AIM: To investigate the prognostic and clinicopathological significance of glypican-3 (GPC3) overexpression in hepatocellular carcinoma (HCC). METHODS: Publications were searched using PubMed, EMBASE, the Cochrane Lib...AIM: To investigate the prognostic and clinicopathological significance of glypican-3 (GPC3) overexpression in hepatocellular carcinoma (HCC). METHODS: Publications were searched using PubMed, EMBASE, the Cochrane Library and the Chinese Biomedical Literature Database up to March 2013. Inclusion and exclusion criteria were established to screen eligible studies for meta-analysis. The hazard ratios (HRs) of the eligible studies were pooled using RevMan 5.2 software to evaluate the impact of GPC3 overexpression on overall survival (OS) and disease-free survival (DFS) in HCC patients. The correlation between GPC3 expression and clinicopathological parameters of HCC was also analyzed. RESULTS: A total of five studies with 493 patients were included in the meta-analysis. The combined HRs indicated that GPC3 overexpression can predict poor OS (n = 362 in 3 studies, HR = 2.18, 95%CI: 1.47-3.24, Z = 3.86, P = 0.0001) and DFS (n = 325 in 3 studies, HR = 2.05, 95%CI: 1.43-2.93, Z = 3.94, P < 0.0001) in HCC patients without heterogeneity. Egger's and Begg's tests were applied to detect publication bias, and the results showed that there was no evidence of publication bias detected in the OS studies (the P value for Egger's test was 0.216) or DFS studies (the P value for Egger's test was 0.488). The combined odds ratios (ORs) suggested that GPC3 expression tends to be associated with tumor vascular invasion (OR = 2.74, 95%CI: 1.15-6.52, P = 0.02), hepatic cirrhosis (OR = 2.10, 95%CI: 1.31-3.36, P = 0.002), poor tumor differentiation (OR = 0.22, 95%CI: 0.13-0.40, P < 0.00001) and advanced TNM stage (OR = 0.31, 95%CI: 0.18-0.51, P < 0.00001). CONCLUSION: From this study, we conclude that GPC3 overexpression tends to be associated with a poor prognosis (poor OS or DFS) in HCC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.展开更多
Objective: to explore the application value of personalized breastfeeding in children with severe pneumonia and febrile convulsion. Methods: severe pneumonia and febrile convulsion (n=100) treated in our hospital from...Objective: to explore the application value of personalized breastfeeding in children with severe pneumonia and febrile convulsion. Methods: severe pneumonia and febrile convulsion (n=100) treated in our hospital from January 2017 to January 2021 were analyzed. Combined with different treatment methods, 50 patients were included in the control group (routine nursing) and 50 patients in the observation group (personalized nursing). The application indicators of different interventions were compared. Results: After lactation, the treatment satisfaction of patients with severe pneumonia and febrile convulsion in the observation group (98.00%) was significantly higher than that in the control group (82.00%), P<0.05. The fever relief time, shock stop time and shock time in the observation group were shorter than those in the control group (P<0.05). In terms of complications, compared with the control group (18.00%), the incidence of complications in the observation group (2.00%) was lower (P<0.05). The quality of life score of observation group was higher than that of control group (P<0.05). The recurrence rate of epilepsy in observation group was lower than that in control group, but there was no significant difference between the two groups (P>0.05). There was no significant difference between the two groups before intervention (P>0.05). After intervention, the compliance score of observation group was higher than that of control group (P<0.05). Conclusion: severe pulmonary disease. During the treatment of inflammatory convulsions, personalized care can not only improve clinical symptoms, but also help reduce complications and improve quality of life. The family members are very satisfied with the nursing service, which greatly improves the nursing level and is worthy of clinical application.展开更多
