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Study on Effect of Nursing Risk Management on Patients with Acute Attack of Bronchial Asthma Complicated with Acute Upper Respiratory Tract Infection
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作者 JIANGLiqiong 《外文科技期刊数据库(文摘版)医药卫生》 2022年第5期206-209,共4页
Objective: to study the possible problems and risks in nursing management of patients with acute attack of bronchial asthma complicated with acute upper respiratory tract infection. Methods: 80 patients with acute att... Objective: to study the possible problems and risks in nursing management of patients with acute attack of bronchial asthma complicated with acute upper respiratory tract infection. Methods: 80 patients with acute attack of bronchial asthma complicated with acute upper respiratory tract infection treated in our hospital from February 2020 to February 2021 were randomly divided into study group (nursing risk management) and control group (routine nursing), with 40 cases in each group. After nursing, the nursing effects were compared. Results: the incidence of nursing adverse events in the control group was significantly higher than that in the study group (P < 0.05), and its treatment compliance, nursing satisfaction and nursing quality were significantly lower than those in the control group (P < 0.05). Conclusion: in the actual clinical treatment of patients with acute attack of bronchial asthma complicated with acute upper respiratory tract infection, in order to better improve the nursing effect and reduce the incidence of nursing adverse events, the majority of medical institutions need to take nursing risk management as the starting point, strengthen nursing risk management, eliminate the occurrence of nursing adverse events, and fundamentally promote the improvement of clinical nursing quality. 展开更多
关键词 acute attack of bronchial asthma acute upper respiratory tract infection nursing risk management
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Clinical Observation of Dingchuan Decoction(定喘汤)Combined with Omazumab in Treating Acute Attack of Bronchial Asthma(Heat Asthma Syndrome)
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作者 YANG Zhi SONG Zhen-xi 《World Journal of Integrated Traditional and Western Medicine》 2022年第2期12-19,共8页
Objective:To explore the therapeutic effect of Dingchuan Decoction combined with omazumab on acute attack of bronchial asthma.Methods:From January 2020 to November 2021,90 patients with acute asthma were treated in ou... Objective:To explore the therapeutic effect of Dingchuan Decoction combined with omazumab on acute attack of bronchial asthma.Methods:From January 2020 to November 2021,90 patients with acute asthma were treated in our hospital,which belonged to heat asthma syndrome according to TCM syndrome differentiation in our hospital.They were divided into control group and observation group with 45 cases in each group.The control group was treated with omazumab,while the observation group was treated with omazumab combined with Dingchuan Decoction.The changes of lung function,exhaled nitric oxide(FeNO),blood gas indexes and hematological indexes were observed before and after treatment,and the adverse reactions and asthma recurrence within 3 months were observed.At the same time,animal experiments were carried out to verify the curative effect of Dingchuan.Results:After treatment,the total effective rate,FeNO,pulmonary function,partial pressure of blood oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),interleukin-6(IL-6),interleukin-5(IL-5),immunoglobulin E(IgE)and asthma recurrence in 3 months in the observation group were better than those in the control group;There was no significant difference in pulse oxygen saturation(SaO_(2))and