Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system ...Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system of China as an example,we evaluated inequality in the public health workforce distribution across different regions in China between 2008 and 2017,with the aim of providing information for policymakers to support resource allocation and address growing health inequities.Methods We used three standard public health workforce inequality indices-Gini coefficient,Theil L,and Theil T-and spatial autocorrelation analysis to explore spatial clusters of the workforce in different provinces,visualized with geographical tools.Results The aggregate workforce-to-population ratio decreased from 1.47 to 1.42 per 10,000 population from 2008 to 2017,and was consistently lower than the National Health Commission’s(NHC)recommended critical shortage threshold of 1.75.The workforce distribution inequality indices varied by regional socioeconomic and health system development.Geographic clustering of CDCs workforce distribution was evident,with H–H and L–L clusters in western China and the Guangdong-Fujian region,respectively.Conclusions Our study addressed key issues for government and policymakers in allocation of public health human resources.There is an urgent need for careful identification of analytic questions that will help carry out public health functions in the new era,alongside policy implications for an equitable distribution of the public health workforce focusing on the western region and low–low cluster areas.展开更多
In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mi...In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mimicked the mechanical properties of myocardium in both directions.Cardiosphere-derived cells(CDCs) were seeded on these PLA patch fabrics,and using scanning electron microscopy(SEM) characterization and an MTT assay the cells proliferated and attached successfully to the PLA fabrics.Based on the results,the rib stitch structure is the most promising candidate for fabricating cardiac patches due to its high elasticity and its ability to promote cell proliferation.展开更多
目的探究CDC40在结直肠癌组织中的表达特征及其与临床病理特征的相关性,为结直肠癌的早期诊断、靶向治疗及预后评估提供依据。方法采用免疫组织化学染色评估70例结直肠癌患者组织中CDC40表达水平,并分析其与临床病理特征关系;运用R软件...目的探究CDC40在结直肠癌组织中的表达特征及其与临床病理特征的相关性,为结直肠癌的早期诊断、靶向治疗及预后评估提供依据。方法采用免疫组织化学染色评估70例结直肠癌患者组织中CDC40表达水平,并分析其与临床病理特征关系;运用R软件包进行生存曲线和多因素预后分析;使用结直肠癌细胞系SW620和Caco-2进行细胞培养、CDC40质粒转染、细胞增殖实验、蛋白质印迹及裸鼠成瘤实验,以验证CDC40对细胞增殖的影响,实验数据采用IBM SPSS Statistics Version 22软件进行统计分析。结果70例患者中CDC40高表达组占51.4%,其表达高低与肿瘤分化程度、T分期、淋巴结转移及增殖指数Ki67水平相关,与性别、年龄、远处转移无关;多因素和单因素生存分析显示CDC40高表达与患者更差的生存预后相关;体外实验中过表达CDC40促进结直肠癌细胞系增殖;裸鼠成瘤实验表明过表达CDC40促进肿瘤生长。结论CDC40在结直肠癌发生发展中起重要作用,可作为潜在分子标志物和治疗靶点。展开更多
1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025...1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025年美国成年人免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。展开更多
1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展...1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展服务。2025年美国儿童和青少年免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。展开更多
说起新闻学,在信息化高度发达的今天,为了获得受众关注,其用一些夸张或是带有感情色彩的词汇本无可厚非,新闻稿件作者本人的情感体现其中也属正常。国人,特别是科研人员对于《Science》、《Nature》等顶级期刊学术影响力的认可,使得我...说起新闻学,在信息化高度发达的今天,为了获得受众关注,其用一些夸张或是带有感情色彩的词汇本无可厚非,新闻稿件作者本人的情感体现其中也属正常。国人,特别是科研人员对于《Science》、《Nature》等顶级期刊学术影响力的认可,使得我们对《Science》在线新闻提供的信息格外关注。2025年11月21日《Science》以在线新闻的形式提供了这样一个报道“Exclusive:CDC to end all monkey research”,副标题为“Studies related to HIV and other infectious diseases will be phased out,sources say;fate of the agency’s animals remains unclear”,作者是《Science》杂志的在线新闻编辑大卫·格里姆[1]。展开更多
基金funded by China CDC’s Public Health and Emergency Response Mechanism Programme[131031001000150001]。
文摘Objective Allocation of human resources to address inequalities in the public health system has increasingly attracted societal and political attention.Using the Centers for Disease Control and Prevention(CDCs)system of China as an example,we evaluated inequality in the public health workforce distribution across different regions in China between 2008 and 2017,with the aim of providing information for policymakers to support resource allocation and address growing health inequities.Methods We used three standard public health workforce inequality indices-Gini coefficient,Theil L,and Theil T-and spatial autocorrelation analysis to explore spatial clusters of the workforce in different provinces,visualized with geographical tools.Results The aggregate workforce-to-population ratio decreased from 1.47 to 1.42 per 10,000 population from 2008 to 2017,and was consistently lower than the National Health Commission’s(NHC)recommended critical shortage threshold of 1.75.The workforce distribution inequality indices varied by regional socioeconomic and health system development.Geographic clustering of CDCs workforce distribution was evident,with H–H and L–L clusters in western China and the Guangdong-Fujian region,respectively.Conclusions Our study addressed key issues for government and policymakers in allocation of public health human resources.There is an urgent need for careful identification of analytic questions that will help carry out public health functions in the new era,alongside policy implications for an equitable distribution of the public health workforce focusing on the western region and low–low cluster areas.
