Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system ...Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system of China as an example,we evaluated inequality in the public health workforce distribution across different regions in China between 2008 and 2017,with the aim of providing information for policymakers to support resource allocation and address growing health inequities.Methods We used three standard public health workforce inequality indices-Gini coefficient,Theil L,and Theil T-and spatial autocorrelation analysis to explore spatial clusters of the workforce in different provinces,visualized with geographical tools.Results The aggregate workforce-to-population ratio decreased from 1.47 to 1.42 per 10,000 population from 2008 to 2017,and was consistently lower than the National Health Commission’s(NHC)recommended critical shortage threshold of 1.75.The workforce distribution inequality indices varied by regional socioeconomic and health system development.Geographic clustering of CDCs workforce distribution was evident,with H–H and L–L clusters in western China and the Guangdong-Fujian region,respectively.Conclusions Our study addressed key issues for government and policymakers in allocation of public health human resources.There is an urgent need for careful identification of analytic questions that will help carry out public health functions in the new era,alongside policy implications for an equitable distribution of the public health workforce focusing on the western region and low–low cluster areas.展开更多
In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mi...In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mimicked the mechanical properties of myocardium in both directions.Cardiosphere-derived cells(CDCs) were seeded on these PLA patch fabrics,and using scanning electron microscopy(SEM) characterization and an MTT assay the cells proliferated and attached successfully to the PLA fabrics.Based on the results,the rib stitch structure is the most promising candidate for fabricating cardiac patches due to its high elasticity and its ability to promote cell proliferation.展开更多
1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025...1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025年美国成年人免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。展开更多
1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展...1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展服务。2025年美国儿童和青少年免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。展开更多
针对监测抽水蓄能电站发电电动机运行数据存在冗余问题,致使存储数据延迟时间长,提出基于区块链的抽水蓄能电站发电电动机运行监测数据存储方法,通过存储数据身份验证维护存储数据安全。数据层运用数据采集平台获取抽水蓄能电站发电电...针对监测抽水蓄能电站发电电动机运行数据存在冗余问题,致使存储数据延迟时间长,提出基于区块链的抽水蓄能电站发电电动机运行监测数据存储方法,通过存储数据身份验证维护存储数据安全。数据层运用数据采集平台获取抽水蓄能电站发电电动机运行监测数据,采用变更数据捕获(change data capture,CDC)算法消除采集数据冗余,并通过发送终端将消冗后数据传输至分布式存储层;分布式存储层的区块链按时间戳的顺序确定数据区块的存储顺序,通过身份注册验证待上传的数据身份;分布式存储数据库采用HBase技术对通过身份验证数据进行多维排序映射存储;通过应用层客户端展示存储结果并提供数据共享服务。实验结果表明:该方法的数据消冗效果较好,可实现电动机运行监测数据存储,且存储数据延迟时间短,上传数据时的身份注册开销比较稳定,可保障存储数据安全。展开更多
BACKGROUND Chronic kidney disease(CKD)is a major independent stroke risk factor.This study characterizes 22-year national trends and disparities in stroke mortality among United States adults with CKD.AIM To evaluate ...BACKGROUND Chronic kidney disease(CKD)is a major independent stroke risk factor.This study characterizes 22-year national trends and disparities in stroke mortality among United States adults with CKD.AIM To evaluate 22-year national trends and demographic disparities in stroke mortality among United States adults with CKD to inform targeted strategies for reducing cerebrovascular risk in this vulnerable population.METHODS Using Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause-of-Death data(1999-2020),we analyzed stroke deaths(underlying cause)with CKD(contributing cause)among adults≥25 years.Age-adjusted mortality rates per 100000 population were calculated.Joinpoint regression estimated annual percentage changes(APCs)and average APCs with 95%confidence intervals,stratified by sex,race/ethnicity,region,and urbanization.RESULTS Among 37308 stroke deaths with CKD,the overall age-adjusted stroke mortality rates(AAMR)declined from 1.08(95%CI:1.03-1.13)in 1999 to 0.71(95%CI:0.68-0.75)in 2020(average annual percent change:-1.79%).Significant trends included a decline from 1999-2009(APC:-4.25%),followed by an increase from 2009-2012(APC:23.25%),a sharp decline from 2012-2015(APC:-28.10%),and another increase from 2015-2020(APC:8.72%).Males had higher mortality than females(AAMR 0.79 vs 0.71).Non-Hispanic Black individuals had the highest AAMR(1.95),followed by Hispanic(0.87)and Non-Hispanic White individuals(0.63).Regionally,the West had the highest AAMR(0.89).State-level mortality varied more than three-fold(District of Columbia:1.27 vs Arizona:0.38).Small metropolitan areas had the highest urbanization-stratified AAMR.CONCLUSION While stroke mortality among United States adults with CKD significantly declined over two decades,reflecting improvements in prevention and management,substantial disparities persist.The findings underscore the critical need for targeted public health interventions to address underlying biological,structural,and systemic determinants of cerebrovascular risk in this vulnerable population.展开更多