the incidence of adverse reactions between the two groups.Animal experiments show that Dingchuan Decoction can effectively improve lung inflammation.Conclusion:The combination of Dingchua Decoction and omazumab has a good curative effect in the treatment of acute attack of bronchial asthma,which can effectively improve the lung function and blood gas index of patients,reduce the levels of inflammatory factors and IgE,and has no obvious increase in adverse reactions,and effectively control the recurrence of asthma within 3 months.It can be used as an auxiliary maintenance treatment for patients with mild and moderate acute attack and clinical remission of asthma,thus reducing the utilization rate of hormones and having high application value. 展开更多
关键词 Dingchuan Decoction Omazumab acute attack of asthma Syndrome of heat asthma Clinical observation
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Clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma
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作者 Yan-Feng Zhang Jin-Fang Zhou 《Journal of Hainan Medical University》 2018年第16期63-66,共4页
Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in ... Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in our hospital between January 2015 and January 2018 were selected as the research subjects, and the therapies were reviewed and used to divide the patients into the control group (n=30) who received conventional inhalant therapy and the interferon group (n=26) who received interferon combined with inhalant therapy. Control group received salbutamol aerosol inhalation, and interferon group received interferon combined with salbutamol aerosol inhalation. The differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were compared between the two groups immediately after admission and after 48 h of treatment.Results:Immediately after admission, the differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were not statistically significant between the two groups of patients. After 48 h of treatment, serum inflammatory factors IL-8, IL-17, IL-18, IL-25, IL-27 and IL-33 levels of interferon group were lower than those of control group;airway remodeling indexes VEGF, MMP-9 and TIMP1 levels were lower than those of control group;immunoglobulins IgA, IgG and IgM levels were higher than those of control group whereas IgE level was lower than that of control group.Conclusion:interferon combined with inhalant therapy can effectively reduce systemic inflammatory response, inhibit airway remodeling and optimize humoral immune function in patients with acute attack of bronchial asthma. 展开更多
关键词 acute attack of bronchial asthma INTERFERON Inflammatory response AIRWAY REMODELING IMMUNOGLOBULIN
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Effects of Suhuang Zhike Capsules on Pulmonary Function and Peripheral Blood Eosinophil Count and Exhaled Nitric Oxide in Patients with Acute Attack of Bronchial Asthma
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作者 Geng Xinpu Liu Rong +1 位作者 Le Zhaoxi Liu Shoulin 《World Journal of Integrated Traditional and Western Medicine》 2019年第4期16-20,共5页
OBJECTIVE: To observe the effects of Suhuang Zhike Capsules on lung function and peripheral blood eosinophil count (EOS) and exhaled nitric oxide (eNO) in patients with acute asthma attack.METHODS: A total of 80 patie... OBJECTIVE: To observe the effects of Suhuang Zhike Capsules on lung function and peripheral blood eosinophil count (EOS) and exhaled nitric oxide (eNO) in patients with acute asthma attack.METHODS: A total of 80 patients with acute exacerbation of bronchial asthma admitted to Huai'an Cancer Hospital from January 2017 to January 2018 were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given conventional treatment