基金the College of Textiles,North Carolina State University,Raleigh,USA“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024)
文摘In order to regenerate myocardium and provide appropriate mechanical support after a heart attack,jersey,tuck and rib stitch structures were knitted from polylactic acid(PLA)yarns to fabricate a cardiac patch,which mimicked the mechanical properties of myocardium in both directions.Cardiosphere-derived cells(CDCs) were seeded on these PLA patch fabrics,and using scanning electron microscopy(SEM) characterization and an MTT assay the cells proliferated and attached successfully to the PLA fabrics.Based on the results,the rib stitch structure is the most promising candidate for fabricating cardiac patches due to its high elasticity and its ability to promote cell proliferation.
文摘目的探究CDC40在结直肠癌组织中的表达特征及其与临床病理特征的相关性,为结直肠癌的早期诊断、靶向治疗及预后评估提供依据。方法采用免疫组织化学染色评估70例结直肠癌患者组织中CDC40表达水平,并分析其与临床病理特征关系;运用R软件包进行生存曲线和多因素预后分析;使用结直肠癌细胞系SW620和Caco-2进行细胞培养、CDC40质粒转染、细胞增殖实验、蛋白质印迹及裸鼠成瘤实验,以验证CDC40对细胞增殖的影响,实验数据采用IBM SPSS Statistics Version 22软件进行统计分析。结果70例患者中CDC40高表达组占51.4%,其表达高低与肿瘤分化程度、T分期、淋巴结转移及增殖指数Ki67水平相关,与性别、年龄、远处转移无关;多因素和单因素生存分析显示CDC40高表达与患者更差的生存预后相关;体外实验中过表达CDC40促进结直肠癌细胞系增殖;裸鼠成瘤实验表明过表达CDC40促进肿瘤生长。结论CDC40在结直肠癌发生发展中起重要作用,可作为潜在分子标志物和治疗靶点。
文摘1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≥19岁成年人推荐免疫接种程序。2025年免疫接种程序更新部分内容,建议按照新免疫程序和人群实际情况开展规范服务。2025年美国成年人免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。
文摘1背景2024年10月,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)批准了2025年美国≤18岁儿童和青少年的推荐免疫接种程序。2025年免疫接种程序更新了部分内容,建议按照新免疫程序和人群实际情况规范开展服务。2025年美国儿童和青少年免疫接种程序由ACIP推荐并得到美国疾病预防控制中心(Center for disease prevention and control,CDC)、美国儿科学会、美国家庭医师学会、美国妇产科医师学会、美国护士助产士学院、美国医师学会和美国儿科执业护士协会同意。
文摘说起新闻学,在信息化高度发达的今天,为了获得受众关注,其用一些夸张或是带有感情色彩的词汇本无可厚非,新闻稿件作者本人的情感体现其中也属正常。国人,特别是科研人员对于《Science》、《Nature》等顶级期刊学术影响力的认可,使得我们对《Science》在线新闻提供的信息格外关注。2025年11月21日《Science》以在线新闻的形式提供了这样一个报道“Exclusive:CDC to end all monkey research”,副标题为“Studies related to HIV and other infectious diseases will be phased out,sources say;fate of the agency’s animals remains unclear”,作者是《Science》杂志的在线新闻编辑大卫·格里姆[1]。