Background:Lung adenocarcinoma,the most prevalent lung cancer subtype,is increasingly diagnosed in non-smokers and females.The cell cycle regulator CDC20(Cell Division Cycle 20),a crucial activator of the Anaphase-Pro...Background:Lung adenocarcinoma,the most prevalent lung cancer subtype,is increasingly diagnosed in non-smokers and females.The cell cycle regulator CDC20(Cell Division Cycle 20),a crucial activator of the Anaphase-Promoting Complex/Cyclosome(APC/C),is frequently overexpressed in various cancers,including lung adenocarcinoma,and is implicated in tumorigenesis.Preclinical studies indicate that inhibiting the CDC20-APC/C signaling axis can enhance chemotherapy-induced apoptosis.Analysis of The Cancer Genome Atlas(TCGA)data confirms that elevated CDC20 expression in lung adenocarcinoma is significantly associated with poorer patient prognosis and correlates with immune cell infiltration.These collective findings highlight CDC20 as a promising prognostic biomarker and a potential novel therapeutic target for lung adenocarcinoma.Methods:We collected 539 patients with LUAD and 59 normal controls of clinical data from the Cancer Genome Atlas(TCGA)for bioinformatics analysis to investigate the role of CDC20 in LUAD and address the above questions.We evaluated the association between CDC20 expression and clinicopathological features using the Kruskal Wallis test and multivariate logistic regression.Prognostic values were assessed using Cox regression and Kaplan-Meier survival analyses.We further used single-sample gene set enrichment analysis(ssGSEA)to explore correlations between CDC20 expression and immune infiltration levels.Results:CDC20 expression in LUAD tissues was significantly higher than that in normal controls(p<0.001)and showed high diagnostic accuracy(AUC[area under the curve]=0.979).Kaplan-Meier analysis revealed that high CDC20 expression predicted poorer overall survival(OS;HR=1.47,95%CI:1.10–1.97,p=0.009),although no significant association emerged with progression-free interval(p=0.172).ssGSEA indicated a strong positive correlation between CDC20 and T helper 2 cell infiltration(R=0.764,p<0.001),but negative correlations with mast cells(R=−0.469,p<0.001)and eosinophils(R=−0.343,p<0.001).Functional enrichment analyses(Gene ontology/Kyoto Encyclopedia of Genes and Genomes[GO/KEGG])of CDC20-associated genes provided additional mechanistic insights.Conclusions:The significantly elevated expression of CDC20 in LUAD tissues,coupled with its high diagnostic accuracy(AUC=0.979),underscores its potential utility in differentiating LUAD from normal tissue.More importantly,the strong association between high CDC20 expression and poorer overall survival(OS)establishes its independent prognostic value for predicting adverse patient outcomes.Beyond its correlation with clinical parameters,our findings illuminate potential mechanisms underlying CDC20's oncogenic role.The distinct positive correlation with T helper 2(Th2)cell infiltration and negative correlations with mast cells and eosinophils suggest that CDC20 may actively shape an immunosuppressive tumor microenvironment,potentially facilitating tumor immune evasion and progression.Functional enrichment analyses of CDC20-coexpressed genes further support its involvement in key oncogenic pathways,including cell cycle regulation and mitotic processes.Collectively,this study not only validates CDC20 as a valuable prognostic factor but also provides novel mechanistic insights linking its overexpression to altered immune landscapes in LUAD.展开更多
基金funded by China CDC’s Public Health and Emergency Response Mechanism Programme[131031001000150001]。
