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A New Inversion-free Iterative Method for Solving the Nonlinear Matrix Equation and Its Application in Optimal Control
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作者 GAO Xiangyu XIE Weiwei ZHANG Lina 《应用数学》 北大核心 2026年第1期143-150,共8页
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ... In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method. 展开更多
关键词 Nonlinear matrix equation Maximal positive definite solution Inversion-free iterative method Optimal control
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Healthcare professionals’perspectives on disclosure of diagnosis and related issues in childhood cancer:A mixed methods systematic review
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作者 Run Xie Xiaoyan Huang +4 位作者 Yiran Du Ying Gu Qiongfang Kang Hongsheng Wang Daqian Zhu 《International Journal of Nursing Sciences》 2026年第1期96-104,I0006,共10页
Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of... Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process. 展开更多
关键词 Communication CANCER DISCLOSURE Healthcare professionals Mixed methods PEDIATRIC Systematic review
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Investigation of equivalent strength parameters of soil-rock mixture using numerical manifold method
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作者 Junfeng Li Yongtao Yang +2 位作者 Yang Xia Hong Zheng Shuilin Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期637-650,共14页
As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalen... As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalent parameters of SRMs,which are typically obtained through experimental and numerical methods.In contrasted to other numerical methods,the numerical manifold method(NMM)is more effective in addressing SRM problems.This is because the high-precision regular mathematical meshes in NMM can be used without aligning with the soil-rock interfaces and boundaries of SRMs.In the current research,the equivalent strength parameters of SRMs,i.e.the equivalent cohesion ce and internal friction angleϕ_(e),are determined using NMM.Initially,an NMM triaxial numerical model is established and validated based on triaxial experiments.Subsequently,the soil and rock parameters are derived through parameter inversion.Moreover,the impacts of rock content,size,shape and rock blocks'major-axis orientation on ce andϕ_(e) of SRMs are thoroughly examined using the NMM triaxial numerical model.Additionally,a fitting function is proposed to linkϕ_(e) to the rock content and size of SRMs.When other influencing factors are fixed,the above fitting model leads to the following conclusions:(1)the predictedϕ_(e) of SRMs increase with the increase of rock content;and(2)SRM samples with smaller rocks display a higher predictedϕ_(e). 展开更多
关键词 Soil-rock mixtures Equivalent strength parameters Numerical manifold method
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Subtitle Translation Methods of The Good Wife From Functional Equivalence Perspective
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作者 WANG Ya-kun BAO De-wang 《Journal of Literature and Art Studies》 2026年第1期26-30,共5页
The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to... The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to analyze the methods of its English-to-Chinese subtitle translation by considering social,cultural,and historic backgrounds between China and America.After data collection and case analysis,the study found that:(1)Five major translation methods are adopted in the subtitle translation of The Good Wife.They are free translation,variation,literal translation,addition,and omission.Among them,free translation is the most frequently used,while omission is used least.(2)The subtitle translation of films and TV series is limited by time and space restrictions,social-cultural differences,and other factors.When translating,translators should try to use humorous words,euphemism,intonation,and other ways,and combine different methods such as literal translation,free translation,variation,addition,omission,and other methods to seek equivalence both in the meaning and function of subtitles under the guidance of Functional Equivalence Theory. 展开更多
关键词 subtitle translation Functional Equivalence Theory The Good Wife translation methods