Objective: to explore the clinical effect of Yangyin Qingyu Decoction on children with HSPN. Methods: 60 children with Henoch-Schonlein purpura nephritis diagnosed from 2017 to 2020 were selected and randomly divided ...Objective: to explore the clinical effect of Yangyin Qingyu Decoction on children with HSPN. Methods: 60 children with Henoch-Schonlein purpura nephritis diagnosed from 2017 to 2020 were selected and randomly divided into the control group and the research group according to the order of admission. Subsequently, the control group was treated with glucocorticoid. The study group used Yangyin Qingyu Decoction. Finally, the two groups of children's urine protein, urine red blood cells, urine occult blood and other indicators were compared. Results: urine protein, urine occult blood and urine red blood cells in the study group were significantly lower than those in the control group, and the effective rate was significantly higher than that in the control group, with statistical significance (P < 0.05). The TCM syndrome score of the children in the study group was lower than that of the control group, the difference was statistically significant (P < 0.05). Conclusion: using Yangyin Qingyu Decoction to treat the children with HSPN can reduce the urine protein, urine occult blood, urine red blood cells and TCM syndrome score of the children, and has better clinical curative effect and improves the quality of life of the children.展开更多
Purpose:To compare the differences in the clinical characteristics of multifocal choroiditis(MFC) and punctate inner choriodopathy(PIC).Methods:A cross-sectional study,consisting of 22 cases(37 eyes) with MFC and 11 c...Purpose:To compare the differences in the clinical characteristics of multifocal choroiditis(MFC) and punctate inner choriodopathy(PIC).Methods:A cross-sectional study,consisting of 22 cases(37 eyes) with MFC and 11 cases(18 eyes) with PIC,was carried out.Multiple indexes were measured and analysed to compare the differences in clinical characteristics of the subjects between two groups,including BCVA,avergae age,sex composition,presence of intraocular inflammation,choroidal neovascularization(CNV),and intraocular inflammation complications,such as cataract,cystoid macular edema(CME) and epiretinal membrane(ERM).Results:The avergae age of the MFC and PIC patients were(48.1±13.9) years and(32.1±10.2) years with a significant difference(P=0.043).CNV occurred more frequently in patients with PIC(PIC,55.6%;MFC,21.6%;P=0.016) compared with those with MFC.MFC patients had a higher frequency of intraocular inflammation complications,such as,cataract(27.0%),CME(35.1%),ERM(5.4%).PIC patients presented none of these complications.MFC subjects presented with more visual impairments than PIC patients.Totally 51.4% of MFC patients had visual impairments and 22.2% of PIC patients had BCVA < 0.3(P=0.047).Conclusion:Both MFC and PIC are categorized into the umbrella term of "white spot syndromes".Although sharing similar ocular expressions,they present with different clinical characteristics.Patients with PIC had a higher frequency of CNV but a lower frequency of structural complications caused by intraocular inflammation and lower frequency of visual impairments compared with MFC counterparts.展开更多
文摘AIM: To investigate the prognostic and clinicopathological significance of glypican-3 (GPC3) overexpression in hepatocellular carcinoma (HCC). METHODS: Publications were searched using PubMed, EMBASE, the Cochrane Library and the Chinese Biomedical Literature Database up to March 2013. Inclusion and exclusion criteria were established to screen eligible studies for meta-analysis. The hazard ratios (HRs) of the eligible studies were pooled using RevMan 5.2 software to evaluate the impact of GPC3 overexpression on overall survival (OS) and disease-free survival (DFS) in HCC patients. The correlation between GPC3 expression and clinicopathological parameters of HCC was also analyzed. RESULTS: A total of five studies with 493 patients were included in the meta-analysis. The combined HRs indicated that GPC3 overexpression can predict poor OS (n = 362 in 3 studies, HR = 2.18, 95%CI: 1.47-3.24, Z = 3.86, P = 0.0001) and DFS (n = 325 in 3 studies, HR = 2.05, 95%CI: 1.43-2.93, Z = 3.94, P < 0.0001) in HCC patients without heterogeneity. Egger's and Begg's tests were applied to detect publication bias, and the results showed that there was no evidence of publication bias detected in the OS studies (the P value for Egger's test was 0.216) or DFS studies (the P value for Egger's test was 0.488). The combined odds ratios (ORs) suggested that GPC3 expression tends to be associated with tumor vascular invasion (OR = 2.74, 95%CI: 1.15-6.52, P = 0.02), hepatic cirrhosis (OR = 2.10, 95%CI: 1.31-3.36, P = 0.002), poor tumor differentiation (OR = 0.22, 95%CI: 0.13-0.40, P < 0.00001) and advanced TNM stage (OR = 0.31, 95%CI: 0.18-0.51, P < 0.00001). CONCLUSION: From this study, we conclude that GPC3 overexpression tends to be associated with a poor prognosis (poor OS or DFS) in HCC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