文摘Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system of China as an example,we evaluated inequality in the public health workforce distribution across different regions in China between 2008 and 2017,with the aim of providing information for policymakers to support resource allocation and address growing health inequities.Methods We used three standard public health workforce inequality indices-Gini coefficient,Theil L,and Theil T-and spatial autocorrelation analysis to explore spatial clusters of the workforce in different provinces,visualized with geographical tools.Results The aggregate workforce-to-population ratio decreased from 1.47 to 1.42 per 10,000 population from 2008 to 2017,and was consistently lower than the National Health Commission’s(NHC)recommended critical shortage threshold of 1.75.The workforce distribution inequality indices varied by regional socioeconomic and health system development.Geographic clustering of CDCs workforce distribution was evident,with H–H and L–L clusters in western China and the Guangdong-Fujian region,respectively.Conclusions Our study addressed key issues for government and policymakers in allocation of public health human resources.There is an urgent need for careful identification of analytic questions that will help carry out public health functions in the new era,alongside policy implications for an equitable distribution of the public health workforce focusing on the western region and low–low cluster areas.
基金the College of Textiles,North Carolina State University,Raleigh,USA“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024)
文摘In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mimicked the mechanical properties of myocardium in both directions.Cardiosphere-derived cells(CDCs) were seeded on these PLA patch fabrics,and using scanning electron microscopy(SEM) characterization and an MTT assay the cells proliferated and attached successfully to the PLA fabrics.Based on the results,the rib stitch structure is the most promising candidate for fabricating cardiac patches due to its high elasticity and its ability to promote cell proliferation.
文摘1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025年美国成年人免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。
文摘1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展服务。2025年美国儿童和青少年免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。
文摘针对监测抽水蓄能电站发电电动机运行数据存在冗余问题,致使存储数据延迟时间长,提出基于区块链的抽水蓄能电站发电电动机运行监测数据存储方法,通过存储数据身份验证维护存储数据安全。数据层运用数据采集平台获取抽水蓄能电站发电电动机运行监测数据,采用变更数据捕获(change data capture,CDC)算法消除采集数据冗余,并通过发送终端将消冗后数据传输至分布式存储层;分布式存储层的区块链按时间戳的顺序确定数据区块的存储顺序,通过身份注册验证待上传的数据身份;分布式存储数据库采用HBase技术对通过身份验证数据进行多维排序映射存储;通过应用层客户端展示存储结果并提供数据共享服务。实验结果表明:该方法的数据消冗效果较好,可实现电动机运行监测数据存储,且存储数据延迟时间短,上传数据时的身份注册开销比较稳定,可保障存储数据安全。
文摘BACKGROUND Chronic kidney disease(CKD)is a major independent stroke risk factor.This study characterizes 22-year national trends and disparities in stroke mortality among United States adults with CKD.AIM To evaluate 22-year national trends and demographic disparities in stroke mortality among United States adults with CKD to inform targeted strategies for reducing cerebrovascular risk in this vulnerable population.METHODS Using Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause-of-Death data(1999-2020),we analyzed stroke deaths(underlying cause)with CKD(contributing cause)among adults≥25 years.Age-adjusted mortality rates per 100000 population were calculated.Joinpoint regression estimated annual percentage changes(APCs)and average APCs with 95%confidence intervals,stratified by sex,race/ethnicity,region,and urbanization.RESULTS Among 37308 stroke deaths with CKD,the overall age-adjusted stroke mortality rates(AAMR)declined from 1.08(95%CI:1.03-1.13)in 1999 to 0.71(95%CI:0.68-0.75)in 2020(average annual percent change:-1.79%).Significant trends included a decline from 1999-2009(APC:-4.25%),followed by an increase from 2009-2012(APC:23.25%),a sharp decline from 2012-2015(APC:-28.10%),and another increase from 2015-2020(APC:8.72%).Males had higher mortality than females(AAMR 0.79 vs 0.71).Non-Hispanic Black individuals had the highest AAMR(1.95),followed by Hispanic(0.87)and Non-Hispanic White individuals(0.63).Regionally,the West had the highest AAMR(0.89).State-level mortality varied more than three-fold(District of Columbia:1.27 vs Arizona:0.38).Small metropolitan areas had the highest urbanization-stratified AAMR.CONCLUSION While stroke mortality among United States adults with CKD significantly declined over two decades,reflecting improvements in prevention and management,substantial disparities persist.The findings underscore the critical need for targeted public health interventions to address underlying biological,structural,and systemic determinants of cerebrovascular risk in this vulnerable population.
