In high-intensity electromagnetic warfare,radar systems are persistently subjected to multi-jammer attacks,including potentially novel unknown jamming types that may emerge exclusively under wartime conditions.These j...In high-intensity electromagnetic warfare,radar systems are persistently subjected to multi-jammer attacks,including potentially novel unknown jamming types that may emerge exclusively under wartime conditions.These jamming signals severely degrade radar detection performance.Precise recognition of these unknown and compound jamming signals is critical to enhancing the anti-jamming capabilities and overall reliability of radar systems.To address this challenge,this article proposes a novel open-set compound jamming cognition(OSCJC)method.The proposed method employs a detection-classification dual-network architecture,which not only overcomes the false alarm and misdetection issues of traditional closed-set recognition methods when dealing with unknown jamming but also effectively addresses the performance bottleneck of existing open-set recognition techniques focusing on single jamming scenarios in compound jamming environments.To achieve unknown jamming detection,we first employ a consistency labeling strategy to train the detection network using diverse known jamming samples.This strategy enables the network to acquire highly generalizable jamming features,thereby accurately localizing candidate regions for individual jamming components within compound jamming.Subsequently,we introduce contrastive learning to optimize the classification network,significantly enhancing both intra-class clustering and inter-class separability in the jamming feature space.This method not only improves the recognition accuracy of the classification network for known jamming types but also enhances its sensitivity to unknown jamming types.Simulations and experimental data are used to verify the effectiveness of the proposed OSCJC method.Compared with the state-of-the-art open-set recognition methods,the proposed method demonstrates superior recognition accuracy and enhanced environmental adaptability.展开更多
BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T...BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.展开更多
This review explores the use of agent-based modeling(ABM)within the framework of study human emotion and cognition in the context of its ability to simulate complex social interactions,adaptive changes,and evolutionar...This review explores the use of agent-based modeling(ABM)within the framework of study human emotion and cognition in the context of its ability to simulate complex social interactions,adaptive changes,and evolutionary processes.By representing agents and their defined environments with probabilistic interactions,ABM allows the assessment of the effects of individual behavior at the micro level on the greater social phenomena at the macro level.The review looks into the applications of ABM in portraying some of the key components of emotions and cognition-empathy,cooperation,decision making,and emotional transmission-and analyzes the problems including scalability,empirical validation,and description of sensitive emotional states.The most important conclusion is that merging ABM with information neurobiological data and artificial intelligence(AI)techniques would allow for deepening the interactions within the system and enhancing its responsiveness to stimuli.This review highlights approaches that aim to exploit the ABM methodology more fully and integrates methods from biology,neuroscience,and engineering.This integration could contribute to our understanding of the human behavior evolution and adaptation within systems relevant to policymaking,healthcare,and education.展开更多
Social cognition constitutes a fundamental component in establishing and maintaining healthy interpersonal relationships,achieving social goals,and effectively regulating emotions within social contexts.Inspired by a ...Social cognition constitutes a fundamental component in establishing and maintaining healthy interpersonal relationships,achieving social goals,and effectively regulating emotions within social contexts.Inspired by a recent study examining the chain mediating roles of perceived social adversity and security in the relationship between impulsive personality and suicidal behaviors among depressed adolescents,this editorial synthesizes advances in social cognition research specific to adolescent depression.Research methodologies,theoretical frameworks,and neuroscientific insights in this domain have evolved substantially over the past fifteen years.Whereas earlier investigations primarily emphasized broad behavioral observations,contemporary research increasingly integrates neuroimaging techniques,computational modeling,and refined experimental paradigms.Current understanding of specific cognitive biases such as distinctions between interpretive and attentional biases has also grown more nuanced.This editorial reflects the evolving nature of the field by presenting shifts in research focus and demonstrating how these changes have deepened our understanding of social-cognitive functioning in adolescent depression.Building on this synthesis,we outline limitations of extant research and suggest promising directions for future inquiry.展开更多
The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the...The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the opportunities,challenges,and future directions of research on children’s language learning from the perspective of embodied cognition.It concludes that multisensory engagement can greatly improve children’s comprehension and memorization of language knowledge and that language acquisition is intimately tied to bodily perception,movement,and emotional experience.In addition,children’s language acquisition can also be effectively aided by embodied cognition techniques as multimedia aids,gesture and enactment,and imagery.Based on previous evidence,we propose an integrated language learning framework and a new relevance-integration taxonomy for children’s language learning from the perspectives of embodied cognition and cognitive load theories.In order to support the long-term growth of children’s language education,future research should focus more on the requirement of embodied language learning in the preschool-primary transition and optimize the teaching objectives and contents.展开更多
Early-life stress(ES)leads to cognitive dysfunction in female adolescents,but the underlying neural mechanisms remain elusive.Recent evidence suggests that the cell adhesion molecules NECTIN1 and NECTIN3 play a role i...Early-life stress(ES)leads to cognitive dysfunction in female adolescents,but the underlying neural mechanisms remain elusive.Recent evidence suggests that the cell adhesion molecules NECTIN1 and NECTIN3 play a role in cognition and ES-related cognitive deficits in male rodents.In this study,we aimed to investigate whether and how nectins contribute to ES-induced cognitive dysfunction in female adolescents.Applying the well-established limited bedding and nesting material paradigm,we found that ES impairs recognition memory,suppresses prefrontal NECTIN1 and hippocampal NECTIN3 expression,and upregulates corticotropin-releasing hormone(Crh)and its receptor 1(Crhr1)mRNA levels in the hippocampus of adolescent female mice.Genetic experiments revealed that the reduction of dorsal CA1(dCA1)NECTIN3 mediates ES-induced object recognition memory deficits,as knocking down dCA1 NECTIN3 impaired animals’performance in the novel object recognition task,while overexpression of dCA1 NECTIN3 successfully reversed the ES-induced deficits.Notably,prefrontal NECTIN1 knockdown did not result in significant cognitive impairments.Furthermore,acute systemic administration of antalarmin,a CRHR1 antagonist,upregulated hippocampal NECTIN3 levels and rescued object and spatial memory deficits in stressed mice.Our findings underscore the critical role of dCA1 NECTIN3 in mediating ES-induced object recognition memory deficits in adolescent female mice,highlighting it as a potential therapeutic target for stress-related psychiatric disorders in women.展开更多
