This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretat...This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretative limitations are identified.The study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold values.The nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with cirrhosis.Moreover,the study's limitations,such as selection bias and confounding factors,are not adequately addressed.Future research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.展开更多
Environmental DNA(e DNA)methods have emerged as a promising tool for studying a broad spectrum of biological taxa.However,metabarcoding studies of avian biodiversity using e DNA have received little attention.In this ...Environmental DNA(e DNA)methods have emerged as a promising tool for studying a broad spectrum of biological taxa.However,metabarcoding studies of avian biodiversity using e DNA have received little attention.In this study,we compared waterbird biodiversity derived from e DNA metabarcoding with that obtained from traditional point counting surveys at 23 sites in Tai Lake of eastern China and evaluated the accuracy of e DNA metabarcoding for waterbird community studies.The point counting method recorded a higher total number of waterbird species(22)compared to the e DNA technique(16).While e DNA achieved a 74.5%detection rate for waterbird species and was able to identify a significantly greater number of species(12.48±1.97)at each sampling site than point counting method(6.13±2.69),particularly highlighting several rare and elusive species,it failed to detect some species commonly observed by the point counting method.The alpha diversity analysis revealed no significant differences in waterbird diversity between the e DNA method and the point counting method,except that the e DNA method exhibited lower Pielou evenness.Waterbird e DNA sequencing abundance correlated significantly with species occurrence,whereas Spearman's analysis indicated no significant difference between e DNA sequence abundance and species abundance from the point counting method.e DNA method detected no significant difference in waterbird composition between sampling sites,while the point counting method revealed significant differences.Consequently,e DNA is an effective complementary tool for assessing the diversity of wintering waterbirds in lakes,though it is unable to capture the full diversity of waterbird communities.It is crucial to develop sampling strategies that comprehensively monitor species composition and integrate e DNA with traditional survey methods for accurate evaluation of community structure.展开更多
According to the World Health Organization(WHO)manual,sperm concentration should be measured using an improved Neubauer hemocytometer,while sperm motility should be measured by manual assessment.However,in China,thous...According to the World Health Organization(WHO)manual,sperm concentration should be measured using an improved Neubauer hemocytometer,while sperm motility should be measured by manual assessment.However,in China,thousands of laboratories do not use the improved Neubauer hemocytometer or method;instead,the Makler counting chamber is one of the most widely used chambers.To study sources of error that could impact the measurement of the apparent concentration and motility of sperm using the Makler counting chamber and to verify its accuracy for clinical application,67 semen samples from patients attending the Department of Andrology,West China Second University Hospital,Sichuan University(Chengdu,China)between 13 September 2023 and 27 September 2023,were included.Compared with applying the cover glass immediately,delaying the application of the cover glass for 5 s,10 s,and 30 s resulted in average increases in the sperm concentration of 30.3%,74.1%,and 107.5%,respectively(all P<0.0001)and in the progressive motility(PR)of 17.7%,30.8%,and 39.6%,respectively(all P<0.0001).However,when the semen specimens were fixed with formaldehyde,a delay in the application of the cover glass for 5 s,10 s,and 30 s resulted in an average increase in the sperm concentration of 6.7%,10.8%,and 14.6%,respectively,compared with immediate application of the cover glass.The accumulation of motile sperm due to delays in the application of the cover glass is a significant source of error with the Makler counting chamber and should be avoided.展开更多