基金funded by the Liaoning Province Science and Technology Plan Joint Project(No.2023JH2/101700140).The funder had no role in the design of the studyin the collection,analyses,or interpretation of data+1 种基金in the writing of the manuscriptor in the decision to publish the results.
文摘Background:Lung adenocarcinoma,the most prevalent lung cancer subtype,is increasingly diagnosed in non-smokers and females.The cell cycle regulator CDC20(Cell Division Cycle 20),a crucial activator of the Anaphase-Promoting Complex/Cyclosome(APC/C),is frequently overexpressed in various cancers,including lung adenocarcinoma,and is implicated in tumorigenesis.Preclinical studies indicate that inhibiting the CDC20-APC/C signaling axis can enhance chemotherapy-induced apoptosis.Analysis of The Cancer Genome Atlas(TCGA)data confirms that elevated CDC20 expression in lung adenocarcinoma is significantly associated with poorer patient prognosis and correlates with immune cell infiltration.These collective findings highlight CDC20 as a promising prognostic biomarker and a potential novel therapeutic target for lung adenocarcinoma.Methods:We collected 539 patients with LUAD and 59 normal controls of clinical data from the Cancer Genome Atlas(TCGA)for bioinformatics analysis to investigate the role of CDC20 in LUAD and address the above questions.We evaluated the association between CDC20 expression and clinicopathological features using the Kruskal Wallis test and multivariate logistic regression.Prognostic values were assessed using Cox regression and Kaplan-Meier survival analyses.We further used single-sample gene set enrichment analysis(ssGSEA)to explore correlations between CDC20 expression and immune infiltration levels.Results:CDC20 expression in LUAD tissues was significantly higher than that in normal controls(p<0.001)and showed high diagnostic accuracy(AUC[area under the curve]=0.979).Kaplan-Meier analysis revealed that high CDC20 expression predicted poorer overall survival(OS;HR=1.47,95%CI:1.10–1.97,p=0.009),although no significant association emerged with progression-free interval(p=0.172).ssGSEA indicated a strong positive correlation between CDC20 and T helper 2 cell infiltration(R=0.764,p<0.001),but negative correlations with mast cells(R=−0.469,p<0.001)and eosinophils(R=−0.343,p<0.001).Functional enrichment analyses(Gene ontology/Kyoto Encyclopedia of Genes and Genomes[GO/KEGG])of CDC20-associated genes provided additional mechanistic insights.Conclusions:The significantly elevated expression of CDC20 in LUAD tissues,coupled with its high diagnostic accuracy(AUC=0.979),underscores its potential utility in differentiating LUAD from normal tissue.More importantly,the strong association between high CDC20 expression and poorer overall survival(OS)establishes its independent prognostic value for predicting adverse patient outcomes.Beyond its correlation with clinical parameters,our findings illuminate potential mechanisms underlying CDC20's oncogenic role.The distinct positive correlation with T helper 2(Th2)cell infiltration and negative correlations with mast cells and eosinophils suggest that CDC20 may actively shape an immunosuppressive tumor microenvironment,potentially facilitating tumor immune evasion and progression.Functional enrichment analyses of CDC20-coexpressed genes further support its involvement in key oncogenic pathways,including cell cycle regulation and mitotic processes.Collectively,this study not only validates CDC20 as a valuable prognostic factor but also provides novel mechanistic insights linking its overexpression to altered immune landscapes in LUAD.
