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不同情况下Bite Turbos对上颌中切牙作用的三维有限元分析
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作者 王玉琛 林新平 +2 位作者 邹明媛 弓国梁 余飞 《口腔医学研究》 北大核心 2025年第4期320-326,共7页
目的:通过分析不同情况下咬合垫(Bite Turbos)在打开前牙咬合时上颌中切牙的移动变化来探究影响上颌中切牙唇倾度的相关因素。方法:利用Minics、Geomagic Wrap 2017、SolidWork等软件进行模型的制作,用Workbench对模型设置运行条件,计... 目的:通过分析不同情况下咬合垫(Bite Turbos)在打开前牙咬合时上颌中切牙的移动变化来探究影响上颌中切牙唇倾度的相关因素。方法:利用Minics、Geomagic Wrap 2017、SolidWork等软件进行模型的制作,用Workbench对模型设置运行条件,计算出上颌中切牙的位移距离及方向。结果:作用位点Bite Turbos咬合面后1/3各组模型上中切牙均表现为舌倾改变,Turbos咬合面前1/3各组上中切牙均为唇倾改变;较标准唇倾度中切牙组,唇倾组中模型D1、E1、F1上中切牙更多舌倾变化,其余6组更多唇倾变化,舌倾组中G3、H3、I3表现为更少唇倾变化,其余6组多数表现更多舌倾;Turbos咬合面唇向倾斜,较水平组而言,各组模型上中切牙均表现更舌倾,而咬合面舌向倾斜所有模型表现均更唇倾;垂直向各组模型上中切牙整体表现为压低,除H1上中切牙切缘少量伸长(0.002 mm)外,其余各组切缘及根尖均压低表现。结论:Bite Turbos打开咬合时,上颌中切牙唇倾度的变化与其自身的唇倾度、Bite Turbos咬合面倾斜度及其咬合接触点密切相关。咬合力的作用力线及阻抗中心位置的关系影响上颌中切牙的唇倾度变化。 展开更多
关键词 三维有限元 bite Turbos 生物力学机制 深覆[牙合] 上颌中切牙唇倾度
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Exploring the spatially and temporally varying impacts of built environment factors on rail transit ridership 被引量:1
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作者 HU Mingxing WANG Chunxin 《Journal of Southeast University(English Edition)》 2025年第2期235-243,共9页
This study examined the influence of the built environment surrounding rail stations on rail transit ridership and its spatiotemporal variations,aiming to enhance rail transit operational efficiency and inform station... This study examined the influence of the built environment surrounding rail stations on rail transit ridership and its spatiotemporal variations,aiming to enhance rail transit operational efficiency and inform station planning and development.Data from 159 metro stations in Nanjing,collected over a 14-d period,were analyzed to identify changes in weekday and weekend ridership patterns.The analysis included explanatory variables grouped into three categories:urban spatial variables,socioeconomic vari-ables,and transit service variables.A geographically and temporally weighted regression(GTWR)model was developed,and its performance was compared with that of ordinary least squares(OLS)and geographically weighted regression(GWR)models.The results demonstrated that the GTWR model outperformed others in analyzing the relationship between rail transit ridership and the built environment.In addition,the coefficients of explanatory variables showed significant variation across spatiotemporal dimensions,revealing distinct patterns.Notably,the influence of commuter flows led to more pronounced temporal heterogeneity in the coefficients observed on weekdays.These findings offer valuable insights for optimizing urban public transportation systems and advancing integrated urban rail development. 展开更多
关键词 built environment rail transit ridership spatio-temporal analysis geographically and temporally weighted regression(GTWR)
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Sexual differences in bite force are not related to testosterone level in the wild-derived red junglefowl
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作者 Xiaodong Rao Daiping Wang Wei Liang 《Current Zoology》 2025年第1期33-39,共7页
Bite force is an important performance indicator of individual fitness that is closely related to food acquisition,male competition,and mating selection.It is also affected by a variety of factors and different mechan... Bite force is an important performance indicator of individual fitness that is closely related to food acquisition,male competition,and mating selection.It is also affected by a variety of factors and different mechanisms.Therefore,it is relatively difficult to understand the evolutionary driving forces of changes in bite force.In this study,the driving factors affecting the bite force of wild-derived red junglefowl(Gallus gallus jabouillei)were investigated from the aspects of morphological indicators and physiological characteristics.Results showed that the bite force of wild-derived red junglefowl was directly related to sex,showing obvious sexual differences.However,there was no correlation between the plasma testosterone level and bite force.The bite force of males was significantly greater than that of females,and the body index(i.e.,PC1 of five body measures,namely body mass,body length,wing length,tail length,and tarsus length),the grasp index(i.e.,tomial length×bill width)of males were significantly greater than those of females.Sexual selection may have played a key role in the evolution of bite force in the red junglefowl.Future studies should examine other key factors affecting changes in bite force to verify the correlation between secondary sexual characteristics and bite force in red junglefowls. 展开更多
