Nine patients did not receive chemotherapy after intervention with a median progression-free survival of 3.2 months（mean 5.0）. The rate of local tumor control was 91% in both groups after 12 months.CONCLUSION： CT-HDRBT was safe and effective for the treatment of liver metastases of pancreatic cancer.
文摘目的探讨基于CT引导的3D打印三维插植后装放疗治疗宫颈癌的临床疗效。方法选取2022年6月至2024年12月于赣州市肿瘤医院行宫颈癌后装放疗治疗的60例患者作为研究对象,采用抽签法分为对照组与观察组,每组30例。对照组采用常规三维插植后装放疗,观察组采用基于CT引导下的3D打印三维插植后装放疗。比较两组高危肿瘤靶区90%体积受照剂量(dose received by 90%of high-risk-gross tumor volume,HR-GTV D_(90))、中危肿瘤靶区90%体积受照剂量(dose received by 90%of intermediate-gross tumor volume,IR-GTV D_(90))及其对应2 Gy分次放射等效剂量(equivalent dose in 2-Gy fractions,EQD_(2)),危及器官的危及器官的单次照射2 cm^(3)体积所接受剂量(D_(2)cm^(3))及其对应EQD_(2),插植针数、插植时间、CT扫描次数及放疗后放射性直肠炎、放射性膀胱炎严重程度。结果观察组靶区及其对应EQD_(2)的HR-GTV D_(90)及IR-GTV D_(90)均高于对照组,差异有统计学意义(P<0.05)。观察组直肠、乙状结肠、膀胱D_(2)cm^(3)及其对应EQD_(2)均低于对照组,差异有统计学意义(P<0.05)。观察组插植针数、CT扫描次数均少于对照组,插植时间短于对照组,差异有统计学意义(P<0.05)。观察组放射性直肠炎、放射性膀胱炎的严重程度均优于对照组,差异有统计学意义(P<0.05)。结论基于CT引导下的3D打印三维插植后装放疗治疗局部晚期宫颈癌有明显剂量学优势,可提高靶区剂量,降低危及器官受量,减少放射不良反应发生,且操作简便,用时短,临床可推广应用。
