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Surgical Management of Appendicular Endometriosis: A Series of Cases
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作者 Haley Calcagnotto Gabriela Françoes Rostirolla +2 位作者 Arthur Henry Michelon Élvio Heitor Michelon Eduardo Brambilla 《Open Journal of Obstetrics and Gynecology》 2024年第12期1867-1872,共6页
Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity. This tissue, found in the inner lining of the uterus, develops in other pelvic organs, such as the ovaries, ... Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity. This tissue, found in the inner lining of the uterus, develops in other pelvic organs, such as the ovaries, fallopian tubes, peritoneum, and bowel. In cases of deep endometriosis, the appendix may be affected, and consequently, appendectomy becomes a perioperative possibility. From February 2018 to February 2023, the surgical team performed 133 laparoscopic procedures. The number of appendectomies by the time of the surgical procedure was 19.5% (26 cases), with 50% of these (13 cases) confirming the histological presence of appendiceal endometriosis (AE), no increasing of postoperative complications was noticed. This report is important to reinforce multidisciplinary training, review postoperative complications, and provide training in advanced pelvic surgery. Furthermore, it aims to emphasize that appendectomy performed during the surgical act is a safe and viable procedure that does not increase complication rates. 展开更多
关键词 ENDOMETRIOSIS APPENDIX appendicular Endometriosis APPENDECTOMY LAPAROSCOPY
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Appendicular Mucocele: About a Case Observed in Bamako
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作者 Amara Coulibaly Abdoul Karim Simaga +4 位作者 Moussa Sissoko Sekou Koumare Sidiki Konare Mamedy Doumbia Zimogo Zié Sanogo 《Surgical Science》 2022年第12期577-584,共8页
It is a globally rare condition that can present in a variety of clinical syndromes or can occur as an incidental surgical finding. It poses the double problem of its possible malignancy and the risk of gelatinous dis... It is a globally rare condition that can present in a variety of clinical syndromes or can occur as an incidental surgical finding. It poses the double problem of its possible malignancy and the risk of gelatinous disease of the peritoneum in the event of perforation. We report a case treated in the “A” Surgery Department of the Point-G University Hospital Center (CHU) in Mali in 2022. It was a 62-year-old woman, a housewife who presented to the department. “A” surgery at the Point G University Hospital Center for pain in the iliac fossa. As a medical history, she was hypertensive on atenolol and a known diabetic on diet and metformin-based treatment, as well as symptomatic sickle cell disease (AS) and an undocumented history of peptic ulcer disease. The biological assessments revealed hyperleukocyte with granulocyte predominance. C-reactive protein was positive at 32 mg/l. Ultrasound revealed a 27 mm cystic dilation of the appendicitis in favor of appendicular mucocele. We proceeded with the appendix. The surgical specimen containing gelatinous fluid was removed and histological examination was in favor of a mucinous adenocarcinoma of the appendix. 展开更多
关键词 appendicular Mucocele appendicular Tumor BAMAKO
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Appendicular Mucosal Tube Implant with Dartos Wrap Operation for Hypospadias
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作者 Sagar Jawale 《Open Journal of Urology》 2020年第5期134-144,共11页