关键词 bite force evolution morphometric indices red junglefowl TESTOSTERONE
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Improved super-elastic Ti-Ni alloy wire for the angle class III patient with anterior open bite:A case report
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作者 Yu Fan Jian-Hong Yu Yuan-Hou Chen 《World Journal of Clinical Cases》 2025年第15期32-41,共10页
BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully c... BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully corrected with improved super-elastic Ti-Ni alloy wire(ISW).CASE SUMMARY A 19 years old male came to our clinic with a chief complaint of anterior open bite and crossbite and not able to chew food well.Clinical examination revealed an angle class III malocclusion with anterior open bite,crossbite and spaced arch.Ra-diographic and clinical examination showed a skeletal class III pattern.We used ISW to level the upper and lower arch and to correct the anterior open bite and crossbite.Intermaxillary elastics were also used to achieve a better interdigitation.Finally,adequate overbite,overjet and a desirable occlusion were achieved.The active treatment time took 2 years and 2 months.CONCLUSION In a case of class III angular malocclusion with open bite and crossbite in the ante-rior teeth,ideal results were achieved using the ISW technique and the patient was satisfied with the outcome. 展开更多
关键词 Dentistry Orthodontics Angle class III malocclusion Anterior open bite Anterior open bite Improved super-elastic Ti-Ni alloy wire Case report
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Spinal cord ischemia:The“snake bite sign”
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作者 Nikolaos-Achilleas Arkoudis Anastasia Karachaliou +3 位作者 George Triantafyllou Andreas Papadopoulos Christos Koutserimpas Georgios Velonakis 《World Journal of Radiology》 2025年第7期87-90,共4页
Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake ... Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake eyes”sign.We discuss how these signs,while visually apt,convey no pathophysiologic context and propose renaming this finding the“snake bite sign”.The image still evokes two punctate marks,yet the metaphor extends to a snake bite(two fang-like dots)rather than two bright foci(eyes)staring back at the viewer.Moreover,besides the sign metaphorically resembling a traumatic puncture of the two fangs,on the occasion of a venomous snake bite occurring elsewhere,additional neurological consequences may occur,paralleling the neurological deficits seen in anterior spinal artery infarction and several mimicking myelopathies,thus further high-lighting the analogy.Such clinically driven terminology may facilitate teaching,enable diagnostic recall,and improve interdisciplinary communication. 展开更多
关键词 RADIOLOGY NEUROIMAGING NEURORADIOLOGY Spinal CORD Ischemia SNAKE bite Eyes Owl
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Analysis of Reinforcement Techniques for Newly Built Tunnel Defects
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作者 Yike Wei 《Journal of Architectural Research and Development》 2025年第1期1-7,共7页
