A concise approach to the synthesis of organoiron intermediate from organoboron and Fe(III)has been developed,and the reactivity of the intermediate with a series of electrophiles has been investigated.The results rev...A concise approach to the synthesis of organoiron intermediate from organoboron and Fe(III)has been developed,and the reactivity of the intermediate with a series of electrophiles has been investigated.The results revealed that pinacol substituent of organoboron is crucial for C—B cleavage.The resulted organoiron intermediate is not stable,with weak nucleophicility.The coupling reactions of organoiron intermediate with acyl chlorides,anhydrides,isocyanates have been performed.展开更多
目的探讨孕晚期生殖道B群链球菌(group B streptococcus,GBS)感染联合胎儿脐带血降钙素原(procalcitonin,PCT)和超敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)检测对胎膜早破新生儿感染的预测价值。方法选取2021年7月至2...目的探讨孕晚期生殖道B群链球菌(group B streptococcus,GBS)感染联合胎儿脐带血降钙素原(procalcitonin,PCT)和超敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)检测对胎膜早破新生儿感染的预测价值。方法选取2021年7月至2024年7月于宁波大学附属第一医院定期产检并分娩的胎膜早破孕妇(n=200)及新生儿(n=200)作为研究对象,根据新生儿出生后72h内是否发生感染分为感染组(n=52)与未感染组(n=148)。比较两组孕妇的GBS阳性率及胎儿脐带血PCT、hs-CRP水平,采用Logistic多因素回归分析胎膜早破新生儿感染的风险因素,采用受试者操作特征曲线分析GBS、PCT及hs-CRP检测对胎膜早破新生儿感染的预测效能。结果感染组孕妇胎膜早破持续时间、GBS阳性占比,胎儿脐带血PCT及hs-CRP水平均高于未感染组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果表明,胎膜早破持续时间、GBS阳性、胎儿脐带血PCT及hs-CRP是胎膜早破新生儿感染的风险因素。受试者操作特征曲线分析结果表明,GBS,胎儿脐带血PCT、hs-CRP单独及联合检测对胎膜早破新生儿感染均有一定的预测价值,三者联合预测的曲线下面积为0.925,敏感度为90.20%,特异性为80.5%,预测效能显著优于各单一指标(P<0.05)。结论孕晚期生殖道GBS感染联合胎儿脐带血PCT、hs-CRP检测可有效预测胎膜早破新生儿感染的发生。展开更多
文摘A concise approach to the synthesis of organoiron intermediate from organoboron and Fe(III)has been developed,and the reactivity of the intermediate with a series of electrophiles has been investigated.The results revealed that pinacol substituent of organoboron is crucial for C—B cleavage.The resulted organoiron intermediate is not stable,with weak nucleophicility.The coupling reactions of organoiron intermediate with acyl chlorides,anhydrides,isocyanates have been performed.
文摘目的探讨孕晚期生殖道B群链球菌(group B streptococcus,GBS)感染联合胎儿脐带血降钙素原(procalcitonin,PCT)和超敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)检测对胎膜早破新生儿感染的预测价值。方法选取2021年7月至2024年7月于宁波大学附属第一医院定期产检并分娩的胎膜早破孕妇(n=200)及新生儿(n=200)作为研究对象,根据新生儿出生后72h内是否发生感染分为感染组(n=52)与未感染组(n=148)。比较两组孕妇的GBS阳性率及胎儿脐带血PCT、hs-CRP水平,采用Logistic多因素回归分析胎膜早破新生儿感染的风险因素,采用受试者操作特征曲线分析GBS、PCT及hs-CRP检测对胎膜早破新生儿感染的预测效能。结果感染组孕妇胎膜早破持续时间、GBS阳性占比,胎儿脐带血PCT及hs-CRP水平均高于未感染组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果表明,胎膜早破持续时间、GBS阳性、胎儿脐带血PCT及hs-CRP是胎膜早破新生儿感染的风险因素。受试者操作特征曲线分析结果表明,GBS,胎儿脐带血PCT、hs-CRP单独及联合检测对胎膜早破新生儿感染均有一定的预测价值,三者联合预测的曲线下面积为0.925,敏感度为90.20%,特异性为80.5%,预测效能显著优于各单一指标(P<0.05)。结论孕晚期生殖道GBS感染联合胎儿脐带血PCT、hs-CRP检测可有效预测胎膜早破新生儿感染的发生。