Aims and Objective: To develop a better operation for hypospadias patients with poor and bad quality urethral plate and damaged urethral plate as in hypospadias cripples. Materials and Methods: I operated 21 cases of ... Aims and Objective: To develop a better operation for hypospadias patients with poor and bad quality urethral plate and damaged urethral plate as in hypospadias cripples. Materials and Methods: I operated 21 cases of hypospadias with Appendicular mucosal tube implant with Dartos wrap operation from 17/04/2017 to 03/03/2019, in Jawale Institute of pediatric Surgery, and that group was labeled as group A. 27 cases of hypospadias were operated in same time span with conventional techniques such as extended Snodgrass operation and Byar’s two-stage operation (group B), kept as control. 7 patients (33.33%) were cases of hypospadias cripples with multiple surgeries done in the past. 4 patients (9.52%) patients had congenital short urethra. Remaining 10 patients (50%) were fresh cases with no operation done in past but with bad and fibrotic urethral plate. The longest follow up was 3 years and the shortest of 1 year. Technique of Operation: Appendicectomy performed by open technique and the serosa of Appendix cut longitudinally and stripped off the mucosal tube. The proximal hypospadias opening sutured with the appendicular mucosal tube with 6 sutures of 5-0 Vicryl. Dartos fascia is raised from the scrotum wrapped over the tube and 8 - 10 interrupted stitches taken with 5-0 Vicryl. Glanuloplasty performed over it. Suprapubic diversion did and kept for 3 weeks postoperatively. Results: In group A, 3 patients developed fistula and only 1 (4.76%) required repair at the end of 6 weeks. 2 (9.52%) patients developed grade 3 infection and settled with conservative treatment. UFR was normal at the end of 12 weeks (12.85 Ml/sec. In group B, 11 patients developed fistula and 9 (33.33%) required repaired. 9 (33.33%) patients developed strictures and all of them required multiple urethral dilatation under GA. 7 (25.92%) patients developed meatal stenosis.UFR was badly reduced with average of 5.78 ML/Sec. Conclusion: The operation proves to be a much better option compared to the conventional for group A patients. We need a series with longer follow up and larger number of patients. 展开更多
关键词 HYPOSPADIAS HYPOSPADIAS Cripples appendicular MUCOSAL TUBE IMPLANT appendicular MUCOSAL TUBE IMPLANT with Dartos Wrap
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Appendicular Abscess in the Service of General Surgery at the Teaching Hospital Gabriel Toure, Bamako, Mali
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作者 Madiassa Konate Traore Amadou +19 位作者 Coulibaly Yacaria Dembele Bakary Tiéntigui Karembe Boubacar Keita Soumaila Amadou Issa Mangane Moustaphissa Diop Thierno Madani Almeimoune Abdoul Hamidou Togo Adégné Pierre Kante Lassana Traore Alhassane Maiga Amadou Bah Amadou Sidibe Boubacaryoro Diamoutene Kolo Tolo Maimouna Samake Moussa Mounimezié Diarra Diakite Ibrahim Diallo Gangaly 《Surgical Science》 2018年第8期281-285,共5页
Objectives: To determine hospital frequency and to write the diagnostic and therapeutic aspects of appendicular abscess in adults in the General Surgery Department of teaching Hospital Gabriel Touré from 2005 to ... Objectives: To determine hospital frequency and to write the diagnostic and therapeutic aspects of appendicular abscess in adults in the General Surgery Department of teaching Hospital Gabriel Touré from 2005 to 2017. Material and Methods: This was a retrospective study conducted from January 1, 2005 to December 31, 2017 in the General Surgery De-partment of Gabriel Touré University Hospital in all patients with appen-dicular abscess. Results: In 13 years, 1420 cases of acute appendicitis have been reported, including 105 cases of appendicular abscess (7.4%). Mean age of the patients was 32 years with extremes of 16 years and 70 years. Abdominal pain and fever were present in all patients. Pain sat in the right iliac fossa in 73.3% and was epigastric in 11.4%. In almost all cases abdominal defense was present (97.1%). There was generalized abdominal contracture in 2.8% of cases. Average duration of evolution was 27 days with extremes of 1 day and 60 days. Ultrasonography was performed in 42.6% of cases and found peri-appendicular effusion in 29 cases (27.6%). 90 incisions were made by incision of Mac Burney, 8 by median umbilical, 7 by midline above and below umbilical. The amount of fluid aspirated was greater than 100 cc in 47 patients. We performed an appendectomy with appendicular stump burying followed by washing plus drainage of the abdominal cavity in 65 patients. Morbidity rate was 14.3%. No deaths were recorded. Average duration of hospitalization was 6.5 days with extremes of 2 days and 26 days. 展开更多