Newly built tunnels often encounter a series of defects within the first few years of operation.If not promptly addressed and reinforced,these defects threaten the tunnel's durability and stability and bring sever... Newly built tunnels often encounter a series of defects within the first few years of operation.If not promptly addressed and reinforced,these defects threaten the tunnel's durability and stability and bring severe challenges to its safe operation.This study aims to explore reinforcement techniques for addressing defects in newly built tunnels.The research begins with an analysis of common defects found in newly built tunnels,followed by a case study of the Jinfeng Tunnel in Chongqing,examining the post-construction defects.The actual reinforcement strategies and methods employed for the tunnel are then discussed.Finally,based on the research findings,this study provides insights and references for tunnel operation and construction units in China,aiming to enhance the overall quality of tunnel engineering in the country,align with sustainable development goals,and promote further improvements at a macro level. 展开更多
关键词 Newly built tunnels Defect treatment and reinforcement Initial support deformation Lining cracking
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Influence of built environment and socio-economic status on residents'low-carbon lifestyle:An empirical analysis of Zhengzhou city,China
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作者 ZHANG Jingfei ZHANG Lijun +1 位作者 RONG Peijun QIN Yaochen 《Journal of Geographical Sciences》 2025年第11期2443-2466,共24页
A low-carbon lifestyle presents new opportunities for sustainable urban development.While previous studies have verified the impact of the built environment and socioeconomic status(SES)on low-carbon lifestyles,they h... A low-carbon lifestyle presents new opportunities for sustainable urban development.While previous studies have verified the impact of the built environment and socioeconomic status(SES)on low-carbon lifestyles,they have primarily focused on direct effects.At present,there is still a lack of analysis on the interaction effects on low-carbon lifestyles,and limited attention has been given to the peer effect in low-carbon lifestyles,especially in the context of residential differentiation.Therefore,we take Zhengzhou city as the case area and first calculate the low-carbon lifestyle of 1485 families from three dimensions:low-carbon action(A),low-carbon interest(I)and low-carbon opinion(O).We then analyze the direct and interactive impacts of the built environment and SES on low-carbon lifestyles and explore the peer effect.Our findings indicate that families with higher SES have higher levels of low-carbon interest and low-carbon opinion,but relatively low levels of low-carbon action.This suggests an interest-action bias in the low-carbon lifestyles of high-SES families.POI density,road network density and accessibility positively affect low-carbon lifestyles—that is,residents living in areas with well-developed infrastructure and convenient transportation tend to be green in their daily behavior.The peer effect influences low-carbon action,interest,and opinion by 54.6%,34.9%,and 16%,respectively,indicating that the peer effect is most evident in low-carbon action.That is,the peer effect is more obvious in low-carbon action.In addition,the built environment affects the low-carbon lifestyles of different SES groups.Land-use mix positively increases low-carbon action and low-carbon interest among high-SES groups but reduces low-carbon opinion.Road network density positively affects the low-carbon action of high-SES groups and the low-carbon interest and low-carbon opinion of low-SES groups.This study explores low-carbon lifestyles from a situational perspective,providing a practical basis for policies aimed at accelerating a transition to sustainable living. 展开更多
关键词 built environment socio-economic status(SES) low-carbon lifestyle peer effect Zhengzhou
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Review of research advances in microbial sterilization technologies and applications in the built environment
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作者 Xinran Zeng Chunhui Li +2 位作者 Zhenhai Li Zhizheng Tao Mingtong Li 《Journal of Environmental Sciences》 2025年第8期314-348,共35页