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Pile installation effects in natural soft clays:A semi-analytical solution using strain path method
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作者 Liang Li Pan Zhou +3 位作者 Jingpei Li Seyedmohsen Miraei Peng Feng Mingdong Wei 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期728-744,共17页
This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture ... This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP. 展开更多
关键词 Pile penetration Strain path method Natural soft clays Anisotropy evolution Destructuration
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Crushing evolution in pebble bed based on a novel method:a crushable DEM study
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作者 Jian Wang Ming‑Zhun Lei +4 位作者 Ming‑Zong Liu Qi‑Gang Wu Zi‑Cong Cai Kai‑Song Wang Hai‑Shun Deng 《Nuclear Science and Techniques》 2026年第1期212-224,共13页
In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical m... In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing. 展开更多
关键词 Crushing behavior Granular material Discrete element method Pebble bed Fractal theory
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Centralized Circumcentered-Reflection Method for Solving the Convex Feasibility Problem in Sparse Signal Recovery
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作者 Chunmei LI Bangjun CHEN Xuefeng DUAN 《Journal of Mathematical Research with Applications》 2026年第1期119-133,共15页
Convex feasibility problems are widely used in image reconstruction, sparse signal recovery, and other areas. This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recov... Convex feasibility problems are widely used in image reconstruction, sparse signal recovery, and other areas. This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery. We first derive the projection formulas for a vector onto the feasible sets. The centralized circumcentered-reflection method is designed to solve the convex feasibility problem. Some numerical experiments demonstrate the feasibility and effectiveness of the proposed algorithm, showing superior performance compared to conventional alternating projection methods. 展开更多
关键词 convex feasibility problem centralized circumcentered-re ection method sparse signal recovery compressed sensing
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Numerical Simulation of the Welding Deformation of Marine Thin Plates Based on a Temperature Gradient-thermal Strain Method
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作者 Lin Wang Yugang Miao +3 位作者 Zhenjian Zhuo Chunxiang Lin Benshun Zhang Duanfeng Han 《哈尔滨工程大学学报(英文版)》 2026年第1期122-135,共14页
Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The t... Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The traditional thermal elastic-plastic finite element method(TEP-FEM)can accurately predict welding deformation.However,its efficiency is low because of the complex nonlinear transient computation,making it difficult to meet the needs of rapid engineering evaluation.To address this challenge,this study proposes an efficient prediction method for welding deformation in marine thin plate butt welds.This method is based on the coupled temperature gradient-thermal strain method(TG-TSM)that integrates inherent strain theory with a shell element finite element model.The proposed method first extracts the distribution pattern and characteristic value of welding-induced inherent strain through TEP-FEM analysis.This strain is then converted into the equivalent thermal load applied to the shell element model for rapid computation.The proposed method-particularly,the gradual temperature gradient-thermal strain method(GTG-TSM)-achieved improved computational efficiency and consistent precision.Furthermore,the proposed method required much less computation time than the traditional TEP-FEM.Thus,this study lays the foundation for future prediction of welding deformation in more complex marine thin plates. 展开更多
关键词 Marine thin plate Welding deformation Numerical simulation Temperature gradient-thermal strain method Shell element
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Statistical method for quantifying the strain localization process in Beishan granite under multi-creep triaxial compression based on distributed optical fiber sensing
