This paper deeply studies the intelligent Home embedded system based on B/S architecture. Firstly, analysis requirement of Home function based on the existing software development mode, and proposed a system framework...This paper deeply studies the intelligent Home embedded system based on B/S architecture. Firstly, analysis requirement of Home function based on the existing software development mode, and proposed a system framework of intelligent Home system, and designed the communication scheme of the whole Home system, also gives the system each function module realization. This paper achieve two basic service system based on Intelligent Home through a series of analysis and design： outdoor remote intelligent Home monitoring service and the indoor intelligent management service.展开更多
Hyperglycemia resulting from diabetes mellitus(DM)exacerbates osteoporosis and fractures,damaging bone regeneration due to impaired healing capacity.Stem cell therapy offers the potential for bone repair,accelerating ...Hyperglycemia resulting from diabetes mellitus(DM)exacerbates osteoporosis and fractures,damaging bone regeneration due to impaired healing capacity.Stem cell therapy offers the potential for bone repair,accelerating the healing of bone defects by introducing stem cells with osteogenic differentiation ability.Dental follicle stem cells(DFSCs)are a newly emerging type of dental stem cells that not only have the potential for multipotent differentiation but also hold easy accessibility and can stand longterm storage.However,DM-associated oxidative stress and inflammation elevate the risk of DFSCs dysfunction and apoptosis,diminishing stem cell therapy efficacy.Recent nanomaterial advances,particularly in DNA nanostructures like tetrahedral framework nucleic acids(tFNAs),have been promising candidates for modulating cellular behaviors.Accumulating experiments have shown that tFNAs’cell proliferation and migration-promoting ability and induce osteogenic differentiation of stem cells.Meanwhile,tFNAs can scavenge reactive oxygen species(ROS)and downregulate the secretion of inflammatory factors by inhibiting various inflammation-related signaling pathways.Here,we applied tFNAs to modify DFSCs and observed enhanced osteogenic differentiation alongside ROS scavenging and anti-inflammatory effects mediated by suppressing the ROS/mitogen-activated protein kinases(MAPKs)/nuclear factor kappa-B(NF-κB)signaling pathway.This intervention reduced stem cell apoptosis,bolstering stem cell therapy efficacy in DM.Our study establishes a simple yet potent tFNAs-DFSCs system,offering potential as a bone repair agent for future DM treatment.展开更多
目的:探讨血清高迁移率族蛋白B1(HMGB1)、S100β联合脑电双频指数(BIS)在脓毒症相关性脑病(SAE)早期诊断中的应用价值。方法:回顾性分析脓毒症病人87例临床资料,根据是否合并SAE,分为SAE组35例和非SAE组52例。比较2组病人相关临床资料...目的:探讨血清高迁移率族蛋白B1(HMGB1)、S100β联合脑电双频指数(BIS)在脓毒症相关性脑病(SAE)早期诊断中的应用价值。方法:回顾性分析脓毒症病人87例临床资料,根据是否合并SAE,分为SAE组35例和非SAE组52例。比较2组病人相关临床资料和血清HMGB1、S100β水平及24 h BIS,分析脓毒症病人发生SAE的影响因素和HMGB1、S100β、BIS联合检测早期诊断SAE的临床价值。结果:SAE组病人APACHEⅡ评分、SOFA评分均明显高于非SAE组(P<0.01);SAE组血清HMGB1、S100β水平均明显高于非SAE组(P<0.01),而BIS明显低于非SAE组(P<0.01)。APACHEⅡ评分、SOFA评分和HMGB1、S100β、BIS均为脓毒症病人发生SAE的独立影响因素(P<0.01)。ROC曲线分析显示,血清HMGB1、S100β联合BIS早期诊断脓毒症病人发生SAE的AUC为0.891,敏感度为91.43%,特异度为84.62%,优于各指标独立诊断。结论:血清HMGB1、S100β联合BIS在SAE早期诊断中具有较好的临床应用价值。展开更多
海洋标量场可视化对于科研人员分析海洋极端天气、划定船只航线以及预测鱼群数量具有重要作用。本文以海洋环境再分析产品为基础,构建了网格海洋环境数据的文本格式转化方法,并借助ArcGISAPIforJa⁃vaScript完成可视化,实现了海洋标量场...海洋标量场可视化对于科研人员分析海洋极端天气、划定船只航线以及预测鱼群数量具有重要作用。本文以海洋环境再分析产品为基础,构建了网格海洋环境数据的文本格式转化方法,并借助ArcGISAPIforJa⁃vaScript完成可视化,实现了海洋标量场的轻量级架构展示,解决了以往服务器资源占用多、系统响应速度慢等问题。本文提出的可视化架构支撑了海水温度、盐度、海面高等各类海洋环境标量数据在西太海洋数据和信息网络(Ocean Data and Information Network for the WESTPAC,ODINWESTPAC)系统中的有效展示,可为海洋管理者及科研人员提供信息服务。展开更多
随着清洁能源的发展,风电作为一种清洁、可再生的能源,具有巨大的发展潜力。然而,风电的开发需要精确的风能资源测量和评估,以及选择适当的风电场址。因此,开发了基于B/S(Browser/Server,浏览器/服务器)端的风电场规划设计平台。该平台...随着清洁能源的发展,风电作为一种清洁、可再生的能源,具有巨大的发展潜力。然而,风电的开发需要精确的风能资源测量和评估,以及选择适当的风电场址。因此,开发了基于B/S(Browser/Server,浏览器/服务器)端的风电场规划设计平台。该平台提供了多种功能,包括项目管理、风能资源评估、风电场选址、中尺度数据处理和方案管理等。该平台利用GIS(Geographic Information System,地理信息系统)技术和模型计算方法,能够对风能资源进行多方面评估和分析,根据地理信息、环境和建设要求等因素,优化风电场选址。同时,该平台具有用户友好的界面和数据交互功能,使得开发者可以更加便捷地实现风电项目开发。实际应用结果表明,该平台在风电场选址、风电资源评估等方面具有较强的竞争力,能够有效促进风电产业的发展。展开更多
文摘This paper deeply studies the intelligent Home embedded system based on B/S architecture. Firstly, analysis requirement of Home function based on the existing software development mode, and proposed a system framework of intelligent Home system, and designed the communication scheme of the whole Home system, also gives the system each function module realization. This paper achieve two basic service system based on Intelligent Home through a series of analysis and design： outdoor remote intelligent Home monitoring service and the indoor intelligent management service.