Early risk detection and management are essential for cognitive preservation.While particulate matter with a diameter smaller than 2.5μm(PM_(2.5))is considered harmful to cognition,the effect of smaller,more penetrat...Early risk detection and management are essential for cognitive preservation.While particulate matter with a diameter smaller than 2.5μm(PM_(2.5))is considered harmful to cognition,the effect of smaller,more penetrative particulate matter with a diameter smaller than 1μm(PM_(1))requires further evidence and explicit safety thresholds.In this study,we explored the effects of long-term PM_(1) exposure on early cognitive impairment and longitudinal cognitive changes in middle-aged and older populations.This study assessed data from two large-scale longitudinal surveys:the China Health and Retirement Longitudinal Study(CHARLS)and UK Biobank(UKB).Cross-sectional,longitudinal,and trajectory analyses were conducted to investigate the association between long-term PM_(1) exposure and cognition.Additionally,the expo sure-response curves were fitted to determine the customized thresholds.The findings indicated that sustained PM_(1) exposure may lead to mild cognitive impairment,particularly at concentrations exceeding 30 and 5.6μg·m^(-3) in CHARLS and UKB participants,respectively.Furthermore,we found that long-term PM_(1) exposure can contribute to rapid cognitive decline at concentrations exceeding 23 and 5.5μg·m^(-3) in CHARLS and UKB participants,respectively.In conclusion,reducing PM_(1) exposure can improve the cognitive health of middle-aged and older adults.展开更多
Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite ...Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite this understanding,the neural circuit mechanisms underlying this phenomenon remain elusive.In this study,we present a biophysical computational model encompassing three crucial regions,including the dorsolateral prefrontal cortex,subgenual anterior cingulate cortex,and ventromedial prefrontal cortex.The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes.The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks.Furthermore,our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex,and network functionality was restored through intervention in the dorsolateral prefrontal cortex.This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.展开更多
Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older a...Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older adults(n=130)were randomly divided into a control(CG,n=68)group and an exercise group(EG,n=62)in a 12-week intervention,which included stride gait training with wearable sensors;aerobic exercise;and resistance,flexibility,balance,and cognitive training.Primary outcomes(physical fitness)were evaluated via the SPPB and SFT.Secondary outcomes(cognitive ability,quality of life and frailty)were evaluated via the MoCA-BC,SF-36 and Fried frailty criteria,respectively.Results:After the 12-week intervention,the EG demonstrated significant improvements(p<0.05)vs.the CG in gait speed(β_(3)=0.424,coefficient of interaction effect between group and time from the generalized linear mixed model),chair stand(β_(3)=0.501)and total score(β_(3)=65.466)of SPPB and all SFT components including 6MWT(walked distance,β_(3)=1.098;walking speed,β_(3)=0.105;stride length,β_(3)=0.041),back scratch(β_(3)=4.926),chair sit and reach(β_(3)=3.762),30s arm curl(β_(3)=6.124),30s sit-to-stand(β_(3)=3.04),and TUG(β_(3)=−6.712).The MoCA-BC total,verbal fluency and delayed recall scores;the physical function,general health,vitality,and mental health scores of the SF-36;and the frailty phenotype in the EG were significantly improved compared with those of the CG.Conclusions:The progressive wearable-sensor-assisted multicomponent exercise program designed in this study enhanced physical fitness,cognitive ability and quality of life and slowed down the progression of frailty in frail older adults,supporting its potential as a feasible communitybased health intervention.展开更多
The nature of pramāṅa system,outlined by Dignāga(c.480-540 CE)and further elaborated upon by Dharmakīrti(c.600-660 CE),is an important part of the Buddhist logico-epistemological tradition.Within this pramāṅa syst...The nature of pramāṅa system,outlined by Dignāga(c.480-540 CE)and further elaborated upon by Dharmakīrti(c.600-660 CE),is an important part of the Buddhist logico-epistemological tradition.Within this pramāṅa system,self-awareness(svasaṃvedana)is considered a hallmark of the access to the mental states and factors.However,some of the key research often focuses on interpreting the valid cognition system and self-awareness separately,lacking specific descriptions of their interrelationship.This paper argues that self-awareness is not merely a byproduct of valid cognition but is intimately connected to it.Specifically,I posit that self-awareness should be regarded as the ultimate result of valid cognition within the Pramāṇa system.展开更多
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A...In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.展开更多
BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed ...BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.展开更多
BACKGROUND Ischemic stroke(IS)survivors face an elevated risk of epileptic seizures,and recurrent seizures following the first episode often signal worsening functional outcomes.AIM To investigate risk factors associa...BACKGROUND Ischemic stroke(IS)survivors face an elevated risk of epileptic seizures,and recurrent seizures following the first episode often signal worsening functional outcomes.AIM To investigate risk factors associated with seizure recurrence after a first episode in patients with IS and explore their associations with cognitive function,anxiety,and depression.METHODS A total of 100 patients with IS admitted to Shaanxi Provincial People’s Hospital between January 2017 and January 2024 were enrolled in this study.After a 1-5-year follow-up,patients were categorized into recurrence(n=43)and nonrecurrence(n=57)groups.Their medical records were collected and analyzed using univariate and multivariate analyses to determine potential predictors of seizure recurrence.Variables with statistical significance in the univariate analysis were incorporated into a binary logistic regression model for multivariate analysis.The risk model’s predictive performance was evaluated using the receiver operating characteristic curve.How independent risk factors,identified in multivariate analysis,related to cognitive[Montreal Cognitive Assessment(MoCA)]and emotional[Self-Rating Anxiety Scale(SAS)/Self-Rating Depression Scale(SDS)]outcomes,were assessed.RESULTS Recurrent seizures were significantly associated with age,stroke severity(National Institutes of Health Stroke Scale),late-onset seizures,electroenceph-alogram abnormalities,cortical involvement,hemorrhagic infarction,and extensive cerebral infarctions,with lateonset seizures,cortical involvement,and hemorrhagic infarction serving as independent predictors.The risk model revealed an area under the curve of 0.732,with 88.37%specificity and 42.11%sensitivity.These three were also correlated with lower MoCA scores and higher SAS and SDS scores.CONCLUSION In patients with IS,recurrent seizures after the first episode can be independently predicted by late-onset seizures,cortical involvement,and hemorrhagic cerebral infarction-factors also correlating with cognitive impairment and emotional distress.These findings underscore the need for close clinical monitoring and targeted interventions(e.g.,cognitive rehabilitation and psychological support)to mitigate seizure recurrence in high-risk individuals.展开更多