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作者 Xiujun Zhang Peng-Zhi Pan Shuting Miao 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期398-415,共18页
To investigate the damage evolution caused by stress-driven and sub-critical crack propagation within the Beishan granite under multi-creep triaxial compressive conditions,the distributed optical fiber sensing and X-r... To investigate the damage evolution caused by stress-driven and sub-critical crack propagation within the Beishan granite under multi-creep triaxial compressive conditions,the distributed optical fiber sensing and X-ray computed tomography were combined to obtain the strain distribution over the sample surface and internal fractures of the samples.The Gini and skewness(G-S)coefficients were used to quantify strain localization during tests,where the Gini coefficient reflects the degree of clustering of elements with high strain values,i.e.,strain localization/delocalization.The strain localization-induced asymmetry of data distribution is quantified by the skewness coefficient.A precursor to granite failure is defined by the rapid and simultaneous increase of the G-S coefficients,which are calculated from strain increment,giving an earlier warning of failure by about 8%peak stress than those from absolute strain values.Moreover,the process of damage accumulation due to stress-driven crack propagation in Beishan granite is different at various confining pressures as the stress exceeds the crack initiation stress.Concretely,strain localization is continuous until brittle failure at higher confining pressure,while both strain localization and delocalization occur at lower confining pressure.Despite the different stress conditions,a similar statistical characteristic of strain localization during the creep stage is observed.The Gini coefficient increases,and the skewness coefficient decreases slightly as the creep stress is below 95%peak stress.When the accelerated strain localization begins,the Gini and skewness coefficients increase rapidly and simultaneously. 展开更多
关键词 Statistical method Multi-creep triaxial compression Strain localization quantification Distributed optical fiber sensing Precursor identification
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Geometrically Nonlinear Analyses of Isotropic and Laminated Shells by a Hierarchical Quadrature Element Method
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作者 Yingying Lan Bo Liu 《Computer Modeling in Engineering & Sciences》 2026年第1期345-373,共29页
In this work,the Hierarchical Quadrature Element Method(HQEM)formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells.The stress res... In this work,the Hierarchical Quadrature Element Method(HQEM)formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells.The stress resultant formulation is developed within the HQEM framework,consequently significantly simplifying the computations of residual force and stiffness matrix.The present formulation inherently avoids shear and membrane locking,benefiting from its high-order approximation property.Furthermore,HQEM’s independent nodal distribution capability conveniently supports local p-refinement and flexibly facilitates mesh generation in various structural configurations through the combination of quadrilateral and triangular elements.Remarkably,in lateral buckling analysis,the HQEM outperforms the weak-form quadrilateral element(QEM)in accuracy with identical nodal degrees of freedom(three displacements and two rotations).Under high-load nonlinear response,the QEM exhibits a maximum relative deviation of approximately 9.5%from the reference,while the HQEM remains closely aligned with the benchmark results.In addition,for the cantilever beam under tip moment,HQEM produces virtually no out-of-plane deviation,compared to a slight deviation of 0.00001 with QEM,confirming its superior numerical reliability.In summary,the method demonstrates high accuracy,superior convergence,and robustness in handling large rotations and complex post-buckling behaviors across a series of benchmark problems. 展开更多
关键词 Geometrically exact shell hierarchical quadrature element method geometrically nonlinear laminated shells local p-refinement shear and membrane locking post-buckling behaviors
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Tunnel ahead prospecting methods and intelligent interpretation of adverse geology:A review