关键词 appendicular ABSCESS ADULT APPENDECTOMY MALI
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Appendicular Abscess in General Surgery at the Bocar Sidi Sall University Hospital in Kati
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作者 Abdoulaye Diarra Koniba Keita +12 位作者 Amadou Traoré Assitan Koné Idrissa Tounkara Issa Traore Souleymane Thiam Fadima K. Tall Daouda Diallo Madiassa Konate Aboubacar Koné Deborah Sanra Sanogo Ismaël Konare Alhassane Traoré Adégné Togo 《Surgical Science》 2020年第12期479-485,共7页
<strong>Introduction:</strong> Appendicular abscess is a progressive complication of acute appendicitis in which the spread of infection is contained by the greater omentum and the slender loops resulting ... <strong>Introduction:</strong> Appendicular abscess is a progressive complication of acute appendicitis in which the spread of infection is contained by the greater omentum and the slender loops resulting in the formation of a true septate abscess of the large peritoneal cavity. <strong>Materials and Methods:</strong> This was a retrospective study from January 2010 to December 2019 carried out at the Bocar Sidi Sall University Hospital in Kati (CHU BSS in Kati) in general surgery. It concerned all patients operated on for appendicular abscess in the department. <strong>Results:</strong> 75 cases of appendicular abscess were collected, which represented 5.76% of surgical emergencies and 25% of acute appendicitis. The average age of the patients was 29 years. The male sex represented 67% of our patients with a sex ratio of 2. The average consultation time was 5 days. Abdominal pain was noted in all patients. It was localized in the right iliac fossa in 80% (n = 60) and diffuse in 2.7% of cases (n = 2). It was accompanied by nausea and vomiting in 93% of cases (n = 70), urinary disorders in 20% (n = 15), fever in 94% (n = 71), cessation of materials and gas in 1.33% (n = 1). Abdominal ultrasound was performed in 86% (n = 65). It made it possible to suggest a peri-appendicular effusion. Biological examination revealed a neutrophilic hyperleukocytosis greater than 20,000/mm3 in 47 patients, or 63%. All the patients were operated on by laparotomy (Marc Burney or midline subumbilical) under general anesthesia. The length of hospitalization was 6 days. We have not recorded any deaths. Morbidity was 8% (n = 6) represented by parietal suppuration. The postoperative course was straightforward in 92% of cases (n = 69). <strong>Conclusion:</strong> Appendicular abscess is a frequent medico-surgical emergency, the prognosis of which depends greatly on early diagnosis and adequate and immediate management. 展开更多
关键词 appendicular Abscess SURGERY Kati MALI
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Peritonitis Management through Appendicular Perforation in the Department of Surgery Bougouni Hospital (Mali)
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作者 Sidiki Keita Koniba Keita +8 位作者 Mahamadou Coulibaly Moussa Sissoko Lamine Soumare Oumar Sacko Sekou Koumaré Adama K. Koita Soumaîla Keita M. Doumbia Dramane Zimogo Zié Sanogo 《Surgical Science》 2020年第12期446-452,共7页
<strong>Introduction:</strong> Appendicular peritonitis is a complication of acute appendicitis characterized by the spread of the infectious process in the peritoneal cavity thus achieving wide spread or ... <strong>Introduction:</strong> Appendicular peritonitis is a complication of acute appendicitis characterized by the spread of the infectious process in the peritoneal cavity thus achieving wide spread or localized purulent peritonitis;it’s a medico-surgical emergency. Our objectives are to determine the frequency, describe the clinical, therapeutic and prognostic aspects of peritonitis by appendicular perforations. <strong>Patients-Method:</strong> This was a 24-month retro, prospective, descriptive study from January 1, 2018 to December 31, 2019;conducted in the Bougouni Reference Health Center Surgery Unit. All patients of appendicular peritonitis at the Bougouni