Second-harmonic generation(SHG)is a fundamental nonlinear optical process widely used in photonics;however,it is strictly forbidden in the bulk of centrosymmetric materials due to their inversion symmetry.Nevertheless...Second-harmonic generation(SHG)is a fundamental nonlinear optical process widely used in photonics;however,it is strictly forbidden in the bulk of centrosymmetric materials due to their inversion symmetry.Nevertheless,applying an external electric field breaks this inversion symmetry.It induces an effective second-order nonlinear response known as the electric-field-induced second-harmonic generation(EFISH)effect.This mechanism enables SHG in centrosymmetric media and provides a effective mechanism for electrically tunable nonlinear nanophotonics.Here,we present a comprehensive overview of the EFISH effect,covering the fundamentals,various material platforms(including bulk semiconductor crystals,ferroelectrics,van der Waals materials,and polymers),as well as diverse strategies for electric field engineering.We distinguish EFISH from related effects including currentinduced SHG and the quantum-confined Stark effect,and highlight emerging applications of EFISH in tunable photonic devices,carrier dynamics probing,and nonlinear optical modulation across optical,electronic,and THz regimes.Finally,we outline key challenges and prospects for the future development of electrically controlled nonlinear optical systems.展开更多
High-performance lithium metal batteries benefit from the construction of composite polymer electrolytes(CPEs)which are synthesized by incorporating inorganic fillers into polymer matrices[1].However,the random distri...High-performance lithium metal batteries benefit from the construction of composite polymer electrolytes(CPEs)which are synthesized by incorporating inorganic fillers into polymer matrices[1].However,the random distribution of added fillers within the polymer matrix can lead to tortuous ion pathways and longer transmission distances(Fig.1).As a result,the ion transport capability of CPEs may decrease,while interface contact may deteriorate.Therefore,the organized arrangement of fillers emerges as a crucial consideration in constructing electrolyte membranes.One highly effective approach is the adoption of a vertically aligned filler configuration,where ceramic fillers are constructed to be perpendicular to the electrolyte membrane.If so,the filler/electrolyte interface impedance can be significantly reduced,while continuous ion transport channels along the specified direction are formed,thus significantly enhancing the ion conduction(Fig.1(a))[1].展开更多
近年来,健康医疗大数据产业被列入国家大数据战略布局,带来了健康医疗模式的深刻变化,但医疗行业整体数据安全和个人信息保护也面临着更大的威胁。本研究通过对传统远程医疗行业痛点的分析,提出了一种基于5G移动边缘计算的远程云诊疗平...近年来,健康医疗大数据产业被列入国家大数据战略布局,带来了健康医疗模式的深刻变化,但医疗行业整体数据安全和个人信息保护也面临着更大的威胁。本研究通过对传统远程医疗行业痛点的分析,提出了一种基于5G移动边缘计算的远程云诊疗平台设计。该设计采用5G端到端网络切片结合多重服务质量(Quality of Service,QoS)技术,实现了业务差异化服务水平协议(Service Level Agreement,SLA)保障,构筑了端到端安全、可靠,以及带宽和时延满足业务要求的虚拟专网,持续提高了智慧医疗行业的便捷化、自动化和智能化,从多方面保障了人们健康,显著提升了医疗服务水平。展开更多
目的:探讨CPE的表达与细胞衰老的相关性。方法:选取接受手术清创的健康人供体(5~20岁)分离的人包皮的成纤维细胞(NHSF细胞)将其进行传代,在此我们定义“小于15代的NHSFs为N1组、15~25代的NHSFs为N2组、大于45代的NHSF为N3组”。随后用UV...目的:探讨CPE的表达与细胞衰老的相关性。方法:选取接受手术清创的健康人供体(5~20岁)分离的人包皮的成纤维细胞(NHSF细胞)将其进行传代,在此我们定义“小于15代的NHSFs为N1组、15~25代的NHSFs为N2组、大于45代的NHSF为N3组”。随后用UVA和H2O2分别处理细胞使其衰老,建立早衰模型。此后进行CPE的慢病毒转染,获得CPE稳定敲除的细胞株。通过qRT-PCR和WB技术,检测CPE和衰老标志物蛋白及mRNA的表达。分别采用cck8和SA-β-gal染色检测CPE敲降后NHSFs的增殖和衰老程度。最后采用qRT-PCR检测CPE敲降后NHSFs促炎症因子的表达水平。结果:N1组CPE蛋白和mRNA表达最高,其次是N2组,N3组最少,早衰细胞模型中CPE蛋白和mRNA的表达减低,CPE敲降后NHSFs蛋白和mRNA的表达均升高、细胞活性降低、细胞衰老程度明显加快和促炎症因子mRNA表达升高。结论:CPE可作为潜在衰老标志物且其高表达可延缓衰老。