As globalization accelerates,microbial contamination in the built environment poses a major public health challenge.Especially since Corona Virus Disease 2019(COVID-19),microbial sterilization technology has become a ... As globalization accelerates,microbial contamination in the built environment poses a major public health challenge.Especially since Corona Virus Disease 2019(COVID-19),microbial sterilization technology has become a crucial research area for indoor air pollution control in order to create a hygienic and safe built environment.Based on this,the study reviews sterilization technologies in the built environment,focusing on the principles,efficiency and applicability,revealing advantages and limitations,and summarizing current research advances.Despite the efficacy of single sterilization technologies in specific environments,the corresponding side effects still exist.Thus,this review highlights the efficiency of hybrid sterilization technologies,providing an in-depth understanding of the practical application in the built environment.Also,it presents an outlook on the future direction of sterilization technology,including the development of new methods that are more efficient,energy-saving,and targeted to better address microbial contamination in the complex and changing built environment.Overall,this study provides a clear guide for selecting technologies to handle microbial contamination in different building environments in the future,as well as a scientific basis for developing more effective air quality control strategies. 展开更多
关键词 built environment Single sterilization technology Hybrid sterilization technology Energy consumption Practical application
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Nonlinear effects of the urban built environment on urban vitality:A case study of Hangzhou,China
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作者 ZHAN Dongsheng WANG Yufeng +1 位作者 WU Qianbo ZHANG Wenzhong 《Journal of Geographical Sciences》 2025年第6期1183-1203,共21页
The effects of the built environment factors on urban vitality have attracted wide attention in the urban planning fields in recent years,but few studies have considered the variables’relative importance and their no... The effects of the built environment factors on urban vitality have attracted wide attention in the urban planning fields in recent years,but few studies have considered the variables’relative importance and their nonlinear effects on urban vitality.Taking a Chinese metropolis—Hangzhou as a case study,this study applied the gradient boosting decision tree(GBDT)model to explore the nonlinear effects of the 5D factors of the urban built environment on urban social vitality and economic vitality and the importance of variables.The results show that the GBDT model has better goodness of fit than the traditional ordinary least squares(OLS)regression in the urban vitality models.The urban built environment plays an important role in affecting urban vitality,while built environment designs witness the most important effect.Specifically,the density of shopping facilities,medical facilities,and road networks are the most important factors affecting urban social vitality,while road network density,destination accessibility,and population density play the most important roles in affecting urban economic vitality.Finally,the urban built environment factors have nonlinear threshold effects on both urban economic and social vitality in Hangzhou,with differing nonlinear response patterns observed between social and economic dimensions. 展开更多
关键词 built environment urban vitality nonlinear effect gradient boosting decision tree model Hangzhou
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English Translation of Culture-Loaded Words Concerning Food in A Bite of China from a Perspective of Eco-Translatology
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作者 AN Wen-cai GAO Wen-cheng 《Journal of Literature and Art Studies》 2025年第11期842-845,共4页