文摘Objective: to explore the application value of personalized breastfeeding in children with severe pneumonia and febrile convulsion. Methods: severe pneumonia and febrile convulsion (n=100) treated in our hospital from January 2017 to January 2021 were analyzed. Combined with different treatment methods, 50 patients were included in the control group (routine nursing) and 50 patients in the observation group (personalized nursing). The application indicators of different interventions were compared. Results: After lactation, the treatment satisfaction of patients with severe pneumonia and febrile convulsion in the observation group (98.00%) was significantly higher than that in the control group (82.00%), P<0.05. The fever relief time, shock stop time and shock time in the observation group were shorter than those in the control group (P<0.05). In terms of complications, compared with the control group (18.00%), the incidence of complications in the observation group (2.00%) was lower (P<0.05). The quality of life score of observation group was higher than that of control group (P<0.05). The recurrence rate of epilepsy in observation group was lower than that in control group, but there was no significant difference between the two groups (P>0.05). There was no significant difference between the two groups before intervention (P>0.05). After intervention, the compliance score of observation group was higher than that of control group (P<0.05). Conclusion: severe pulmonary disease. During the treatment of inflammatory convulsions, personalized care can not only improve clinical symptoms, but also help reduce complications and improve quality of life. The family members are very satisfied with the nursing service, which greatly improves the nursing level and is worthy of clinical application.
文摘Objective: to explore the clinical effect of Yangyin Qingyu Decoction on children with HSPN. Methods: 60 children with Henoch-Schonlein purpura nephritis diagnosed from 2017 to 2020 were selected and randomly divided into the control group and the research group according to the order of admission. Subsequently, the control group was treated with glucocorticoid. The study group used Yangyin Qingyu Decoction. Finally, the two groups of children's urine protein, urine red blood cells, urine occult blood and other indicators were compared. Results: urine protein, urine occult blood and urine red blood cells in the study group were significantly lower than those in the control group, and the effective rate was significantly higher than that in the control group, with statistical significance (P < 0.05). The TCM syndrome score of the children in the study group was lower than that of the control group, the difference was statistically significant (P < 0.05). Conclusion: using Yangyin Qingyu Decoction to treat the children with HSPN can reduce the urine protein, urine occult blood, urine red blood cells and TCM syndrome score of the children, and has better clinical curative effect and improves the quality of life of the children.
文摘Purpose:To compare the differences in the clinical characteristics of multifocal choroiditis(MFC) and punctate inner choriodopathy(PIC).Methods:A cross-sectional study,consisting of 22 cases(37 eyes) with MFC and 11 cases(18 eyes) with PIC,was carried out.Multiple indexes were measured and analysed to compare the differences in clinical characteristics of the subjects between two groups,including BCVA,avergae age,sex composition,presence of intraocular inflammation,choroidal neovascularization(CNV),and intraocular inflammation complications,such as cataract,cystoid macular edema(CME) and epiretinal membrane(ERM).Results:The avergae age of the MFC and PIC patients were(48.1±13.9) years and(32.1±10.2) years with a significant difference(P=0.043).CNV occurred more frequently in patients with PIC(PIC,55.6%;MFC,21.6%;P=0.016) compared with those with MFC.MFC patients had a higher frequency of intraocular inflammation complications,such as,cataract(27.0%),CME(35.1%),ERM(5.4%).PIC patients presented none of these complications.MFC subjects presented with more visual impairments than PIC patients.Totally 51.4% of MFC patients had visual impairments and 22.2% of PIC patients had BCVA < 0.3(P=0.047).Conclusion:Both MFC and PIC are categorized into the umbrella term of "white spot syndromes".Although sharing similar ocular expressions,they present with different clinical characteristics.Patients with PIC had a higher frequency of CNV but a lower frequency of structural complications caused by intraocular inflammation and lower frequency of visual impairments compared with MFC counterparts.
