Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential...Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.展开更多
Vestibular Migraine (VM) is a common neurological disorder characterized by recurrent episodes of vertigo and migraine symptoms. The pathogenesis of VM is complex and involves multiple genetic and environmental factor...Vestibular Migraine (VM) is a common neurological disorder characterized by recurrent episodes of vertigo and migraine symptoms. The pathogenesis of VM is complex and involves multiple genetic and environmental factors. Recent studies have suggested that the pathogenesis of vestibular migraine may be associated with variations in the CACNA1A gene, which is an important gene target for controlling calcium ion channels. Such variations may further affect the functions of the vestibular nervous system, thereby causing a series of vestibular nervous system-related symptoms. This article will summarize the genetic association studies of vestibular migraine, vestibular function studies, and research on how to establish relevant animal models to illustrate the possible association between CACNA1A variations and the pathogenesis of VM, providing new ideas for clarifying the pathogenesis of VM.展开更多
基金supported by the National Natural Science Foundation of China(32100773 and U20A6005)the National Science and Technology Innovation 2030-Major Project of China(2021ZD0202500)+4 种基金Shenzhen Medical Research Fund(B2402024)China Postdoctoral Science Foundation(2021M693296)Shenzhen Science and Technology Program(JCYJ20230807093815032)Guangdong High-level Hospital Construction Fund(ynkt2021-zz33 and LCYJ2022093)the Natural Science Foundation of Guangdong Province,China(2022A1515010297).
文摘Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.
文摘Vestibular Migraine (VM) is a common neurological disorder characterized by recurrent episodes of vertigo and migraine symptoms. The pathogenesis of VM is complex and involves multiple genetic and environmental factors. Recent studies have suggested that the pathogenesis of vestibular migraine may be associated with variations in the CACNA1A gene, which is an important gene target for controlling calcium ion channels. Such variations may further affect the functions of the vestibular nervous system, thereby causing a series of vestibular nervous system-related symptoms. This article will summarize the genetic association studies of vestibular migraine, vestibular function studies, and research on how to establish relevant animal models to illustrate the possible association between CACNA1A variations and the pathogenesis of VM, providing new ideas for clarifying the pathogenesis of VM.