This paper aims to explore the cognition and demand of nature education.Through the analysis of its connotation,significance,current situation and challenges,corresponding countermeasures and suggestions are put forwa...This paper aims to explore the cognition and demand of nature education.Through the analysis of its connotation,significance,current situation and challenges,corresponding countermeasures and suggestions are put forward.Nature education is a kind of education mode based on the natural environment,which enables learners to integrate with nature through scientific and effective means.This kind of education method has a far-reaching impact on shaping the overall quality of teenagers and cultivating the correct world outlook and values.By means of literature review,case analysis and other means,combined with the development practice of nature education at home and abroad,this study deeply analyzes the cognitive status and demand characteristics of nature education,which provides guidance and basis for the dissemination and development of nature education.展开更多
BACKGROUND Surgery is a common treatment for gastrointestinal tumors.General anesthesia(GA),while effective,can cause oxidative stress reactions and neuroinflammation,potentially leading to postoperative cognitive dys...BACKGROUND Surgery is a common treatment for gastrointestinal tumors.General anesthesia(GA),while effective,can cause oxidative stress reactions and neuroinflammation,potentially leading to postoperative cognitive dysfunction and gastrointestinal dysfunction.The stellate ganglion block(SGB)can reduce sympathetic excitability and stress responses.This study aims to investigate whether combining SGB with GA can mitigate these adverse effects in patients undergoing gastrointestinal surgery.AIM To analyze the effects of SGB plus GA on hemodynamic stability,oxidative stress,neuroinflammation,cognitive function,and gastrointestinal function in patients undergoing gastrointestinal surgery.METHODS Patients undergoing gastrointestinal surgery between October 2022 and December 2024 were divided into two groups:A single GA group and an SGB combined with GA group(40 patients each).Hemodynamics,oxidative stress response,laboratory indices,cognitive function,and gastrointestinal function were compared preoperatively and 24 hours postoperatively between the two groups.Pain levels and complications were also recorded.RESULTS Before anesthesia induction,no significant differences were found in various indexes(including hemodynamics,oxidative stress indicators,laboratory indices,cognitive function scores,and gastrointestinal function indicators)between the two groups(P>0.05).At tracheal intubation,3 minutes after,and extubation,the GA-only group had significantly higher mean arterial pressure and heart rate postoperatively than preoperatively and compared to the SGB-GA combined group(P<0.05).Twentyfour hours postoperatively,oxidative stress indicators(malondialdehyde and nitric oxide)were significantly higher and superoxide dismutase was significantly lower in the GA group than in the SGB-GA combined group(P<0.05).Cognitive function scores[Mini-Mental State Examination and Montreal Cognitive Assessment(MoCA)]and gastrointestinal function indicators(motilin)were also significantly better in the SGB-GA combined group(P<0.05).The 24-hour postoperative MoCA score was 0.98 points higher in the SGB-GA combined group.No significant differences were found in the time of first postoperative ambulation,catheter removal time,and 24-hour postoperative pain between groups(P>0.05).CONCLUSION Combining SGB with GA can maintain perioperative hemodynamic stability,reduce oxidative stress and neuroinflammatory injury,and attenuate postoperative cognitive decline and gastrointestinal dysfunction in patients undergoing gastrointestinal surgery.展开更多
The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail...The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail sampling the received signal at a Nyquist rate,and they are not viable for wideband signals due to their high cost.This paper expounds on how sub-Nyquist sampling in conjunction with deep learning can be leveraged to remove this limitation.To this end,we propose a multi-task learning(MTL)framework using convolutional neural networks for the joint inference of the underlying narrowband signal number,their modulation scheme,and their location in a wideband spectrum.We demonstrate the effectiveness of the proposed framework for real-world millimeter-wave wideband signals collected by physical devices,exhibiting a 91.7% accuracy in the joint inference task when considering up to two narrowband signals over a wideband spectrum.Ultimately,the proposed data-driven approach enables on-the-fly wideband spectrum sensing,combining accuracy,and computational efficiency,which are indispensable for CR and opportunistic networking.展开更多
The battlefield environment is changing rapidly,and fast and accurate identification of the tactical intention of enemy targets is an important condition for gaining a decision-making advantage.The current Intention R...The battlefield environment is changing rapidly,and fast and accurate identification of the tactical intention of enemy targets is an important condition for gaining a decision-making advantage.The current Intention Recognition(IR)method for air targets has shortcomings in temporality,interpretability and back-and-forth dependency of intentions.To address these problems,this paper designs a novel air target intention recognition method named STABC-IR,which is based on Bidirectional Gated Recurrent Unit(Bi GRU)and Conditional Random Field(CRF)with Space-Time Attention mechanism(STA).First,the problem of intention recognition of air targets is described and analyzed in detail.Then,a temporal network based on Bi GRU is constructed to achieve the temporal requirement.Subsequently,STA is proposed to focus on the key parts of the features and timing information to meet certain interpretability requirements while strengthening the timing requirements.Finally,an intention transformation network based on CRF is proposed to solve the back-and-forth dependency and transformation problem by jointly modeling the tactical intention of the target at each moment.The experimental results show that the recognition accuracy of the jointly trained STABC-IR model can reach 95.7%,which is higher than other latest intention recognition methods.STABC-IR solves the problem of intention transformation for the first time and considers both temporality and interpretability,which is important for improving the tactical intention recognition capability and has reference value for the construction of command and control auxiliary decision-making system.展开更多
