Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular st...Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.展开更多
Monocot root systems comprise a large number of lateral roots to allow them to survive and colonize land.Auxin signaling pathways centered on Aux/IAA play a crucial role in lateral root development.However,in non-mode...Monocot root systems comprise a large number of lateral roots to allow them to survive and colonize land.Auxin signaling pathways centered on Aux/IAA play a crucial role in lateral root development.However,in non-model monocot plants,the effects of Aux/IAA on lateral root initiation and number remain largely unknown.The present study transformed PheIAA17,a member of the Aux/IAA family of Moso bamboo,into rice and found that it significantly drove plants to produce lateral roots and improved the rooting rate.Quantitative experiments showed that PheIAA17 overexpression significantly affected the expression of ARF family members.Phylogenetic and promoter analyses indicate that PheARF3-2 belongs to class B ARF,and the promoter region contains auxin response elements.The results of yeast one-hybrid and dual-luciferase reporter assays confirmed that PheIAA17 bound specific fragments of the PheARF3-2 promoter to repress its transcriptional activity.Y2H and BiFC assay have shown that PheIAA17 and PheIAA30-3 could physically interact in vitro and in vivo.Taken together,this study reports a new molecular module centered on PheIAA17,which directs plants to alter root morphology through an increase in lateral roots.展开更多
We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R ...We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R module in σ[M] is S ( quasi )continuous if and only if every left R module in σ[M] is S continuous, where S is the set of all simple left R modules. We also show that a left R module M is a locally noetherian V module if and only if every semisimple left R module (in σ[M]) is M injective if and only if every essential extension in σ[M] of every semisimple left R module in σ[M] is S ? 2 (quasi )continuous, where S ? 2 is the set of all semisimple left R modules.展开更多
In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the con...In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the concepts of（R,S）-bi-Γ-submodules,quasi-Γ-submodules and regular Γ-modules.Meanwhile,some illustrative examples are given to show the rationality of the definitions introduced in this paper.Second,several new kinds of generalized fuzzy soft Γ-submodules are proposed,and related properties and mutual relationships are also investigated.Third,we discover some intrinsic connections between the generalized fuzzy soft Γ-submodules presented in this paper and crisp Γ-submodules,and describe the relationships between regular Γ-modules and the generalized fuzzy soft Γ-submodules presented in this paper.展开更多
1.设计思路语言学习应以应用为目标,着重培养学生的交际能力,并能解决实际的生活问题。在目前的英语教学里,教师一般会在同一堂课里进行'听'与'说'的技能训练,其中'听'是'说'的前提,'说'是'...1.设计思路语言学习应以应用为目标,着重培养学生的交际能力,并能解决实际的生活问题。在目前的英语教学里,教师一般会在同一堂课里进行'听'与'说'的技能训练,其中'听'是'说'的前提,'说'是'听'的延伸。在听说课里,听力策略和会话技巧是帮助学生实现交流目的和信息沟通的桥梁,这也是教学设计的重点。2.教材分析本课的内容是牛津英语9B Module 2 Unit 3 The environment的听说课。展开更多
目的探析脑梗死患者髓鞘碱性蛋白(myelin basic protein,MBP)、S100钙结合蛋白B(S100 calcium-binding protein B,S100-B)水平与介入治疗后早期神经功能恶化的关联性。方法纳入2021年7月–2024年7月期间本院收治的258例脑梗死患者,采用...目的探析脑梗死患者髓鞘碱性蛋白(myelin basic protein,MBP)、S100钙结合蛋白B(S100 calcium-binding protein B,S100-B)水平与介入治疗后早期神经功能恶化的关联性。方法纳入2021年7月–2024年7月期间本院收治的258例脑梗死患者,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分评估患者的神经功能状况,将死亡患者或介入治疗24 h后NIHSS评分增加4分及以上患者纳入早期神经功能恶化组,其余患者纳入未恶化组。测定所有患者MBP、S100-B水平,并分析其水平变化与介入治疗后神经功能恶化风险的关系。结果脑梗死患者早期神经功能恶化组血清MBP、S100-B水平高于未恶化组〔t=9.062(95%CI:2.348~3.663)、7.708(95%CI:0.221~0.375),P<0.001〕;Spearman相关性显示:恶化组血清MBP、S100-B水平与NIHSS评分增加情况呈正相关〔r=0.323(95%CI:0.095~0.542)、0.292(95%CI:0.066~0.488),P<0.05〕;分层回归分析显示:血清MBP〔比值比(odds ratio,OR)=1.996,95%CI:1.607~2.478〕、S100-B(OR=1.005,95%CI:1.003~1.007)水平是影响脑梗死患者早期神经功能恶化的危险因素(P<0.05),即使校正混杂因素后依然是其危险因素,此外入院NIHSS评分(OR=1.224,95%CI:1.142~1.310)及合并高血压(OR=2.542,95%CI:1.139~5.669)、高脂血症(OR=2.618,95%CI:1.101~6.228),其中入院NIHSS评分与MBP存在交互作用(OR=1.081,95%CI:1.034~1.130);受试者工作特征曲线显示:血清MBP、S100-B水平评估脑梗死患者早期神经功能恶化的曲线下面积分别为0.822(95%CI:0.764~0.879)、0.788(95%CI:0.724~0.853)。结论脑梗死患者介入治疗后血清MBP、S100-B水平较高与早期神经功能恶化风险相关,且对神经功能恶化风险有一定的评估价值。展开更多
基金supported by the National Italian Research Council(CNR)“Progetto DSB.AD007.305.001”to Monica Rinaldi。
文摘Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.