with western medicine,and the observation group was given Suhuang Zhike Capsules on the basis of the treatment method of the control group.After 1 week of treatment,the improvement of individual symptoms (cough,wheezing,wheezing rale),lung function [1 second forced expiratory volume (FEV1),forced expiratory volume occupational capacity of vital capacity (FVC) in 1 second and peak expiratory flow (PEF)] and peripheral blood EOS and eNO levels and efficacy before and after the treatment were observed and assessed.RESULTS: The total effective rate of the observation group was 92.5%,which was significantly higher than the total effective rate of the control group (75.0%)(P < 0.05).The cough,wheezing and wheezing scores of the 2 groups were significantly decreased after treatment (P < 0.05).The scores of the above symptoms were significantly lower in the observation group than in the control group (P < 0.05).The FEV1,FVC and PEF were significantly increased after treatment (P < 0.05),and the above lung functions in the observation group were significantly higher than the control group (all P < 0.05).The EOS and eNO levels in the peripheral blood of the 2 groups were significantly decreased after treatment (P < 0.05),and the EOS and eNO levels in the peripheral blood in the observation group were significantly lower than those in the control group (P < 0.05).CONCLUSION: Suhuang Zhike Capsules can reduce the levels of EOS and eNO in peripheral blood of patients with acute asthma attack,improve the lung function of patients,relieve the clinical symptoms and improve the prognosis. 展开更多
关键词 Suhuang Zhike CAPSULES acute attack of bronchial asthma Lung function AIRWAY HYPERRESPONSIVENESS EOS ENO
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Clinical Application Value of Nursing Intervention in Nursing Care of Patients with Acute Exacerbation of Bronchial Asthma
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作者 TIANXue 《外文科技期刊数据库(文摘版)医药卫生》 2022年第7期083-086,共4页
Patients with bronchial asthma will be very painful in acute exacerbation period, which is manifested as dyspnea, dyspnea and so on. Therefore, for this kind of patients, it is necessary to do a good job of comprehens... Patients with bronchial asthma will be very painful in acute exacerbation period, which is manifested as dyspnea, dyspnea and so on. Therefore, for this kind of patients, it is necessary to do a good job of comprehensive nursing to help them relieve their pain. In this experiment, 60 patients with bronchial asthma in acute exacerbation were selected by contrast method. These patients were divided into observation group and control group with 30 cases in each group. The control group received general nursing, while the observation group received comprehensive nursing. The nursing effects of the two groups were analyzed. After a period of intervention, through the comparative analysis of data, it can be concluded that the comprehensive nursing mode used by the observation group is better than the general nursing mode. Besides the total effective rate of treatment, the incidence of adverse reactions is relatively low. This shows that for this kind of patients, it is best to use comprehensive nursing in clinic, which can effectively improve the clinical situation of patients. 展开更多
关键词 bronchial asthma acute exacerbation period comprehensive nursing lung function quality of life
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Analysis of the Curative Effect of Shegan Mahuang Decoction Combined with Acupoint Application in the Treatment of Acute Exacerbation of Bronchial Asthma in Children
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作者 BUXiaohui 《外文科技期刊数据库(文摘版)医药卫生》 2022年第6期027-031,共5页