Purpose–To address the encapsulation challenge of fiber Bragg grating(FBG)sensors in complex railway environments,this paper designs a clip-on composite sensor enabling installation-friendly deployment and long-term ...Purpose–To address the encapsulation challenge of fiber Bragg grating(FBG)sensors in complex railway environments,this paper designs a clip-on composite sensor enabling installation-friendly deployment and long-term axle counting system monitoring.Design/methodology/approach–Wheel–rail mechanical behavior was simulated via finite element analysis(FEA)to determine optimal sensor placement.A clip-on composite sensor was subsequently engineered.Stress transduction efficacy was validated through FEA quantification of stress responses at the axle counter location.Findings–The proposed FBG axle counter integrates temperature compensation and anti-detachment monitoring as well as advantages such as simplified installation with minimal maintenance and sustained operational reliability.It effectively transmits stress,yielding a measured strain of 39μe under static loading conditions without sensitivity-enhancing elements.Originality/value–This study performs FEA of wheel-rail stress distribution and engineers the dual-slot composite sensor,FEAwas conducted to quantify the stress magnitude at the axle sensor position of the dual-slot composite sensor.Additionally,FEA was performed on sensors with different structural configurations,including adjustments to the axle sensor position,number of slots and axle position.The results confirmed that the designed composite sensor exhibits superior stress transfer characteristics.展开更多
Background:Lipemia,characterized by elevated triglyceride levels in blood samples,is a prevalent preanalytical interferent in clinical hematology.It leads to erroneous measurements of key complete blood count(CBC)para...Background:Lipemia,characterized by elevated triglyceride levels in blood samples,is a prevalent preanalytical interferent in clinical hematology.It leads to erroneous measurements of key complete blood count(CBC)parameters,including falsely elevated hemoglobin(Hgb)and platelet(PLT)counts.These inaccuracies can compromise diagnostic reliability and patient management.Objective:This review systematically evaluates existing correction methods for lipemic interference in CBC analysis,comparing their efficacy,limitations,and applicability in clinical settings.Methods:We analyze saline replacement,formula-based correction,instrument-specific algorithms,and emerging technologies,supported by experimental and clinical validation data.Conclusion:An optimized,context-dependent strategy is proposed,integrating multiple correction approaches based on lipemia severity.Future research directions,including artificial intelligence(AI)-enhanced corrections and standardized protocols,are discussed to advance hematology testing accuracy.展开更多
The particle identification(PID)of hadrons plays a crucial role in particle physics experiments,especially in flavor physics and jet tagging.The cluster counting method,which measures the number of primary ionizations...The particle identification(PID)of hadrons plays a crucial role in particle physics experiments,especially in flavor physics and jet tagging.The cluster counting method,which measures the number of primary ionizations in gaseous detectors,is a promising breakthrough in PID.However,developing an effective reconstruction algorithm for cluster counting remains challenging.To address this challenge,we propose a cluster counting algorithm based on long short-term memory and dynamic graph convolutional neural networks for the CEPC drift chamber.Experiments on Monte Carlo simulated samples demonstrate that our machine learning-based algorithm surpasses traditional methods.It improves the K/πseparation of PID by 10%,meeting the PID requirements of CEPC.展开更多
This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data ...This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital(Beijing,China)between January 2011 and December 2022.Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol.A total of 8290 couples were included in the analysis.The mean±standard deviation(s.d.)age of women was 32.0±3.5 years.We categorized groups based on the post-wash TPMSC(×10^(6))levels in the first IUI cycle:group 1(0<TPMSC<1,n=1290),group 2(1≤TPMSC<2,n=863),group 3(2≤TPMSC<3,n=800),group 4(3≤TPMSC<4,n=783),group 5(4≤TPMSC<5,n=1541),group 6(5≤TPMSC<6,n=522),group 7(6≤TPMSC<7,n=547),group 8(7≤TPMSC<8,n=175),group 9(8≤TPMSC<9,n=556),group 10(9≤TPMSC<10,n=192),and group 11(TPMSC≥10,n=1021).The primary outcome was live birth rate of the second IUI cycle.Live birth rates were 7.9%,5.8%,7.6%,7.4%,7.3%,8.4%,7.5%,7.4%,8.8%,8.9%,and 7.6%in each group,respectively.There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC<1×10^(6).In an IUI program for unexplained and mild male factor infertility,the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.展开更多
Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pip...Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pipes based on the improved YOLO11n is proposed.This method realizes the high-precision detection of targets at drill pipe ends in the image by optimizing the target detection model,and combines a post-processing correction mechanism to improve the drill pipe counting accuracy.In order to alleviate the low-precision problem of YOLO11n algorithm for small target recognition in the complex underground background,the YOLO11n algorithm is improved.First,the key module C3k2 in the backbone network was improved,and Poly Kernel Inception(PKI)Block was introduced to replace Bottleneck in it to fully integrate the target context information and the model’s capability of feature extraction;Second,within the model’s neck network,a new feature fusion pyramid ISOP(Improved Small Object Pyramid)is proposed,SPDConv is introduced to strengthen the P2 feature,and CSP and OmniKernel are combined to integrate multi-scale features;Finally,the default loss function is substituted with Powerful-IoU(PIoU)to solve the anchor box expansion problem.On the self-built dataset,experimental verification was conducted.The findings showed that the Recall rose by 6.4%,mAP@0.5 increased by 4.5%,and mAP@0.5:0.95 improved by 6%compared with the baseline model,effectively solving the issues of false detection and missed detection problems in small target detection task.Meanwhile,we conducted counting tests on drilling videos from 5 different scenarios,achieving an average accuracy of 97.3%,which meets the accuracy needs for drill pipe recognition and counting in coal mine drilling sites.The research findings offer theoretical basis and technical backing for promoting the intelligent development of coal mine gas extraction drilling sites.展开更多
In this paper,we study composition operators on weighted Bergman spaces of Dirichlet series.We first establish some Littlewood-type inequalities for generalized mean counting functions.Then we give sufficient conditio...In this paper,we study composition operators on weighted Bergman spaces of Dirichlet series.We first establish some Littlewood-type inequalities for generalized mean counting functions.Then we give sufficient conditions for a composition operator with zero characteristic to be bounded or compact on weighted Bergman spaces of Dirichlet series.The corresponding sufficient condition for compactness in the case of positive characteristics is also obtained.展开更多
The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differ...The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differences between SHS and cobalt-60 isotope(^(60)Co)radiation treatment.The number of total plate count(TPC)and mold colonies(MC)remained within the limits of the standards after SHS treatment at 140℃for 2 min.Neither TPC nor MC were detected after^(60)Co irradiation.Peroxidase(POD)and polyphenol oxidase(PPO)activities significantly decreased with increasing temperature and duration of SHS,while^(60)Co radiation completely inactivated PPO.Compared to^(60)Co radiation,SHS treatment inhibited the deterioration of rape bee pollen by avoiding hydroperoxide production and lipid oxidation due to lack of oxygen.These results suggested SHS under 140℃for 2 min was the most suitable to inactivate the microorganisms and enzymes in rape bee pollen with minimal lipid oxidation.展开更多
The analysis of the ejaculate,better known as spermiogram,represents the first and main step to identify whether a series of sperm quality parameters are within the norm and therefore are consistent with normal sperm ...The analysis of the ejaculate,better known as spermiogram,represents the first and main step to identify whether a series of sperm quality parameters are within the norm and therefore are consistent with normal sperm fertilizing capacity.Among these,sperm concentration and motility are the first parameters to be evaluated through an estimation carried out by expert examiners.展开更多
Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involve...Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.展开更多
Precise risk stratification is crucial for selecting the optimal risk-adapted treatment for newly diagnosed multiple myeloma (NDMM) patients. Various prognostic factors and staging systems have been developed to predi...Precise risk stratification is crucial for selecting the optimal risk-adapted treatment for newly diagnosed multiple myeloma (NDMM) patients. Various prognostic factors and staging systems have been developed to predict NDMM patient outcomes. The Durie-Salmon (D-S) staging system reflects tumor burden and clinical progression staging with prognostic value.展开更多