基金supported by the National Natural Science Foundation of China (Nos. 82101077, 82370929)Sichuan Science and Technology Program (Nos. 2023NSFSC1516, 2023NSFSC1706)+3 种基金Postdoctoral Science Foundation of China (Nos. 2021M692271, 2023T160455, BX20220220, 2022M722251)West China School/Hospital of Stomatology Sichuan University (No. RCDWJS2023–5)Fundamental Research Funds for the Central UniversitiesResearch and Develop Program, West China Hospital of Stomatology Sichuan University
文摘Hyperglycemia resulting from diabetes mellitus(DM)exacerbates osteoporosis and fractures,damaging bone regeneration due to impaired healing capacity.Stem cell therapy offers the potential for bone repair,accelerating the healing of bone defects by introducing stem cells with osteogenic differentiation ability.Dental follicle stem cells(DFSCs)are a newly emerging type of dental stem cells that not only have the potential for multipotent differentiation but also hold easy accessibility and can stand longterm storage.However,DM-associated oxidative stress and inflammation elevate the risk of DFSCs dysfunction and apoptosis,diminishing stem cell therapy efficacy.Recent nanomaterial advances,particularly in DNA nanostructures like tetrahedral framework nucleic acids(tFNAs),have been promising candidates for modulating cellular behaviors.Accumulating experiments have shown that tFNAs’cell proliferation and migration-promoting ability and induce osteogenic differentiation of stem cells.Meanwhile,tFNAs can scavenge reactive oxygen species(ROS)and downregulate the secretion of inflammatory factors by inhibiting various inflammation-related signaling pathways.Here,we applied tFNAs to modify DFSCs and observed enhanced osteogenic differentiation alongside ROS scavenging and anti-inflammatory effects mediated by suppressing the ROS/mitogen-activated protein kinases(MAPKs)/nuclear factor kappa-B(NF-κB)signaling pathway.This intervention reduced stem cell apoptosis,bolstering stem cell therapy efficacy in DM.Our study establishes a simple yet potent tFNAs-DFSCs system,offering potential as a bone repair agent for future DM treatment.
文摘目的:探讨血清高迁移率族蛋白B1(HMGB1)、S100β联合脑电双频指数(BIS)在脓毒症相关性脑病(SAE)早期诊断中的应用价值。方法:回顾性分析脓毒症病人87例临床资料,根据是否合并SAE,分为SAE组35例和非SAE组52例。比较2组病人相关临床资料和血清HMGB1、S100β水平及24 h BIS,分析脓毒症病人发生SAE的影响因素和HMGB1、S100β、BIS联合检测早期诊断SAE的临床价值。结果:SAE组病人APACHEⅡ评分、SOFA评分均明显高于非SAE组(P<0.01);SAE组血清HMGB1、S100β水平均明显高于非SAE组(P<0.01),而BIS明显低于非SAE组(P<0.01)。APACHEⅡ评分、SOFA评分和HMGB1、S100β、BIS均为脓毒症病人发生SAE的独立影响因素(P<0.01)。ROC曲线分析显示,血清HMGB1、S100β联合BIS早期诊断脓毒症病人发生SAE的AUC为0.891,敏感度为91.43%,特异度为84.62%,优于各指标独立诊断。结论:血清HMGB1、S100β联合BIS在SAE早期诊断中具有较好的临床应用价值。
文摘海洋标量场可视化对于科研人员分析海洋极端天气、划定船只航线以及预测鱼群数量具有重要作用。本文以海洋环境再分析产品为基础,构建了网格海洋环境数据的文本格式转化方法,并借助ArcGISAPIforJa⁃vaScript完成可视化,实现了海洋标量场的轻量级架构展示,解决了以往服务器资源占用多、系统响应速度慢等问题。本文提出的可视化架构支撑了海水温度、盐度、海面高等各类海洋环境标量数据在西太海洋数据和信息网络(Ocean Data and Information Network for the WESTPAC,ODINWESTPAC)系统中的有效展示,可为海洋管理者及科研人员提供信息服务。
文摘随着清洁能源的发展,风电作为一种清洁、可再生的能源,具有巨大的发展潜力。然而,风电的开发需要精确的风能资源测量和评估,以及选择适当的风电场址。因此,开发了基于B/S(Browser/Server,浏览器/服务器)端的风电场规划设计平台。该平台提供了多种功能,包括项目管理、风能资源评估、风电场选址、中尺度数据处理和方案管理等。该平台利用GIS(Geographic Information System,地理信息系统)技术和模型计算方法,能够对风能资源进行多方面评估和分析,根据地理信息、环境和建设要求等因素,优化风电场选址。同时,该平台具有用户友好的界面和数据交互功能,使得开发者可以更加便捷地实现风电项目开发。实际应用结果表明,该平台在风电场选址、风电资源评估等方面具有较强的竞争力,能够有效促进风电产业的发展。