Objective: to apply the combined therapy of shegan mahuang decoction and acupoint application in the treatment of acute exacerbation of bronchial asthma in children. Methods: the children with acute exacerbation of br... Objective: to apply the combined therapy of shegan mahuang decoction and acupoint application in the treatment of acute exacerbation of bronchial asthma in children. Methods: the children with acute exacerbation of bronchial asthma who were treated in our hospital from January 2021 to January 2022 were selected as the research subjects, and the effects of different treatments were compared, including shegan mahuang decoction and acupoint application + shegan mahuang decoction. Results: after the effective treatment plan was implemented, the condition improved, especially the children treated with acupoint application + shegan mahuang decoction had a higher total effective rate, a lower incidence of adverse reactions, a good trend in FVC and other levels, and symptoms and signs. The scores were lower, and the children who received acupoint application treatment were relatively poor, and the difference was significant (P<0.05). Conclusion: in the treatment of acute exacerbation of bronchial asthma in children, shegan mahuang decoction combined with acupoint application has obvious application value and high safety, and plays a positive role in further shortening the course of the disease in children. 展开更多
关键词 shegan mahuang decoction acupoint application acute exacerbation of bronchial asthma in children
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Analysis of effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children
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作者 Xin Shao Jun Qian Hui-Dong Cai 《Journal of Hainan Medical University》 2020年第6期59-62,共4页
Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:One hundred and fifty children with acute attack of asthma a... Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:One hundred and fifty children with acute attack of asthma and lobar pneumonia were randomly divided into routine group(seventy-five cases)and combined group(seventy-five cases).The routine group was given routine treatment.The study group was treated with routine therapy plus terbutaline sulfate plus shunning.The changes of pulmonary function and serum inflammatory factors before and after treatment,clinical effect and safety were compared between the two groups.Results:Respiratory time/inspiratory time(Ti/Te),peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE),tidal volume per kilogram(Vt/kg)were increased in both groups after treatment(P<0.05),which in the combined group were higher than the routine group after treatment(P<0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in both groups decreased significantly(P<0.05),and those in the combined group were lower than those in the routine group(P<0.05).There was a significant difference in clinical effect distribution between the two groups(P<0.05).The total effective rate of the combined group was higher than that of the routine group(P<0.05).The incidence of adverse reactions in the combined group was slightly higher than that in the routine group(P>0.05).Conclusion:On the basis of routine treatment,terbutaline sulfate combined with shunning can significantly improve pulmonary function and serum inflammatory factors in children with acute attack of asthma and lobar pneumonia,with ideal effect and safe. 展开更多
关键词 TERBUTALINE SULFATE Shunning acute asthma attack LOBAR PNEUMONIA
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Expression and Significance of ECP, 25-(OH)D3 and M2 receptors in Children with Acute Attack of Asthma
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作者 Jun-Xiu Pan Lei Zhang +1 位作者 Jun-Li He Chu-Ping Fan 《Journal of Hainan Medical University》 2019年第20期43-47,共5页