This study presents a drone-based aerial imaging method for automated rice seedling detection and counting in paddy fields.Utilizing a drone equipped with a high-resolution camera,images are captured 14 days postsowin...This study presents a drone-based aerial imaging method for automated rice seedling detection and counting in paddy fields.Utilizing a drone equipped with a high-resolution camera,images are captured 14 days postsowing at a consistent altitude of six meters,employing autonomous flight for uniform data acquisition.The approach effectively addresses the distinct growth patterns of both single and clustered rice seedlings at this early stage.The methodology follows a two-step process:first,the GoogleNet deep learning network identifies the location and center points of rice plants.Then,the U-Net deep learning network performs classification and counting of individual plants and clusters.This combination of deep learning models achieved a 90%accuracy rate in classifying and counting both single and clustered seedlings.To validate the method’s effectiveness,results were compared against traditional manual counting conducted by agricultural experts.The comparison revealed minimal discrepancies,with a variance of only 2–4 clumps per square meter,confirming the reliability of the proposed method.This automated approach offers significant benefits by providing an efficient,accurate,and scalable solution for monitoring seedling growth.It enables farmers to optimize fertilizer and pesticide application,improve resource allocation,and enhance overall crop management,ultimately contributing to increased agricultural productivity.展开更多
Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially av...Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.展开更多
GM管广泛应用于辐射测量,由于传统的测量方法受到GM管死时间的影响,其测量精度不高。介绍了没有死时间影响,可以提高测量精度的T im e-to-Coun t技术的测量方法,并从理论上论证了采用该方法的数学原理,在此基础上,提出对辐射强度的新估...GM管广泛应用于辐射测量,由于传统的测量方法受到GM管死时间的影响,其测量精度不高。介绍了没有死时间影响,可以提高测量精度的T im e-to-Coun t技术的测量方法,并从理论上论证了采用该方法的数学原理,在此基础上,提出对辐射强度的新估计式,并证明该估计是无偏的渐近最优的,是形式中最优的。并通过计算机仿真证明了该方法的正确性。展开更多
文摘This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretative limitations are identified.The study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold values.The nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with cirrhosis.Moreover,the study's limitations,such as selection bias and confounding factors,are not adequately addressed.Future research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.
基金funded by the National Key Research and Development Program of China(Award Number:2022YFC3202104)。
文摘Environmental DNA(e DNA)methods have emerged as a promising tool for studying a broad spectrum of biological taxa.However,metabarcoding studies of avian biodiversity using e DNA have received little attention.In this study,we compared waterbird biodiversity derived from e DNA metabarcoding with that obtained from traditional point counting surveys at 23 sites in Tai Lake of eastern China and evaluated the accuracy of e DNA metabarcoding for waterbird community studies.The point counting method recorded a higher total number of waterbird species(22)compared to the e DNA technique(16).While e DNA achieved a 74.5%detection rate for waterbird species and was able to identify a significantly greater number of species(12.48±1.97)at each sampling site than point counting method(6.13±2.69),particularly highlighting several rare and elusive species,it failed to detect some species commonly observed by the point counting method.The alpha diversity analysis revealed no significant differences in waterbird diversity between the e DNA method and the point counting method,except that the e DNA method exhibited lower Pielou evenness.Waterbird e DNA sequencing abundance correlated significantly with species occurrence,whereas Spearman's analysis indicated no significant difference between e DNA sequence abundance and species abundance from the point counting method.e DNA method detected no significant difference in waterbird composition between sampling sites,while the point counting method revealed significant differences.Consequently,e DNA is an effective complementary tool for assessing the diversity of wintering waterbirds in lakes,though it is unable to capture the full diversity of waterbird communities.It is crucial to develop sampling strategies that comprehensively monitor species composition and integrate e DNA with traditional survey methods for accurate evaluation of community structure.
