Chronic social defeat stress induces diverse effects in mice of different strains and even in animals of the same strain. This paper aims to study the effect of repeated social defeats and, for contrast, repeated aggr...Chronic social defeat stress induces diverse effects in mice of different strains and even in animals of the same strain. This paper aims to study the effect of repeated social defeats and, for contrast, repeated aggression in daily agonistic interactions on the behaviors of CD-1 male mice. The behavior of animals that have the same winning and losing track record during 3, 10, 21 days is studied in different tests. The level of aggressiveness, as estimated by the number and total time of attacks, decreases;nevertheless, direct and indirect forms of aggression demonstrated by the aggressive mice (winners) remain significantly high. The number of stereotypic behaviors (rotations and jumps) and total time of digging behaviors are significantly increased in the winners after 21 days compared to 3 and 10 days of intermale confrontations. Among the losers, chronic experience of social defeats is accompanied by the development of pronounced anxiety and a depression-like state estimated by the elevated plus-maze and the Porsolt test scores, respectively. Both groups of male mice with alternative social behaviors demonstrate abnormal locomotor and exploratory behaviors in the open-field test. This phenomenon may be viewed as hyperactivity developed under chronic agonistic interactions and specific for the outbred CD-1 mice. We believe that these animals may be potentially used for modeling the key symptoms of bipolar disorder.展开更多
On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present stud...On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present study examined spatial encoding and retrieval in male CD-1 mice at 4, 9, and 12 months of age in a complex dry-land maze. The total time to reach the goal zone was age-dependent favoring mice at 4 months of age. We showed previously that moving time represents encoding of spatial information and resting time represents recall of previously learned spatial information. The average moving time decreased from 69.8 ± 5.3 s (mean ± SEM), 69.7 ± 8.0 s, and 78.9 ± 4.9 s to 17.0 ± 2.3 s (p < 0.001 ), 24.7 ± 2.7 s (p < 0.001), and 31.0 ± 3.5 s (p < 0.001) at 4, 9, and 12 months of age, respectively. The average resting time decreased from 34.9 ± 5.6 s, 22.2 ± 4.2 s, and 41.7 ± 5.3 s to 3.6 ± 1.2 s (p < 0.001), 5.3 ± 1.8 s (p = 0.009), and 22.7 ± 4.9 s (p = 0.007) at 4, 9, and 12 months of age, respectively. We conclude that age-related deficits of spatial memory in mice manifest with an encoding deficit prior to a retrieval deficit.展开更多
Prior to the installation of the Cd-liner in one of the large outer irradiation channels of NIRR-1, a Monte Carlo simulation was performed using MCNP5 version 1.4 code. This was done to investigate the effect of insta...Prior to the installation of the Cd-liner in one of the large outer irradiation channels of NIRR-1, a Monte Carlo simulation was performed using MCNP5 version 1.4 code. This was done to investigate the effect of installation of Cd-liner in either an inner or outer irradiation channel on reactor physics parameters. Data obtained indicate that the core excess reactivity in both inner and outer irradiations channels is reduced by 3.60 ± 0.07 mk and 0.64 ± 0.06 mk, respectively. Considering the fact that NIRR-1 has a cold core excess reactivity of 3.77 mk, results obtained show that installation of the 1 mm thick Cd-sheet in one of the large outer irradiation channels would have no significant impact on the core physics data. After installation of a 1 mm Cd sheath in a large outer irradiation channel, the neutron flux distribution and the stability in the irradiation channels were monitored by foil activation method. Results indicate that the uniformity of neutron flux distribution in the irradiation channel is preserved and the neutron flux data were found to be comparable with the data obtained before the installation.展开更多
We present the first evidence for the binarity of four targets in the TESS field.The temperatures are estimated by SED analysis and the orbital periods are determined.The TESS light curves of the systems are analyzed ...We present the first evidence for the binarity of four targets in the TESS field.The temperatures are estimated by SED analysis and the orbital periods are determined.The TESS light curves of the systems are analyzed and the orbital and the absolute parameters are derived.The targets are also compared to wellstudied binary systems with the same morphological type and their evolutionary states are discussed.Our results indicate that the stars belong to the class of eclipsing detached binary systems.展开更多
文摘Chronic social defeat stress induces diverse effects in mice of different strains and even in animals of the same strain. This paper aims to study the effect of repeated social defeats and, for contrast, repeated aggression in daily agonistic interactions on the behaviors of CD-1 male mice. The behavior of animals that have the same winning and losing track record during 3, 10, 21 days is studied in different tests. The level of aggressiveness, as estimated by the number and total time of attacks, decreases;nevertheless, direct and indirect forms of aggression demonstrated by the aggressive mice (winners) remain significantly high. The number of stereotypic behaviors (rotations and jumps) and total time of digging behaviors are significantly increased in the winners after 21 days compared to 3 and 10 days of intermale confrontations. Among the losers, chronic experience of social defeats is accompanied by the development of pronounced anxiety and a depression-like state estimated by the elevated plus-maze and the Porsolt test scores, respectively. Both groups of male mice with alternative social behaviors demonstrate abnormal locomotor and exploratory behaviors in the open-field test. This phenomenon may be viewed as hyperactivity developed under chronic agonistic interactions and specific for the outbred CD-1 mice. We believe that these animals may be potentially used for modeling the key symptoms of bipolar disorder.