BACKGROUND Apolipoprotein E epsilon 4(APOE4)is recognized as a genetic risk factor for cognitive decline and neurodegeneration in both type 2 diabetes mellitus(T2DM)and Alzheimer’s disease,while glycated hemoglobin(H...BACKGROUND Apolipoprotein E epsilon 4(APOE4)is recognized as a genetic risk factor for cognitive decline and neurodegeneration in both type 2 diabetes mellitus(T2DM)and Alzheimer’s disease,while glycated hemoglobin(HbA1c)reflects persistent hyperglycemia and serves as a key indicator of long-term glycemic control in T2DM.Although both factors have been individually linked to neurobehavioral deficits,it remains uncertain whether HbA1c contributes to APOE4-related cognitive and olfactory impairment in individuals with T2DM.AIM To investigate the role of HbA1c in APOE4-associated cognitive and olfactory dysfunction in patients with T2DM.METHODS Of 636 T2DM patients were recruited from five medical centers in Wuhan,Hubei Province,China.APOE genotyping was evaluated by polymerase chain reaction using Gerard’s method.Cognitive and olfactory functions were assessed by mini-mental state examination and Connecticut chemosensory clinical research center test,respectively.Regression analysis was employed to assess the independent and interactive effects of HbA1c on APOE4-associated cognitive and olfactory function.RESULTS APOE4 was associated with increased risks of cognitive impairment[odds ratios(OR)=1.815,P=0.021]and olfactory dysfunction(OR=2.588,P<0.001).Higher HbA1c levels were also related to worse cognitive(OR=1.189,P<0.001)and olfactory performance(OR=1.149,P=0.011).HbA1c exerted a moderating effect,yet not a mediating effect,between APOE4 and its impacts on cognition and olfaction.Specifically,a higher level of HbA1c exacerbated the damaging effect of APOE4,as shown by significant interaction effects on both cognitive impairment(OR=2.687,P<0.001)and olfactory dysfunction(OR=1.440,P=0.027).CONCLUSION Elevated HbA1c levels are associated with increased risks of cognitive and olfactory impairments in patients with T2DM and may exacerbate the detrimental effects of APOE4.These findings underscore the need for early preventive strategies targeting individuals with both poor glycemic control and APOE4 carriage to mitigate neurodegenerative risk.展开更多
There has been a revolutionary advance in the treatment and management of schizophrenia from a clinical aspect yet the social and functional outcomes remain poor. Cognitive function is impaired in schizophrenia and sh...There has been a revolutionary advance in the treatment and management of schizophrenia from a clinical aspect yet the social and functional outcomes remain poor. Cognitive function is impaired in schizophrenia and shows various domains of dysfunction like verbal memory, processing speed and working memory. It is also known to be a factor associated with poor outcome in schizophrenia. Resilience is a new concept psychobiological concept which is defined as individual’s ability to adapt swiftly to adverse life events and bounces back to normalcy. Resilience has genetic, neurobiological, neurochemical and psychological underpinnings. It is the ability to effectively deal with psychosocial stressors and appears to be one of the many factors associated with favourable outcomes in schizophrenia. Besides several neurobiological abnormalities associated with resilience, neucognitive functions are of particular interest. Persistent psychosocial stressors also lead to significant neurobiological changes which may be synergetic to poor outcome due to cognitive changes. Though there has been extensive research in the field of cognitive function in schizophrenia, the trajectory of its pathway of poor outcome remains undetermined. Resilience being a protective factor may be one of the psychobiological functions which modulate the effect of neurocognition on the outcome of schizophrenia. There has been some success with interventions aimed at improving cognitive function in schizophrenia whether pharmacological or non pharmacological. In this paper, we discuss a hypothesis that resilience may be a “linkage” between cognition and outcome. There is a need for interventions aimed at increasing resilience in patients with schizophrenia and we hypothesize giving evidence that this may in turn improve outcome and neurocognitive functioning in schizophrenia.展开更多
Anji Ecomuseum is the kind of ＂grown-up ecomuseum＂ which differs from the traditional eco-museum in the sense of those originating in 1970s France, and transferred to China （Via Norway） inGuizhou and later in Guan...Anji Ecomuseum is the kind of ＂grown-up ecomuseum＂ which differs from the traditional eco-museum in the sense of those originating in 1970s France, and transferred to China （Via Norway） inGuizhou and later in Guangxi. Anji Ecomuseum created the ＂cognition center＂ instead of ＂informationcenter＂. Cognition center adds more values to the community, encourages the locals and audiences fromoutside to understand （not only learn from） Eco-community as a whole, emphasizing the living heritage,self-cognition and self-education. Graburn discussed this evolution was closer to the root of Eco.展开更多
文摘In high-intensity electromagnetic warfare,radar systems are persistently subjected to multi-jammer attacks,including potentially novel unknown jamming types that may emerge exclusively under wartime conditions.These jamming signals severely degrade radar detection performance.Precise recognition of these unknown and compound jamming signals is critical to enhancing the anti-jamming capabilities and overall reliability of radar systems.To address this challenge,this article proposes a novel open-set compound jamming cognition(OSCJC)method.The proposed method employs a detection-classification dual-network architecture,which not only overcomes the false alarm and misdetection issues of traditional closed-set recognition methods when dealing with unknown jamming but also effectively addresses the performance bottleneck of existing open-set recognition techniques focusing on single jamming scenarios in compound jamming environments.To achieve unknown jamming detection,we first employ a consistency labeling strategy to train the detection network using diverse known jamming samples.This strategy enables the network to acquire highly generalizable jamming features,thereby accurately localizing candidate regions for individual jamming components within compound jamming.Subsequently,we introduce contrastive learning to optimize the classification network,significantly enhancing both intra-class clustering and inter-class separability in the jamming feature space.This method not only improves the recognition accuracy of the classification network for known jamming types but also enhances its sensitivity to unknown jamming types.Simulations and experimental data are used to verify the effectiveness of the proposed OSCJC method.Compared with the state-of-the-art open-set recognition methods,the proposed method demonstrates superior recognition accuracy and enhanced environmental adaptability.