基金supported by the Natural Science Foundation of China(No.32171264 and No.81974226)the Sichuan Science and Technology Program(2023NSFSC1609)。
文摘According to the World Health Organization(WHO)manual,sperm concentration should be measured using an improved Neubauer hemocytometer,while sperm motility should be measured by manual assessment.However,in China,thousands of laboratories do not use the improved Neubauer hemocytometer or method;instead,the Makler counting chamber is one of the most widely used chambers.To study sources of error that could impact the measurement of the apparent concentration and motility of sperm using the Makler counting chamber and to verify its accuracy for clinical application,67 semen samples from patients attending the Department of Andrology,West China Second University Hospital,Sichuan University(Chengdu,China)between 13 September 2023 and 27 September 2023,were included.Compared with applying the cover glass immediately,delaying the application of the cover glass for 5 s,10 s,and 30 s resulted in average increases in the sperm concentration of 30.3%,74.1%,and 107.5%,respectively(all P<0.0001)and in the progressive motility(PR)of 17.7%,30.8%,and 39.6%,respectively(all P<0.0001).However,when the semen specimens were fixed with formaldehyde,a delay in the application of the cover glass for 5 s,10 s,and 30 s resulted in an average increase in the sperm concentration of 6.7%,10.8%,and 14.6%,respectively,compared with immediate application of the cover glass.The accumulation of motile sperm due to delays in the application of the cover glass is a significant source of error with the Makler counting chamber and should be avoided.
文摘Purpose–To address the encapsulation challenge of fiber Bragg grating(FBG)sensors in complex railway environments,this paper designs a clip-on composite sensor enabling installation-friendly deployment and long-term axle counting system monitoring.Design/methodology/approach–Wheel–rail mechanical behavior was simulated via finite element analysis(FEA)to determine optimal sensor placement.A clip-on composite sensor was subsequently engineered.Stress transduction efficacy was validated through FEA quantification of stress responses at the axle counter location.Findings–The proposed FBG axle counter integrates temperature compensation and anti-detachment monitoring as well as advantages such as simplified installation with minimal maintenance and sustained operational reliability.It effectively transmits stress,yielding a measured strain of 39μe under static loading conditions without sensitivity-enhancing elements.Originality/value–This study performs FEA of wheel-rail stress distribution and engineers the dual-slot composite sensor,FEAwas conducted to quantify the stress magnitude at the axle sensor position of the dual-slot composite sensor.Additionally,FEA was performed on sensors with different structural configurations,including adjustments to the axle sensor position,number of slots and axle position.The results confirmed that the designed composite sensor exhibits superior stress transfer characteristics.
文摘Background:Lipemia,characterized by elevated triglyceride levels in blood samples,is a prevalent preanalytical interferent in clinical hematology.It leads to erroneous measurements of key complete blood count(CBC)parameters,including falsely elevated hemoglobin(Hgb)and platelet(PLT)counts.These inaccuracies can compromise diagnostic reliability and patient management.Objective:This review systematically evaluates existing correction methods for lipemic interference in CBC analysis,comparing their efficacy,limitations,and applicability in clinical settings.Methods:We analyze saline replacement,formula-based correction,instrument-specific algorithms,and emerging technologies,supported by experimental and clinical validation data.Conclusion:An optimized,context-dependent strategy is proposed,integrating multiple correction approaches based on lipemia severity.Future research directions,including artificial intelligence(AI)-enhanced corrections and standardized protocols,are discussed to advance hematology testing accuracy.
基金supported by National Natural Science Foundation of China(NSFC)(Nos.12475200 and 12275296)Joint Fund of Research utilizing Large-Scale Scientific Facility of the NSFC and CAS(No.U2032114)Institute of High Energy Physics(Chinese Academy of Sciences)Innovative Project on Sciences and Technologies(Nos.E3545BU210 and E25456U210).
文摘The particle identification(PID)of hadrons plays a crucial role in particle physics experiments,especially in flavor physics and jet tagging.The cluster counting method,which measures the number of primary ionizations in gaseous detectors,is a promising breakthrough in PID.However,developing an effective reconstruction algorithm for cluster counting remains challenging.To address this challenge,we propose a cluster counting algorithm based on long short-term memory and dynamic graph convolutional neural networks for the CEPC drift chamber.Experiments on Monte Carlo simulated samples demonstrate that our machine learning-based algorithm surpasses traditional methods.It improves the K/πseparation of PID by 10%,meeting the PID requirements of CEPC.