文摘On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present study examined spatial encoding and retrieval in male CD-1 mice at 4, 9, and 12 months of age in a complex dry-land maze. The total time to reach the goal zone was age-dependent favoring mice at 4 months of age. We showed previously that moving time represents encoding of spatial information and resting time represents recall of previously learned spatial information. The average moving time decreased from 69.8 ± 5.3 s (mean ± SEM), 69.7 ± 8.0 s, and 78.9 ± 4.9 s to 17.0 ± 2.3 s (p < 0.001 ), 24.7 ± 2.7 s (p < 0.001), and 31.0 ± 3.5 s (p < 0.001) at 4, 9, and 12 months of age, respectively. The average resting time decreased from 34.9 ± 5.6 s, 22.2 ± 4.2 s, and 41.7 ± 5.3 s to 3.6 ± 1.2 s (p < 0.001), 5.3 ± 1.8 s (p = 0.009), and 22.7 ± 4.9 s (p = 0.007) at 4, 9, and 12 months of age, respectively. We conclude that age-related deficits of spatial memory in mice manifest with an encoding deficit prior to a retrieval deficit.
文摘Prior to the installation of the Cd-liner in one of the large outer irradiation channels of NIRR-1, a Monte Carlo simulation was performed using MCNP5 version 1.4 code. This was done to investigate the effect of installation of Cd-liner in either an inner or outer irradiation channel on reactor physics parameters. Data obtained indicate that the core excess reactivity in both inner and outer irradiations channels is reduced by 3.60 ± 0.07 mk and 0.64 ± 0.06 mk, respectively. Considering the fact that NIRR-1 has a cold core excess reactivity of 3.77 mk, results obtained show that installation of the 1 mm thick Cd-sheet in one of the large outer irradiation channels would have no significant impact on the core physics data. After installation of a 1 mm Cd sheath in a large outer irradiation channel, the neutron flux distribution and the stability in the irradiation channels were monitored by foil activation method. Results indicate that the uniformity of neutron flux distribution in the irradiation channel is preserved and the neutron flux data were found to be comparable with the data obtained before the installation.
基金the TESS mission is provided by NASA’s Science Mission DirectorateSupport for MAST for non-HST data is provided by the NASA Office of Space Science via grant NNX13AC07G and by other grants and contracts+1 种基金This publication makes use of VOSA,developed under the Spanish Virtual Observatory project supported by the Spanish MINECO through grant AyA2017–84089VOSA has been partially updated by using funding from the European Union’s Horizon 2020 Research and Innovation Programme,under Grant Agreement No.776403(EXOPLANETS-A)。
文摘We present the first evidence for the binarity of four targets in the TESS field.The temperatures are estimated by SED analysis and the orbital periods are determined.The TESS light curves of the systems are analyzed and the orbital and the absolute parameters are derived.The targets are also compared to wellstudied binary systems with the same morphological type and their evolutionary states are discussed.Our results indicate that the stars belong to the class of eclipsing detached binary systems.