Reference Health Centre were included. <strong>Results:</strong> During the study period, 68 cases of generalized acute peritonitis including 30 appendicular peritonitis cases were collected. Appendicular peritonitis accounted for 44.1% of surgical procedures. Males accounted for 71.0% with a sex ratio of 1.2 at risk of men, the average age was 26.07 years. Abdominal pain and vomiting were the reasons for consultation in 86.7% and 76.7% of cases. Physical examination was used in most cases to make the diagnosis. X-ray of the abdomen without preparation, and abdominal ultrasound were performed systematically. Surgical treatment consisted of an appendectomy with peritoneal toilet followed by drainage. The average length of hospitalization was 8.8 days with extremes of 1 - 44 days. Hospital mortality was 3.3%;morbidity and high mortality were related to delayed consultation. <strong>Conclusion:</strong> Appendicular generalized acute peritonitis is a medical-surgical emergency with a high mortality rate associated with delayed management. 展开更多
关键词 appendicular PERITONITIS Surgical Emergencies APPENDECTOMY
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Appendicular Abscess: Unusual Clinico-Radiological Appearance
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作者 Ayoub Boutahar Imane Oualili +4 位作者 Abderrahim Kamli Othman El Alaoui Abdelhalim Mahmoudi Khalid Khattala Youssef Bouabdallah 《Open Journal of Pediatrics》 CAS 2022年第4期647-651,共5页
Introduction: Appendicitis is the most common surgical emergency in childhood. It’s a common surgical disease that can be presented with a wide variety of atypical clinical features. Clinical Case: We report a case o... Introduction: Appendicitis is the most common surgical emergency in childhood. It’s a common surgical disease that can be presented with a wide variety of atypical clinical features. Clinical Case: We report a case of a 7-year-old female patient admitted for abdominal pain dating back 20 days, radiological exploration suggested a right ovarian teratoma, while laparoscopic exploration has objective an appendicular abscess. Conclusion: This case has allowed us to clarify an atypical case of complicated appendicitis, and also to show the contribution of laparoscopy. 展开更多
关键词 appendicular Abscess Ovarian Teratoma Laparoscopic Exploration
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Appendicular Mucocele with Robotic Partial Typhlectomy and Correction of Rectus Abdominal Muscles’ Diastasis: A Case Report
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作者 Marina Gabrielle Epstein Gabriel Garbato +3 位作者 Gabriel Maccapani Camille Diem Benatti Amanda Domit Dall’Alba Nina Petroni Haiat 《Surgical Science》 2023年第4期289-294,共6页
Low-grade appendiceal mucinous neoplasm (LAMN) is rare, and patients are often asymptomatic or have nonspecific symptoms. Appendicectomy should be performed with care and limited handling of the appendix, with extract... Low-grade appendiceal mucinous neoplasm (LAMN) is rare, and patients are often asymptomatic or have nonspecific symptoms. Appendicectomy should be performed with care and limited handling of the appendix, with extraction of the specimen through an extraction bag to prevent perforation and spillage of mucin, which can result in the development of pseudomyxoma peritonei (PMP). This case report aims to shed light on the approach to appendicular mucocele in contemporary medicine. The reported case shows a presentation of mucocele in a young female patient with symptoms compatible with appendicitis. This case report serves as an example of how to diagnose, manage, and follow-up on appendicular mucocele treatment for colleagues who may encounter similar conditions. 展开更多
关键词 appendicular Mucocele LAMN Diagnosis Treatment
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Appendicular Peritonitis in the General Surgery Department of Gabriel TOURE CHU
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作者 Maïga Amadou Diakité Ibrahima +16 位作者 Bah Amadou Diallo Aly Boubacar Traoré Bathio Moussa Diassana Sidibé Boubacar Yoro Koné Tani Doumbia Arouna Adama Traoré Amadou Saye Zakari Saadé Oumou Hélène Kanté Lassana Konaté Madiassa Dembélé Souleymane Samaké Moussa Dembélé Bakary Tientigui Traoré Alhassane Togo Adégné 《Surgical Science》 2022年第1期9-14,共6页