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作者 Shucai Li Bin Liu +4 位作者 Lei Chen Huaifeng Sun Lichao Nie Zhengyu Liu Yuxiao Ren 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期1-19,共19页
Geological prospecting and the identification of adverse geological features are essential in tunnel construction,providing critical information to ensure safety and guide engineering decisions.As tunnel projects exte... Geological prospecting and the identification of adverse geological features are essential in tunnel construction,providing critical information to ensure safety and guide engineering decisions.As tunnel projects extend into deeper and more mountainous terrains,engineers face increasingly complex geological conditions,including high water pressure,intense geo-stress,elevated geothermal gradients,and active fault zones.These conditions pose substantial risks such as high-pressure water inrush,largescale collapses,and tunnel boring machine(TBM)blockages.Addressing these challenges requires advanced detection technologies capable of long-distance,high-precision,and intelligent assessments of adverse geology.This paper presents a comprehensive review of recent advancements in tunnel geological ahead prospecting methods.It summarizes the fundamental principles,technical maturity,key challenges,development trends,and real-world applications of various detection techniques.Airborne and semi-airborne geophysical methods enable large-scale reconnaissance for initial surveys in complex terrain.Tunnel-and borehole-based approaches offer high-resolution detection during excavation,including seismic ahead prospecting(SAP),TBM rock-breaking source seismic methods,fulltime-domain tunnel induced polarization(TIP),borehole electrical resistivity,and ground penetrating radar(GPR).To address scenarios involving multiple,coexisting adverse geologies,intelligent inversion and geological identification methods have been developed based on multi-source data fusion and artificial intelligence(AI)techniques.Overall,these advances significantly improve detection range,resolution,and geological characterization capabilities.The methods demonstrate strong adaptability to complex environments and provide reliable subsurface information,supporting safer and more efficient tunnel construction. 展开更多
关键词 Tunnel geological ahead prospecting Complex geological and environmental conditions Airborne geophysical methods Tunnel geophysical detection Borehole geophysical prospecting Intelligent geological interpretation
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Combining Random Forest and Monte Carlo Method to Determine the Driving Factors and Uncertainty of Forest Age Prediction in Northwest China
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作者 ZENG Jia LIU Jincheng +1 位作者 LI Limin KHAN Tauheed Ullah 《Chinese Geographical Science》 2026年第1期144-156,I0004-I0007,共17页
Stand age plays a crucial role in forest biomass estimation and carbon cycle modeling.Assessing the uncertainty of stand age prediction models and identifying the key driving factors in the modeling process have becom... Stand age plays a crucial role in forest biomass estimation and carbon cycle modeling.Assessing the uncertainty of stand age prediction models and identifying the key driving factors in the modeling process have become major challenges in forestry research.In this study,we selected the Shaanxi-Gansu-Ningxia region of Northeast China as the research area and utilized multi-source datasets from the summer of 2019 to extract information on spectral,textural,climatic,water balance,and stand characteristics.By integrating the Random Forest(RF)model with Monte Carlo(MC)simulation,we constructed six regression models based on different combina-tions of features and evaluated the uncertainty of each model.Furthermore,we investigated the driving factors influencing stand age modeling by analyzing the effects of different types of features on age inversion.Model performance and accuracy were assessed using the root mean square error(RMSE),mean absolute error(MAE),and the coefficient of determination(R^(2)),while the relative root mean square error(rRMSE)was employed to quantify model uncertainty.The results indicate that the scenarios with more obvious improve-ment in accuracy and effective reduction in uncertainty were Scenario 3 