Objective:To study the expression and significance of ECP, 25-(OH)D3 and M2 receptors in children with acute attack of asthma.Methods: Seventy children with bronchial asthma who first visited our hospital from Septemb... Objective:To study the expression and significance of ECP, 25-(OH)D3 and M2 receptors in children with acute attack of asthma.Methods: Seventy children with bronchial asthma who first visited our hospital from September 2016 to September 2018 were divided into chronic persistence group, remission group and acute attack group. Thirty healthy children who underwent physical examination in our hospital were selected and divided into control group. The levels of ECP, 25-(OH) D3 and M2 receptors were analyzed by ELISA, and Pearson correlation analysis was performed.Results: Compared with the control group, the levels of ECP and M2 receptors in chronic persistence group, remission group and acute attack group increased, while the levels of 25-(OH)D3 decreased, with statistical difference (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in chronic persistence group, and the levels of 25-(OH)D3 were lower than those in chronic persistence group (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in remission group, and the levels of 25-(OH)D3 were lower than those in remission group (P<0.05). Compared with mild children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in moderate and severe children (P<0.05). Compared with moderate children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in severe children (P<0.05).There was a negative correlation between ECP and 25-(OH)D3 (r=-0.380, P=0.038);a negative correlation between 25-(OH)D3 and M2 receptor (r=-0.448,P=0.013);and a positive correlation between ECP and M2 receptor (r=0.450,P=0.013).Conclusions:The expression of ECP and M2 receptors increased during the acute attack of bronchial asthma in children, while the expression of 25-hydroxyvitamin D3 decreased during the acute attack of bronchial asthma in children. The correlation among ECP, 25-(OH) D3 and M2 receptors is significant in the clinical diagnosis of acute attack of bronchial asthma in children. 展开更多
关键词 EOSINOPHIL cationic protein 25-hydroxyvitamin D3 M2 receptor bronchial asthma acute EPISODE
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自拟温肺化痰汤联合布地奈德治疗急性支气管哮喘的疗效
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作者 陈元粉 叶小丹 +2 位作者 曾林生 王利粉 祝庆华 《辽宁中医杂志》 北大核心 2025年第8期116-119,共4页
目的探讨自拟温肺化痰汤联合布地奈德治疗急性支气管哮喘(bronchial asthma,BA)的疗效。方法选择2023年2月—2024年3月该院收治的84例急性BA患者为研究对象,按照随机数字表法分为对照组与治疗组,每组42例。对照组在常规治疗基础上联合... 目的探讨自拟温肺化痰汤联合布地奈德治疗急性支气管哮喘(bronchial asthma,BA)的疗效。方法选择2023年2月—2024年3月该院收治的84例急性BA患者为研究对象,按照随机数字表法分为对照组与治疗组,每组42例。对照组在常规治疗基础上联合布地奈德治疗,治疗组在对照组基础上联合自拟温肺化痰汤治疗。比较两组治疗2周后临床疗效、中医证候积分、哮喘控制测试(asthma control test,ACT)评分、肺功能、C反应蛋白、嗜酸性粒细胞水平。结果治疗2周后,治疗组总有效率较对照组高(P<0.05)。治疗2周后,两组中医证候积分、C反应蛋白及嗜酸性粒细胞水平均降低,治疗组以上指标较对照组低(P<0.05);两组肺功能指标,ACT评分均增加,治疗组肺功能指标、ACT评分较对照组高(P<0.05)。结论自拟温肺化痰汤联合布地奈德治疗急性BA的短期效果良好,可提高疗效,在减轻患者症状,促进肺功能和炎症反应方面更具优势,值得推广。 展开更多
关键词 急性发作 支气管哮喘 温肺化痰汤 布地奈德 疗效
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两种血清指标与支气管哮喘急性发作期肺功能、气道炎症及复发的关系分析
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作者 代妍 刘晓宇 +4 位作者 宋路 勾海超 杨晓燕 刘运秋 孙丽明 《实用医院临床杂志》 2025年第2期163-166,共4页
目的探讨支气管哮喘患者血清膜型基质金属蛋白酶-1(MT1-MMP,又名MMP-14)、热休克蛋白27(HSP27)水平与急性发作期肺功能、气道炎症及复发的关系。方法选取2018年2月至2023年2月我院收治的140例支气管哮喘患者,86例急性发作期患者纳入急性... 目的探讨支气管哮喘患者血清膜型基质金属蛋白酶-1(MT1-MMP,又名MMP-14)、热休克蛋白27(HSP27)水平与急性发作期肺功能、气道炎症及复发的关系。方法选取2018年2月至2023年2月我院收治的140例支气管哮喘患者,86例急性发作期患者纳入急性组,54例缓解期患者纳入缓解组。采用酶联免疫吸附法(ELISA)检测患者血清MMP-14、HSP27水平,对比两组一般资料[年龄、性别、体质量指数、吸烟史、哮喘控制测试(ACT)评分],血清MMP-14、HSP27水平,肺功能[第1秒用力呼气容积(FEV_(1))、一秒率预计值(FEV_(1)%)、6 min步行距离(6MWD)],气道炎症指标[白介素-6(IL-6)、人免疫球蛋白E(IgE)、白介素-17(IL-17)、人转化生长因子-β(TGF-β)];分析血清MMP-14、HSP27水平与急性发作期肺功能、气道炎症的关系。治疗结束后对86例急性发作期患者随访1年,根据是否复发分为复发组和未复发组,对比两组血清MMP-14、HSP27水平。结果急性组ACT评分、FEV_(1)、FEV_(1)%、6MWD低于慢性组,血清MMP-14、HSP27、IL-6、IgE、IL-17、TGF-β水平高于慢性组(P<0.05)。血清MMP-14、HSP27水平与急性发作期FEV_(1)、FEV_(1)%、6MWD呈负相关,与IL-6、IgE、IL-17、TGF-β呈正相关(P<0.05);随访1年共有35例急性发作期患者复发,复发组血清MMP-14、HSP27水平高于未复发组(P<0.05)。结论支气管哮喘急性发作期患者血清MMP-14、HSP27水平升高,二者与急性发作期患者肺功能、气道炎症、复发有关。 展开更多
