A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of ...A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of vacancy and antisite were also calculated. The present calculations are in agreement with the experimental data and the theoretical results obtained by other authors.展开更多
The outer divertor plasma of HL-2A and its associated scrape-off plasma have been simulated using a two-dimensional multi-species fluid code of Braams with a simplified neutral gas model. HL-2A has a double-null close...The outer divertor plasma of HL-2A and its associated scrape-off plasma have been simulated using a two-dimensional multi-species fluid code of Braams with a simplified neutral gas model. HL-2A has a double-null closed divertor in separate divertor chambers above and below the nearly circular plasma tours. The computed numerical grid is developed according to an ideal magnetic surface. The calculation is involved only with pure hydrogen plasma. The emphasis has been focused on parametric studies involving variation of the assumptions made for the core plasma. The peak temperatures and the heat flux near the target are of the principal concern.展开更多
Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications...Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.展开更多
From a business model perspective,both traditional B2B model and eB2B model are made up of the same elements while they have differentiating features separately.
Electronic business impacts differently the busines s process in or between the corporations in variant degree. In view of the new fea tures of the internet, critical questions to be answered inclued: what are t he em...Electronic business impacts differently the busines s process in or between the corporations in variant degree. In view of the new fea tures of the internet, critical questions to be answered inclued: what are t he emerging business models and related to this, which strategic marketing appro aches are applied,or emerging. In the paper, the business models in B2B are clas sified into four types as e-procurement, e-marketplace, e-trade exchange, and collaborative trading community from the value viewpoint.And then the paper giv es the measure among the four business models by providing a framework that has been developed on the basis of current commercial Internet business and experime ntal work. The difference between the value chain in traditional commerce and th e one in e-business is compared. And we give the success factors by a case stud y and the barriers to electronic business in the developing B2B business model.展开更多
Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in...Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.展开更多
Focusing on B2B market, this paper studies the effect of product differentiation on business model perlbrmance. After interviewing several experts and analyzing numbers of distributing questionnaires. the author disco...Focusing on B2B market, this paper studies the effect of product differentiation on business model perlbrmance. After interviewing several experts and analyzing numbers of distributing questionnaires. the author discovered that product differentiation has a positive effect on business model performance. Through SEM. it is revealed that product differentiation at each level have positive effect on business model, with different effect weight. The main contributions of this research are summarized as follows： Firstly, the proposed model of the product differentiation on business model performance lays the basis for scientific measurement of product differentiation and its effect on business model performance; Secondly, this research ranks the importance of product differentiation at different level in B2B market; Finally, this research provides a good reference for enterprises to update their product strategy for better business model performance.展开更多
It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, ...It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, this work chose to research the first phase of the process, which is initial trust. The Writer established dynamic model of initial trust formation biased on theory of planned behavior with other theories, such as TAM and social exchange theory, after micro-analyzing this formation mechanism from. in order to confirming effectiveness of the dynamic model, the writer adopted empirical study, from which writer got an order of. From the result of empirical study, we got the strength order of main factors that can influence the establishment of initial trust.展开更多
在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的...在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的框架原型,提出一种基于构架和构件的B/S结构模型,称为CB Model。并且介绍在研究过程中开发的组装支持工具BSAppBuilder。展开更多
文摘A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of vacancy and antisite were also calculated. The present calculations are in agreement with the experimental data and the theoretical results obtained by other authors.
基金Tenth-Five-Year Nuclear Energy Development of the Commision of Science TechnologyIndustry for National DefenseChina Natioanl Nuclear Corporation
文摘The outer divertor plasma of HL-2A and its associated scrape-off plasma have been simulated using a two-dimensional multi-species fluid code of Braams with a simplified neutral gas model. HL-2A has a double-null closed divertor in separate divertor chambers above and below the nearly circular plasma tours. The computed numerical grid is developed according to an ideal magnetic surface. The calculation is involved only with pure hydrogen plasma. The emphasis has been focused on parametric studies involving variation of the assumptions made for the core plasma. The peak temperatures and the heat flux near the target are of the principal concern.
基金supported by NIAMS,of the National Institutes of Health,under award numbers R01AR062074 (to DJD) and R01AR060636 (to S-JL)the Harry Headley Charitable and Research Foundation,Punta Gorda,FL(to ELG-L)
文摘Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.
文摘From a business model perspective,both traditional B2B model and eB2B model are made up of the same elements while they have differentiating features separately.
文摘Electronic business impacts differently the busines s process in or between the corporations in variant degree. In view of the new fea tures of the internet, critical questions to be answered inclued: what are t he emerging business models and related to this, which strategic marketing appro aches are applied,or emerging. In the paper, the business models in B2B are clas sified into four types as e-procurement, e-marketplace, e-trade exchange, and collaborative trading community from the value viewpoint.And then the paper giv es the measure among the four business models by providing a framework that has been developed on the basis of current commercial Internet business and experime ntal work. The difference between the value chain in traditional commerce and th e one in e-business is compared. And we give the success factors by a case stud y and the barriers to electronic business in the developing B2B business model.
基金supported by the Jiangsu Provincial Key Research and Development Program (Grant No.BE2020616)the National Key R&D Program of China (Grant No.2018YFC1200603)+1 种基金the National Science and Technology Major Project (Grant No.2019SWAQ05-5-4)Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University.
文摘Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.
文摘Focusing on B2B market, this paper studies the effect of product differentiation on business model perlbrmance. After interviewing several experts and analyzing numbers of distributing questionnaires. the author discovered that product differentiation has a positive effect on business model performance. Through SEM. it is revealed that product differentiation at each level have positive effect on business model, with different effect weight. The main contributions of this research are summarized as follows： Firstly, the proposed model of the product differentiation on business model performance lays the basis for scientific measurement of product differentiation and its effect on business model performance; Secondly, this research ranks the importance of product differentiation at different level in B2B market; Finally, this research provides a good reference for enterprises to update their product strategy for better business model performance.
文摘It has been widely believed that trust is the basis for on-line trading by both academia and practice. The process of f initial trust formation is a dynamic and repeated process. In the electric business environment, this work chose to research the first phase of the process, which is initial trust. The Writer established dynamic model of initial trust formation biased on theory of planned behavior with other theories, such as TAM and social exchange theory, after micro-analyzing this formation mechanism from. in order to confirming effectiveness of the dynamic model, the writer adopted empirical study, from which writer got an order of. From the result of empirical study, we got the strength order of main factors that can influence the establishment of initial trust.
文摘在对软件构架和B/S应用程序体系结构的研究过程中,提出了如何运用构架和构件组装技术,通过对可复用构件的组装进行B/S应用程序的设计和快速开发。文章拟以C2构架风格作为在整合应用系统的业务逻辑的基础设施,以B/S Model 2作为表示层的框架原型,提出一种基于构架和构件的B/S结构模型,称为CB Model。并且介绍在研究过程中开发的组装支持工具BSAppBuilder。