with the inclusion of climate and water balance information(RMSE=25.54 yr,MAE=18.03 yr,R^(2)=0.51,rRMSE=19.17%)and Scenario 5 with the inclusion of stand characterization informa-tion(RMSE=18.47 yr,MAE=13.05 yr,R^(2)=0.74,rRMSE=16.99%).Scenario 6,incorporating all feature types,achieved the highest accuracy(RMSE=17.60 yr,MAE=12.06 yr,R^(2)=0.77,rRMSE=14.19%).In this study,elevation,minimum temperature,and diameter at breast height(DBH)emerged as the key drivers of stand-age modeling.The proposed method can be used to identify drivers and to quantify uncertainty in stand-age estimation,providing a useful reference for improving model accuracy and uncertainty assessment. 展开更多
关键词 stand age Randon Forest(RF)model Monte Carlo(MC)method Sentinel-2 National Forest Inventory(NFI) Shaanxi-Gansu-Ningxia(SGN) Northwest China
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Predicting the Dielectric Strength of c-C_4F_8 and SF_6 Gas Mixtures by Monte Carlo Method 被引量:3
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作者 吴变桃 肖登明 《Journal of Shanghai Jiaotong university(Science)》 EI 2007年第1期121-124,共4页
An improved Monte Carlo method was used to simulate the motion of electrons in c-C4F8 and SF6 gas mixtures for pulsed townsend discharge. The electron swarm parameters such as effective ionization coefficient, -↑α a... An improved Monte Carlo method was used to simulate the motion of electrons in c-C4F8 and SF6 gas mixtures for pulsed townsend discharge. The electron swarm parameters such as effective ionization coefficient, -↑α and drift velocity over the E/N range from 280~700 Td(1Td=10^-21 V·m^2) were calculated by employing a set of cross sections available in literature. From the variation cure of -↑α with SF6 partial pressure p, the limiting field (E/N)lim of gas mixture at different gas content was determined. It is found that the limiting field of c-C4F8 and SF6 gas mixture is higher than that of pure SF6 at any SF6 mixture ratio. Simulation results show excellent agreement with experiment data available in previous literature. 展开更多
关键词 c-c4F8 and SF6 gas mixture Monte Carlo limiting field dielectric strength
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Sinc-Collocation Method for Solving Linear and Nonlinear System of Second-Order Boundary Value Problems 被引量:1
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作者 Mohamed El-Gamel 《Applied Mathematics》 2012年第11期1627-1633,共7页
Sinc methods are now recognized as an efficient numerical method for problems whose solutions may have singularities, or infinite domains, or boundary layers. This work deals with the sinc-collocation method for solvi... Sinc methods are now recognized as an efficient numerical method for problems whose solutions may have singularities, or infinite domains, or boundary layers. This work deals with the sinc-collocation method for solving linear and nonlinear system of second order differential equation. The method is then tested on linear and nonlinear examples and a comparison with B-spline method is made. It is shown that the sinc-collocation method yields better results. 展开更多
关键词 Sinc Function COLLOCATION method SYSTEM Numerical Solution
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Numerical Solution of Troesch’s Problem by Sinc-Collocation Method 被引量:1
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作者 Mohamed El-Gamel 《Applied Mathematics》 2013年第4期707-712,共6页
A new algorithm is presented for solving Troesch’s problem. The numerical scheme based on the sinc-collocation technique is deduced. The equation is reduced to systems of nonlinear algebraic equations. Some numerical... A new algorithm is presented for solving Troesch’s problem. The numerical scheme based on the sinc-collocation technique is deduced. The equation is reduced to systems of nonlinear algebraic equations. Some numerical experiments are made. Compared with the modified homotopy perturbation technique (MHP), the variational iteration method and the Adomian decomposition method. It is shown that the sinc-collocation method yields better results. 展开更多
关键词 Sinc Function COLLOCATION method Troesch’s PROBLEM NUMERICAL Solution
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血清趋化因子C-C配体19与21水平在住院心力衰竭患者中的预后价值
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作者 曾文飞 李玲 +3 位作者 林凯玲 黄道昕 李力 余惠珍 《中华高血压杂志(中英文)》 北大核心 2025年第7期669-679,共11页