基金supported by National Key Research and Development Program(2022YFC2705305)clinical key project of Peking University Third Hospital(BYSYZD2023007)National Science Fund for Distinguished Young Scholars(81925013).
文摘This study aimed to investigate the associations between the post-wash total progressively motile sperm count(TPMSC)in the first intrauterine insemination(IUI)cycle and pregnancy outcomes of the second IUI cycle.Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital(Beijing,China)between January 2011 and December 2022.Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol.A total of 8290 couples were included in the analysis.The mean±standard deviation(s.d.)age of women was 32.0±3.5 years.We categorized groups based on the post-wash TPMSC(×10^(6))levels in the first IUI cycle:group 1(0<TPMSC<1,n=1290),group 2(1≤TPMSC<2,n=863),group 3(2≤TPMSC<3,n=800),group 4(3≤TPMSC<4,n=783),group 5(4≤TPMSC<5,n=1541),group 6(5≤TPMSC<6,n=522),group 7(6≤TPMSC<7,n=547),group 8(7≤TPMSC<8,n=175),group 9(8≤TPMSC<9,n=556),group 10(9≤TPMSC<10,n=192),and group 11(TPMSC≥10,n=1021).The primary outcome was live birth rate of the second IUI cycle.Live birth rates were 7.9%,5.8%,7.6%,7.4%,7.3%,8.4%,7.5%,7.4%,8.8%,8.9%,and 7.6%in each group,respectively.There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC<1×10^(6).In an IUI program for unexplained and mild male factor infertility,the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.
基金Henan Province University Science and Technology Innovation Team Support Program Project(22IRTSTHN005)..
文摘Aiming at problems such as large errors and low efficiency in manual counting of drill pipes during drilling depth measurement,an intelligent detection and counting method for the small targets at the end of drill pipes based on the improved YOLO11n is proposed.This method realizes the high-precision detection of targets at drill pipe ends in the image by optimizing the target detection model,and combines a post-processing correction mechanism to improve the drill pipe counting accuracy.In order to alleviate the low-precision problem of YOLO11n algorithm for small target recognition in the complex underground background,the YOLO11n algorithm is improved.First,the key module C3k2 in the backbone network was improved,and Poly Kernel Inception(PKI)Block was introduced to replace Bottleneck in it to fully integrate the target context information and the model’s capability of feature extraction;Second,within the model’s neck network,a new feature fusion pyramid ISOP(Improved Small Object Pyramid)is proposed,SPDConv is introduced to strengthen the P2 feature,and CSP and OmniKernel are combined to integrate multi-scale features;Finally,the default loss function is substituted with Powerful-IoU(PIoU)to solve the anchor box expansion problem.On the self-built dataset,experimental verification was conducted.The findings showed that the Recall rose by 6.4%,mAP@0.5 increased by 4.5%,and mAP@0.5:0.95 improved by 6%compared with the baseline model,effectively solving the issues of false detection and missed detection problems in small target detection task.Meanwhile,we conducted counting tests on drilling videos from 5 different scenarios,achieving an average accuracy of 97.3%,which meets the accuracy needs for drill pipe recognition and counting in coal mine drilling sites.The research findings offer theoretical basis and technical backing for promoting the intelligent development of coal mine gas extraction drilling sites.
基金supported by the National Natural Science Foundation of China(12171373)Chen's work also supported by the Fundamental Research Funds for the Central Universities of China(GK202207018).
文摘In this paper,we study composition operators on weighted Bergman spaces of Dirichlet series.We first establish some Littlewood-type inequalities for generalized mean counting functions.Then we give sufficient conditions for a composition operator with zero characteristic to be bounded or compact on weighted Bergman spaces of Dirichlet series.The corresponding sufficient condition for compactness in the case of positive characteristics is also obtained.