Objective: To explore the correlation between the expression of CPE and cellular senescence. Methods: Human foreskin fibroblasts (NHSF cells) isolated from healthy human donors (5~20 years old) who underwent surgical defibrillation were selected for passage. Here, we defined “NHSFs of less than 15 generations as group N1, NHSFs of 15~25 generations as group N2, and NHSF of more than 45 generations as group N3”. Then the cells were treated with UVA and H2O2 respectively to make them senescent, and the premature aging model was established. Then lentiviral transfection of CPE was performed to obtain stable CPE knockout cell lines. The expression of CPE and aging marker protein and mRNA were detected by qRT-PCR and WB. The proliferation and senescence of NHSFs after CPE knockdown were detected by cck8 and SA-β-gal staining, respectively. Finally, the expression level of NHSFs proinflammatory factors after CPE knock-down was detected by qRT-PCR. Results: The expressions of CPE protein and mRNA were the highest in N1 group, followed by N2 group and N3 group, and the expressions of CPE protein and mRNA were decreased in the progeria cell model. After CPE knockdown, the expressions of NHSFs protein and mRNA were both increased, the cell activity was decreased, the degree of cell senility was significantly accelerated, and the mRNA expression of proinflammatory factors was increased. Conclusion: CPE can be used as a potential senescence marker and its high expression can delay senescence.展开更多
In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics char...In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics characteristics of the PHN-induced common phase error and inter-Doppler interference are investigated.Then,a column-shaped pilot structure is designed,and training pilots are used to realize linear-complexity PHN tracking and compensation.Numerical results demonstrate that the proposed scheme enables the signal to noise ratio loss to be restrained within 1 dB in contrast to the no PHN case.展开更多
基金supported by Priority 2030 FederalAcademic Leadership ProgramBASIS Foundation
文摘Second-harmonic generation(SHG)is a fundamental nonlinear optical process widely used in photonics;however,it is strictly forbidden in the bulk of centrosymmetric materials due to their inversion symmetry.Nevertheless,applying an external electric field breaks this inversion symmetry.It induces an effective second-order nonlinear response known as the electric-field-induced second-harmonic generation(EFISH)effect.This mechanism enables SHG in centrosymmetric media and provides a effective mechanism for electrically tunable nonlinear nanophotonics.Here,we present a comprehensive overview of the EFISH effect,covering the fundamentals,various material platforms(including bulk semiconductor crystals,ferroelectrics,van der Waals materials,and polymers),as well as diverse strategies for electric field engineering.We distinguish EFISH from related effects including currentinduced SHG and the quantum-confined Stark effect,and highlight emerging applications of EFISH in tunable photonic devices,carrier dynamics probing,and nonlinear optical modulation across optical,electronic,and THz regimes.Finally,we outline key challenges and prospects for the future development of electrically controlled nonlinear optical systems.
基金supported by the National Natural Science Foundation of China(No.51972293)Hangzhou Key Research Program Project(2023SZD0099)LingYan Project(2024C01090).
文摘High-performance lithium metal batteries benefit from the construction of composite polymer electrolytes(CPEs)which are synthesized by incorporating inorganic fillers into polymer matrices[1].However,the random distribution of added fillers within the polymer matrix can lead to tortuous ion pathways and longer transmission distances(Fig.1).As a result,the ion transport capability of CPEs may decrease,while interface contact may deteriorate.Therefore,the organized arrangement of fillers emerges as a crucial consideration in constructing electrolyte membranes.One highly effective approach is the adoption of a vertically aligned filler configuration,where ceramic fillers are constructed to be perpendicular to the electrolyte membrane.If so,the filler/electrolyte interface impedance can be significantly reduced,while continuous ion transport channels along the specified direction are formed,thus significantly enhancing the ion conduction(Fig.1(a))[1].