基金supported by the National Key Research and Development Program of China(2021YFD2200505)the National Natural Science Foundation of China(32071849)。
文摘Monocot root systems comprise a large number of lateral roots to allow them to survive and colonize land.Auxin signaling pathways centered on Aux/IAA play a crucial role in lateral root development.However,in non-model monocot plants,the effects of Aux/IAA on lateral root initiation and number remain largely unknown.The present study transformed PheIAA17,a member of the Aux/IAA family of Moso bamboo,into rice and found that it significantly drove plants to produce lateral roots and improved the rooting rate.Quantitative experiments showed that PheIAA17 overexpression significantly affected the expression of ARF family members.Phylogenetic and promoter analyses indicate that PheARF3-2 belongs to class B ARF,and the promoter region contains auxin response elements.The results of yeast one-hybrid and dual-luciferase reporter assays confirmed that PheIAA17 bound specific fragments of the PheARF3-2 promoter to repress its transcriptional activity.Y2H and BiFC assay have shown that PheIAA17 and PheIAA30-3 could physically interact in vitro and in vivo.Taken together,this study reports a new molecular module centered on PheIAA17,which directs plants to alter root morphology through an increase in lateral roots.
文摘We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R module in σ[M] is S ( quasi )continuous if and only if every left R module in σ[M] is S continuous, where S is the set of all simple left R modules. We also show that a left R module M is a locally noetherian V module if and only if every semisimple left R module (in σ[M]) is M injective if and only if every essential extension in σ[M] of every semisimple left R module in σ[M] is S ? 2 (quasi )continuous, where S ? 2 is the set of all semisimple left R modules.
基金Supported by the National Natural Science Foundation of China (61175055)the Innovation Term of Higher Education of Hubei Province,China (T201109)+1 种基金the Natural Science Foundation of Hubei Province (2012FFB01101)the Natural Science Foundation of Education Committee of Hubei Province (D20131903)
文摘In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the concepts of（R,S）-bi-Γ-submodules,quasi-Γ-submodules and regular Γ-modules.Meanwhile,some illustrative examples are given to show the rationality of the definitions introduced in this paper.Second,several new kinds of generalized fuzzy soft Γ-submodules are proposed,and related properties and mutual relationships are also investigated.Third,we discover some intrinsic connections between the generalized fuzzy soft Γ-submodules presented in this paper and crisp Γ-submodules,and describe the relationships between regular Γ-modules and the generalized fuzzy soft Γ-submodules presented in this paper.
文摘1.设计思路语言学习应以应用为目标,着重培养学生的交际能力,并能解决实际的生活问题。在目前的英语教学里,教师一般会在同一堂课里进行'听'与'说'的技能训练,其中'听'是'说'的前提,'说'是'听'的延伸。在听说课里,听力策略和会话技巧是帮助学生实现交流目的和信息沟通的桥梁,这也是教学设计的重点。2.教材分析本课的内容是牛津英语9B Module 2 Unit 3 The environment的听说课。
文摘目的探析脑梗死患者髓鞘碱性蛋白(myelin basic protein,MBP)、S100钙结合蛋白B(S100 calcium-binding protein B,S100-B)水平与介入治疗后早期神经功能恶化的关联性。方法纳入2021年7月–2024年7月期间本院收治的258例脑梗死患者,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分评估患者的神经功能状况,将死亡患者或介入治疗24 h后NIHSS评分增加4分及以上患者纳入早期神经功能恶化组,其余患者纳入未恶化组。测定所有患者MBP、S100-B水平,并分析其水平变化与介入治疗后神经功能恶化风险的关系。结果脑梗死患者早期神经功能恶化组血清MBP、S100-B水平高于未恶化组〔t=9.062(95%CI:2.348~3.663)、7.708(95%CI:0.221~0.375),P<0.001〕;Spearman相关性显示:恶化组血清MBP、S100-B水平与NIHSS评分增加情况呈正相关〔r=0.323(95%CI:0.095~0.542)、0.292(95%CI:0.066~0.488),P<0.05〕;分层回归分析显示:血清MBP〔比值比(odds ratio,OR)=1.996,95%CI:1.607~2.478〕、S100-B(OR=1.005,95%CI:1.003~1.007)水平是影响脑梗死患者早期神经功能恶化的危险因素(P<0.05),即使校正混杂因素后依然是其危险因素,此外入院NIHSS评分(OR=1.224,95%CI:1.142~1.310)及合并高血压(OR=2.542,95%CI:1.139~5.669)、高脂血症(OR=2.618,95%CI:1.101~6.228),其中入院NIHSS评分与MBP存在交互作用(OR=1.081,95%CI:1.034~1.130);受试者工作特征曲线显示:血清MBP、S100-B水平评估脑梗死患者早期神经功能恶化的曲线下面积分别为0.822(95%CI:0.764~0.879)、0.788(95%CI:0.724~0.853)。结论脑梗死患者介入治疗后血清MBP、S100-B水平较高与早期神经功能恶化风险相关,且对神经功能恶化风险有一定的评估价值。