文摘BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.
文摘This review explores the use of agent-based modeling(ABM)within the framework of study human emotion and cognition in the context of its ability to simulate complex social interactions,adaptive changes,and evolutionary processes.By representing agents and their defined environments with probabilistic interactions,ABM allows the assessment of the effects of individual behavior at the micro level on the greater social phenomena at the macro level.The review looks into the applications of ABM in portraying some of the key components of emotions and cognition-empathy,cooperation,decision making,and emotional transmission-and analyzes the problems including scalability,empirical validation,and description of sensitive emotional states.The most important conclusion is that merging ABM with information neurobiological data and artificial intelligence(AI)techniques would allow for deepening the interactions within the system and enhancing its responsiveness to stimuli.This review highlights approaches that aim to exploit the ABM methodology more fully and integrates methods from biology,neuroscience,and engineering.This integration could contribute to our understanding of the human behavior evolution and adaptation within systems relevant to policymaking,healthcare,and education.
基金Supported by the National Natural Science Foundation of China,No.82101595.
文摘Social cognition constitutes a fundamental component in establishing and maintaining healthy interpersonal relationships,achieving social goals,and effectively regulating emotions within social contexts.Inspired by a recent study examining the chain mediating roles of perceived social adversity and security in the relationship between impulsive personality and suicidal behaviors among depressed adolescents,this editorial synthesizes advances in social cognition research specific to adolescent depression.Research methodologies,theoretical frameworks,and neuroscientific insights in this domain have evolved substantially over the past fifteen years.Whereas earlier investigations primarily emphasized broad behavioral observations,contemporary research increasingly integrates neuroimaging techniques,computational modeling,and refined experimental paradigms.Current understanding of specific cognitive biases such as distinctions between interpretive and attentional biases has also grown more nuanced.This editorial reflects the evolving nature of the field by presenting shifts in research focus and demonstrating how these changes have deepened our understanding of social-cognitive functioning in adolescent depression.Building on this synthesis,we outline limitations of extant research and suggest promising directions for future inquiry.
基金supported by the Humanities and Social Science Fund of the Ministry of Education of China(23YJA190012)Guangdong Provincial College Student Innovation and Entrepreneurship Training Program(S202410577105)+1 种基金Huizhou Philosophy and Social Sciences Discipline Co-Construction Project(HZ2023GJ128)Characteristic Innovation Project of Colleges and Universities in Guangdong Province(2021WTSCX090).
文摘The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the opportunities,challenges,and future directions of research on children’s language learning from the perspective of embodied cognition.It concludes that multisensory engagement can greatly improve children’s comprehension and memorization of language knowledge and that language acquisition is intimately tied to bodily perception,movement,and emotional experience.In addition,children’s language acquisition can also be effectively aided by embodied cognition techniques as multimedia aids,gesture and enactment,and imagery.Based on previous evidence,we propose an integrated language learning framework and a new relevance-integration taxonomy for children’s language learning from the perspectives of embodied cognition and cognitive load theories.In order to support the long-term growth of children’s language education,future research should focus more on the requirement of embodied language learning in the preschool-primary transition and optimize the teaching objectives and contents.
基金supported by the National Natural Science Foundation of China(82271569,82001418,82371530,82171529,and 82071528)the Beijing Natural Science Foundation(7222236)the Capital Medical Development Research Fund(2022-1-4111)。
文摘Early-life stress(ES)leads to cognitive dysfunction in female adolescents,but the underlying neural mechanisms remain elusive.Recent evidence suggests that the cell adhesion molecules NECTIN1 and NECTIN3 play a role in cognition and ES-related cognitive deficits in male rodents.In this study,we aimed to investigate whether and how nectins contribute to ES-induced cognitive dysfunction in female adolescents.Applying the well-established limited bedding and nesting material paradigm,we found that ES impairs recognition memory,suppresses prefrontal NECTIN1 and hippocampal NECTIN3 expression,and upregulates corticotropin-releasing hormone(Crh)and its receptor 1(Crhr1)mRNA levels in the hippocampus of adolescent female mice.Genetic experiments revealed that the reduction of dorsal CA1(dCA1)NECTIN3 mediates ES-induced object recognition memory deficits,as knocking down dCA1 NECTIN3 impaired animals’performance in the novel object recognition task,while overexpression of dCA1 NECTIN3 successfully reversed the ES-induced deficits.Notably,prefrontal NECTIN1 knockdown did not result in significant cognitive impairments.Furthermore,acute systemic administration of antalarmin,a CRHR1 antagonist,upregulated hippocampal NECTIN3 levels and rescued object and spatial memory deficits in stressed mice.Our findings underscore the critical role of dCA1 NECTIN3 in mediating ES-induced object recognition memory deficits in adolescent female mice,highlighting it as a potential therapeutic target for stress-related psychiatric disorders in women.