<span style="font-family:Verdana;">The appendicular peritonitis is complications of acute appendicitis which are characterized by the diffusion of the infectious process to the peritoneal cavity thus c... <span style="font-family:Verdana;">The appendicular peritonitis is complications of acute appendicitis which are characterized by the diffusion of the infectious process to the peritoneal cavity thus carr</span><span style="font-family:Verdana;">ying out a generalized or located purulent peritonitis. It can appear from the start or follow the stage of appendicular abscess.</span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Our objectives were to determine the frequency, to describe the clinic and para clinic aspects, to identify the principal germs and their sensitivities to antibiotics</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> to describe the operative continuations.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Our prospective and descriptive study focused on patients treated for appendicular peritonitis, from January 1</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;"> to December 31</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;"> 2016, in the General Surgery Department of the Hospital of Sikasso.</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">During the period of our study, 31 cases of appendicular peritonitis were collected, which</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">represented 4.36% of surgical interventions, 19.25% of urgent surgeries.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The male sex accounted for 71.0% with a sex-ratio of 2.44 at the risk of males, the average age was of 20 years</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">± 12.99, the abdominal pain + vomiting was the reason for consultation in 54.8% of cases. The physical examination allowed in most </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">cases to make the diagnosis. In doubtful cases some additional examinations have been requested (abdomen without preparation, abdominal ultrasound).</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The surgical treatment consisted of an appendectomy with peritoneal lavage followed by drainage.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The average length of hospital stay was 8.8 days with extremes of 1</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">44 days. Hospital mortality was 9.7%. Delay in consultation and age were factors of morbidity and high mortality.</span></span></span> 展开更多
关键词 appendicular Peritonitis Surgical Emergencies Hospital of Sikasso
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基于孟德尔随机化分析瘦体重与肺功能的双向因果关系及中介因素
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作者 高立轩 潘录录 +6 位作者 朱含章 程志清 林苏进 潘蓉蓉 支英豪 周龙寿 缪江 《浙江临床医学》 2025年第5期719-722,共4页
目的通过双向孟德尔随机化(MR)分析瘦体重(ALM)与肺功能的双向因果关系,并探讨基础代谢率(BMR)的中介效应。方法选取显著差异的单核苷酸多态性(SNPs)作为工具变量,应用以逆方差加权法(IVW)为主的4种孟德尔随机化分析ALM水平与肺功能的... 目的通过双向孟德尔随机化(MR)分析瘦体重(ALM)与肺功能的双向因果关系,并探讨基础代谢率(BMR)的中介效应。方法选取显著差异的单核苷酸多态性(SNPs)作为工具变量,应用以逆方差加权法(IVW)为主的4种孟德尔随机化分析ALM水平与肺功能的双向因果关系,并通过中介分析探究BMR的中介效应。结果正向MR研究IVW方法结果显示:ALM与一秒用力呼气容积(FEV_(1))(OR=1.33,95%CI:1.30~1.35,P<0.05)和呼吸末峰值(PEF)(OR=1.14,95%CI:1.13~1.16,P<0.05)呈正因果关系,反向MR研究IVW方法结果显示:FEV_(1)(OR=1.25,95%CI:1.08~1.45,P<0.05)、用力肺活量(FVC)(OR=1.35,95%CI:1.27~1.43,P<0.05)和PEF(OR=1.18,95%CI:1.11~1.26,P<0.05)与ALM存在正向因果关系。中介分析发现BMR是ALM与肺功能互相影响的中介因素。在ALM对FEV_(1)和PEF的因果影响中BMR中介效应占比分别为28.68%、28.44%。在FEV_(1)、PEF和FVC对ALM的因果影响中BMR中介效应占比分别为51.84%、21.89%、26.32%。结论低ALM可能是PEF和FEV_(1)下降的危险因素,而PEF、FEV_(1)和FVC下降可能增加ALM下降风险。BMR在这一因果联系中存在部分中介作用。 展开更多
关键词 瘦体重 肺功能 孟德尔随机化 中介因素
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黄鳍金枪鱼仔鱼脊柱及附肢骨骼的发育
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作者 王晓东 吕莉欣 +1 位作者 赵恒权 钟俊生 《上海海洋大学学报》 北大核心 2025年第2期333-340,共8页