基金supported by National Natural Science Foundations of China(32472396,31871861 and 31501548)The Apicultural Industry Technology System(NCYTI-43-KXJ17)The Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2015-IAR)。
文摘The effect of superheated steam(SHS)treatment on the quality characteristics of rape bee pollen were studied,and the efficiency of inactivation and inhibition of lipid oxidation were analyzed to investigate the differences between SHS and cobalt-60 isotope(^(60)Co)radiation treatment.The number of total plate count(TPC)and mold colonies(MC)remained within the limits of the standards after SHS treatment at 140℃for 2 min.Neither TPC nor MC were detected after^(60)Co irradiation.Peroxidase(POD)and polyphenol oxidase(PPO)activities significantly decreased with increasing temperature and duration of SHS,while^(60)Co radiation completely inactivated PPO.Compared to^(60)Co radiation,SHS treatment inhibited the deterioration of rape bee pollen by avoiding hydroperoxide production and lipid oxidation due to lack of oxygen.These results suggested SHS under 140℃for 2 min was the most suitable to inactivate the microorganisms and enzymes in rape bee pollen with minimal lipid oxidation.
文摘The analysis of the ejaculate,better known as spermiogram,represents the first and main step to identify whether a series of sperm quality parameters are within the norm and therefore are consistent with normal sperm fertilizing capacity.Among these,sperm concentration and motility are the first parameters to be evaluated through an estimation carried out by expert examiners.
基金supported by the National Natural Science Foundation of China(grant nos.82025030,82222063,and 82388102)the National Key Research and Development Program of China(grant no.2023YFC3603400)。
文摘Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.
基金supported by the National Natural Science Foundation of China (Grant nos. 82470209 and 82170141)the Jiaxing Key Discipiline of Medcine-Nephrology (Grant no. 2023-ZC-011)。
文摘Precise risk stratification is crucial for selecting the optimal risk-adapted treatment for newly diagnosed multiple myeloma (NDMM) patients. Various prognostic factors and staging systems have been developed to predict NDMM patient outcomes. The Durie-Salmon (D-S) staging system reflects tumor burden and clinical progression staging with prognostic value.
基金funded by the Ministry of Education and Training Project(code number:B2023-TCT-08).
文摘This study presents a drone-based aerial imaging method for automated rice seedling detection and counting in paddy fields.Utilizing a drone equipped with a high-resolution camera,images are captured 14 days postsowing at a consistent altitude of six meters,employing autonomous flight for uniform data acquisition.The approach effectively addresses the distinct growth patterns of both single and clustered rice seedlings at this early stage.The methodology follows a two-step process:first,the GoogleNet deep learning network identifies the location and center points of rice plants.Then,the U-Net deep learning network performs classification and counting of individual plants and clusters.This combination of deep learning models achieved a 90%accuracy rate in classifying and counting both single and clustered seedlings.To validate the method’s effectiveness,results were compared against traditional manual counting conducted by agricultural experts.The comparison revealed minimal discrepancies,with a variance of only 2–4 clumps per square meter,confirming the reliability of the proposed method.This automated approach offers significant benefits by providing an efficient,accurate,and scalable solution for monitoring seedling growth.It enables farmers to optimize fertilizer and pesticide application,improve resource allocation,and enhance overall crop management,ultimately contributing to increased agricultural productivity.
基金supported by the Sponsored by Tianjin Health Research Project(Grant No.TJWJ2023ZD003)the Chinese Society of Clinical Oncology Beijing Xisike Clinical Oncology Research Foundation(Grant Nos.Y-NCJH202201-0027 and Y-2022YMJN/MS-0001).
文摘Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.
文摘GM管广泛应用于辐射测量,由于传统的测量方法受到GM管死时间的影响,其测量精度不高。介绍了没有死时间影响,可以提高测量精度的T im e-to-Coun t技术的测量方法,并从理论上论证了采用该方法的数学原理,在此基础上,提出对辐射强度的新估计式,并证明该估计是无偏的渐近最优的,是形式中最优的。并通过计算机仿真证明了该方法的正确性。
