New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the ...New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the mangrove soil-derived fungus Arthrinium sp.SCSIO 41305.Extensive spectroscopic analysis and X-Ray crystallographic analysis were used to elucidate the structure of(E)-2-(hydroxyimino)-4-methylpentanamide(1),including its absolute configuration.All the isolated compounds(1–12)were evaluated for their antimicrobial and enzyme inhibitory activities against acetylcholinesterase(ACh E),neuraminidase(NAs),and phosphatidylinositol 3-kinase(PI3K).Among them,compounds 1 and 3 exhibited strong neuraminidase inhibitory activity with IC_(50)values of 12.04,1.92μmol L^(-1)(IC_(50)20μmol L^(-1)for oseltamivir acid),while compounds 5,6,8,and 10showed moderate neuraminidase inhibitory activity,and compounds 6–10 displayed weak enzyme inhibitory activities against PI3K.展开更多
A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designate...A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL^(−1).展开更多
Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xe...Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.展开更多
基金the Guangdong Basic and Applied Basic Research Foundation(Nos.2021 A1515011523,2021B1515120046)the Guangdong MEPP Funds(No.GDNRC[2021]48)+1 种基金the Finance Science and Technology Project of Hainan Province(No.ZDKJ202018)National Natural Science Foundation of China(No.41776169)。
文摘New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the mangrove soil-derived fungus Arthrinium sp.SCSIO 41305.Extensive spectroscopic analysis and X-Ray crystallographic analysis were used to elucidate the structure of(E)-2-(hydroxyimino)-4-methylpentanamide(1),including its absolute configuration.All the isolated compounds(1–12)were evaluated for their antimicrobial and enzyme inhibitory activities against acetylcholinesterase(ACh E),neuraminidase(NAs),and phosphatidylinositol 3-kinase(PI3K).Among them,compounds 1 and 3 exhibited strong neuraminidase inhibitory activity with IC_(50)values of 12.04,1.92μmol L^(-1)(IC_(50)20μmol L^(-1)for oseltamivir acid),while compounds 5,6,8,and 10showed moderate neuraminidase inhibitory activity,and compounds 6–10 displayed weak enzyme inhibitory activities against PI3K.
基金supported by the National Natural Science Foundation of China(No.82003956)the Henan Young Elite Scientists Sponsorship Program(No.2023HYTP032)。
文摘A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL^(−1).
基金supported financially by the National Natural Science Foundation of China(No.81874298)the CAS“Light of West China”program(Pema-Tenzin Puno)the Yunnan Science Fund for Distinguished Young Scholars(2019FJ002).
文摘Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.