Chinese food culture boasts a long history and rich connotations.As an important window for disseminating Chinese food culture,A Bite of China’s English translation plays a crucial role in the international spread of... Chinese food culture boasts a long history and rich connotations.As an important window for disseminating Chinese food culture,A Bite of China’s English translation plays a crucial role in the international spread of culture.Culture-loaded words concerning food carry profound cultural heritages,posing numerous challenges to translation.This study takes Eco-Translatology as the theoretical framework,and adopts the case-study method to explore English translation of such words.It selects a large number of translation cases of culture-loaded words related to food from the English version of A Bite of China and deeply analyzes them.This study demonstrates that Eco-Translatology has significant guiding value for the English translation of culture-loaded food words in A Bite of China.Its multi-dimensional transformation strategies contribute to improving translation quality,providing practical references for the translation of Chinese food culture into foreign languages,and playing a positive role in promoting food culture exchange. 展开更多
关键词 ECO-TRANSLATOLOGY A bite of China culture-loaded words concerning food English translation strategies
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Impact of Built Environment on Urban Vitality in Shrinking Cities:Moderating Effect of Housing Vacancy
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作者 FU Hui ZHOU Guolei +3 位作者 SUN Hongri JIN Yu WU Hanchun LIU Yanjun 《Chinese Geographical Science》 2025年第6期1428-1443,共16页
Urban vitality is one of the key indicators of sustainable urban development and an important factor for shrinking cities to achieve internal optimization.The relationship between the built environment and urban vital... Urban vitality is one of the key indicators of sustainable urban development and an important factor for shrinking cities to achieve internal optimization.The relationship between the built environment and urban vitality has been extensively discussed.However,the moderating effect of housing vacancy on the built environment’s effect on urban vitality in shrinking cities has not been explored in detail.This paper selected Yichun District in Yichun City of Heilongjiang Province,a typical shrinking city in Northeast China,as the study area,focusing on the effect of the built environment on urban vitality in shrinking cities based on residential and commercial electricity consumption data for 2013 and 2018.Moreover,this study also explored the moderating mechanisms of residential and commercial housing vacancies on the built environment’s effect on urban vitality.The results demonstrate that the spatial pattern of urban vitality in the Yichun District is‘high in the center and low in the periphery’.Population density,building age,road density,and catering facilities are recognized as the main built environment factors affecting the vitality of shrinking cities.Residential and commercial housing vacancies have a significant moderating effect on the built environment’s effect on urban vitality.Residential housing vacancies enhance the positive effect of road density and the negative effect of greening rate.In addition,commercial housing vacancies suppress the positive effect of building density and enhance the positive effect of accessibility to urban service facilities.The study indicates that built environment factors exhibit heterogeneous effects on vitality in the context of urban shrinkage,as moderated by housing vacancies.Targeted regulation of built environment factors is of practical significance in realizing the internal development and vitality enhancement of shrinking cities. 展开更多
关键词 housing vacancy urban vitality built environment shrinking cities Yichun District Yichun City China
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新型双特异性单链抗体BiTEs及其在肿瘤治疗中的应用前景 被引量:2
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作者 于蕊 陈昭烈 《中国生物工程杂志》 CAS CSCD 2004年第4期1-6,共6页
BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促... BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促进CD3复合体和肿瘤靶标的连接 ,并且它不受T细胞受体和靶细胞上MHCⅠ类分子的约束 ,不需要共刺激分子的参与 ,是一种极具应用潜力的抗体形式。就BiTEs的结构、作用机理及其在肿瘤临床上的应用前景几个方面做一综述。 展开更多
关键词 biteS 双特异性单链抗体 细胞毒性T细胞 肿瘤 临床治疗
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用AHP方法优化电子装备测试点的BITE与ATE分配 被引量:1