为了探明黄鳍金枪鱼(Thunnus albacares)脊柱及附肢骨骼的发育特征,基于2022年8月15日—9月9日在菲律宾海用大型仔稚鱼网(口径1.3 m、网目0.5 mm)进行表层水平拖网所采集的黄鳍金枪鱼仔鱼样本,采用软骨-硬骨双染色透明技术,观察了黄鳍... 为了探明黄鳍金枪鱼(Thunnus albacares)脊柱及附肢骨骼的发育特征,基于2022年8月15日—9月9日在菲律宾海用大型仔稚鱼网(口径1.3 m、网目0.5 mm)进行表层水平拖网所采集的黄鳍金枪鱼仔鱼样本,采用软骨-硬骨双染色透明技术,观察了黄鳍金枪鱼仔鱼(前弯曲期9尾,弯曲期12尾,后弯曲期12尾,体长3.1~8.0 mm)脊柱及附肢骨骼的早期发育。结果显示,各鳍形成顺序是胸鳍、尾鳍、第一背鳍和腹鳍、第二背鳍和臀鳍,最后为小鳍;椎体由体前部向尾部逐渐形成;髓弓由体前部向尾部和由体中部向两端生长,脉弓由体中部向两端生长;尾下骨1和2先愈合为一个整体,随后侧尾下骨和尾下骨1+2的基部软骨联合,尾下骨3和4两端愈合,尾下骨5独立;体长8.0 mm个体形成躯椎18枚,尾椎21枚,侧尾下骨1枚,尾下骨5枚,尾上骨2枚。研究表明,侧尾下骨和尾下骨愈合为黄鳍金枪鱼提供了强劲的游泳动力。本研究可作为黄鳍金枪鱼早期阶段的鉴定依据,并为其仔鱼阶段的漂流机制形成提供参考。 展开更多
关键词 黄鳍金枪鱼 骨骼发育 脊柱 附肢骨骼 软骨-硬骨双染色透明技术
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老年人四肢骨骼肌质量指数与肌肉力量的相关性研究:基于2024年全国常态化国民体质监测数据
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作者 肖辰辉 王成龙 +2 位作者 冯强 范超群 王晶晶 《协和医学杂志》 北大核心 2025年第3期627-633,共7页
目的探索老年人四肢骨骼肌质量指数(appendicular skeletal muscle index,ASMI)与肌肉力量的剂量效应关系。方法以2024年全国常态化国民体质监测数据库中60~79岁老年人为研究对象,采用ASMI评价其肌肉质量,采用握力、30 s坐站次数反映其... 目的探索老年人四肢骨骼肌质量指数(appendicular skeletal muscle index,ASMI)与肌肉力量的剂量效应关系。方法以2024年全国常态化国民体质监测数据库中60~79岁老年人为研究对象,采用ASMI评价其肌肉质量,采用握力、30 s坐站次数反映其肌肉力量。控制年龄与体质量指数,对ASMI与握力、30 s坐站次数进行线性回归分析,并应用限制性立方样条模型(restricted cubic spline,RCS)进行剂量效应分析。结果共纳入60~79岁老年人68038名,其中女性占比56.3%,平均年龄(68.0±5.4)岁。男性握力[(33.6±7.8)kg比(23.4±5.6)kg,P<0.001]、ASMI[(13.6±1.3)kg/m^(2)比(11.4±1.2)kg/m^(2),P<0.001]显著高于女性。线性回归分析结果显示,ASMI与握力(β=0.940,95%CI:0.930~0.950,P<0.001)及30 s坐站次数(β=0.008,95%CI:0.005~0.011,P<0.001)均呈显著正相关性,且此相关性在不同性别中均存在。RCS结果显示,老年男性ASMI对握力影响的临界值为13.55 kg/m^(2)(P<0.001),而对30 s坐站次数未呈现出剂量效应关系(P=0.090);老年女性ASMI对握力、30 s坐站次数影响的临界值均为11.25 kg/m^(2)(P均<0.001)。当老年人ASMI低于临界值时,其肌肉力量随ASMI减少而快速下降。结论老年人肌肉质量与肌肉力量间存在显著正相关性。当老年男性ASMI低于13.55 kg/m^(2),老年女性ASMI低于11.25 kg/m^(2)时,应为其提供个性化的肌肉健康干预方案,以降低其肌肉力量下降速度。 展开更多
关键词 四肢骨骼肌质量指数 握力 30 s坐站次数 肌肉质量 肌肉力量 临界值
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糖尿病与左心耳功能和血栓形成相关的研究进展
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作者 孟旭阳 汪芳 《中国循环杂志》 北大核心 2025年第4期402-405,共4页
左心耳是心房颤动(房颤)患者血栓形成的最常见部位,左心耳血栓一旦脱落会引起脑卒中、体循环栓塞等严重并发症。糖尿病不仅是房颤的独立危险因素,还促进了房颤患者左心耳功能受损和血栓形成。本文综述了糖尿病与左心耳功能和血栓形成相... 左心耳是心房颤动(房颤)患者血栓形成的最常见部位,左心耳血栓一旦脱落会引起脑卒中、体循环栓塞等严重并发症。糖尿病不仅是房颤的独立危险因素,还促进了房颤患者左心耳功能受损和血栓形成。本文综述了糖尿病与左心耳功能和血栓形成相关的研究,初步探索潜在机制,旨在寻找可靠的评价和预测指标以及有效的治疗靶点。 展开更多
关键词 左心耳 左心耳重构 左心耳功能 左心耳血栓 糖尿病
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胃癌与肌肉减少症——孟德尔随机化分析
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作者 郑志定 石晓兰 +2 位作者 邹嘉缪 陈彦君 严苏 《智慧健康》 2025年第1期54-59,共6页
目的 采用两样本孟德尔随机化(mendelian randomization,MR)探究胃癌与肌肉减少症相关性状的因果关系。方法 以四肢瘦体重(appendicular lean mass,ALM)、握力作为肌肉减少症的相关性状,获取胃癌、ALM、低握力的全基因组关联研究数据,... 目的 采用两样本孟德尔随机化(mendelian randomization,MR)探究胃癌与肌肉减少症相关性状的因果关系。方法 以四肢瘦体重(appendicular lean mass,ALM)、握力作为肌肉减少症的相关性状,获取胃癌、ALM、低握力的全基因组关联研究数据,选取符合条件的单核苷酸多态性作为工具变量,主要采用逆方差加权(inverse variance weighted,IVW)、MR Egger及加权中位数进行MR分析,并行敏感性分析来验证结果的可靠性。结果 IVW结果显示ALM与胃癌存在因果关系,ALM与胃癌发生风险增加有关(OR=1.102,95%CI[1.015,1.197],P=0.02);未发现低握力与胃癌之间存在因果关系(OR=0.947,95%CI[0.728,1.231],P=0.682)。反向MR分析发现,胃癌与低握力存在潜在因果关系,胃癌与低握力发生风险增加可能有关(OR=1.068,95%CI[1.008,1.131],P=0.026);未发现胃癌与ALM之间存在因果关系(OR=0.990,95%CI[0.969,1.012],P=0.367)。敏感性分析结果表明上述因果关系稳健。结论 胃癌与肌肉减少症相关性状之间存在因果关系,ALM与胃癌发生风险增加有因果关系,胃癌与低握力发生风险增加有潜在因果关系。 展开更多
关键词 孟德尔随机化 胃癌 肌肉减少症 四肢瘦体重 握力
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绝经后骨质疏松症:肌肉质量、握力、四肢骨骼肌质量指数的预测价值
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作者 杨志杰 赵瑞 +6 位作者 杨昊霖 李小韵 李扬博 黄佳纯 林燕平 万雷 黄宏兴 《中国组织工程研究》 北大核心 2026年第5期1073-1080,共8页
背景:绝经后女性骨质疏松症的发病率较高,但目前对于肌肉质量、握力以及这些因素如何影响骨质疏松症的研究尚不充分,它们之间的确切联系尚未明确。目的:探讨绝经后女性骨质疏松症患者的肌肉质量、握力、四肢骨骼肌质量指数与骨密度之间... 背景:绝经后女性骨质疏松症的发病率较高,但目前对于肌肉质量、握力以及这些因素如何影响骨质疏松症的研究尚不充分,它们之间的确切联系尚未明确。目的:探讨绝经后女性骨质疏松症患者的肌肉质量、握力、四肢骨骼肌质量指数与骨密度之间的相关性,并评估这些指标在预测和诊断绝经后骨质疏松症方面的潜在价值。方法:于2023年2月至2024年1月在广州中医药大学第三附属医院门诊根据纳排标准收集83例绝经后女性作为研究对象,收集一般资料,检测骨密度并记录T值、各部位肌肉质量、握力,计算体质量指数和四肢骨骼肌质量指数。按T值及骨折史将患者分为非骨质疏松组(n=17)和绝经后骨质疏松症组(n=66),进行相应的统计学分析。结果与结论:①非骨质疏松组的体质量、体质量指数、腰椎整体骨密度、肌肉质量及四肢骨骼肌质量指数均高于绝经后骨质疏松症组(P<0.05);②肌肉质量与腰椎整体骨密度及各个椎体骨密度之间均呈正相关(P<0.05);③多元逐步线性回归分析表明,体质量和握力与肌肉质量呈线性正相关;身高和肌肉质量与握力呈线性正相关,体质量与握力呈线性负相关;体质量指数与骨密度呈线性正相关,年龄与骨密度呈线性负相关;④受试者工作特征曲线分析显示,肌肉质量(曲线下面积、灵敏度、特异性、临界值分别为0.744,76.50%,74.20%和36.50 kg,P=0.002)和四肢骨骼肌质量指数(曲线下面积、灵敏度、特异性、临界值分别为0.739,82.40%,62.10%和5.81 kg/m^(2),且P=0.002)对绝经后骨质疏松症均具有良好的预测价值。结果显示:肌肉质量及四肢骨骼肌质量指数下降有助于绝经后骨质疏松症发生风险的预测,当绝经后女性肌肉质量<36.50 kg或四肢骨骼肌质量指数<5.81 kg/m^(2)时,就要重视骨质疏松发生的可能,以预防绝经后骨质疏松症的发生。 展开更多
关键词 绝经后骨质疏松症 肌肉质量 握力 四肢骨骼肌质量指数 骨密度 工程化组织构建