文摘近年来,健康医疗大数据产业被列入国家大数据战略布局,带来了健康医疗模式的深刻变化,但医疗行业整体数据安全和个人信息保护也面临着更大的威胁。本研究通过对传统远程医疗行业痛点的分析,提出了一种基于5G移动边缘计算的远程云诊疗平台设计。该设计采用5G端到端网络切片结合多重服务质量(Quality of Service,QoS)技术,实现了业务差异化服务水平协议(Service Level Agreement,SLA)保障,构筑了端到端安全、可靠,以及带宽和时延满足业务要求的虚拟专网,持续提高了智慧医疗行业的便捷化、自动化和智能化,从多方面保障了人们健康,显著提升了医疗服务水平。
文摘目的:探讨CPE的表达与细胞衰老的相关性。方法:选取接受手术清创的健康人供体(5~20岁)分离的人包皮的成纤维细胞(NHSF细胞)将其进行传代,在此我们定义“小于15代的NHSFs为N1组、15~25代的NHSFs为N2组、大于45代的NHSF为N3组”。随后用UVA和H2O2分别处理细胞使其衰老,建立早衰模型。此后进行CPE的慢病毒转染,获得CPE稳定敲除的细胞株。通过qRT-PCR和WB技术,检测CPE和衰老标志物蛋白及mRNA的表达。分别采用cck8和SA-β-gal染色检测CPE敲降后NHSFs的增殖和衰老程度。最后采用qRT-PCR检测CPE敲降后NHSFs促炎症因子的表达水平。结果:N1组CPE蛋白和mRNA表达最高,其次是N2组,N3组最少,早衰细胞模型中CPE蛋白和mRNA的表达减低,CPE敲降后NHSFs蛋白和mRNA的表达均升高、细胞活性降低、细胞衰老程度明显加快和促炎症因子mRNA表达升高。结论:CPE可作为潜在衰老标志物且其高表达可延缓衰老。Objective: To explore the correlation between the expression of CPE and cellular senescence. Methods: Human foreskin fibroblasts (NHSF cells) isolated from healthy human donors (5~20 years old) who underwent surgical defibrillation were selected for passage. Here, we defined “NHSFs of less than 15 generations as group N1, NHSFs of 15~25 generations as group N2, and NHSF of more than 45 generations as group N3”. Then the cells were treated with UVA and H2O2 respectively to make them senescent, and the premature aging model was established. Then lentiviral transfection of CPE was performed to obtain stable CPE knockout cell lines. The expression of CPE and aging marker protein and mRNA were detected by qRT-PCR and WB. The proliferation and senescence of NHSFs after CPE knockdown were detected by cck8 and SA-β-gal staining, respectively. Finally, the expression level of NHSFs proinflammatory factors after CPE knock-down was detected by qRT-PCR. Results: The expressions of CPE protein and mRNA were the highest in N1 group, followed by N2 group and N3 group, and the expressions of CPE protein and mRNA were decreased in the progeria cell model. After CPE knockdown, the expressions of NHSFs protein and mRNA were both increased, the cell activity was decreased, the degree of cell senility was significantly accelerated, and the mRNA expression of proinflammatory factors was increased. Conclusion: CPE can be used as a potential senescence marker and its high expression can delay senescence.
基金supported by the National Natural Science Foundation of China(62071097)the Sichuan Science and Technology Program(2023NSFSC0458).
文摘In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics characteristics of the PHN-induced common phase error and inter-Doppler interference are investigated.Then,a column-shaped pilot structure is designed,and training pilots are used to realize linear-complexity PHN tracking and compensation.Numerical results demonstrate that the proposed scheme enables the signal to noise ratio loss to be restrained within 1 dB in contrast to the no PHN case.