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作者 杜敏杰 蔡金燕 刘利民 《电光与控制》 北大核心 2012年第6期84-87,91,共5页
针对故障诊断中测试冗余、测试资源分配不合理的问题,首先用解析冗余关系(ARRs)优选出测试点;分析了影响测试资源选择的因素,用层次分析法(AHP)建立了评价指标集的递阶层次结构,确定了各指标的综合权重,最后用模糊综合决策方法实现了测... 针对故障诊断中测试冗余、测试资源分配不合理的问题,首先用解析冗余关系(ARRs)优选出测试点;分析了影响测试资源选择的因素,用层次分析法(AHP)建立了评价指标集的递阶层次结构,确定了各指标的综合权重,最后用模糊综合决策方法实现了测试点的BITE与ATE分层优化,对提高电子装备的诊断能力、降低测试费用具有指导意义。 展开更多
关键词 电子装备 故障诊断 解析冗余关系 自检设备 自动测试设备 测试资源分配
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基于MSFG的机载BITE故障定位算法研究 被引量:1
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作者 刘家学 杨梦娜 耿宏 《科学技术与工程》 北大核心 2016年第8期132-136,170,共6页
故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定... 故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定义,进而提出一种简单、有效的故障定位算法。实例验证表明,该算法能够对系统中的故障源进行准确定位。 展开更多
关键词 故障定位 多信号流图模型 机载bite系统 故障定位矩阵
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微环DNA表达抗EpCAM/抗CD3双特异BiTE分子的抗卵巢癌细胞体外实验研究 被引量:1
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作者 陈远群 谌平 +1 位作者 陈国创 韦枝红 《中国医药导报》 CAS 2019年第30期12-16,共5页
目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-... 目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-8μg/mL)抗EpCAM/抗CD3 BsAb分子蛋白加至卵巢癌细胞及T细胞中,经6 h和12 h培育后,利用倒置荧光显微镜观察活细胞与死亡细胞数量及形态变化。结果倒置显微镜下可见加抗体后卵巢癌细胞与T细胞明显聚集成块,周围见大量死亡细胞。相同时间下,随着浓度的增加,T细胞介导的卵巢癌肿瘤细胞的杀伤效果并不会一直增强。当浓度达到1×10^-4μg/mL时,培育6 h和12 h时的杀伤均达到最大,差异均有统计学意义(P<0.05)。结论新型的微环DNA表达系统所表达的抗EpCAM/抗CD3 BsAb对体外卵巢癌细胞生长具有抑制作用,未来可作为一种有效的抗卵巢癌肿瘤的靶向治疗药物。 展开更多
关键词 EPCAM CD3 双特异bite分子蛋白 卵巢癌 靶向治疗
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Bite turbo配合早期牵引治疗前牙反牙合的疗效分析
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作者 薛楠 赵阳 +1 位作者 戚琳 张扬 《口腔医学》 CAS 2016年第7期624-627,共4页
目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。... 目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。咬合打开后SNB减小、ANB增大,下颌平面角、下面高、下面高/全面高增大,上下磨牙均伸长、下切牙被压低,反覆盖解除,覆牙合减小。结论 Bite turbo配合早期Ⅲ类牵引可以快速打开咬合,解除前牙反牙合。 展开更多
关键词 bite TURBO 前牙反牙合 早期牵引
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双特异性单链抗体BiTE在肿瘤靶向治疗中的研究进展
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作者 董琼娜 蒋华 李宗海 《中国科技论文》 CAS 北大核心 2012年第12期963-966,共4页
BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏F... BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏Fc段,免疫源性低,是一种极具发展潜力的新型抗体形式。对BiTE的发展历程、结构和作用机制以及在肿瘤靶向治疗中的应用做简要综述。 展开更多
关键词 双特异性抗体 bite 定向杀伤 肿瘤靶向治疗
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组件内BITE模块电路的设计 被引量:4
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作者 王强 《现代雷达》 CSCD 北大核心 2004年第8期52-54,共3页
对固态组件内BITE电路的功能和原理进行了阐述 ,提出了通用的设计思路 ,并提供了具体的设计举例。
关键词 固态雷达发射机 固态组件 机内测试没备 模块电路
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TADs联合Bite Turbo矫正治疗深覆[牙合]的效果 被引量:1
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作者 李超 杜珊珊 童锦发 《浙江临床医学》 2021年第12期1770-1772,共3页
目的探讨种植支抗钉(TADs)联合固定式平面导板(Bite Turbo)矫正治疗深覆[牙合]的效果。方法36例口腔科深覆[牙合]患者随机分为观察组、对照1组和对照2组,每组各12例。观察组使用TADs联合Bite Turbo治疗,对照1组应用TADs,对照2组使用Bite... 目的探讨种植支抗钉(TADs)联合固定式平面导板(Bite Turbo)矫正治疗深覆[牙合]的效果。方法36例口腔科深覆[牙合]患者随机分为观察组、对照1组和对照2组,每组各12例。观察组使用TADs联合Bite Turbo治疗,对照1组应用TADs,对照2组使用Bite Turbo。比较三组深覆[牙合]咬合打开的临床效果,测量分析每组咬合打开前后的研究模型及X线片。结果观察组咬合完全打开需要平均3.2个月,覆盖平均减小3.63 mm;对照1组咬合完全打开需要平均4.8个月,覆盖平均减小3.44 mm;对照2组咬合完全打开需要平均5.1个月,覆盖平均减小3.51 mm;两个对照组与观察组的差异均有统计学意义(P<0.05);两个对照组之间差异无统计学意义(P>0.05)。结论TADs联合Bite Turbo矫正治疗深覆[牙合],咬合打开具有快速、高效、舒适、便捷等明显优势。 展开更多
关键词 种植支抗钉 固定式平面导板 深覆[牙合] 咬合打开
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共表达BiTE的溶瘤病毒对胶质瘤的抗肿瘤活性研究
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作者 许琼冠 欧阳一彬 谢镇明 《现代肿瘤医学》 CAS 北大核心 2022年第8期1354-1359,共6页
目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质... 目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质瘤细胞U118的感染能力及BiTE的表达情况;流式细胞术检测HSV-BiTE感染后U118的凋亡情况;小鼠移植瘤模型验证HSV-BiTE的体内抑瘤活性;免疫组化法检测肿瘤组织中Ki67和Cleaved Caspase3(Cl-Cas3)的表达;流式细胞术检测肿瘤浸润T细胞中IFN-γ和Granzyme B的表达情况。结果:HSV-BiTE可以有效感染U118细胞并表达BiTE;感染HSV-BiTE可以显著诱导U118细胞凋亡(P<0.001);HSV-BiTE较HSV而言可以有效抑制小鼠体内的肿瘤生长(P<0.001);HSV-BiTE治疗的小鼠较HSV治疗组可以降低肿瘤中Ki67的表达(P<0.01),同时增加Cl-Cas3的表达(P<0.01);HSV-BiTE治疗的小鼠较HSV治疗组可以显著提升肿瘤浸润T细胞中IFN-γ(P<0.001)和Granzyme B(P<0.0001)的表达水平。结论:HSV-BiTE在小鼠皮下移植瘤模型中显著抑制肿瘤生长,同时诱导肿瘤部位的T细胞发挥抗肿瘤功能。这种治疗方法优于未经改造的HSV治疗,支持进一步研究其在胶质瘤中的应用。 展开更多
关键词 胶质瘤 HSV bite 溶瘤病毒
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