基金supported by the National Key Research and Development Program of China(2021YFC2701102)the China-US Program for Biomedical Collaborative Research(NSFC-NIH)(81961128022)+1 种基金the US National Institute for Environmental Health Sciences(NIEHS)(R01ES031322)the National Science Fund for Young Scholars(82304095)。
文摘Early risk detection and management are essential for cognitive preservation.While particulate matter with a diameter smaller than 2.5μm(PM_(2.5))is considered harmful to cognition,the effect of smaller,more penetrative particulate matter with a diameter smaller than 1μm(PM_(1))requires further evidence and explicit safety thresholds.In this study,we explored the effects of long-term PM_(1) exposure on early cognitive impairment and longitudinal cognitive changes in middle-aged and older populations.This study assessed data from two large-scale longitudinal surveys:the China Health and Retirement Longitudinal Study(CHARLS)and UK Biobank(UKB).Cross-sectional,longitudinal,and trajectory analyses were conducted to investigate the association between long-term PM_(1) exposure and cognition.Additionally,the expo sure-response curves were fitted to determine the customized thresholds.The findings indicated that sustained PM_(1) exposure may lead to mild cognitive impairment,particularly at concentrations exceeding 30 and 5.6μg·m^(-3) in CHARLS and UKB participants,respectively.Furthermore,we found that long-term PM_(1) exposure can contribute to rapid cognitive decline at concentrations exceeding 23 and 5.5μg·m^(-3) in CHARLS and UKB participants,respectively.In conclusion,reducing PM_(1) exposure can improve the cognitive health of middle-aged and older adults.
基金supported by the Major Research Instrument Development Project of the National Natural Science Foundation of China(82327810)the Foundation of the President of Hebei University(XZJJ202202)the Hebei Province“333 talent project”(A202101058).
文摘Within the prefrontal-cingulate cortex,abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions,contributing to the development of mental disorders such as depression.Despite this understanding,the neural circuit mechanisms underlying this phenomenon remain elusive.In this study,we present a biophysical computational model encompassing three crucial regions,including the dorsolateral prefrontal cortex,subgenual anterior cingulate cortex,and ventromedial prefrontal cortex.The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes.The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks.Furthermore,our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex,and network functionality was restored through intervention in the dorsolateral prefrontal cortex.This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.
基金supported by the project of Guangzhou Sports Science and Technology Collaborative Innovation Center(No.SL2022B04J00034)National Key Research and Development Program of China(No.2020YFC2002900)。
文摘Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older adults(n=130)were randomly divided into a control(CG,n=68)group and an exercise group(EG,n=62)in a 12-week intervention,which included stride gait training with wearable sensors;aerobic exercise;and resistance,flexibility,balance,and cognitive training.Primary outcomes(physical fitness)were evaluated via the SPPB and SFT.Secondary outcomes(cognitive ability,quality of life and frailty)were evaluated via the MoCA-BC,SF-36 and Fried frailty criteria,respectively.Results:After the 12-week intervention,the EG demonstrated significant improvements(p<0.05)vs.the CG in gait speed(β_(3)=0.424,coefficient of interaction effect between group and time from the generalized linear mixed model),chair stand(β_(3)=0.501)and total score(β_(3)=65.466)of SPPB and all SFT components including 6MWT(walked distance,β_(3)=1.098;walking speed,β_(3)=0.105;stride length,β_(3)=0.041),back scratch(β_(3)=4.926),chair sit and reach(β_(3)=3.762),30s arm curl(β_(3)=6.124),30s sit-to-stand(β_(3)=3.04),and TUG(β_(3)=−6.712).The MoCA-BC total,verbal fluency and delayed recall scores;the physical function,general health,vitality,and mental health scores of the SF-36;and the frailty phenotype in the EG were significantly improved compared with those of the CG.Conclusions:The progressive wearable-sensor-assisted multicomponent exercise program designed in this study enhanced physical fitness,cognitive ability and quality of life and slowed down the progression of frailty in frail older adults,supporting its potential as a feasible communitybased health intervention.
文摘The nature of pramāṅa system,outlined by Dignāga(c.480-540 CE)and further elaborated upon by Dharmakīrti(c.600-660 CE),is an important part of the Buddhist logico-epistemological tradition.Within this pramāṅa system,self-awareness(svasaṃvedana)is considered a hallmark of the access to the mental states and factors.However,some of the key research often focuses on interpreting the valid cognition system and self-awareness separately,lacking specific descriptions of their interrelationship.This paper argues that self-awareness is not merely a byproduct of valid cognition but is intimately connected to it.Specifically,I posit that self-awareness should be regarded as the ultimate result of valid cognition within the Pramāṇa system.
基金supported by STI2030-Major Projects,No.2021ZD 0201801(to JG)Shanxi Province Basic Research Program,No.20210302123429(to QS).
文摘In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.
基金Supported by the Wuxi Municipal Health Commission Youth Fund Project,No.Q202268Wuxi Scientific and technological breakthrough of“Light of the Taihu Lake”(Basic Research),No.K20221039+4 种基金Jiangsu Shuangchuang Doctoral Program,No.JSSCBS20221991Beijing Municipal Administration of Hospital Incubating Program,No.PX2023070 and No.PX2024072Capital’s Funds for Health Improvement and Research,No.SF2024-4-2134Beijing Hospitals Authority Youth Program,No.QML20232003the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee,No.HB2023089.