关键词 支气管哮喘 膜型基质金属蛋白酶-1 热休克蛋白27 急性发作期 肺功能 气道炎症
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痰液IL-37、RAMP-1、TSLP水平与支气管哮喘急性发作关系及联合预测重度发作效能研究
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作者 曹敬 王伯丽 +3 位作者 赫坤 徐海博 晁灵善 阎锡新 《现代中西医结合杂志》 2025年第11期1468-1474,共7页
目的研究痰液白细胞介素-37(IL-37)、受体活性修饰蛋白-1(RAMP-1)、胸腺基质淋巴生成素(TSLP)与支气管哮喘(哮喘)急性发作关系及联合预测哮喘重度发作效能。方法选取2023年7—12月河北医科大学第二医院收治的哮喘临床缓解期患者109例,根... 目的研究痰液白细胞介素-37(IL-37)、受体活性修饰蛋白-1(RAMP-1)、胸腺基质淋巴生成素(TSLP)与支气管哮喘(哮喘)急性发作关系及联合预测哮喘重度发作效能。方法选取2023年7—12月河北医科大学第二医院收治的哮喘临床缓解期患者109例,根据3个月内是否急性发作分为发作组和未发作组,比较2组患者基线资料及痰液IL-37、RAMP-1、TSLP水平,比较发作组不同发作程度患者痰液IL-37、RAMP-1、TSLP水平,Spearman分析痰液IL-37、RAMP-1、TSLP水平与发作程度相关性,随机森林模型对哮喘急性发作特征变量进行重要性排序和各相关变量的筛选,受试者工作特征曲线(ROC)分析痰液IL-37、RAMP-1、TSLP水平预测哮喘中度、重度急性发作的效能。结果发作组37例,未发作组72例,发作组过去1年因急性发作住院患者占比及伴过敏性鼻炎、慢性阻塞性肺疾病、鼻窦炎、鼻息肉患者占比均明显高于未发作组(P均<0.05),痰液IL-37水平明显低于未发作组(P<0.05),痰液RAMP-1、TSLP水平均明显高于未发作组(P均<0.05)。发作组重度患者痰液IL-37水平明显低于轻度、中度患者(P均<0.05),中度患者明显低于轻度患者(P<0.05);重度患者痰液RAMP-1、TSLP水平明显高于轻度、中度患者(P均<0.05),中度患者明显高于轻度患者(P<0.05)。相关性分析显示,痰液IL-37水平与哮喘发作程度呈负相关(r=-0.751,P<0.001),痰液RAMP-1、TSLP水平与哮喘发作程度呈正相关(r=-0.777,0.799,P均<0.001)。随机森林模型分析显示,哮喘急性发作特征变量重要性排序依次是TSLP、IL-37、RAMP-1、过去1年因急性发作住院、慢性阻塞性肺疾病、过敏性鼻炎、鼻窦炎、鼻息肉,当变量数为3时,袋外数据错误率最低,因此固定mtry=3,筛选出重要性排名前3的变量为TSLP、IL-37、RAMP-1;痰液IL-37、RAMP-1、TSLP水平联合预测中度、重度哮喘发作的曲线下面积(AUC)大于对应的单独指标,预测敏感度分别为83.33%和80.00%(P均<0.05),预测特异度分别为98.61%和98.61%(P均<0.05)。结论痰液IL-37水平降低和RAMP-1、TSLP水平升高与哮喘急性发作及发作严重程度有关,联合检测可作为预测哮喘中重度急性发作的一个有效方案,可为哮喘的临床管理、治疗等提供客观指导。 展开更多
关键词 支气管哮喘 痰液 白细胞介素-37 受体活性修饰蛋白-1 胸腺基质淋巴生成素 急性发作 预测效能
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补充维生素D对支气管哮喘急性发作期患儿肺功能的影响
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作者 王辉 杨波 《临床误诊误治》 2025年第8期68-72,共5页
目的探讨补充维生素D(VD)治疗对支气管哮喘急性发作期患儿肺功能的影响。方法选取2021年1月至2022年6月儿科门诊收治的80例支气管哮喘急性发作期患儿,采用随机数字表法分为观察组和对照组各40例。对照组在常规治疗基础上给予布地奈德气... 目的探讨补充维生素D(VD)治疗对支气管哮喘急性发作期患儿肺功能的影响。方法选取2021年1月至2022年6月儿科门诊收治的80例支气管哮喘急性发作期患儿,采用随机数字表法分为观察组和对照组各40例。对照组在常规治疗基础上给予布地奈德气雾剂雾化吸入治疗,观察组在对照组基础上给予维生素D滴剂治疗,2组均治疗8周。比较2组临床症状、体征消失时间,治疗前后嗜酸粒细胞(EOS)、总免疫球蛋白E(TIgE)、血清25-羟维生素D 3[25-(OH)D 3]水平,治疗前后第1秒用力呼气容积(FEV1)、FEV1占用力肺活量比值(FEV1/FVC)、呼气峰值流速(PEF)、呼气高峰流量(PEFR),治疗前后儿童哮喘控制测试(C-ACT)评分、儿童生命质量量表(PedsQL)哮喘模块评分,以及治疗期间不良反应。结果观察组气喘、咳嗽、呼吸困难、肺哮鸣音消失时间均短于对照组(P<0.01)。治疗后,2组EOS、TIgE均低于治疗前(P<0.05),但组间比较无差异(P>0.05);治疗后,观察组25-(OH)D 3水平高于治疗前,且高于对照组(P<0.05,P<0.01)。治疗后,2组FEV1、FEV1/FVC、PEF、PEFR水平均高于治疗前,且观察组高于对照组(P<0.05,P<0.01)。治疗后,2组C-ACT评分、PedsQL哮喘模块评分均高于治疗前(P<0.05),但组间比较无差异(P>0.05)。治疗期间观察组不良反应发生率为20.00%(8/40),对照组为17.50%(7/40),比较差异无统计学意义(P>0.05)。结论补充VD治疗可明显缩短支气管哮喘急性发作期患儿临床症状体征持续时间,提高肺功能,且安全性较好。 展开更多
关键词 支气管哮喘 急性发作 儿童 维生素D 嗜酸粒细胞 第1秒用力呼气容积 儿童哮喘控制测试 药物毒性
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血清LTBP-2、PON-1水平对支气管哮喘患儿病情严重程度及急性发作的预测价值
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作者 阴悦 李若晗 +4 位作者 柴小龙 张艳玲 王靓靓 刘文杰 苏文硕 《保健医学研究与实践》 2025年第6期58-63,共6页
目的探讨血清转化生长因子结合蛋白2(LTBP-2)、对氧磷脂酶-1(PON-1)水平对支气管哮喘患儿病情严重程度、急性发作的评估价值,以期为临床治疗提供参考。方法选取2020年8月—2024年6月秦皇岛市第一医院收治的116例支气管哮喘患儿为研究对... 目的探讨血清转化生长因子结合蛋白2(LTBP-2)、对氧磷脂酶-1(PON-1)水平对支气管哮喘患儿病情严重程度、急性发作的评估价值,以期为临床治疗提供参考。方法选取2020年8月—2024年6月秦皇岛市第一医院收治的116例支气管哮喘患儿为研究对象。根据患儿病情分为轻度组(n=52)、中度组(n=38)和重度组(n=26);再根据支气管哮喘患儿是否处于急性发作期将其分为急性组(n=71)与缓解组(n=45);另选取同期于本院体检的健康儿童100例作为健康组。收集所有研究对象的年龄、性别等一般资料及LTBP-2、PON-1水平;检测支气管哮喘患儿第一秒用力呼气容积(FEV_(1))、FEV_(1)占预计值百分比。结果轻度组、中度组、重度组支气管哮喘患儿血清LTBP-2水平明显高于健康组,血清PON-1水平低于健康组,差异均有统计学意义(P<0.05);随着病情的加重,患儿血清LTBP-2水平逐渐升高,血清PON-1水平逐渐下降,差异均有统计学意义(P<0.05)。急性组支气管哮喘患儿血清LTBP-2水平高于缓解组,血清PON-1、FEV_(1)水平及FEV_(1)占预计值百分比低于缓解组,差异均有统计学意义(P<0.05)。支气管哮喘患儿血清LTBP-2水平与病情严重程度呈正相关,与FEV_(1)、FEV_(1)占预计值百分比呈负相关(P<0.001);支气管哮喘患儿血清PON-1水平与病情严重程度呈负相关,与FEV_(1)、FEV_(1)占预计值百分比呈正相关(P<0.001)。血清LTBP-2、PON-1、LTBP-2+PON-1评估支气管哮喘患儿急性发作的曲线下面积(AUC)分别为0.784(95%CI:0.739~0.834)、0.837(95%CI:0.792~0.887)、0.919(95%CI:0.874~0.969)。结论血清LTBP-2、PON-1水平与支气管哮喘患儿病情严重程度及肺功能存在显著相关性。临床中可通过监测这2种指标的水平变化,评估患儿病情进展情况及急性发作风险;且二者联合检测对支气管哮喘患儿急性发作的评估价值高于单一指标检测,能为临床诊疗提供更可靠的参考依据。 展开更多