目的观察血清趋化因子C-C配体19(CCL19)和CCL21水平在住院心力衰竭(心衰)患者中的预后价值。方法入选2018年12月至2021年10月于福建省立医院南院心内科住院的心衰患者共221例(心衰组),同期健康体检的55名体检者作为对照组,出院后定期随... 目的观察血清趋化因子C-C配体19(CCL19)和CCL21水平在住院心力衰竭(心衰)患者中的预后价值。方法入选2018年12月至2021年10月于福建省立医院南院心内科住院的心衰患者共221例(心衰组),同期健康体检的55名体检者作为对照组,出院后定期随访。采用酶联免疫吸附试验法检测血清CCL19和CCL21水平,收集两组患者临床基线资料信息。采用时间依赖性受试者操作特征(ROC)曲线、Kaplan-Meier生存曲线和Cox回归分析评估CCL19和CCL21对心衰的预后价值。结果最终纳入心衰患者170例,中位随访时间为722.5(396.5,898.0)d,全因死亡30例,78例发生复合终点事件(包括全因死亡、急性心肌梗死、恶性心律失常、猝死和心衰再入院)。心衰患者血清CCL19和CCL21浓度较对照组高。多因素Cox回归分析显示,校正心血管危险因素后,CCL19、CCL21升高以及CCL19与CCL21均升高与心衰患者全因死亡风险相关[HR(95%CI)分别为3.904(1.561~9.760)、3.946(1.561~9.978)、6.048(2.646~13.824)];CCL21以及CCL19与CCL21均升高与复合终点事件发生率升高相关[HR(95%CI)分别为2.204(1.350~3.599)、1.883(1.157~3.066)]。时间依赖性ROC曲线分析提示,CCL19、CCL21以及CCL19联合CCL21均升高可以预测各时间点心衰患者的全因死亡和远期复合终点事件的发生。Kaplan-Meier曲线显示,血清CCL19、CCL21以及CCL19联合CCL21均升高的心衰患者全因死亡率及复合终点事件发生率高(P<0.05)。结论心衰患者血清CCL19和CCL21水平明显升高,与心衰患者全因死亡相关,CCL21升高与心衰患者复合终点事件发生相关。 展开更多
关键词 趋化因子c-c配体19 趋化因子c-c配体21 心力衰竭 预后
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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury 被引量:1
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作者 Xiangzi Wang Xiaofei Niu +4 位作者 Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi 《Neural Regeneration Research》 SCIE CAS 2025年第8期2231-2244,共14页
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand... Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury. 展开更多
关键词 apoptosis c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 pathway c-c motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method
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二甲双胍调节C-C基序趋化因子配体2/C-C基序趋化因子受体2轴对糖尿病大鼠17型辅助T细胞/调节性T细胞平衡影响的研究
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作者 刘前华 周俊洪 +2 位作者 李朝敏 吴宇 谭薇 《中国糖尿病杂志》 北大核心 2025年第8期623-630,共8页
目的探讨二甲双胍(Met)调节C-C基序趋化因子配体2(CCL2)/C-C基序趋化因子受体2(CCR2)轴对DM大鼠17型辅助T细胞(Th17)/调节性T细胞(Treg)平衡的影响。方法取SD大鼠50只随机分为正常对照(NC)组、模型(Mod)组、Met(100 mg/kg)组、Met+空载(... 目的探讨二甲双胍(Met)调节C-C基序趋化因子配体2(CCL2)/C-C基序趋化因子受体2(CCR2)轴对DM大鼠17型辅助T细胞(Th17)/调节性T细胞(Treg)平衡的影响。方法取SD大鼠50只随机分为正常对照(NC)组、模型(Mod)组、Met(100 mg/kg)组、Met+空载(Met+oe-NC)组、Met+CCL2过表达(Met+oe-CCL2)组,每组10只。观察各组FBG变化,HE染色检测各组胰腺中胰岛组织变化并进行病理评分,流式细胞术检测各组外周血Th17/Treg比值,ELISA检测各组血清IL-17、TNF-α、TGF-β、IL-10水平,免疫荧光检测各组胰腺组织Th17、Treg浸润比例,RT-PCR和Western blot检测各组胰腺组织视黄酸受体相关孤儿受体γt(ROR-γt)、叉头框蛋白P3(FOXP3)、CCL2、CCR2 mRNA及蛋白表达。结果NC组胰岛组织中胰岛结构完好且边界清晰,无病理损伤,Mod组胰岛组织呈现明显病理损伤,可见胰岛结构受损明显且体积缩小,与周围组织间分界不清,胰岛内细胞分布杂乱且缺失明显,与Mod组比较,Met、Met+oe-NC组胰岛组织病理损伤均减轻,与Met组比较,Met+oe-CCL2组病理损伤加重。Mod组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达高于NC组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达低于NC组(P<0.05)。Met、Met+oe-NC组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达低于Mod组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达高于Mod组(P<0.05)。Met+oe-CCL2组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达高于Met组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达高于Met组(P<0.05)。结论Met可通过抑制CCL2/CCR2轴激活促使Th17/Treg细胞平衡向Treg方向漂移,抑制炎症反应发生发展,减轻DM大鼠胰岛损伤,改善其糖代谢。 展开更多
关键词 二甲双胍 c-c基序趋化因子配体2/c-c基序趋化因子受体2轴 糖尿病 17型辅助T细胞/调节性T细胞比值
原文传递
A Data Treatment Method of Carbon Saturated Solubility in Fe-C-Cr Melt
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作者 Haichuan Wang Shijun Wang +1 位作者 Yuanchi Dong Wenchao Li 《Journal of University of Science and Technology Beijing》 CSCD 2002年第1期16-19,共4页
Based on the current situation of studying the thermodynamic property of Fe-C-Cr melt using the carbon saturated solubility, an experimental data treatment method of the carbon saturated solubility was put forward. Wi... Based on the current situation of studying the thermodynamic property of Fe-C-Cr melt using the carbon saturated solubility, an experimental data treatment method of the carbon saturated solubility was put forward. With this method a linear relationship ex- pression of the carbon saturated solubility in Fe-C-Cr melt was obtained, which intercept is dependent on temperature and independent of third component [Cr], but which slope is dependent on third component [Cr] and independent of temperature. Through this expression activity interaction coefficients at different temperatures were calculated and the relationship between activity interaction coefficients and temperature is also obtained. 展开更多
关键词 data treatment method intercept slope carbon-saturated solubility Fe-c-cr melt
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