文摘BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.
文摘BACKGROUND Ischemic stroke(IS)survivors face an elevated risk of epileptic seizures,and recurrent seizures following the first episode often signal worsening functional outcomes.AIM To investigate risk factors associated with seizure recurrence after a first episode in patients with IS and explore their associations with cognitive function,anxiety,and depression.METHODS A total of 100 patients with IS admitted to Shaanxi Provincial People’s Hospital between January 2017 and January 2024 were enrolled in this study.After a 1-5-year follow-up,patients were categorized into recurrence(n=43)and nonrecurrence(n=57)groups.Their medical records were collected and analyzed using univariate and multivariate analyses to determine potential predictors of seizure recurrence.Variables with statistical significance in the univariate analysis were incorporated into a binary logistic regression model for multivariate analysis.The risk model’s predictive performance was evaluated using the receiver operating characteristic curve.How independent risk factors,identified in multivariate analysis,related to cognitive[Montreal Cognitive Assessment(MoCA)]and emotional[Self-Rating Anxiety Scale(SAS)/Self-Rating Depression Scale(SDS)]outcomes,were assessed.RESULTS Recurrent seizures were significantly associated with age,stroke severity(National Institutes of Health Stroke Scale),late-onset seizures,electroenceph-alogram abnormalities,cortical involvement,hemorrhagic infarction,and extensive cerebral infarctions,with lateonset seizures,cortical involvement,and hemorrhagic infarction serving as independent predictors.The risk model revealed an area under the curve of 0.732,with 88.37%specificity and 42.11%sensitivity.These three were also correlated with lower MoCA scores and higher SAS and SDS scores.CONCLUSION In patients with IS,recurrent seizures after the first episode can be independently predicted by late-onset seizures,cortical involvement,and hemorrhagic cerebral infarction-factors also correlating with cognitive impairment and emotional distress.These findings underscore the need for close clinical monitoring and targeted interventions(e.g.,cognitive rehabilitation and psychological support)to mitigate seizure recurrence in high-risk individuals.
基金Research Project of Basic Education in Jiangxi Province(SZUNDZH2021-1136,SZUNDZH2020-1138).
文摘This paper aims to explore the cognition and demand of nature education.Through the analysis of its connotation,significance,current situation and challenges,corresponding countermeasures and suggestions are put forward.Nature education is a kind of education mode based on the natural environment,which enables learners to integrate with nature through scientific and effective means.This kind of education method has a far-reaching impact on shaping the overall quality of teenagers and cultivating the correct world outlook and values.By means of literature review,case analysis and other means,combined with the development practice of nature education at home and abroad,this study deeply analyzes the cognitive status and demand characteristics of nature education,which provides guidance and basis for the dissemination and development of nature education.
文摘BACKGROUND Surgery is a common treatment for gastrointestinal tumors.General anesthesia(GA),while effective,can cause oxidative stress reactions and neuroinflammation,potentially leading to postoperative cognitive dysfunction and gastrointestinal dysfunction.The stellate ganglion block(SGB)can reduce sympathetic excitability and stress responses.This study aims to investigate whether combining SGB with GA can mitigate these adverse effects in patients undergoing gastrointestinal surgery.AIM To analyze the effects of SGB plus GA on hemodynamic stability,oxidative stress,neuroinflammation,cognitive function,and gastrointestinal function in patients undergoing gastrointestinal surgery.METHODS Patients undergoing gastrointestinal surgery between October 2022 and December 2024 were divided into two groups:A single GA group and an SGB combined with GA group(40 patients each).Hemodynamics,oxidative stress response,laboratory indices,cognitive function,and gastrointestinal function were compared preoperatively and 24 hours postoperatively between the two groups.Pain levels and complications were also recorded.RESULTS Before anesthesia induction,no significant differences were found in various indexes(including hemodynamics,oxidative stress indicators,laboratory indices,cognitive function scores,and gastrointestinal function indicators)between the two groups(P>0.05).At tracheal intubation,3 minutes after,and extubation,the GA-only group had significantly higher mean arterial pressure and heart rate postoperatively than preoperatively and compared to the SGB-GA combined group(P<0.05).Twentyfour hours postoperatively,oxidative stress indicators(malondialdehyde and nitric oxide)were significantly higher and superoxide dismutase was significantly lower in the GA group than in the SGB-GA combined group(P<0.05).Cognitive function scores[Mini-Mental State Examination and Montreal Cognitive Assessment(MoCA)]and gastrointestinal function indicators(motilin)were also significantly better in the SGB-GA combined group(P<0.05).The 24-hour postoperative MoCA score was 0.98 points higher in the SGB-GA combined group.No significant differences were found in the time of first postoperative ambulation,catheter removal time,and 24-hour postoperative pain between groups(P>0.05).CONCLUSION Combining SGB with GA can maintain perioperative hemodynamic stability,reduce oxidative stress and neuroinflammatory injury,and attenuate postoperative cognitive decline and gastrointestinal dysfunction in patients undergoing gastrointestinal surgery.
文摘The utilization of millimeter-wave frequencies and cognitive radio(CR)are promising ways to increase the spectral efficiency of wireless communication systems.However,conventional CR spectrum sensing techniques entail sampling the received signal at a Nyquist rate,and they are not viable for wideband signals due to their high cost.This paper expounds on how sub-Nyquist sampling in conjunction with deep learning can be leveraged to remove this limitation.To this end,we propose a multi-task learning(MTL)framework using convolutional neural networks for the joint inference of the underlying narrowband signal number,their modulation scheme,and their location in a wideband spectrum.We demonstrate the effectiveness of the proposed framework for real-world millimeter-wave wideband signals collected by physical devices,exhibiting a 91.7% accuracy in the joint inference task when considering up to two narrowband signals over a wideband spectrum.Ultimately,the proposed data-driven approach enables on-the-fly wideband spectrum sensing,combining accuracy,and computational efficiency,which are indispensable for CR and opportunistic networking.