关键词 转化生长因子结合蛋白-2 对氧磷脂酶-1 支气管哮喘 急性发作期
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布地奈德+沙丁胺醇雾化吸入治疗支气管哮喘急性发作的价值研讨
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作者 徐宜全 《中国现代药物应用》 2025年第14期79-82,共4页
目的分析支气管哮喘急性发作过程中布地奈德+沙丁胺醇雾化吸入的疗效。方法以60例支气管哮喘急性发作患者为样本,按随机数字表法分组,联合组、对照组的样本量均为30例。对照组接受常规治疗+沙丁胺醇雾化吸入治疗,联合组在对照组基础上... 目的分析支气管哮喘急性发作过程中布地奈德+沙丁胺醇雾化吸入的疗效。方法以60例支气管哮喘急性发作患者为样本,按随机数字表法分组,联合组、对照组的样本量均为30例。对照组接受常规治疗+沙丁胺醇雾化吸入治疗,联合组在对照组基础上联合布地奈德治疗。比较两组疗效、症状持续时间、炎症因子水平、肺功能指标。结果联合组总有效率达到96.67%(29/30),高于对照组的73.33%(22/30),有差异(P<0.05)。联合组胸闷、咳嗽及哮鸣音持续时间分别为(3.15±0.17)、(5.23±0.35)、(4.42±0.55)d,均短于对照组的(4.67±0.41)、(7.11±0.38)、(6.78±0.53)d,有差异(P<0.05)。治疗后,两组呼气峰值流量(PEF)、第1秒用力呼气容积(FEV1)、FEV1与用力肺活量(FVC)比值(FEV1/FVC)均较治疗前好转,且联合组优于对照组,有差异(P<0.05)。治疗后,两组白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均较治疗前好转,且联合组低于对照组,有差异(P<0.05)。结论对支气管哮喘急性发作患者而言,布地奈德+沙丁胺醇雾化吸入的方案可缩短症状持续时间,临床有效率高,对其炎症因子、肺功能有较好的改善作用,值得借鉴。 展开更多
关键词 布地奈德 沙丁胺醇 支气管哮喘 急性发作 炎症因子 肺功能
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不同流速HFNC在支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者中的急救效果
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作者 刘艳 曾薪月 李丹 《中国急救复苏与灾害医学杂志》 2025年第8期1067-1070,共4页
目的 探究不同流速经鼻高流量氧疗(HFNC)在支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者中的急救效果。方法 前瞻性选取2020年8月—2023年5月在内江市第一人民医院治疗的84例支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者,采用随机数字表法分为... 目的 探究不同流速经鼻高流量氧疗(HFNC)在支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者中的急救效果。方法 前瞻性选取2020年8月—2023年5月在内江市第一人民医院治疗的84例支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者,采用随机数字表法分为低流速组(n=42,常规治疗+30 L/min流速HFNC治疗)和高流速组(n=42,常规治疗+50 L/min流速HFNC治疗),比较两组急救疗效、临床症状消失时间以及治疗前后血气分析指标[pH值、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))]、呼吸频率水平、呼吸困难程度和呼吸舒适度。结果 高流速组急救总有效率(95.24%)高于低流速组(80.95%)(χ^(2)=4.086,P<0.05);高流速组患者临床症状消失时间短于低流速组相(P<0.05);治疗1 h,高流速组呼吸频率低于低流速组(t=4.432,P<0.05);治疗后,与低流速组相比,高流速组患者PaCO_(2)水平、呼吸困难程度评分更低,呼吸舒适度评分、PaO_(2)水平更高(t=3.037、4.263、6.546、5.865,P<0.05)。结论 相比低流速HFNC,高流速HFNC治疗支气管哮喘急性发作合并Ⅰ型呼吸衰竭患者急救有效率更高,临床症状消失更快,血气指标改善更加明显,且对患者呼吸舒适度、呼吸困难程度以及呼吸频率也有影响。 展开更多
关键词 支气管哮喘急性发作 Ⅰ型呼吸衰竭 流速 经鼻高流量氧疗
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IgE、IL-4、IL-1β、FeNO动态水平对小儿支气管哮喘急性发作的疗效评估价值
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作者 刘硕 薛萍 +2 位作者 李小琴 张美娟 王晓红 《中南医学科学杂志》 2025年第2期338-340,344,共4页
目的 分析免疫球蛋白E(IgE)、白细胞介素(IL)-4、IL-1β及呼出气一氧化氮(FeNO)水平对小儿支气管哮喘急性发作疗效的评估价值。方法 选取118例支气管哮喘急性发作的患儿为研究对象,实施个体化治疗方案后,根据疗效分为病情控制组(89例)... 目的 分析免疫球蛋白E(IgE)、白细胞介素(IL)-4、IL-1β及呼出气一氧化氮(FeNO)水平对小儿支气管哮喘急性发作疗效的评估价值。方法 选取118例支气管哮喘急性发作的患儿为研究对象,实施个体化治疗方案后,根据疗效分为病情控制组(89例)与未控制组(29例)。比较118例患儿治疗前后以及控制组与未控制组患儿治疗后IgE、IL-4、IL-1β、FeNO水平。采用Pearson相关性分析IgE、IL-4、IL-1β、FeNO指标之间的相关性;采用ROC曲线分析IgE、IL-4、IL-1β、FeNO对哮喘患儿的疗效评估价值。结果 治疗后,118例哮喘患儿IgE、IL-4、IL-1β、FeNO水平均降低(P<0.05)。控制组IgE、IL-4、IL-1β、FeNO水平均低于未控制组(P<0.05)。哮喘患儿IgE、IL-4、IL-1β、FeNO指标之间相互呈正相关(P<0.05)。ROC曲线结果显示,IgE、IL-4、IL-1β、FeNO联合评估急性发作哮喘患儿临床疗效的AUC值均高于单一指标评估的AUC值(P<0.05)。结论 动态监测IgE、IL-4、IL-1β及FeNO可有效评估哮喘急性发作疗效,联合检测较单独指标检测具有更高预测效能。 展开更多
关键词 小儿支气管哮喘 急性发作 IGE IL-4 IL-1Β FENO 疗效评估
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支气管哮喘急性发作期患儿血清PTX3、IL-37水平及其对疾病的诊断价值
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作者 文海波 卢玉容 +1 位作者 杨佳 蔡强 《检验医学与临床》 2025年第10期1374-1378,共5页