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Long-term disease-free survival in a dog with appendicular osteosarcoma
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作者 Kumiko Ishigaki Kazushi Asno +7 位作者 Yoshiya Yoshida Rikiya Nishimura Hiromi Aoki Gentoku Iida Orie Yoshida Mamiko Seki Kenji Teshima Kazuya Edamura 《畜牧与兽医》 北大核心 2012年第S2期62-62,共1页
Postoperative prognosis is generally poor even with adjuvant chemotherapy in dogs with an appendicular osteosarcoma. The purpose of this report was to present the long-term disease-free survival time in a dog with app... Postoperative prognosis is generally poor even with adjuvant chemotherapy in dogs with an appendicular osteosarcoma. The purpose of this report was to present the long-term disease-free survival time in a dog with appendicular osteosarcoma receiving amputation,adjuvant chemotherapy and adoptive immunotherapy. A 12-year-old spayed Golden retriever was referred to our hospital with a suspicion of osteosarcoma in right distal radius. The patient underwent the computed tomography (CT) and incisional biopsy on the next day after the first presentation. The CT revealed the osteolysis in the right distal radius and no metastases in the lungs and lymph nodes. The histopathologic diagnosis was made as an osteosarcoma. On the 13th day after,the patient underwent right forelimb amputation. Six doses of carboplatin (250 mg / m2) were postoperatively administered every 3 weeks. The intravenous infusion of lymphokine-activated killer (LAK) cells suspension was performed every 3 ~ 4 weeks after the adjuvant chemotherapy. At the time of our writing this abstract (on the 880thday after the first presentation),no recurrences and metastases were observed after the 32 transfers of LAK cells. In canine appendicular osteosarcoma,some reports have described that postoperative median survival times were 235 ~ 540 d with adjuvant chemotherapy. In our report,the disease free interval and survival time were prolonged compared with the previous reports. We strongly believed that early diagnosis and surgical intervention and adoptive immunotherapy had a great impact on the improvement of survival time in canine appendicular osteosarcoma. 展开更多
关键词 ADOPTIVE IMMUNOTHERAPY ADJUVANT chemotherapy appendicular osteosarcoma dog LONG-TERM disease-free survival
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中国肿瘤住院患者肌肉减少症调查报告 被引量:1
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作者 宋春花 程好晴 +51 位作者 崔久嵬 许红霞 王昆华 翁敏 郭增清 周福祥 林源 巴一 袁凯涛 胡雯 马虎 李苏宜 冯长艳 李增宁 赵青川 李纪鹏 郑瑾 吕全军 李涛 陈俊强 贺英 高茜 吴静 王辉 姚庆华 杨家君 刘明 宋新霞 陈公琰 丛明华 马文君 余亚英 罗素霞 周岚 乔秋阁 王巍 冯永东 罗琪 邱红 施咏梅 姜海平 齐玉梅 管文贤 陈甲信 黄河 余震 方玉 陈子华 付振明 王畅 李薇 石汉平 《肿瘤代谢与营养电子杂志》 2024年第5期638-650,共13页
目的报告中国恶性肿瘤患者肌肉减少症的流行病学调查结果。方法纳入中国肿瘤营养队列研究常见恶性肿瘤营养状态与临床结局相关性研究(INSCOC)数据库2013年7月至2023年12月86家三级甲等医院19种恶性肿瘤患者61627例。采用亚洲肌肉减少症... 目的报告中国恶性肿瘤患者肌肉减少症的流行病学调查结果。方法纳入中国肿瘤营养队列研究常见恶性肿瘤营养状态与临床结局相关性研究(INSCOC)数据库2013年7月至2023年12月86家三级甲等医院19种恶性肿瘤患者61627例。采用亚洲肌肉减少症工作组(AWGS)2019年肌肉减少症诊断标准诊断肿瘤患者肌肉减少症。χ2检验或Fisher确切概率法分析比较不同特征肿瘤患者肌肉减少症患病情况。结果肿瘤患者中肌肉减少症的患病率为18.1%(11175/61627)。肌肉减少症患病率因肿瘤类型、TNM分期、年龄、性别、地理区域及治疗情况不同而存在差异:消化系统肿瘤患者肌肉减少症患病率较高,其中胰腺癌患者患病率最高[32.4%(311/961)];肌肉减少症患病率随TNM分期增高而增大(P<0.05);70岁以上患者肌肉减少症患病率最高[34.7%(3510/10129)];女性肿瘤患者肌肉减少症患病率高于男性患者[16.1%(5544/34381)比20.7%(5631/27246),P<0.05];东北地区的患者患病率最低[14.7%(2398/16300)],接受手术治疗的患者患病率最高[22.1%(1635/7412)]。此外,在某些肿瘤类型中,不同医疗保险类型、职业、教育水平、民族、居住地的患者肌肉减少症患病率存在显著性差异,文化水平低、农民患者发生肌肉减少症的风险更高。结论本研究首次以大规模数据报告了肿瘤患者肌肉减少症的患病率,消化道系统、老年、农民、低教育水平及进展期肿瘤患者等是发生肌肉减少症的高风险人群。 展开更多
关键词 恶性肿瘤 肌肉减少症 四肢骨骼肌指数 现况调查 患病率 影响因素 老年 消化道系统
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Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients 被引量:1
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作者 De-Qing Chen Yong-Xin Wu +4 位作者 Ying-Xiao Zhang Hai-Ling Yang Huan-Huan Huang Jiang-Yan Lv Qian Xiao 《World Journal of Diabetes》 SCIE 2024年第12期2285-2292,共8页