基金supported by the National Natural Science Foundation of China(Nos.62106283 and 72001214)。
文摘The battlefield environment is changing rapidly,and fast and accurate identification of the tactical intention of enemy targets is an important condition for gaining a decision-making advantage.The current Intention Recognition(IR)method for air targets has shortcomings in temporality,interpretability and back-and-forth dependency of intentions.To address these problems,this paper designs a novel air target intention recognition method named STABC-IR,which is based on Bidirectional Gated Recurrent Unit(Bi GRU)and Conditional Random Field(CRF)with Space-Time Attention mechanism(STA).First,the problem of intention recognition of air targets is described and analyzed in detail.Then,a temporal network based on Bi GRU is constructed to achieve the temporal requirement.Subsequently,STA is proposed to focus on the key parts of the features and timing information to meet certain interpretability requirements while strengthening the timing requirements.Finally,an intention transformation network based on CRF is proposed to solve the back-and-forth dependency and transformation problem by jointly modeling the tactical intention of the target at each moment.The experimental results show that the recognition accuracy of the jointly trained STABC-IR model can reach 95.7%,which is higher than other latest intention recognition methods.STABC-IR solves the problem of intention transformation for the first time and considers both temporality and interpretability,which is important for improving the tactical intention recognition capability and has reference value for the construction of command and control auxiliary decision-making system.
基金Supported by the China Postdoctoral Science Foundation General Program,No.2024M762504the Intramural Research Program of Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.2023 LYYYGZRP0004.
文摘BACKGROUND Apolipoprotein E epsilon 4(APOE4)is recognized as a genetic risk factor for cognitive decline and neurodegeneration in both type 2 diabetes mellitus(T2DM)and Alzheimer’s disease,while glycated hemoglobin(HbA1c)reflects persistent hyperglycemia and serves as a key indicator of long-term glycemic control in T2DM.Although both factors have been individually linked to neurobehavioral deficits,it remains uncertain whether HbA1c contributes to APOE4-related cognitive and olfactory impairment in individuals with T2DM.AIM To investigate the role of HbA1c in APOE4-associated cognitive and olfactory dysfunction in patients with T2DM.METHODS Of 636 T2DM patients were recruited from five medical centers in Wuhan,Hubei Province,China.APOE genotyping was evaluated by polymerase chain reaction using Gerard’s method.Cognitive and olfactory functions were assessed by mini-mental state examination and Connecticut chemosensory clinical research center test,respectively.Regression analysis was employed to assess the independent and interactive effects of HbA1c on APOE4-associated cognitive and olfactory function.RESULTS APOE4 was associated with increased risks of cognitive impairment[odds ratios(OR)=1.815,P=0.021]and olfactory dysfunction(OR=2.588,P<0.001).Higher HbA1c levels were also related to worse cognitive(OR=1.189,P<0.001)and olfactory performance(OR=1.149,P=0.011).HbA1c exerted a moderating effect,yet not a mediating effect,between APOE4 and its impacts on cognition and olfaction.Specifically,a higher level of HbA1c exacerbated the damaging effect of APOE4,as shown by significant interaction effects on both cognitive impairment(OR=2.687,P<0.001)and olfactory dysfunction(OR=1.440,P=0.027).CONCLUSION Elevated HbA1c levels are associated with increased risks of cognitive and olfactory impairments in patients with T2DM and may exacerbate the detrimental effects of APOE4.These findings underscore the need for early preventive strategies targeting individuals with both poor glycemic control and APOE4 carriage to mitigate neurodegenerative risk.
文摘There has been a revolutionary advance in the treatment and management of schizophrenia from a clinical aspect yet the social and functional outcomes remain poor. Cognitive function is impaired in schizophrenia and shows various domains of dysfunction like verbal memory, processing speed and working memory. It is also known to be a factor associated with poor outcome in schizophrenia. Resilience is a new concept psychobiological concept which is defined as individual’s ability to adapt swiftly to adverse life events and bounces back to normalcy. Resilience has genetic, neurobiological, neurochemical and psychological underpinnings. It is the ability to effectively deal with psychosocial stressors and appears to be one of the many factors associated with favourable outcomes in schizophrenia. Besides several neurobiological abnormalities associated with resilience, neucognitive functions are of particular interest. Persistent psychosocial stressors also lead to significant neurobiological changes which may be synergetic to poor outcome due to cognitive changes. Though there has been extensive research in the field of cognitive function in schizophrenia, the trajectory of its pathway of poor outcome remains undetermined. Resilience being a protective factor may be one of the psychobiological functions which modulate the effect of neurocognition on the outcome of schizophrenia. There has been some success with interventions aimed at improving cognitive function in schizophrenia whether pharmacological or non pharmacological. In this paper, we discuss a hypothesis that resilience may be a “linkage” between cognition and outcome. There is a need for interventions aimed at increasing resilience in patients with schizophrenia and we hypothesize giving evidence that this may in turn improve outcome and neurocognitive functioning in schizophrenia.
文摘Anji Ecomuseum is the kind of ＂grown-up ecomuseum＂ which differs from the traditional eco-museum in the sense of those originating in 1970s France, and transferred to China （Via Norway） inGuizhou and later in Guangxi. Anji Ecomuseum created the ＂cognition center＂ instead of ＂informationcenter＂. Cognition center adds more values to the community, encourages the locals and audiences fromoutside to understand （not only learn from） Eco-community as a whole, emphasizing the living heritage,self-cognition and self-education. Graburn discussed this evolution was closer to the root of Eco.