目的探讨支气管哮喘急性发作期患儿血清正五聚蛋白3(PTX3)、白细胞介素-37(IL-37)水平及其对支气管哮喘急性发作期的诊断价值。方法选取2020年10月至2023年11月该院接收的232例支气管哮喘患儿作为研究对象,依据患儿入院时的喘息控制状... 目的探讨支气管哮喘急性发作期患儿血清正五聚蛋白3(PTX3)、白细胞介素-37(IL-37)水平及其对支气管哮喘急性发作期的诊断价值。方法选取2020年10月至2023年11月该院接收的232例支气管哮喘患儿作为研究对象,依据患儿入院时的喘息控制状态将其分为136例急性发作期患儿(急性组)和96例临床缓解期患儿(缓解组),依据哮喘急性发作病情严重程度将急性组分为轻度组(56例)、中度组(48例)及重度组(32例);另选取同期在该院进行体检的98例健康体检儿童作为对照组。收集3组血清免疫球蛋(Ig)E水平及嗜酸性粒细胞比例,血清PTX3、IL-37水平检测采用酶联免疫吸附试验,检测急性组患儿第1秒用力呼气量(FEV_(1))占预计值的百分比(FEV_(1)%)、FEV_(1)与用力肺活量比值(FEV_(1)/FVC)、最大呼气峰流速(PEF)等;采用Pearson相关分析急性组患儿血清PTX3、IL-37水平与FEV_(1)%、FEV_(1)/FVC和PEF的相关性;采用受试者工作特征(ROC)曲线分析血清PTX3、IL-37单独及联合检测对支气管哮喘急性发作期的诊断价值。结果急性组、缓解组、对照组嗜酸性粒细胞比例比较,差异均无统计学意义(P>0.05)。急性组血清IgE、PTX3水平高于缓解组与对照组,且缓解组均高于对照组,差异均有统计学意义(P<0.05)。急性组血清IL-37水平低于缓解组及对照组,且缓解组低于对照组,差异均有统计学意义(P<0.05)。重度组血清PTX3水平高于中度组及轻度组,且中度组高于轻度组,差异均有统计学意义(P<0.05)。重度组FEV_(1)%、FEV_(1)/FVC和PEF及血清IL-37水平均低于中度组及轻度组,且中度组均低于轻度组,差异均有统计学意义(P<0.05)。急性组患儿血清PTX3水平与FEV_(1)%、FEV_(1)/FVC和PEF均呈负相关(P<0.05),血清IL-37水平与FEV_(1)%、FEV_(1)/FVC和PEF均呈正相关(P<0.05)。ROC曲线分析结果显示,血清PTX3、IL-37单独诊断哮喘急性发作期的曲线下面积(AUC)分别为0.839、0.836,二者联合诊断的AUC为0.892,大于PTX3、IL-37单独诊断的AUC(Z=2.917、2.210,P=0.004、0.027)。结论支气管哮喘急性发作期患儿血清PTX3水平升高,血清IL-37水平降低,与患儿病情严重程度有关,可辅助诊断支气管哮喘急性发作期,且二者联合诊断效果较好。 展开更多
关键词 支气管哮喘 急性发作期 正五聚蛋白3 白细胞介素-37 诊断
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布地奈德福莫特罗吸入粉雾剂联合经鼻高流量氧疗、孟鲁司特钠治疗支气管哮喘急性发作的效果及对基质金属蛋白酶水平的影响 被引量:4
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作者 陈聪玲 常英 《临床医学研究与实践》 2025年第2期57-60,共4页
目的探讨布地奈德福莫特罗吸入粉雾剂联合经鼻高流量氧疗、孟鲁司特钠治疗支气管哮喘急性发作的效果。方法选择2020年4月至2023年1月收治的98例支气管哮喘急性发作患者为研究对象,以随机数字表法将其分为对照组与观察组,各49例。对照组... 目的探讨布地奈德福莫特罗吸入粉雾剂联合经鼻高流量氧疗、孟鲁司特钠治疗支气管哮喘急性发作的效果。方法选择2020年4月至2023年1月收治的98例支气管哮喘急性发作患者为研究对象,以随机数字表法将其分为对照组与观察组,各49例。对照组给予经鼻高流量氧疗+孟鲁司特钠治疗,观察组在对照组基础上加布地奈德福莫特罗吸入粉雾剂治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制因子-1(TIMP-1)水平低于对照组(P<0.05)。治疗后,观察组的辅助性T细胞1(Th1)、辅助性T细胞1/辅助性T细胞2(Th1/Th2)高于对照组,Th2低于对照组(P<0.05)。治疗后,观察组的哮喘控制测试(ACT)评分高于对照组,圣·乔治呼吸问卷(SGRQ)评分低于对照组(P<0.05)。结论布地奈德福莫特罗吸入粉雾剂联合经鼻高流量氧疗、孟鲁司特钠治疗支气管哮喘急性发作的效果满意,能降低MMP-9、TIMP-1表达,也可调节机体炎症反应,值得推广。 展开更多
关键词 布地奈德福莫特罗吸入粉雾剂 经鼻高流量氧疗 孟鲁司特钠 支气管哮喘急性发作 基质金属蛋白酶
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宣白承气汤联合布地奈德雾化治疗急性支气管哮喘的疗效及对肺功能、血清IL-4、IFN-γ、CRP的影响 被引量:1
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作者 李莹 姚军丽 赵娜 《辽宁中医杂志》 北大核心 2025年第1期94-97,共4页
目的观察宣白承气汤联合布地奈德雾化治疗急性支气管哮喘的疗效及对患者肺功能、白细胞介素-4(血清IL-4)、γ干扰素(IFN-γ)、C-反应蛋白(CRP)的影响。方法选取2020年3月—2023年3月收治的98例急性支气管哮喘患者,随机分为对照组与联用... 目的观察宣白承气汤联合布地奈德雾化治疗急性支气管哮喘的疗效及对患者肺功能、白细胞介素-4(血清IL-4)、γ干扰素(IFN-γ)、C-反应蛋白(CRP)的影响。方法选取2020年3月—2023年3月收治的98例急性支气管哮喘患者,随机分为对照组与联用组各49例,对照组在常规治疗基础上给予布地奈德雾化治疗,联用组在对照度基础上联用宣白承气汤治疗,疗程均为7 d。对比两组疗效、中医证候积分、肺功能、血清炎症因子水平及不良反应发生情况。结果治疗7 d后,联用组的疗效等级及总有效率均高于对照组(P<0.05);两组各项主次证证候积分均降低(P<0.05),且联用组均明显低于对照组(P<0.05);两组用力肺活量(FVC)、第1秒用力呼气容积(FEV_1)及最大呼气流速(PEF)均升高(P<0.05),且联用组均高于对照组(P<0.05);两组血清IL-4、CRP水平均降低,且联用组低于对照组(P<0.05);IFN-γ水平均升高,且联用组高于对照组(P<0.05)。治疗期间,两组不良反应发生率比较无统计学意义(P>0.05)。结论宣白承气汤联合布地奈德雾化治疗急性支气管哮喘疗效显著,可有效改善患者中医症状,减轻炎症反应,改善肺功能。 展开更多
关键词 急性支气管哮喘 宣白承气汤 布地奈德 肺功能 疗效
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杏贝止咳颗粒联合丙酸倍氯米松对支气管哮喘急性发作期患儿炎症-免疫调节作用研究
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作者 胡利娟 杨文婷 +1 位作者 李菲 崔玉芳 《现代生物医学进展》 2025年第7期1168-1175,共8页
目的:探讨杏贝止咳颗粒联合丙酸倍氯米松对支气管哮喘急性发作期患儿的炎症-免疫调节作用。方法:采用随机数字表法,将106例急性发作期支气管哮喘患儿分为对照组(n=53,吸入用丙酸倍氯米松雾化吸入治疗)、研究组(n=53,杏贝止咳颗粒联合吸... 目的:探讨杏贝止咳颗粒联合丙酸倍氯米松对支气管哮喘急性发作期患儿的炎症-免疫调节作用。方法:采用随机数字表法,将106例急性发作期支气管哮喘患儿分为对照组(n=53,吸入用丙酸倍氯米松雾化吸入治疗)、研究组(n=53,杏贝止咳颗粒联合吸入用丙酸倍氯米松雾化吸入治疗)。治疗2周,对比两组临床症状缓解时间、炎症因子[白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)、IL-10]、免疫功能指标[免疫球蛋白(Ig)A、Ig G、Ig M、Ig E和T淋巴细胞亚群],观察两组不良反应发生情况。结果:研究组的咳嗽、气急及哮鸣音等临床症状缓解时间短于对照组(P<0.05)。研究组治疗后CD3^(+)、CD4^(+)、IL-10、CD4^(+)/CD8^(+)高于对照组,IL-6、CD8^(+)、TNF-α低于对照组(P<0.05)。研究组治疗后Ig A、Ig G、Ig M高于对照组,Ig E低于对照组(P<0.05)。两组不良反应发生率组间对比无统计学差异(P>0.05)。结论:杏贝止咳颗粒联合丙酸倍氯米松治疗儿童支气管哮喘急性发作期,可缩短症状缓解时间,且用药安全性良好,与降低炎症因子水平、改善免疫功能有关。 展开更多
关键词 支气管哮喘 丙酸倍氯米松 杏贝止咳颗粒 急性发作期 炎症 免疫
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