BACKGROUND Chronic hyperglycemia can damage the microcirculation,which impairs the function of various organs and tissues and predisposes individuals to chronic complications.Sarcopenia(SP)is the age-related decline i... BACKGROUND Chronic hyperglycemia can damage the microcirculation,which impairs the function of various organs and tissues and predisposes individuals to chronic complications.Sarcopenia(SP)is the age-related decline in muscle mass and function that contributes to the sequelae of type 2 diabetes.In particular,diabetic patients are at higher risk of SP because of insulin resistance,chronic inflam-mation,and decreased physical activity.METHODS A retrospective analysis was conducted on 196 middle-aged and elderly male T2DM inpatients in the First Affiliated Hospital of Chongqing Medical University between June 2021 and June 2023,with 60 concurrent healthy individuals as the control group.Differences in general information,blood biochemistry,glyco-sylated hemoglobin,muscle strength,and detection rate of SP were compared between groups.The BMD,appendicular skeletal muscle(ASM),and fat mass,as well as grip strength and gait speed,were determined for each patient,and the ASM index(ASMI)was counted.The quantitative data were subjected to cor-relation and logistic regression analyses to identify risk factors for SP.RESULTS Fifty-one of the 196 middle-aged and elderly male T2DM patients were diagnosed with SP,which accounted for 26.02%.The middle-aged and elderly T2DM patients with SP exhibited a longer diabetes mellitus(DM)course and a lower body mass index(BMI)and 25(OH)D3 compared with the non-SP patients.The T2DM+SP patients exhibited lower BMI,ASM,ASMI,left-and right-hand grip strength,gait speed,and muscle and fat mass of the upper and lower limbs compared with the diabetic non-SP patients.The femoral neck,total hip,and lumbar spine L1-4 BMD were markedly lower in T2DM+SP patients compared with those in the non-SP diabetics.Long-term DM course,low BMI,and low BMD of the femoral neck,lumbar spine L1-4,and total hip were identified as risk factors for the development of SP.CONCLUSION T2DM patients are at risk for SP;however,measures can be taken to prevent the related risk factors. 展开更多
关键词 MALE Type 2 diabetes mellitus SARCOPENIA Bone mineral density appendicular skeletal muscle
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肌少症与绝经后2型糖尿病患者骨质疏松的相关性研究
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作者 张萍 杜益君 +3 位作者 王跃 王艳秋 徐小群 潘天荣 《安徽医科大学学报》 CAS 北大核心 2024年第10期1871-1874,1880,共5页
目的探讨绝经后2型糖尿病(T2DM)患者四肢骨骼肌质量指数(ASMI)与骨质疏松(OP)的相关性。方法选取164例住院绝经后老年T2DM患者,双能X线吸收法(DXA)测定骨密度(BMD)及四肢骨骼肌肌肉质量,ASMI=四肢骨骼肌肌肉质量/身高2(kg/m^(2)),按T值... 目的探讨绝经后2型糖尿病(T2DM)患者四肢骨骼肌质量指数(ASMI)与骨质疏松(OP)的相关性。方法选取164例住院绝经后老年T2DM患者,双能X线吸收法(DXA)测定骨密度(BMD)及四肢骨骼肌肌肉质量,ASMI=四肢骨骼肌肌肉质量/身高2(kg/m^(2)),按T值分为OP组和非OP组,比较两组患者一般资料、生化指标及ASMI并进行Logistic回归、受试者工作特征曲线(ROC)分析。结果与非OP组比较,OP组肌少症(SAC)患病率高(P<0.05);两组年龄、ASMI、体质指数(BMI)、雌二醇(E2)比较,差异有统计学意义(P<0.05);Logistic回归分析显示ASMI[OR=0.133,95%CI(0.029~0.611)]、BMI[OR=0.785,95%CI(0.625~0.985)]、E2[OR=0.967,95%CI(0.942~0.993)]是OP的保护因素。ROC曲线提示,ASMI对OP患病预测的曲线下面积为0.752[95%CI(0.632~0.872),P<0.001],敏感性为87.5%,特异性为47.8%,最佳诊断值为5.52 kg/m^(2)。结论ASMI、BMI、E2减少与OP发生呈正相关,ASMI是OP的重要保护因素,对老年绝经后T2DM患者应早期进行OP筛查及危险因素评估,尽早采取干预措施,降低跌倒、骨折的发生风险。 展开更多
关键词 2型糖尿病 骨质疏松 骨密度 肌少症 四肢骨骼肌质量指数
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骨骼肌质量和肌肉力量对缺血性脑卒中患者神经功能的预测效能评价 被引量:1
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作者 吴登宠 邵湘芝 朱烈烈 《全科医学临床与教育》 2024年第2期128-132,共5页
目的 探讨并评价缺血性脑卒中患者骨骼肌质量和肌肉力量对脑卒中后3个月神经功能预后的预测效能。方法 纳入117例缺血性脑卒中患者,根据脑卒中后3个月的改良Rankin量表(mRS)评分分为预后不良组(54例)和预后良好组(63例),比较两组骨骼肌... 目的 探讨并评价缺血性脑卒中患者骨骼肌质量和肌肉力量对脑卒中后3个月神经功能预后的预测效能。方法 纳入117例缺血性脑卒中患者,根据脑卒中后3个月的改良Rankin量表(mRS)评分分为预后不良组(54例)和预后良好组(63例),比较两组骨骼肌质量、肌肉力量等相关指标的差异。采用Pearson相关分析骨骼肌质量、肌肉力量与mRS评分之间的相关性,采用logistic回归分析ASM/Ht2、握力与神经功能预后之间的关系,同时应用受试者工作特征(ROC)曲线评估其对神经功能预后的预测效能。结果 与预后良好组相比,预后不良组年龄均数较大、国立卫生研究院脑卒中量表(NIHSS)评分均数较高,合并低肌肉质量的患者比例、合并低肌肉力量的患者比例以及同时合并低肌肉质量与低肌肉力量的患者比例均较高;而ASM/Ht2和握力均数则较低,差异均有统计学意义(t分别=3.55、4.94,χ^(2)分别=7.27、20.35、11.51,t分别=-4.40、-9.56,P均<0.05)。ASM/Ht2、握力与mRS评分呈负相关(r分别=-0.56、-0.74,P均<0.05)。多因素logistic回归分析发现,ASM/Ht2和握力大是神经功能预后不良发生的保护因素(OR分别=0.64、0.54,P均<0.05)。ROC分析显示,握力的曲线下面积(AUC)为0.89,明显大于ASM/Ht2的AUC(0.71),差异有统计学意义(Z=3.05,P<0.05)。结论 脑卒中患者发病早期的骨骼肌质量和肌肉力量均与其康复期神经功能不良预后密切相关。骨骼肌质量和肌肉力量对脑卒中患者神经功能预后均具有较好的预测价值,尤其是握力,其预测效能更优。 展开更多
关键词 脑卒中 四肢肌肉含量 握力 神经功能 康复期 预测
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